ACAMPROSATE

BRAND NAMES

Campral

BASIC INFORMATION

Habit forming? No

Prescription needed? Yes

Available as generic? Yes

Drug class: Alcohol-abuse deterrent

USES

Treatment for alcohol dependence. It is used after alcohol withdrawal to help maintain abstinence by reducing cravings. The drug should be part of a complete treatment plan (e.g., counseling, behavior therapy and support of family and friends). The drug does not diminish or eliminate withdrawal symptoms.

DOSAGE & USAGE INFORMATION

How to take:

Delayed-release tablet—Swallow whole with liquid. May be taken with or without food. Do not chew, crush or split tablet.

When to take:

Usually three times a day at the same times each day (such as at mealtimes).

If you forget a dose:

Take as soon as you remember. If it is almost time for the next dose, wait for that dose (don’t double this dose) and resume regular schedule.

What drug does:

Action is not fully understood. It appears to affect chemicals (called neurotransmitters) in the brain and reduces the craving for alcohol.

Time lapse before drug works:

About one week.

Don’t take with:

Any other medicine or any dietary supplement without consulting your doctor or pharmacist.

OVERDOSE

SYMPTOMS:
Diarrhea and possibly other symptoms.
WHAT TO DO:
If person uses much larger amount than prescribed or if accidentally swallowed, call poison control center 1-800-222-1222 for instructions or dial 911 (emergency) for help.

POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO

Life-threatening:

None expected.

Common:  
Diarrhea, dizziness, itching, nausea, gas, bloating, vomiting, abdominal pain, headache, insomnia. Continue. Call doctor when convenient.
Infrequent:  
Depression, anxiety, increase or decrease in sexual desire, rash or other skin reaction, heart palpitations, fainting, muscle pain, swelling (face, feet or ankles). Continue, but call doctor right away.
Rare:  

• Thoughts of suicide or patient talks of suicide.

Discontinue. Get emergency help.

• Low blood pressure, increased heart rate, other symptoms that may occur (can be due to the drug or are a result of alcohol abuse or alcohol withdrawal symptoms).

Continue. Call doctor when convenient.
WARNINGS & PRECAUTIONS

Don’t take if:

You are allergic to acamprosate. Allergic reactions are rare, but may occur.

Before you start, consult your doctor if:

• You have kidney (renal) disease or severe kidney impairment.

• You suffer from depression, have thoughts about suicide or have history of drug abuse.

Over age 60:

No special problems expected.

Pregnancy:

Decide with your doctor if drug benefits justify risk to unborn baby. Risk category C (see here).

Breastfeeding; Lactation; Nursing Mothers:

This drug is generally acceptable with breastfeeding. Discuss risks and benefits with your doctor.

Infants & children up to age 18:

Safety and effectiveness in this age group have not been established. Consult doctor.

Prolonged use:

Talk to your doctor about the need for follow-up medical examinations or laboratory studies to determine drug’s effectiveness and to monitor for symptoms and suicidal thoughts.

Skin & sunlight:

No problems expected.

Driving, piloting or hazardous work:

• Avoid if the drug makes you feel dizzy; otherwise no problems expected.

• If you start drinking alcohol again, avoid driving, piloting or hazardous work.

Discontinuing:

Do not stop taking acamprosate without talking to your doctor. Continue taking acamprosate even if you start drinking alcohol again.

Others:

• Advise any doctor, dentist or pharmacist whom you consult that you take this medicine.

• Drug may affect the accuracy of some medical tests.

• Contact your doctor if you develop symptoms of depression, have suicidal thoughts or start drinking alcohol again.

POSSIBLE INTERACTION WITH OTHER DRUGS
GENERIC NAME OR DRUG CLASS COMBINED EFFECT

None expected.

POSSIBLE INTERACTION WITH OTHER SUBSTANCES
INTERACTS WITH COMBINED EFFECT
Alcohol: None expected, but all alcohol should be avoided.
Beverages: None expected.
Cocaine: Effects unknown. Avoid.
Foods: None expected. Avoid foods that contain alcohol.
Marijuana: Seek medical advice.
Tobacco: None expected.