Acquisitions Editor: Julie Goolsby

Product Manager: Tom Gibbons

Vendor Manager: Alicia Jackson

Senior Manufacturing Manager: Benjamin Rivera

Marketing Manager: Alexander Burns

Design Coordinator: Teresa Mallon

Production Service: Integra Software Services, Pvt. Ltd.

Second Edition © 2013 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business

Two Commerce Square

2001 Market Street

Philadelphia, PA 19103 USA

LWW.com

© 2007 by Lippincott Williams & Wilkins, a Wolters Kluwer business.

All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright.

Printed in China

Library of Congress Cataloging-in-Publication Data

Higgins, Edmund S.

Neuroscience of clinical psychiatry: the pathophysiology of behavior and mental illness/Edmund S. Higgins, MD, clinical associate professor of family medicine and psychiatry, Medical University of South Carolina, Charleston, South Carolina, Mark S. George, MD, distinguished professor of psychiatry, radiology, and neurosciences, director, MUSC Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, South Carolina; illustrations by Edmund S. Higgins, MD.—Second edition.

pages cm

Includes bibliographical references and index.

ISBN 978-1-4511-0154-6 (hardback)

1.   Mental illness—Pathophysiology. 2. Psychiatry. I. George, Mark S. (Mark Stork), 1958- II. Title.

RC483.H54 2013

616.89—dc23

2012043162

Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner.

The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug.

Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice.

To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300.

Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6 pm, EST.

10 9 8 7 6 5 4 3 2 1