| Date | Event |
| 1800 | Thomas Jefferson is elected the third president. |
| 1803 | The Supreme Court hears the landmark case Marbury v. Madison. The Louisiana Purchase more than doubles the size of the United States. |
| 1804 | The Lewis and Clark expedition begins. |
| 1807 | Robert Fulton invents the steamboat. |
| 1808 | James Madison is elected president. |
| 1812 | The United States declares war on Great Britain. |
| 1814 | The Treaty of Ghent is signed to end the War of 1812. |
| 1816 | James Monroe is elected president. |
| 1819 | A major financial crisis, the Panic of 1819, threatens the Era of Good Feelings. |
| 1820 | The Missouri Compromise is accepted by both the North and South, admitting Missouri and Maine to the Union. |
| 1823 | The Monroe Doctrine is issued. |
| 1828 | Andrew Jackson is elected president. The Tariff of 1828 (“Tariff of Abominations”) is enacted. |
| 1831 | Nat Turner’s slave rebellion takes place in Virginia. |
| 1832 | The Tariff of 1832 escalates states’ rights tensions, prompting the Nullification Crisis. |
| 1833 | William Lloyd Garrison founds the American Antislavery Society. |
| 1838–1839 | The Cherokee Indians are forcibly moved west along the Trail of Tears. |
| 1841 | President William Henry Harrison dies while in office, and John Tyler assumes the presidency. |
| 1848 | The Seneca Falls Convention occurs to promote women’s rights. |