TWGL

TWGL (https://github.com/greggman/twgl.js) is an open-source WebGL library that serves to "make using the WebGL API less verbose". For example, here's a simple TWGL demo that shows its intelligible, yet low-level, API on top of WebGL:

const
  canvas = document.getElementById('webgl-canvas'),
  gl = canvas.getContext('webgl'),
  program = twgl.createProgramInfo(gl, ['vertex-shader', 'fragment-shader']),
  arrays = {
    position: [
      -1, -1, 0,
      1, -1, 0,
      -1, 1, 0,
      -1, 1, 0,
      1, -1, 0,
      1, 1, 0
    ],
  },
  bufferInfo = twgl.createBufferInfoFromArrays(gl, arrays);

function draw(time) {
  const { width, height } = gl.canvas;

  twgl.resizeCanvasToDisplaySize(gl.canvas);
  gl.viewport(0, 0, width, height);

  const uniforms = {
    time: time * 0.001,
    resolution: [width, height],
  };

  gl.useProgram(program.program);

  twgl.setBuffersAndAttributes(gl, program, bufferInfo);
  twgl.setUniforms(program, uniforms);
  twgl.drawBufferInfo(gl, bufferInfo);

  requestAnimationFrame(draw);
}

requestAnimationFrame(draw);

You can see the live demo on their GitHub page, which resembles the following: