CONTENTS

  1. TITLE PAGE
  2. COPYRIGHT NOTICE
  3. DEDICATION
  4. INTRODUCTION
  5. One    One Hundred Years Young
  6. The Mysteries of Aging
  7. What Makes SuperAgers Stay Healthy?
  8. Studying Centenarians
  9. Designing a Study Without a Control Group
  10. Meeting Our First AJ Centenarians and Their Offspring
  11. A Perfect Genome?
  12. Centenarians’ Interactions with Their Environments
  13. Do as I Say, Not as I Do
  14. Two    Why We Age
  15. Recent Theories
  16. The Search for Protection from Aging
  17. Eating Less May Lead to More Healthy Years
  18. Unlocking the Secrets in Fat
  19. Caloric Restriction: A Mixed Bag of Effects
  20. Aging Begins Before We’re Born
  21. SuperAgers’ Top Secrets
  22. Three    Cholesterol: Is More Better?
  23. Unlocking Cholesterol’s Longevity Secrets
  24. Are There Really Good Gene Mutations?
  25. Solving the Mystery of Helpful Gene Mutations
  26. The Benefits of CETP Personified
  27. A Mutation That Adds Years to Life Span?
  28. Four    Growth Hormone: Less Is More
  29. Less Growth May Lead to an Exceptionally Long Life
  30. Growth Hormone Clues from Our Centenarians
  31. Epigenetic Mechanisms Can Increase Longevity
  32. Making the Most of Our Findings
  33. Growth Hormones Don’t “Grow” Life Span
  34. Five    Unraveling the Longevity Mystery Deep Inside Our Cells
  35. A Match Made on Earth
  36. Mitochondria’s Hidden Purpose
  37. Resilient to the End
  38. A CohBar Is Born
  39. Searching for Promising Peptides
  40. Six    The Quest to Prove Aging Can Be Targeted
  41. Choosing an Existing Drug to Prove Our Point
  42. Getting the FDA on Board
  43. How the TAME Study Works
  44. Who’s Going to Pay for All of This?
  45. Metformin Is the Tool, Not the Goal
  46. Seven    Making Eighty the New Sixty
  47. The Price of Progress
  48. Collaboration Is the Key to Speed
  49. Long, Healthy Life Span Versus Immortality
  50. The Gap Between Making Drugs and Making Drugs Available
  51. Eight    Stop the Clock
  52. How Old Is Old?
  53. Use It or Lose It
  54. Antioxidants and Hormesis
  55. Thriving in the Shadow of Stress
  56. Preventing the Loss of Muscle Mass as We Age
  57. Exercise Plus Metformin
  58. Feeding Our Longevity
  59. Hydrating Wisely
  60. Prevent Obesity
  61. Nutraceuticals Are in the Works
  62. The Magic Pills We’ve Been Wishing For
  63. When We Eat Matters
  64. Our DNA Has Something to Say
  65. Stay Mentally Sharp
  66. Other Promising Practices
  67. How to Decide What’s Good for You
  68. Nine    Bright Horizons
  69. The Unparalleled Power of Omics
  70. Personalized Medicine
  71. Advances in Early Detection
  72. Pioneering Explorations
  73. Reversing Cellular Age
  74. Genetic Engineering
  75. ACKNOWLEDGMENTS
  76. INDEX
  77. ABOUT THE AUTHOR
  78. COPYRIGHT