Lizzie Siddal was first performed at the Arcola Theatre, London, on 20 November 2013. The cast was as follows:
| DANTE GABRIEL ROSSETTI | Tom Bateman |
| JOHN RUSKIN/CHARLES HOWELL/MR MITCHELL | Daniel Crossley |
| WILLIAM HOLMAN HUNT | Simon Darwen |
| JOHN EVERETT MILLAIS/MR TEBBS/GREENGROCER | James Northcote |
| LIZZIE SIDDAL | Emma West |
| ANNIE MILLER/GREENGROCER’S MOTHER | Jayne Wisener |
| Director | Lotte Wakeham |
| Set and Costume Designer | David Woodhead |
| Lighting Designer | Howard Hudson |
| Sound Designer | Andrew Graham |
| Casting Director | Emma Green |
| Assistant Director | Georgia Lewis-Smith |
| Production Manager | Andy Reader |
| Stage Manager | Anna Sheard |
| Deputy Stage Manager | Holly Taylor |
| Assistant Stage Manager | Lily Bootman |
| Costume Supervisor | Emily Barratt |
| General Manager | 1505 Management |
| Producers | Copperhead Productions, Peter Huntley Productions |
| Assistant Producer | Annabel Williamson |