INDEX
3-R principle
abundance
accumulation
action limit
activated carbon
activational
active
additive
adverse
Alde (River)
altricial
amphibian
American leopard frog (Rana pipiens)
clawed frog (Xenopus laevis)
firebelly toad (Bombina spp.)
frog
frog species (Xenopus tropicalis and Rana temporaria)
green frog (Rana clamitans)
mink frog (Rana septentrionalis)
northern cricket frog (Acris crepitanis)
snapping turtle (Chelydra serpentina)
tiger salamander (Ambystoma tigrinum)
toad (Bufo marinus)
annelid
earthworm
enchytraeid worm
Apopka (Lake)
apoptosis
ARRIVE guidelines
arthropod
terrestrial arthropod
mite
nontarget arthropod
assessment methods
authorization
ban
base set data
binding assay
bioaccumulation
bioaccumulative
bioconcentration factor (BCF)
biological relevance
bird
American kestrel (Falco sparverius)
bald eagle
black guillemot (Cepphus grille)
California quail (Callipepla californica)
Caspian tern (Hydroprogne caspia)
chicken (Gallus gallus)
cormorants
double-crested cormorant
duck
Forster’s tern (Sterna forsteri)
glaucous gull (Larus hyperboreus)
gull
heron
herring gull (Larus argentatus)
Japanese quail (Coturnix japonica)
kakapo (Strigops habroptila)
kestrel
osprey
peregrine falcon (Falco peregrinus)
predatory
quail
raptor
ring-necked dove (Streptopelia risoria)
seagull
starling (Sturnus vulgaris)
swallow
terns
tree swallow (Tachycineta bicolor)
vulture
zebra finch (Taeniopygia guttata)
body burden
Bouin’s fixative
brood
candidate11, 68, 86, 162, 169, 208, 377
candidate list
castrated
chemical
β-boldenone
17α-ethinylestradiol
17β-trenbolone
2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE)
2,3,7,8-TCDD
4-nonylphenol
4-tert-octylphenol
5α-reductase inhibitor
acyl-CoA:retinol acyltransferase
albumen
alkylphenol
amino sugar
androgen
antagonist
anti-androgen
antiestrogen
anti-foulants
anti-fouling
antimicrobial
ARNT
aromatase
atrazine
azadirachtin
benzoylureas
biochemical
biocide/biocidal product
bisphenol A (BPA)
brominated flame retardant
cadmium
cDNA
chemicals policy
chitin
chlorinated pesticide
cholesterol
cholineesterase (ChE)
choriogenin
chromafenozide
classification
commercial chemical
complex cocktails of EDCs
contraceptive
cosmetic
CYP
CYP1A
cypris major protein
cyproterone acetate
cytochrome
DDE
DDT
DDT metabolite
diacylhydrazine
diclofenac
dicofol
dieldrin
diethyl phthalate
diethylstilbestrol (DES)
dioxin
dioxin receptor-mediated antiestrogenic activity
DNA
EDC mixture
eicosanoid
endocrine active substance (EAS)
endocrine disrupting chemical (EDC)
endocrine disruptor (ED)
environmental EDCs
enzyme
epofenonane
epoxiconazole
ethynylestradiol (EE2)
fatty acid
fenarimol
fenoxycarb
fipronil
fire retardants
fluoranthene
flusilazole
flutamide
formulation
GABA-inhibitor
genistein
halofenozide
heavy metals
heptachlor
herbicide
hexachlorobenzene
high production volume (HPV) chemical
HmG-CoA reductase
hormonally-active compound
hormone disruptor
HSP70
H-W antigen
hydroprene
hydroxyatrazine
hydroxyflutamide
ibuprofen
industrial contaminant
inert chemical
insect growth regulators (IGRs)
insecticide
isoflavones
isoprenoids
juvenile hormone mimics
juvenoid
kepone
ketoconazole
kinoprene
lindane
lyase
management measure
medicinal product
medicine
mercury
MeSO2-PCB metabolite
methimazole
methoprene
methoxychlor
methoxyfenozide
methylmercury
monodeiodinase (MDI)
moxestrol
mycoestrogen
non-ortho substituted PCBs
nonylphenol (NP)
nonylphenols ethoxylates (NPEs)
octylphenol (OP)
OH-PCBs
organic contaminant (OC)
organochlorine
organophosphate insecticide
organostannic
organotin
oxygenase enzymes
p,p’-DDE
PCH
PDBE
penta-BDE DE-71 22
perchlorate
perfluorooctane sulfonate (PFOS)
perfluorooctanoic acid (PFOA)
persistent and bioaccumulative and toxic (PBT) compound
persistent contaminant
persistent organic pollutant (POP)
personal care product
pesticide
pharmaceutical
phosphoproteins
phthalate ester
phthalate plasticizers
phytoestrogen
plant growth stimulator
plant protection product
polyaromatic hydrocarbon
polychlorinated biphenyl (PCB)
polychlorinated dibenzodioxin (PCDD)
polychlorinated dibenzofuran (PCDF)
polycyclic aromatic hydrocarbon (PAH)
polymers
potential endocrine disruptors
precocene
priority chemical
priority hazardous substances (PHSs)
priority substances
procymidone
pseudoestrogens
pyrene
pyriproxifen
regulation (chemical)
retene
retinal palmitate
RNA
safener
sesquiterpenoid
simvastatin
SOX9
spiggin
statins
steroid biosynthesis inhibitor
sterol
substance
substance of very high concern (SVHC)
synergist
synthetic chemical
synthetic glucocorticoid (GC)
synthetic hormone
tamoxifen
tebuconazole
tebufenozide
thyroid peroxidase
toxaphenes
triadimenol
tributyltin (TBT)
triclocarban
triphenyltin (TPT)
triprene
uridine diphosphate glucuronosyl transferase (UDPGT)
very persistent and very bioaccumulative (vPvB) substance
veterinary product
vinclozolin
vitamin A
vitellin
vitellogenin (VTG)
xenobiotic
xeno-estrogen
zona radiata protein (ZRP)
cluster analysis
Clyde (Estuary)
coefficient of variation
Community Strategy for Endocrine Disrupters
computational toxicology
confounding factors
Copenhagen workshop
country
Denmark
France
Germany
Italy
Japan
Korea
United Kingdom (UK)
United States of America (USA)
criteria
critical ‘window’
crustacean
Acartia tonsa
Americamysis bahia
Amphiascus tenuiramis
Balanus amphitrite
calanoid
cladoceran
copepod
copepodites
Corophium volutator
crab
Daphnia magna
Daphnia pulex
daphnid
decapod
Echinogammarus marinus
grass shrimp
harpacticoid copepod
Homarus americanus
lobster
Monoporeia affinis
mysid
Mysidopsis bahia
nauplius/nauplii
Neomysis integer
Nitocra spinipes
Palaemonetes pugio
Procambarus clarkii
shellfish
shore crab (Carcinus maenas)
Tisbe battagliai
Uca pugilator
database
decision-making
definition of EDCs
diapause
diet
dimorphism
directive
diversity
DNA microarray
drinking water
duplication of work
early life stage
echinoderm
ecological relevance
ecological studies
economic interest
ecosystem
ecotoxicogenomics
ecotoxicology
effect
adverse health effect
apical
behavioral effect
carcinogenic
causal relationship
cryptorchidism
demasculinization
derived no-effect level (DNEL)
developmental effects
edema
effect assessment
egg shell thinning
endocrine disrupting effect
epigenetic effect
feminization
feminization
feminization of male
genotoxicity
GLEMEDS
goiter
gonadal abnormality
hemorrhage
hermaphroditism
hypospadias
immunogenic
immunological effect
immunomodulatory changes
immunosuppression
immunotoxicity
imposex
intersex
intersexuality
low-dose effect
masculinization
masculinization of female
mixture effect
mutagenic
non-reproductive effect
non-threshold effect
ovotestis
pathological effect
population decline
population impact
pseudohermaphroditism
reduced fertility
reproductive effect
semen quality
side effects
sperm abnormalities
sterility
TBT-induced masculinization of marine snails
testicular dysgenesis syndrome
testis-ova
thyroid perturbation
vitellogenin (VTG) depression
vitellogenin (VTG) induction
effect directed analysis (EDA)
egg-shell
embryo
embryonic staging system
emerging concern
endangered species
endocrine
endocrinology
endpoint
apical
asynchronous development
behavior
biomarker
body weight
chick edema disease
chitobiase activity
courtship behaviors
dancing
demasculinization
development
development rate
developmental abnormalities
ecdysis
eclosion
egg production
embryonic development
emergence
energy balance
fecundity
fertility
fertilization
gametogenesis
gender reversal
gonadal differentiation
gonadal histopathology
gonadogenesis
gonadosomatic index (GSI)
growth
hatching
hind limb length
histopathology
lactation
metamorphosis
molting
mortality
neuroendocrine stress response
offspring production
oogenesis
population size
preputial separation
puberty onset
pupation
reproduction
reproductive success
secondary sexual characteristics
semen volume
sex determination
sex ratio
sex reversal
sexual development
sexual differentiation
sexual maturation
sexual reproduction
singing
spawning
sperm quality
survival
T4 clearance
tail resorption
testosterone clearance
vaginal opening
vitellogenesis
vocalization
yolk deposition
environmental quality standard (EQS)
enzyme-linked immunosorbent assay (ELISA)
epigenesis
estrous cycle
European Union
evidence
causal relationship
cause-and-effect relationship
multicausal etiology
weight of evidence
wildlife/human connection
expert system
exposure
extrapolation
feeding study
feed restriction
female-producing temperature (FPT)
feminization
feminized
field survey
field monitoring
fish
Atlantic salmon (Salmo salar)
eel (Anguilla anguilla)
fathead minnow (Pimephales promelas)
flounder (Platichthys flesus)
gudgeon (Gobio gobio)
least killifish (Heterandria formosa)
medaka (Oryzias latipes)
mummichog (Fundulus heteroclitus)
perch (Perca fluviatilis)
pike (Esox lucius)
poecilid species, e.g. mosquitofish; white sucker, mummichog
rainbow trout (Oncorhynchus mykiss)
roach (Rutilus rutilus)
salmonid
sand goby (Pomatoschistus minutus)
sheepshead minnow (Cyprinodon variegatus)
three-spined stickleback (Gasterosteus aculeatus)
white sucker (Catostomus commersoni)
whitefish (Coregonus lavaretus)
zebrafish (Danio rerio)
food chain
gavage
gene
genome
genomics
Great Lakes
guidance
harmonization
hazard
hazard evaluation
health
herbivore
hermaphroditic
heterogametic
history of endocrine disruption
homeostasis
homogametic
hormone/receptor
17β-estradiol
20-hydroxyecdysone
25-deoxyecdysone
3-dehydroxyecdysone
9-cis-retinoic acid
adrenaline
agonist
androgen
androgen receptor (AR)
androstenedione
antagonist
anti-androgen
antiestrogen
APGWamide
aryl hydrocarbon receptor (AhR)
corticosteroid
corticosterone (B)
corticotrophin-releasing factor (CRF)
cortisol
crustacean hyperglycemic hormone
dihydrotestosterone
ecdysone
ecdysone receptor agonist
ecdysteroid
ecdysteroid receptor
egg-laying hormone
epidermal growth factor (EGF) receptor
ER-β
ER-α
estradiol
estrogen
estrogen receptor (ERs)
estrogenic
estrone
FMRFamide
follicle stimulating hormone (FSH)
glucocorticoid receptor (GR)
glucocorticoid
glucocorticosteroid (GC)
gonadotropin releasing hormone (GnRH)
hormonal cross talk
hormone receptor
hormone-receptor complex
hypothalamic-pituitary-gonadal (HPG) axis
hypothalamic-pituitary-interrenal/adrenal (HPI/HPA) axis
hypothalamic-pituitary-thyroid (HPT) axis
juvenile hormone (JH)
luteinizing hormone (LH)
mandibular organ inhibiting hormone
methyl farnesoate
mineralocorticoid
molt inhibiting hormone
molting hormone
neurohormone
neuropeptide
neuropeptide Y
penis morphogenic factor (PMF)
peptide
pheromone
phytoestrogen
ponasterone A
pregnenolone
progesterone receptor (PRs)
progesterone
progestogen
prolactin
retinoic acid
retinoid
retinoid X receptor (RXR)
retinol
sex hormone
steroid
steroidogenesis
testosterone
testosterone propionate
TH/bZIP
thyroid hormone (TH)
thyroid hormone receptor (THR)
thyroid response element (TRE)
thyroid stimulating hormone (TSH)
thyroxine (T4)
transport protein
transthyretin
triiodothyronine (T3)
vitamin A
vitellogenesis inhibiting hormone
human health
humans
Humber (Estuary)
immortalization
incubation
industry
in ovo
in ovo exposure
insect
Aleochara bilineata
Anopheles gambiae
Anthonomus grandis
aphid
Aphidius rhopalosiphi
blowfly
Bombyx mori
butterfly
Calliphora
carabid beetle
caterpillar
chironomid
Chironomus riparius
Chironomus spp.
Chrysoperla carnea
Coccinella septempunctuata
Coleoptera
Collembola
Diptera
Dipteran larva
dragonfly
Drosophila melanogaster
dung fly
Folsomia candida
Folsomia fimetaria
fruitfly
Heteroptera
honeybee (Apis mellifera)
Hymenoptera
Insecta
instar
Isotoma viridis
lacewing
ladybird
larva
Lepidoptera
Manduca sexta
mosquito
Musca autumnalis
Neuroptera
nonbiting midge
nymph
Odonata
Orius laevigatus
parasitic wasp
pest species
Philonthus cognatus
Poecilus cupreus
predatory bug
rove beetle
Scathophaga stercoraria
silkworm
social insect
springtail
tobacco hornworm
tomato moth (Lacanobia oleracea)
Trichogramma cacoeciae
in silico
integrated testing strategy
intelligent testing strategy
intermolt
in utero
inventory
in vitro
in vivo
Klimisch Criteria
Lake Michigan
Lake Ontario
larva
legislation
Federal Insecticide Fungicide and Rodenticide Act (FIFRA)
Food Quality Protection Act
legislative framework
legislative instrument
Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
Safe Drinking Water Act (1996) and Amendments
UNECE Convention on Long-Range Transboundary Air Pollution
Water Framework Directive (WFD)
lifecycle
livestock
male-producing temperature (MPT)
mammal
Baltic grey (Halichoerus grypus)
bear
Beluga whale (Delphinapterus leucas)
Canadian river otter (Lutra canadensis)
dolphin
European otter (Lutra lutra)
Florida panther (Puma concolor coryi)
harbour seal (Phoca vitulina)
mink (Mustela vison)
mouse
otter
panther
polar bear (Ursus maritimus)
rat
ringed seal (Phoca hispida baltica)
rodent
sea lion
sea otter
seal
Steller’s sea lion (Eumetopias jubatus)
whale
manufacturer
marine
mechanism
additive effect
agonist
agonistic/antagonistic effect
AhR agonist
antagonistic effect
AR antagonist
aromatase enzyme activity
aromatase inhibition
carcinogenic or/and mutagenic or/and toxic to reproduction (CMR)
causal/cause-effect relationship
concentration-response
dose-response
ecdysteroid agonist
ecdysteroid antagonist124
enzyme induction
ER agonist
ER antagonist
feedback inhibition
genotypic sex determination (GSD)
ligand-binding
mechanism of action
metabolic activation
mode of action
non-receptor mediated pathway
retinoid X receptor (RXR) agonist
synergistic effect
teratogenesis
transcriptional activation
Mersey (Estuary)
metabolism
hemi-metabolism
holo-metabolism
metabolite
metabolome
metabolomics
metamorphic climax
microarray
mineral
mixture
model
3D model
exposure model
population models
predictive model
molecular
molecular genetics
mollusk
Aplysia brasiliana
Aplysia californica
Biomphalaria glabrata
Bithynia tentaculata
bivalve
Bolinus brandaris
Busycon caniculatum
cephalopod
Cerastoderma glaucum
clam
Concholepas concholepas
Corbicula fluminea
Crassostrea gigas
Crassostrea virginica
dogwhelk (Nucella lapillus)
Dreissena polymorpha
European fresh water snail (Planorbarius corneus)
freshwater mussel (Elliptio complanata)
gastropod
golden apple snail (Pomacea bridgesi)
Haliotis rufescens
Haliotis sp. 168t
Helix aspersa
Hexaplex trunculus
Hinia reticulata
Ilyanassa obsoleta
Lithoglyphus naticoides
Littorina littorea
Loligo pealeii
Lottia gigantean
Lymnaea palustris
Lymnaea stagnalis
Mercenaria mercenaria
mussel
Mya arenaria
Mytilus edulis
Mytilus galloprovincialis
Nassarius obsoletus
Nassarius reticulatus
Ocenebra erinacea
Octopus vulgaris
Ostrea edulis
oyster
Patinopecten yessoensis
Physa fontinalis
Physella columbiana
Placopecten magellanicus
Potamopyrgus antipodarum
ramshorn snail (Marisa cornuarietis)
rock shell (Thais clavigera)
Ruditapes decussatus
Saccostrea glomerata
Scrobicularia plana
Sepia officinalis
shellfish
snail
Tapes philippinarum
Tegula atra
Thais emarginata
Valvata piscinalis
Viviparus viviparus
multigeneration
Mutual Acceptance of Data (MAD)
negative control
occupational
OECD Conceptual Framework
oral gavage
organ/tissue
abdominal ganglion
accessory sex gland
accessory sex organ
accessory sex tissue
adrenal glands
albumen gland
allantois
androgenic gland
anterior neostriatum
brain
caudodorsal cells
cerebral ganglia
cloaca
corpora allata
Cowper’s gland
cuticle
egg
egg capsule
epididymis/epididymes
exoskeleton
eyestalk
fibroblast
follicle
ganglion
gland
glans penis
gonad
gonadal-adrenal-mesonephros complex
haemolymph/hemolymph
heart
hepatocyte
hypothalamus
levator ani-bulbocavernosus muscle (LABC)
liver
lobus paraolfactorius
mandibular organ
melanocyte
Müllerian duct
muscle
nephric duct
neurula
nucleus magnocellularis
nucleus roustus archistriatalis
oocyte
ovary
pedal ganglion
penis
perivitelline membrane
pituitary
placenta
pleural ganglion
preovarian duct
preseminiferous tubule
prostate
prothoracic gland
seminal vesicle
shell gland
sperm
stem cells
telencephalic nuclei
tendon
testis/testes
thoracic ganglion
thyroid
uterus
vas deferens
ventral prostate
vitelline membrane
Wolffian ducts
X-organ/sinus gland complex
yolk
Y-organ
organizational
organization/program
American Society for Testing and Materials (ASTM)
authority/competent authority
Centre for Environment, Fisheries and Aquaculture Science (CEFAS)
Endocrine Disrupters Testing and Assessment Advisory Group (EDTA)
Endocrine Disruption in Catchments research program (EDCAT)
Endocrine Disruption in the Marine Environment research program (EDMAR)
Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC)
Endocrine Disruptor Screening Program (EDSP)
Enhanced Tack on Endocrine Disruption (ExTEND)
Environment Canada
EU Framework Programme
EU Joint Research Centre (JRC)
European Chemical Industry Council (CEFIC)
European Commission (EC)
European Environment Agency (EEA)
European Food Safety Authority (EFSA)
European Parliament
EU-US Science and Technology Cooperation Agreement
FIFRA Science Advisory Panel
Intergovernmental Forum on Chemical Safety (IFCS)
International Conference on Chemicals Management in May
International Council on Animal Protection in OECD Programmes (ICAPO)
International Labor Organization (ILO)
International Organisation for Standardization (ISO)
International Programme on Chemical Safety (IPCS)
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
Japanese Ministry of the Environment (MoE)
National Coordinators of the OECD Test Guidelines Program
non-governmental organization (NGO)
OECD Business and Industry Advisory Committee (BIAC)
OECD Test Guidelines Program
OECD Validation Management Group (VMG)
OECD Validation Management Group for Ecotoxicity Tests (VMG-eco)
OECD Working Group of the National Coordinators of the Test Guidelines Programme (WNT)
Organization for Economic Cooperation and Development (OECD)
OSPAR Commission’s Strategy for Hazardous Substances
Registration Review Program
Scientific Committee on Toxicology, Ecotoxicology and the Environment (SCTEE)
Strategic Programs on Environmental Endocrine Disrupters (SPEED
ToxCast program
Toxicological Priority Index (ToxPi)
United Kingdom Department for Environment, Food and Rural Affairs (Defra)
United Kingdom Ministry of Agriculture, Fisheries and Food (MAFF)
United Nations Environment Programme (UNEP)
United States Environmental Protection Agency (USEPA)
United States Office of Pesticide Programs (OPP)
United States Office of Research and Development
World Health Organisation (WHO)
osmoregulation
Our Stolen Future
ovarian
oviparous vertebrates
oviposition
painting
paradigm
parasite
parental behavior
parthenogenetic
pathway
phenotypic anchoring
physicochemical
pigmentation
policy
Pollutant Release and Transfer Register (PRTR)
post partum
plasmid-based standard curve
potency
precautionary
precautionary principle
precocial
predicted environmental concentration (PEC)
predicted no-effect concentration (PNEC)
preening
primary cell cultures
prioritization
priority list
priority setting
prometamorphosis
premetamorphosis
protection goal
proteome
proteomics
pubertal
puberty
public concern
quantitative real-time RT-PCR (Q-PCR)
quantitative structure activity relationship (QSAR)
radio-tagged
Ray (River)
regulation
regulatory action
regulatory concern
regulatory framework
regulatory measure
regulatory strategy
reptile
American alligator (Alligator mississippiensis)
red-eared turtle (Trachemys scripta)
turtle
risk
risk assessment
ecotoxicological risk assessment
environmental risk assessment
risk-based
risk management
risk mitigation
risk reduction
screening
sensitivity
sentinel species
sex chromosome
smoltification
socioeconomic
source of contamination
bleached kraft mill effluent
domestic and industrial effluent
dung
food
milk
nectar
paper and pulp mills
pulp mill effluent
sediment
sewage effluent
sewage sludge
soil
waste
wastewater effluents
wastewater treatment plant (WWTP)
water
Sry region
stakeholder
Standard Evaluation Procedure (SEP)
State-of-the-Science Assessment Report
substitution
sustainable
system (biological)
endocrine system
hormone system
immune system
nervous system
neuroendocrine system
reproductive system
Tees (Estuary)
temperature-dependent sex determination (TSD)
testicular
Thames (Estuary)
therapeutic
thermosensitive period (TSP)
threatened species
tiered
toxicity
toxicokinetics
toxicity identification evaluation
toxicity screening and testing
15 day intact male rodent assay
acute testing
Amphibian Development Growth and Reproductive Assay (ADGRA)
Amphibian Metamorphosis Assay (TG
Androgenised Female Stickleback Screen (GD 148)
apical test
caging experiment
cell line assay
Chironomid Lifecycle Test (TG
chronic testing
Daphnia Reproduction Test (TG
egg injection
Endocrine Disruptor Screening Battery
endocrine screening assay
Extended One-Generation Reproductive Toxicity Study (TG
female pubertal assay
Fish
Fish Early Life Stage Test (TG
Fish Full Lifecycle Toxicity Test
Fish Life Cycle Test
Fish Partial Life Cycle Reproduction Test
Fish Sexual Development Test (TG
Fish Short Term Reproduction Assay (TG
Fish Toxicity Testing Framework
Frog Embryo Teratogenesis Assay - Xenopus (FETAX)
gaps in the testing suite
H295R human adenoma cell line assay
Hershberger Assay (TG
high throughput screening
in ovo testing
in vitro testing
in vivo testing
integrated testing strategy
life-cycle test
luciferase trans-activation assay
male pubertal assay
mesocosm experiment
multigeneration test
No Observed Adverse Effect Level (NOAEL)
No Observed Effect Concentration (NOEC)
OECD Test Guideline (TG)
performance criteria
pupariation assay
regulatory testing protocols
Repeated Dose
sensitivity
specificity
standard test guideline
standardization
subcutaneous injection
test method
test order
test protocol
testing strategy
Tier
Tier
Two-Generation Reproductive Toxicity Study
Uterotrophic Assay (TG
validation
variability
whole lake experiment
Xenopus Metamorphosis Assay (XEMA)
training set
transcriptomics
transgenesis
trophic level
Tyne (Estuary)
uncertainty
weight of evidence (WoE)
Weybridge
wildlife
aquatic wildlife
invertebrate
terrestrial wildlife
top-predators
vertebrate
wildlife health
wildlife populations
wildlife species
yeast