^*Interestingly, Edward Jenner Jr. would become a sickly child with mild mental retardation and would die at age twenty-one of tuberculosis. It has been speculated that secondary infection from the smallpox vaccine may have caused these problems.

^*Doubt has been cast in recent years regarding the originality of Pasteur’s research. A study of his laboratory notebooks by some historians of science has shown a discrepancy between his research data and his published results.