One of the problems with comparing films from different times is the idea of inflation. Movie tickets cost more today than they did five years ago, let alone twenty years ago. So, adjusted for inflation, here are the ten highest-grossing films in the United States based on comic books (as of August 2011).
1 The Dark Knight (2008) $592,028,200
2 Spider-Man (2002) $553,793,400
3 Batman (1989) $501,748,300
4 Spider-Man 2 (2004) $479,465,200
5 Superman (1978) $457,144,300
6 Men in Black (1997) $435,294,900
7 Spider-Man 3 (2007) $389,846,900
8 Iron Man (2008) $322,212,669
9 Iron Man 2 (2010) $312,433,331
10 X-Men: The Last Stand (2006) $253,064,698
Amazingly enough, even adjusted for inflation, The Dark Knight and Spider-Man are still the two highest-grossing comic book movies of all time!