The Hard Problem was first produced on the Dorfman stage of the National Theatre, London, on 21 January 2015. The cast in order of speaking was as follows:

Spike Damien Molon

Hilary Olivia Vinall

Amal Parth Thakerar

Leo Jonathan Coy

Julia Rosie Hilal

Ursula Lucy Robinson

Jerry Anthony Calf

Cathy Hayley Canham / Daisy Jacob / Eloise Webb

Bo Vera Chok

Elaine (on screen) Kristin Atherton

Music by J. S. Bach, arranged by Matthew Scott

Director Nicholas Hytner

Designer Bob Crowley

Lighting Designer Mark Henderson

Sound Designer Paul Arditti

Music Supervisor Matthew Scott

Pianist Benjamin Powell

Company Voice Work Jeannette Nelson

Staff Director Zachary James