Senior Acquisitions Editor: Sharon Zinner
Development Editor: Elizabeth Schaeffer
Editorial Coordinator: Emily Buccieri
Marketing Manager: Rachel Mante-Leung
Production Project Manager: Marian Bellus
Design Coordinator: Joan Wendt
Manufacturing Coordinator: Beth Welsh
Prepress Vendor: S4Carlisle Publishing Services
Fifth edition
Copyright © 2019 Wolters Kluwer.
© 2013 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business. © 2009 by Lippincott Williams & Wilkins, a Wolters Kluwer Business. ©2004 by Lippincott Williams & Wilkins ©2000 by Lippincott Williams & Wilkins
All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at permissions@lww.com, or via our website at lww.com (products and services).
9 8 7 6 5 4 3 2 1
Printed in China
Library of Congress Cataloging-in-Publication Data
Names: Griffin, Brian P., 1956- editor.
Title: Manual of cardiovascular medicine / editor, Brian P. Griffin, MD, FACC, The John and Rosemary Brown Endowed Chair in Cardiovascular Medicine, Vice-Chairman, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Section Head, Section of Cardiovascular Imaging, Cleveland Clinic, Cleveland, Ohio, Venu Menon, MD, Director, Coronary Care Unit, Director Cardiovascular Fellowship Program, Professor of Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio; section editors,Thomas D. Callahan MD, FACC [and four others]; guest editors, Newton Wiggins, MD, Joseph Bumgarner, MD, Chetan Huded, MD.
Description: Fifth edition. | Philadelphia: Wolters Kluwer Health, [2019] | Includes bibliographical references and index.
Identifiers: LCCN 2018028784 | eISBN 9781496395115
Subjects: LCSH: Cardiology—Handbooks, manuals, etc. | Heart—Diseases—Handbooks, manuals, etc. | BISAC: MEDICAL / Cardiology.
Classification: LCC RC682 .M315 2019 | DDC 616.1/2—dc23 LC record available at https://lccn.loc.gov/2018028784
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based on healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data, and other factors unique to the patient. The publisher does not provide medical advice or guidance, and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work, including all medical judgments, and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made, and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings, and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law, or otherwise or from any reference to or use by any person of this work.