Chapter 65
References and Resources
CHAPTER 1: DIET AND NUTRITION

Singh GM, et al. Estimated Global, Regional, and National Disease Burdens Related to SugarSweetened Beverage Consumption in 2010. Circulation. Published online ahead of print 0629-15. doi:10.1161/CirculationAHA.114.010636.

CHAPTER 6: NATURAL MEDICINE CABINET

Gray S, et al. Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study. JAMA Int Med. 2015;175(3):401-407. doi:10.1001/jamainternmed.2014.7663.

Meletis ND, Wilkes K. Seasonal Allergies and Asthma: Removing Total Burden for Powerful Symptom Relief and Whole Body Wellness. Townsend Letter, May 2014. Web. Accessed July 15, 2015.

CHAPTER 10: SKIN CARE

Chalopin M, et al. Estrogen Receptor Alpha as a Key Target of Red Wine Polyphenols Action on the Endothelium. PLoS One. 2010 Jan 1;5(1):e8554.

Cho S, et al. Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin In Vivo. Ann Dermatol. 2009;21(1):6-11. doi:10.5021/ad.2009.21.1.6.

Goldfaden D. Revitalize Aging Skin With Topical Vitamin C, Life Extension Magazine, May 2009. Web. Accessed July 15, 2015.

Goldfaden R, Goldfaden, D. Topical Resveratrol Combats Skin Aging, Life Extension Magazine, November 2011. Web. Accessed July 15, 2015.

Look Younger With This Anti-Aging Plant, Institute for Natural Healing, December 2012. Web. Accessed July 15, 2015.

Optimal Skin Protection With Vitamin D, Life Extension Magazine, June 2010. Web. Accessed July 15, 2015.

Potapovich AI, et al. Plant Polyphenols Differentially Modulate Inflammatory Responses of Human Keratinocytes By Interfering With Activation of Transcription Factors Nfkb and Ahr And EGFR-ERK Pathway. Toxicol Applied Pharmacol. 2011 Jul 12.

Surjushe A, et al. Aloe Vera: A Short Review. Indian J Dermatol. 2008;53(4):163-166. doi:10.4103/0019-5154.44785.

Tabassum N, Hamdani M. Plants Used to Treat Skin Diseases. Pharmacogn Rev. 2014 JanJun;8(15):52–60.

CHAPTER 12: HAIR CARE

Norek D. Vitamins and Herbs for Strong, Healthy Hair. Naturalnews.com, January 23, 2012. Web. Accessed July 23, 2015.

CHAPTER 14: AGING

Chowanadisai W, et al. Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis Through Camp Response Element-Binding Protein Phosphorylation and Increased PGC1alpha Expression. J Biol Chem. 2010 Jan 1;285(1):142-152.

Downey M. Powerful Protection Against Cellular Aging, Life Extension Magazine, 2012. Web. Accessed July 15, 2015.

Klatz R, Goldman R. The Harmony Between Naturopathic Medicine and Anti-Aging Medicine. Townsend Letter, February/March 2015. Web. Accessed July 15, 2015.

Misra HS, et al. Pyrroloquinoline-Quinone and Its Versatile Roles in Biological Processes. J Bioscience. 2012 Jun;37(2):313-325.

Mitchell T. Vitamin K: Stunning New Research Shows that Vitamin K May Be One of the Most Extraordinary Anti-aging Vitamins Ever Discovered. Life Extension Magazine, Feb. 2000. Web. Accessed July 15, 2015.

Rahway, S. The Youth Restoring Benefits of NAD+, Life Extension Magazine, November 2014. Web. Accessed July 15, 2015.

CHAPTER 17: ADDICTION

Darvishzadeh-Mahani F, et al. Ginger (Zingiber officinale Roscoe) Prevents the Development of Morphine Analgesic Tolerance and Physical Dependence in Rats. J Ethnopharmacol. 2012 Jun 14;141(3):901-907. doi: 10.1016/j.jep.2012.03.030. Epub 2012 Mar 26.

Joslin, M. Novel Methods to Cure Drug Addiction. Life Extension Magazine, October 2011. Web. Accessed July 15, 2015.

Lee B, et al. Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats. Evid Based Complementary Altern Med. 2014. http://dx.doi.org/10.1155/2014/216503.

Shivani R, et al. The Effect of a Yoga Intervention on Alcohol and Drug Abuse Risk in Veteran and Civilian Women with Posttraumatic Stress Disorder. J Altern Complement Med. 2014 Oct;20(10): 750-756. doi:10.1089/acm.2014.0014.

CHAPTER 18: ADRENAL FATIGUE

Olsson EM, et al. A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract Shr-5 of the Roots of Rhodiola Rosea in the Treatment of Subjects With Stress-Related Fatigue. Planta Med. 2009 Feb;75(2):105-12. doi: 10.1055/s-00281088346. Epub 2008 Nov 18.

CHAPTER 19: ALZHEIMER’S DISEASE

Ahmed A, et al. Cannabinoids in Late-Onset Alzheimer’s Disease, Clin Pharmacol Ther. 2015 Jun;97(6):597-606. Epub 2015 Apr 17.

Nishteswar K, et al. Role of Indigenous Herbs in the Management of Alzheimer’s Disease.Ancient Sci Life. 2014;34:3-7.

Sang Z, et al. Design, Synthesis and Evaluation of Scutellarein-O-Alkylamines as Multifunctional Agents for the Treatment of Alzheimer’s Disease. Eur J Med Chem. 2015 Apr 13;94:348-Epub 2015 Mar 4.

CHAPTER 20: ANEMIA

Ahmed F, et al. Long-Term Intermittent Multiple Micronutrient Supplementation Enhances Hemoglobin and Micronutrient Status More Than Iron + Folic Acid Supplementation in Bangladeshi Rural Adolescent Girls With Nutritional Anemia. J Nutr. 2010 Oct.;140(10):1879-1886.

Deniau AL, et al. Multiple Beneficial Health Effects of Natural Alkylglycerols From Shark Liver Oil. Mar Drugs 2010;8(7):2175-2184.

Haider BA, et al. Effect of Multiple Micronutrient Supplementation During Pregnancy on Maternal and Birth Outcomes. BMC Public Health 2011;11 Suppl 3:S19.

Kelly A, et al. Safety and Efficacy of High-dose Daily Vitamin D3 Supplementation in Children and Young Adults With Sickle Cell Disease, J Ped Hematol Oncol. 2015;37(5) e308.

Low Vitamin D Levels Raise Anemia Risk in Children, Hopkins-Led Study Shows, John’s Hopkins Children’s Center Press Release, Oct. 2013. Web. Accessed July 15, 2015.

Sim JJ, et al. Vitamin D Deficiency and Anemia: A Cross-Sectional Study. Ann Hematol. 2010 May;89(5):447-452.

CHAPTER 21: ANXIETY

Abdali K, et al. HR. Effect of St John’s Wort on Severity, Frequency, and Duration of Hot Flashes in Premenopausal, Perimenopausal and Postmenopausal Women: A Randomized, DoubleBlind, Placebo-Controlled Study. Menopause. 2010 Mar;17(2):326-331.

Hood SD, et al. Effects of Acute Tryptophan Depletion in Serotonin Reuptake InhibitorRemitted Patients With Generalized Anxiety Disorder. Psychopharmacol. (Berl). 2010 Feb;208(2):223-232.

Lipovac M, et al. Improvement of Postmenopausal Depressive and Anxiety Symptoms After Treatment with Isoflavones Derived from Red Clover Extracts. Maturitas. 2010 Mar;65(3):258-261.

Sartori SB, et al. Magnesium Deficiency Induces Anxiety and HPA Axis Dysregulation: Modulation by Therapeutic Drug Treatment. Neuropharmacol. 2012 ;62(1):304-312.

CHAPTER 22: ARTHRITIS

Tao R, et al. Pyrroloquinoline Quinone Slows Down the Progression of Osteoarthritis by Inhibiting Nitric Oxide Production and Metalloproteinase Synthesis. Inflammation 2015 Aug;38(4):1546-1555.

O’Dell J, et al. Therapies for Active Rheumatoid Arthritis after Methotrexate Failure. N Engl J Med 2013; 369:307-318.

Preston W. Rebuild Aging Joints, Life Extension Magazine, 2011. Web. Accessed July 15, 2015.

Qi, Q. Lv et al. Comparison of Tripterygium Wilfordii Hook F With Methotrexate in the Treatment of Active Rheumatoid Arthritis (TRIFRA): A Randomised, Controlled Clinical Trial. Ann Rheum Dis. 2015;74:1078-1086.

CHAPTER 23: BIRTH CONTROL

Pallone SR, Bergus GR. Fertility Awareness-Based Methods: Another Option for Family Planning. J Am Board Fam Med. 2009 Mar-Apr;22(2): 147-157.

CHAPTER 24: BREAST CANCER AND OTHER BREAST DISEASES

Alipour S, et al. Benefits and Harms of Phytoestrogen Consumption in Breast Cancer Survivors.Asian Pac J Cancer Prev. 2015;16(8):3091-3396.

Aragón F. Modification in the Diet Can Induce Beneficial Effects Against Breast Cancer. World J Clin Oncol. 2014 Aug. 10;5(3):455-464.

Bilal I, et al. Phytoestrogens and Prevention of Breast Cancer: The Contentious Debate. World J Clin Oncol. 2014 Oct 10;5(4):705-712.

Brownstein D. Statins More Than Double Breast Cancer Risk. Dr. Brownstein’s Blog. March 25, 2014. Web. Accessed July 2015.

Elgazar AF, et al. Anti-Hyperglycemic Effect of Saffron Extract in Alloxan-Induced Diabetic Rats. Eur J Biol Sci. 2013;5(1):14-22.

Fritz H, et al. Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review. Shioda T, ed. PLoS One. 2013;8(11):e81968.

Gutheil WG, et al.: An Agent Derived from Saffron for Prevention and Therapy for Cancer.Curr Pharm Biotechnol. 2012 Jan;13(1):173-179.

Holtz, M. Novel Citrus Extract Blocks Deadly Cancer Cell Signaling, Life Extension Magazine, July 2011. Web. Accessed July 15, 2015.

How Curcumin Protects Against Cancer, Life Extension Magazine, 2011. Web. Accessed July 15, 2015.

Kim SH, et al. Proposed Cytotoxic Mechanisms of the Saffron Carotenoids Crocin and Crocetin on Cancer Cell Lines. Biochem Cell Biol. 2014 Apr;92(2):105-111.

Luoma ML, et al. Experiences of Breast Cancer Survivors Participating in a Tailored Exercise Intervention: A Qualitative Study. Anticancer Res. 2014 Mar;34(3):1193-1199.

MacDonald B. Improving Breast Cancer Survivorship with Lifestyle Changes. Townsend Letter, August/September 2014. Web. Accessed July 15, 2015.

Provos J. Anticancer Properties of Saffron, Life Extension Magazine, March 2015. Web. Accessed July 15, 2015.

Teegarden D, et al. Redefining the Impact of Nutrition on Breast Cancer Incidence: Is Epigenetics Involved? Nutr Research Rev. 2012;25(1):68-95.

Woo, HD, et al. Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status. Nutr Cancer 2012;64(2)198-205.

CHAPTER 25: CERVICAL DYSPLASIA, FIBROIDS, AND REPRODUCTIVE SYSTEM CANCERS

Merritt M, et al. Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses’ Health Study (NHS) and NHSII. Cancer Epidemiol Biomarkers Prev. 2015 Feb. 24;466-471; doi:10.1158/1055-9965. EPI-14-0970.

Piyathilake CJ, et al. Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation–Associated Risk of Developing Higher Grades of CIN. Cancer Prev Res. 2014 Nov. 7;1128-1137. doi: 10.1158/1940-6207.

Roshdy E. Treatment of Symptomatic Uterine Fibroids With Green Tea Extract: A Pilot Randomized Controlled Clinical Study. Int J Womens Health 2013;5:477–486. Published online 2013 Aug 7. doi: 10.2147/IJWH.S41021.

Zhang D. Antiproliferative and Proapoptotic Effects of Epigallocatechin Gallate on Human Leiomyoma Cells. Fertil Steril. 2010 Oct;94(5):1887-1893. doi:10.1016/ j.fertnstert.2009.08.065. Epub 2009 Oct 12.

CHAPTER 26: CHRONIC FATIGUE SYNDROME

Belcaro G, et al. Improved Management of Primary Chronic Fatigue Syndrome With the Supplement French Oak Wood Extract (Robuvit®): A Pilot, Registry Evaluation. Panminerva Med. 2014 Mar;56(1):63-72.

Brewer JH, et al. Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome. Toxins 2013;5(4):605–617. doi:10.3390/toxins5040605.

Coenzyme Q10 Levels Reduced in Chronic Fatigue Syndrome. Life Extension Update, February 2010. Web. Accessed July 15, 2015.

Franco M. New Option for Chronic Fatigue Syndrome. Life Extension Magazine, December 2014. Web. Accessed July 15, 2015.

Leong PK, et al. Yang/Qi Invigoration: An Herbal Therapy for Chronic Fatigue Syndrome with Yang Deficiency? Evid. Based Complementary Altern Med. 2015;945901. doi:10.1155/2015/945901.

CHAPTER 27: DEPRESSION

Lewis JE, et al. The Effect of Methylated Vitamin B Complex on Depressive and Anxiety Symptoms and Quality of Life in Adults with Depression. ISRN Psychiatry. 2013; 621453.

Naqvi SH, et al. Predictors of Depression in Women With Polycystic Ovary Syndrome. Arch Womens Ment Health. 2015 Feb;18(1):95-101. doi: 10.1007/s00737-014-0458-z.

Prousky JE. The Manifestations and Triggers of Mental Breakdown, and its Effective Treatment by Increasing Stress Resilience With Psychosocial Strategies, Therapeutic Lifestyle Changes, and Orthomolecular Interventions. Townsend Letter. February/ March 2015. Web. Accessed July 15, 2015.

Stough C, et al. The Effect of 90 Day Administration of a High Dose Vitamin B-Complex on Work Stress. Hum Psychopharmacol. 2011;26:470–476.

CHAPTER 28: DEMENTIA

Chen LP, et al. Clinical Research on Comprehensive Treatment of Senile Vascular Dementia.J Tradit Chin Med. 2011;31(3):178-181.

Jesky R, Hailong C. Are Herbal Compounds the Next Frontier for Alleviating Learning and Memory Impairments? An Integrative Look at Memory, Dementia and the Promising Therapeutics of Traditional Chinese Medicines. [Review]. Phytother Res. 2011;25(8):1105-1118. doi: 10.1002/ptr.3388.

Perry E, Howes MJ. Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging? CNS Neurosci Ther. 2011 Dec;17(6):683-698. Doi: 10.1111/J.1755-5949.2010.00202.X. Epub 2010 Oct 18.

Samaras N, et al. Dementia Prevention: Potential Treatments and How to Target High Risk Patients. Rev Med Suisse. 2013; 9(387):1116-1119.

Wang BS, et al. Effectiveness of Standardized Ginkgo Biloba Extract on Cognitive Symptoms of Dementia With a Six-Month Treatment: A Bivariate Random Effect Meta-Analysis. Pharmacopsych. 2010;43(3):86-91.

CHAPTER 29: DIABETES

Morstein M. The Role of Nutritional and Botanical Agents in the Management of Type 2 Diabetes Mellitus. Townsend Letter, April 2014. Web. Accessed July 15, 2015.

Neelakantan N. Effect of Fenugreek (Trigonella Foenum-Graecum L.) Intake on Glycemia: A Meta-Analysis of Clinical Trials. Nutr. J. 2014;13:7. doi:10.1186/1475-2891-13-7.

Kelleher S, et al. Zinc in Specialized Secretory Tissues: Roles in the Pancreas, Prostate, and Mammary Gland. Adv Nutr. 2011;(2):101-111. doi: 10.3945/an.110.000232.

Rungseesantivanon S, et al.. Curcumin Supplementation Could Improve Diabetes-Induced Endothelial Dysfunction Associated With Decreased Vascular Superoxide Production and PKC Inhibition. BMC Complement Altern Med. 2010;10:57.

Szkudelski T, Szkudelska K. Anti-Diabetic Effects of Resveratrol. Ann N Y Acad Sci. 2011 Jan;1215:34-39. doi:10.1111/j.1749-6632.2010.05844.x.

Takikawa M, et al. Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity Via Activation of AMP-Activated Protein Kinase in Diabetic Mice. J Nutr. March 2010;140(3)527–533.

CHAPTER 30: DIGESTIVE DISORDERS

Dinleyici EC, et al.. Effectiveness and Safety of Saccharomyces Boulardii for Acute Infectious Diarrhea. Exp Opin Biol Ther. 2012 April;(12)4:395-410. doi:10.1517/14712598. 2012.664129.

Fahey JW, et al. Protection of Humans by Plant Glucosinolates: Efficiency of Conversion of Glucosinolates to Isothiocyanates by the Gastrointestinal Microflora. Cancer Prev Res. 2012 April(5):603-611. Published OnlineFirst February 7, 2012. doi:10.1158/1940-6207.CAPR11-0538.

Ishikawa H. Beneficial Effects of Probiotic Bifidobacterium and Galacto-Oligosaccharide in Patients With Ulcerative Colitis: A Randomized Controlled Study. Digestion. 2011;84(2):128133. doi: 10.1159/000322977. Epub 2011 Apr 28.

Parekh, PJ. The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease. Clin Trans Gastroenterol. (2015) 6, e91. doi:10.1038/ctg.2015.16. Published online June 18, 2015.

Saez-Lara MJ, et al. The Role of Probiotic Lactic Acid Bacteria and Bifidobacteria in the Prevention and Treatment of Inflammatory Bowel Disease and Other Related Diseases: A Systematic Review of Randomized Human Clinical Trials. BioMed Res Intern. 2015;2015:505878. doi:10.1155/2015/505878.

Stokel K. Block Acid Reflux to Prevent Esophageal Problems. Life Extension Magazine, November 2013. Web. Accessed July 15, 2015.

Triantafillidis JK, et al. The Role of Enteral Nutrition in Patients with Inflammatory Bowel Disease: Current Aspects. BioMed Res Intern. 2015;2015:197167. doi:10.1155/2015/197167.

CHAPTER 31: EATING DISORDERS

Carei TR, et al. Randomized Controlled Clinical Trial of Yoga in the Treatment of Eating Disorders. J Adolesc Health. 2010 Apr;46(4):346-351.

Ozier AD, Henry BW. Position of the American Dietetic Association: Nutrition Intervention in the Treatment of Eating Disorders. J Am Diet Assoc. 2011 Aug;111(8):1236-1241.

Setnick J. Micronutrient Deficiencies and Supplementation in Anorexia and Bulimia Nervosa: A Review of Literature. Nutr Clin Pract. 2010 Apr;25(2):137-142.

Vancampfort D, et al. A Systematic Review of Physical Therapy Interventions for Patients With Anorexia and Bulemia Nervosa. Disabil Rehabil. 2014; 36(8):628-634.

CHAPTER 32: ENDOMETRIOSIS

Kong S, et al. The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism. Evid-Based Complementary Altern Med, 2014:146383. doi:10.1155/2014/146383.

Rudzitis-Auth J, et al. Resveratrol is a Potent Inhibitor of Vascularization and Cell Proliferation in Experimental Endometriosis. Human Reprod. 2013;28(5):1339–1347.

Wang CC, et al. Prodrug of Green Tea Epigallocatechin-3-Gallate (Pro-EGCG) as a Potent Anti-Angiogenesis Agent for Endometriosis in Mice. Angiogen. 2013;16(1):59–69.

Xiang DF, et al., Effect of Abdominal Acupuncture on Pain of Pelvic Cavity in Patients With Endometriosis. Chin Acupun Moxibust. 2011;31(2):113–116.

Zhang Z, et al. Therapeutic Potential of Wenshen Xiaozheng Tang, A Traditional Chinese Medicine Prescription, For Treating Endometriosis. Reprod Sci. 2013;20(10):1215–1223.

CHAPTER 33: ENVIRONMENTAL ILLNESS

Forsgren S, et al. Mold and Mycotoxins: Often Overlooked Factors in Chronic Lyme Disease. Townsend Letter, July 2014. Web. Accessed July 15, 2015.

Peterson BS, et al. Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood. JAMA Psychiatry. 2015;72(6):531-540.

CHAPTER 34: FIBROMYALGIA

Arranz LI, et al. Fibromyalgia and Nutrition, What Do We Know? Rheumatol Int. 2010 Sep;30(11):1417-1427.

Bagis S, et al. Is Magnesium Citrate Treatment Effective on Pain, Clinical Parameters and Functional Status in Patients With Fibromyalgia? Rheumatol Int. 2013 Jan;33(1):167-172.

Cordero MD, et al. Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement. PLoS One. 2012;7(4): e35677. doi:10.1371/journal.pone.0035677.

Curtis K, et al. An Eight-Week Yoga Intervention is Associated With Improvements in Pain, Psychological Functioning and Mindfulness, and Changes in Cortisol Levels in Women With Fibromyalgia. J Pain Research. 4:189–201. Epub July 2011.

Jones KD, et al. A Randomized Controlled Trial of 8-Form Tai Chi Improves Symptoms and Functional Mobility in Fibromyalgia Patients. Clin Rheum. 2012;31(8):1205–1214.

Klatz RK, Goldman R. An Anti-Aging Approach to Fibromyalgia. Townsend Letter, December 2011. Web. Accessed July 15, 2015.

Onieva-Zafra MD, et al. Effect of Music as Nursing Intervention for People Diagnosed With Fibromyalgia. Pain Manag Nurs. Published online: 29 Nov 2010.

van Middendorp H, et al. The Effects of Anger and Sadness on Clinical Pain Reports and Experimentally-Induced Pain Thresholds in Women With and Without Fibromyalgia. Arthritis Care Res. 2010 Oct;62(10).

Wang C, et al. A Randomized Trial of Tai Chi for Fibromyalgia. N Engl J Med. 2010 Aug;363:743–754.

CHAPTER 36: HEART DISEASE

Ahmadi N, et al. Aged Garlic Extract With Supplement is Associated With Increase in Brown Adipose, Decrease in White Adipose Tissue and Predict Lack of Progression in Coronary Atherosclerosis. Int J Cardio. 2013 Mar 1. Published online: Mar 4, 2013.

Bernstein AM, et al. Major Dietary Protein Sources and Risk of Coronary Heart Disease in Women. Circulation, 2010 Aug;122(9):873-883. Epub 2010 Aug. 16.

Chiuve SE, et al. Plasma and Dietary Magnesium and Risk of Sudden Cardiac Death in Women. Am J Clin Nutr. 2011 Feb;93(2):253-260. doi: 10.3945/ajcn.110.002253. Epub 2010 Nov 24.

Healy GN, et al. Sedentary Time and Cardio-Metabolic Biomarkers in US Adults: NHANES 2003–06. Eur Heart J. 2011 Jan. doi:10.1093/eurheartj/ehq451.

Klatz R, Goldman R. Women Take Heart: An Anti-Aging Approach to Heart Disease.Townsend Letter, April 2011, Web. Accessed July 15, 2015.

Rautiainen S, et al. Multivitamin Use and the Risk of Myocardial Infarction: A Population-Based Cohort of Swedish Women. Am J Clin Nutr. 2010 Nov;92(5):1251-1256. doi: 10.3945/ajcn.2010.29371. Epub 2010 Sep 22.

Uryash A, et al. Non-Invasive Technology That Improves Cardiac Function after Experimental Myocardial Infarction: Whole Body Periodic Acceleration (pGz). PLoS One. 2015 Mar 25;10(3):e0121069. doi: 10.1371/journal.pone.0121069.

CHAPTER 37: HERPES

Antoine TW, et al. Prophylactic, Therapeutic and Neutralizing Effects of Zinc Oxide Tetrapod Structures Against Herpes Simplex Virus Type-2 Infection. Antiviral Res. 2012; 96: 363-375.

Bertol JW, et al. Antiherpes Activity of Glucoevatromonoside, A Cardenolide Isolated From a Brazilian Cultivar of Digitalis Lanata. Antiviral Res. 2011 Oct;92(1):73-80. doi: 10.1016/j.antiviral.2011.06.015.

Health Concerns: Herpes and Shingles. Life Extension website. Accessed July 20, 2015.

Nolkemper S, et al. Mechanism of Herpes Simplex Virus Type 2 Suppression by Propolis Extracts. Phytomed 2010;17:132-138.

Stahl W, Helmut S. B-Carotene and Other Carotenoids in Protection From Sunlight. Am J Clin Nutr., 2012; 96(suppl):1179S-84S.

CHAPTER 38, HIV/AIDS

Health Concerns; HIV/AIDS, Life Extension. Web. Accessed July 15, 2015.

Helfer M, et al. The Root Extract of the Medicinal Plant Pelargonium sidoides Is a Potent HIV1 Attachment Inhibitor. PLoS One. 2014 Jan(9):1. e87487. doi:10.1371/journal.pone. 0087487.

Miller TL, et al. The Effect of a Structured Exercise Program on Nutrition and Fitness Outcomes in Human Immunodeficiency Virus-Infected Children. AIDS Res Hum Retroviruses. 2010 Mar;26(3):313-319. doi: 10.1089/aid.2009.0198.

Peters BS, et al. The Effect of a 12-Week Course of Omega-3 Polyunsaturated Fatty Acids on Lipid Parameters in Hypertriglyceridemic Adult HIV-Infected Patients Undergoing HAART: A Randomized, Placebo-Controlled Pilot Trial. Clin Ther. 2012 Jan;34(1):67-76. doi: 10.1016/j.clinthera.2011.12.001. Epub 2011 Dec 31.

Veljkovic M, et al. Aerobic Exercise Training As a Potential Source of Natural Antibodies Protective Against Human Immunodeficiency Virus-1. Scand J Med Sci Sports. 2010;(20)3:469474. doi: 10.1111/j.1600-0838.2009.00962.x

CHAPTER 40: INFERTILITY

Brogan K. Is Wheat Making You Wait for Babies? The Gluten Infertility Link. GreenMedInfo. December 15, 2013. Web. Accessed July 20, 2015.

Chavaroo JE, et al. Use of Multivitamins, Intake of B Vitamins and Risk of Ovulatory Infertility. Fertil Steril. 2008 Mar;89(3):668–676.

Choi JM, et al. Increased Prevalence of Celiac Disease in Patients with Unexplained Infertility in the United States: A Prospective Study. J Reprod Med. 2011;56(5-6):199-203.

Rice AD, et al. Ten-year Retrospective Study on the Efficacy of a Manual Physical Therapy to Treat Female Infertility. Altern Ther Health Med. 2015 Feb 17. pii: at5233. [Epub ahead of print]

CHAPTER 41: LUPUS

Jordan N, et al. Progress with the Use of Monoclonal Antibodies for the Treatment of Systemic Lupus Erythematosus. Immunother. 2015 Mar;7(3):255-270. doi: 10.2217/imt.14.118.

Kuhn A., et al., Photoprotective Effects of a Broad-Spectrum Sunscreen in Ultraviolet-Induced Cutaneous Lupus Erythematosus: A Randomized, Vehicle-Controlled, Double-Blind Study. J Amer Acad Derm. 2011;64(1):37-48.

Kurien BT, et al. Heat-Solubilized Curry Spice Curcumin Inhibits Antibody-Antigen Interaction in In Vitro Studies: A Possible Therapy to Alleviate Autoimmune Disorders. Molec Nutr Food Research 2010;54(8):1202-1209.

Lupus: Systemic Lupus Erythematosus (SLE). Life Extension website. Accessed July 20, 2015.

Muangchan C, et al. Treatment Algorithms in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2015 Mar 16. doi: 10.1002/acr.22589. [Epub ahead of print]

Paintoni S, et al. Phenotype Modifications of T-Cells and Their Shift Toward a Th2 Response in Patients With Systemic Lupus Erythematosus Supplemented With Different Monthly Regimens of Vitamin D. Lupus. 2015 Apr;24(4-5):490-498. doi: 10.1177/0961203314559090.

Terrier B, et al. Restoration of Regulatory and Effector T Cell Balance and B Cell Homeostasis in Systemic Lupus Erythematosus Patients Through Vitamin D Supplementation. Arthritis Res Ther. 2012 Oct 12;14(5):R221.

Xu JJ, et al. Vitamin D Analog EB1089 Could Repair the Defective Bone Marrow-Derived Mesenchymal Stromal Cells in Patients With Systemic Lupus Erythematosus. Int J Clin Exp Med. 2015;8(1):916-921.

CHAPTER 43: MENOPAUSE

Erkkola R, et al. A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Pilot Study on the Use of a Standardized Hop Extract to Alleviate Menopausal Discomforts. Phytomed. 2010 May;17(6):389-396.

Hagner-Derengowska M, et al. Effects of Nordic Walking and Pilates Exercise Programs on Blood Glucose and Lipid Profile in Overweight and Obese Postmenopausal Women in an Experimental, Nonrandomized, Open-label, Prospective Controlled Trial. Menopause. 2015 Mar[Epub ahead of print]

Manson JE, et al. Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials. JAMA. 2013 Oct 2;310(13):1353-1368.

Nadil A. Safely Manage Menopausal Symptoms. Life Extension Magazine, August 2014. Web. Accessed July 20, 2015.

Nahidi F, et al Effects of Licorice on Relief and Recurrence of Menopausal Hot Flashes. Iran J Pharm Res. 2012 Spring;11(2):541-548.

CHAPTER 44: MENSTRUAL CRAMPS AND IRREGULAR MENSTRUATION

Chao MT, et al. An Innovative Acupuncture Treatment for Primary Dysmenorrhea: A Randomized, Crossover Pilot Study. Altern Ther Health Med. 2014 Jan-Feb;20(1):49-56.

Daily JW, et al. Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Pain Med. 2015 Jul 14. doi: 10.1111/pme.12853. [Epub ahead of print]

CHAPTER 45: MIGRAINES

Gaul C, et al. Improvement of Migraine Symptoms With a Proprietary Supplement Containing Riboflavin, Magnesium and Q10: A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial. J Headache Pain. 2015 Dec;16:516. Doi: 10.1186/S10194-015-0516-6. Epub 2015 Apr 3.

Jackson JL, Kuriyama A, Hayashino Y. Botulinum toxin A for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis. JAMA. 2012;307(16):1736-1745

Shaik MM, Gan SH. Vitamin Supplementation as Possible Prophylactic Treatment Against Migraine With Aura and Menstrual Migraine. Biomed Res Int. 2015;2015:469529. Doi: 10.1155/2015/469529. Epub 2015 Feb 28.

Wells RE, et al. Complementary and Alternative Medicine Use Among Adults with Migraines/ Severe Headaches. Headache. 2011;51(7):1087-1097. doi:10.1111/j.1526-4610.2011.01917.x.

CHAPTER 46: MULTIPLE SCLEROSIS

Fonseca-Kelly Z, et al. Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis. Front Neurol. 2012;3:84. Epub 2012 May 24.

Herges K, et al. Neuroprotective Effect of Combination Therapy of Glatiramer Acetate and Epigallocatechin-3-Gallate in Neuroinflammation. PLoS One. 2011;6(10):e25456. Epub 2011 Oct 13.

Kozela E, et al. Cannabidiol Inhibits Pathogenic T Cells, Decreases Spinal Microglial Activation and Ameliorates Multiple Sclerosis-Like Disease in C57BL/6 Mice. Br J Pharmacol. 2011 Mar 30. Epub 2011 Mar 30.

Marchese, M. Multiple Sclerosis: Environmental Factors and Treatments – Part 2. Townsend Letter, December 2012. Web. Accessed July 20, 2015.

Shindler KS, et al. Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis. J Neuroophthalmol. 2010;30(4):328–339.

Yadav V, et al. Complementary and Alternative Medicine for the Treatment of Multiple Sclerosis. Expert Rev Clin Immunol. 2010; 6(3):381–395.

CHAPTER 48: OBSESSIVE-COMPULSIVE DISORDER

Kisely S, et al. Deep Brain Stimulation for Obsessive Compulsive Disorder: A Systematic Review and Meta-Analysis. Psych Med. 2014; 44(16):3533-3542.

Rector NA, et al. A Pilot Test of the Additive Benefits of Physical Exercise to CBT for OCD. Cogn Behav Ther. 2015 Jun;44(4):328-340. doi: 10.1080/16506073.2015.1016448. Epub 2015 Mar 4.

Valizadeh M, Valizadeh N. Obsessive Compulsive Disorder as Early Manifestation of B12 Deficiency. Indian J Psychol Med. 2011 Jul;33(2):203-204.

CHAPTER 49: OSTEOPOROSIS

Bolland MJ, et al. Effect of Calcium Supplements on Risk of Myocardial Infarction and Cardiovascular Events: Meta-Analysis. BMJ. 2010;341:c3691.

Gaby A. Do Calcium Supplements Cause Cardiovascular Disease? Townsend Letter, January 2011. Web. Accessed July 20, 2015.

Hooshman S, et al. Comparative Effects of Dried Plum and Dried Apple on Bone in Postmenopausal Women. Br J Nutr. 2011 Sep;106(6):923-930. doi: 10.1017/ S000711451100119X. Epub 2011 May 31.

CHAPTER 50: PARKINSON’S DISEASE

Butt MS, Sultan MT. Coffee and Its Consumption: Benefits and Risks. Crit Rev Food Sci Nutr. 2011 Apr;51(4):363-373.

Cassani E, et al. Use of Probiotics for the Treatment of Constipation in Parkinson’s Disease Patients. Minerva Gastroenterol Dietol. 2011 Jun;57(2):117-121.

Dobkin RD, et al. Cognitive-Behavioral Therapy for Depression in Parkinson’s Disease: A Randomized, Controlled Trial. Am J Psychiatry. 2011 Jun 15. [Epub ahead of print]

Gao, X. Habitual Intake of Dietary Flavonoids and Risk of Parkinson Disease. Neurology. 2012 Apr 10;78(15):1138-1145.

Lau YS, et al. Neuroprotective Effects and Mechanisms of Exercise in a Chronic Mouse Model of Parkinson’s Disease With Moderate Neurodegeneration. Eur J Neurosci. 2011 Apr;33(7):1264-1274. doi: 10.1111/j.1460-9568.2011.07626.x. Epub 2011 Mar 7.

Li F, et al. Tai chi and Postural Stability in Patients with Parkinson’s Disease. New Engl J Med. 2012;366:511–519.

Lieu CA, et al. A Water Extract of Mucuna Pruriens Provides Long-Term Amelioration of Parkinsonism With Reduced Risk for Dyskinesias. Parkinsonism Relat Disord. 2010 Aug;16(7):458-465. Epub 2010 May 31.

Parkinson’s Disease, Life Extension website. Accessed July 20, 2015.

CHAPTER 52: PREMENSTRUAL SYNDROME (PMS)

Abdollahifard S, et al. The Effects of Vitamin B1 on Ameliorating the Premenstrual Syndrome Symptoms. Glob J Health Sci. 2014 Jul 29;6(6):144-153. doi: 10.5539/gjhs.v6n6p144.

Canning S, et al. The Efficacy of Hypericum Perforatum (St John’s Wort) for the Treatment of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. CNS Drugs. 2010 Mar;24(3):207-225.

Edilberto A, et al. Essential Fatty Acids for Premenstrual Syndrome and Their Effect on Prolactin and Total Cholesterol Levels: A Randomized, Double Blind, Placebo-Controlled Study. Reprod Health. 2011 Jan 17:8:2.

Ibrahim RM, et al. Effect of Vitex Agnus Custus (VAC) On Premenstrual Syndromes Among Nursing Students. J Amer Sci. 2012;8(4):144-153.

Jang SH, et al. Effects and Treatment Methods of Acupuncture and Herbal Medicine for Premenstrual Syndrome/Premenstrual Dysphoric Disorder: Systematic Review. BMC Comp Altern Med. 2014;14:11.

Nevatte T, et al. ISPMD Consensus on the Management of Premenstrual Disorders. Arch Women’s Mental Health. 2013 Aug;16(4):279-291.

Sohrabi N, et al. Evaluation of the Effect of Omega-3 Fatty Acids in the Treatment of Premenstrual Syndrome: “A Pilot Trial.” Compl Ther Med. 2013 June;21(3):141-146.

van Die MD, et al. Vitex Agnus-Castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials. Planta Medica. 2013 May;79(7):562-575.

CHAPTER 53: SEXUAL DYSFUNCTION

Chiou YL, Lin CY. The Extract of Cordyceps Sinensis Inhibited Airway Inflammation by Blocking NFb Activity. Inflammation. 2012 Jun;35(3):985-993.

Downey M. The Truth About Male and Female Sexual Dysfunction. Life Extension Magazine, October 2013. Web. Accessed July 20, 2015.

Kashani L, et al. Saffron for Treatment of Fluoxetine-Induced Sexual Dysfunction in Women: Randomized Double-Blind Placebo-Controlled Study. Hum Psychopharmacol. 2013 Jan;28(1):54-60.

Simon JA. Identifying and Treating Sexual Dysfunction in Postmenopausal Women: The Role of Estrogen. J Womens Health (Larchmt). 2011 Oct;20(10):1453-1465.

CHAPTER 54: SEXUALLY TRANSMITTED DISEASES

Blitshteyn, S. Postural Tachycardia Syndrome Following Human Papillomavirus Vaccination. Eur J Neurol. 2014 Jan;21(1):135-9. doi: 10.1111/ene.12272. Epub 2013 Sep 16.PMID: 24102827

Kim JH, et al. A Pilot Study to Investigate the Treatment of Cervical Human Papillomavirus Infection With Zinc-Citrate Compound (CIZAR). Gyn Onc. 2011;122:303–306.

McGovern C. HPV Vaccine Linked to Nervous System Disorder and Autoimmunity. Greenmedinfo.com, April 24, 2014. Web. Accessed July 20, 2015.

Tomljenovic L, et al. Human Papillomavirus (HPV) Vaccine Policy and Evidence-Based Medicine: Are They at Odds? Ann Med. 2013 Mar;45(2):182-193. doi: 10.3109/07853890. 2011.645353. Epub 2011 Dec 22.

Tomljenovic L et al. Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants.” J Invest Med High Impact Case Rep 2014;2(1). doi: 10.1177/2324709614527812

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CHAPTER 55: STROKE

Cassidy A, et al. Dietary Flavonoids and Risk of Stroke in Women. Stroke. Published online before print February 23, 2012. doi: 10.1161/STROKEAHA.111.637835

Kastorini CM, et al. Adherence to the Mediterranean Diet in Relation to Ischemic Stroke Nonfatal Events in Nonhypercholesterolemic and Hypercholesterolemic Participants: Results of a Case/Case-Control Study. Angiology. 2012 Oct;63(7):509-515. doi: 10.1177/0003319711427392. Epub 2011 Dec 5.

Oskouei DS, et al. The Effect of Ginkgo biloba on Functional Outcome of Patients with Acute Ischemic Stroke: A Double-blind, Placebo-controlled, Randomized Clinical Trial. J Stroke Cerebrovasc Dis. Published Online: July 22, 2013. doi: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.06.010

Oude Griep LM, et al. Colors of Fruit and Vegetables and 10-Year Incidence of Stroke. Stroke. 2011;42:3190-3195. Published online before print September 15, 2011. doi: 10.1161/STROKEAHA.110.611152

Samieri C, et al. Olive Oil Consumption, Plasma Oleic Acid, and Stroke Incidence: The Three-City Study. Neurology. Published online before print June 15, 2011. doi: 10.1212/WNL.0b013e318220abeb.

CHAPTER 56: THYROID DISEASE

Kvacheniuk AN, Kvacheniuk EL. The Use of Phytotherapy for Treatment of Thyroid Diseases. Lik Sprava. 2012 Apr-Jun;(3-4):99-104.

CHAPTER 57: URINARY INCONTINENCE

Huang AJ, et al. A Group-Based Yoga Therapy Intervention for Urinary Incontinence in Women: A Pilot Randomized Trial. Female Pelvic Med Reconstr Surg. 2014 May-Jun;20(3):147-154.

CHAPTER 58: URINARY TRACT INFECTIONS AND INFLAMMATIONS

Altarac S, Papes D. Use of D-Mannose in Prophylaxis of Recurrent Urinary Tract Infections (UTIs) in Women. BJU Int. 2014;113:9-10.

de Llano DG, et al. Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell Cultures. Int J Mol Sci. 2015 May 27;16(6):12119-12130. doi: 10.3390/ijms160612119.

Gaby A. Editorial, Dr. Wright Does It Again: D-Mannose for UTI Prophylaxis Validated in a Clinical Trial. Townsend Letter, May 2014. Web. Accessed July 20, 2015.

Jepson RG, et al. Cranberries for Preventing Urinary Tract Infections. Cochrane Database Syst Rev. 2012 Oct 17;10:CD001321. doi: 10.1002/14651858.CD001321.pub5.

Kranj ec B, et al. D-Mannose Powder for Prophylaxis of Recurrent Urinary Tract Infections in Women: A Randomized Clinical Trial. World J Urol. 2014;Feb;32(1):79-84. doi: 10.1007/s00345-013-1091-6. Epub 2013 Apr 30.

CHAPTER 60: VARICOSE VEINS

Clachar S. Reducing Dangerous Varicose Veins with Phlebotonics, Life Extension Magazine, May 2012. Web. Accessed July 20, 2015.

CHAPTER 61: VISION PROBLEMS

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Munch IC, et al. Precursors of Age-Related Macular Degeneration: Associations With Physical Activity, Obesity, and Serum Lipids in the Inter99 Eye Study. Invest Ophthalmol Vis Sci. 2013;54:3932-3940.

Ohguro H, et al. Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma. Ophthalmologica. 2012;228:26-35.

Tanaka S, et al. Fruit Intake and Incident Diabetic Neuropathy With Type 2 Diabetes. Epidemiol. 2013 Mar;24:204-211.

Williams PT. Walking and Running are Associated With Similar Reductions in Cataract Risk.Med Sci Sport Exercise. 2013 Jun;45:1089-1096.