(Some birth or death dates are approximate)
203 deaths of Perpetua and Felicitas in Carthage
251–356 Antony of Egypt
254 death of Origen
313 Emperor Constantine decrees religious tolerance throughout the Roman Empire
325 Council of Nicaea
325–380 Macrina
325–410 Marcella
331–385 Gregory of Nyssa
340 birth of Melania the elder
347 births of Paula the elder and of Jerome
364 Valens, supporter of Arian Christians, becomes emperor
368–431 Palladius
around 368 birth of Eustochium
379 Melania the elder settles in Jerusalem; Council of Antioch
380 The Emperors Theodosius and Gratian decree Christianity to be official religion of the Roman Empire
383 birth of Melania the younger
386 Jerome, Paula the elder and Eustochium settle in Bethlehem
around 400 birth of Paula the younger
404 death of Paula the elder
410 Sack of Rome by Alaric and the Visigoths; Melania the younger and her husband Pinianus flee to North Africa; death of Melania the elder
417 Melania the younger and Pinianus settle in Jerusalem
419 deaths of Eustochium and (before 419) Laeta
420 death of Jerome
436 Melania the younger visits Constantinople
439 death of Melania the younger