There are no magic formulas that automatically admit you to, or reject you from, the school of your choice. Rather, your application is like a jigsaw puzzle. Each component—GPA, GRE scores, professional experience, school activities, recommendations—is a different piece of the puzzle.
Outstanding professional experience and personal characteristics may enable you to overcome a mediocre academic record. Conversely, outstanding academic credentials will not ensure your admission to a top-tier program if you do not demonstrate strong relevant skills and experience, as well as solid personal character. Your challenge in preparing your application is to convince the admissions board that all of the pieces in your background fit together to form a substantial and unique puzzle.