TABLE H.39
Effects of Huperzine A (HupA) on Superoxide Dismutase Activities and Lipid Peroxides in Rats Hypoperfused After Bilateral Ligation of the Common Carotoid Arteries1
| Group | Superoxide Dismutase (nU/mg protein) | Lipid Peroxidase (nmol/mg protein) | ||||
|---|---|---|---|---|---|---|
| Cortex | Hippocampus | Striatum | Cortex | Hippocampus | Striatum | |
| Sham-operated | 40.1±1.5** | 46.3±1.9** | 46.2±2.6** | 2.69±0.07** | 2.88±0.10** | 3.55±0.17** |
| Saline-operated | 69.0±2.9 | 74.8±6.0 | 97.3±5.7 | 3.70±0.14 | 4.11±0.17 | 5.38±0.27 |
| HupA-treated5 (0.1 mg/kg) | 36.3±1.7** | 43.0±2.0** | 42.1±1.8** | 2.80±0.07** | 3.08±0.13** | 3.36±0.07** |
1Rats were killed 40 min. after the last administration of huperzine A on day 33 following bilateral ligation of the common carotoid arteries. From day 15 to day 33, huperzine A was administered orally twice per day. **p<0.01 versus saline-treated group.
Source: From Wang et al., Bioorg. Med. Chem. Lett., 10:1029–1032, 2000. With permission.