Adhikarla V, Zeng F, Votaw JR, et al: Compartmental modeling of [(11)C]MENET binding to the norepinephrine transporter in the healthy human brain. Nucl Med Biol 43(5):318–323, 2016 27150035
Aghajanian GK, Marek GJ: Serotonin and hallucinogens. Neuropsychopharmacology 21 (2 suppl):16S–23S, 1999 10432484
Ahlquist RP: A study of the adrenotropic receptors. Am J Physiol 153(3):586–600, 1948 18882199
AhnAllen CG, Bidwell LC, Tidey JW: Cognitive effects of very low nicotine content cigarettes, with and without nicotine replacement, in smokers with schizophrenia and controls. Nicotine Tob Res 17(5): 510–514, 2015 25143294
Akil M, Kolachana BS, Rothmond DA, et al: Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23(6):2008–2013, 2003 12657658
Al-Hasani R, Bruchas MR: Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology 115(6):1363–1381, 2011 22020140
Alexander SP, Benson HE, Faccenda E, et al; CGTP Collaborators: The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol 170(8):1797–1867, 2013a 24528243
Alexander SP, Benson HE, Faccenda E, et al; CGTP Collaborators: The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol 170(8):1459–1581, 2013b 24517644
Alexander SP, Benson HE, Faccenda E, et al; CGTP Collaborators: The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol 170(8):1607–1651, 2013c 24528239
Alexander SP, Benson HE, Faccenda E, et al; CGTP Collaborators: The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels. Br J Pharmacol 170(8):1582–1606, 2013d 24528238
Alexander SP, Benson HE, Faccenda E, et al; CGTP Collaborators: The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors. Br J Pharmacol 170(8):1652–1675, 2013e 24528240
Alexander SP, Benson HE, Faccenda E, et al; CGTP Collaborators: The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol 170(8):1449–1458, 2013f 24528237
Altier C, Zamponi GW: Opioid, cheating on its receptors, exacerbates pain. Nat Neurosci 9(12):1465–1467, 2006 17128281
Altınbaş K, Guloksuz S, Oral ET: Clinical potential of cariprazine in the treatment of acute mania. Psychiatr Danub 25(3):207–213, 2013 24048386
Amat J, Baratta MV, Paul E, et al: Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat Neurosci 8(3):365–371, 2005 15696163
Anand A, Barkay G, Dzemidzic M, et al: Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 13(4):406–413, 2011 21843280
Andén NE, Magnusson T, Rosengren E: On the presence of dihydroxyphenylalanine decarboxylase in nerves. Experientia 20(6):328–329, 1964 5216334
Andrade R, Malenka RC, Nicoll RA: A G protein couples serotonin and GABAB receptors to the same channels in hippocampus. Science 234(4781):1261–1265, 1986 2430334
Andreetta F, Carboni L, Grafton G, et al: Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo. Br J Pharmacol 173(9):1438–1451, 2016 26773257
Ansorge MS, Zhou M, Lira A, et al: Early life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306(5697):879–881, 2004 15514160
Argolo FC, Cavalcanti-Ribeiro P, Netto LR, et al: Prevention of posttraumatic stress disorder with propranolol: a meta-analytic review. J Psychosom Res 79(2):89–93, 2015 25972056
Arnsten AF, Girgis RR, Gray DL, et al: Novel dopamine therapeutics for cognitive deficits in schizophrenia. Biol Psychiatry 81(1):67–77, 2017 26946382
Ayalon G, Stern-Bach Y: Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions. Neuron 31(1):103–113, 2001 11498054
Ballard ED, Luckenbaugh DA, Richards EM, et al: Assessing measures of suicidal ideation in clinical trials with a rapid-acting antidepressant. J Psychiatr Res 68:68–73, 2015 26228403
Bangasser DA, Wiersielis KR, Khantsis S: Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress. Brain Res 1641(pt B):177–188, 2016 26607253
Barria A, Malinow R: NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Neuron 48(2):289–301, 2005 16242409
Bauman AL, Apparsundaram S, Ramamoorthy S, et al: Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 20(20):7571–7578, 2000 11027216
Beaulieu JM, Sotnikova TD, Yao WD, et al: Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A 101(14):5099–5104, 2004 15044694
Bekkers JM, Stevens CF: NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature 341(6239):230–233, 1989 2571090
Bell C, Abrams J, Nutt D: Tryptophan depletion and its implications for psychiatry. Br J Psychiatry 178:399–405, 2001 11331552
Ben Mamou C, Gamache K, Nader K: NMDA receptors are critical for unleashing consolidated auditory fear memories. Nat Neurosci 9(10):1237–1239, 2006 16998481
Beneyto M, Kristiansen LV, Oni-Orisan A, et al: Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 32(9):1888–1902, 2007 17299517
Berman RM, Cappiello A, Anand A, et al: Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47(4):351–354, 2000 10686270
Berry CB, Bubser M, Jones CK, et al: Discovery and characterization of ML398, a potent and selective antagonist of the D4 receptor with in vivo activity. ACS Med Chem Lett 5(9):1060–1064, 2014 25221667
Blier P, Piñeyro G, el Mansari M, et al: Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Ann N Y Acad Sci 861:204–216, 1998 9928258
Bogdanski DF, Pletscher A, Brodie BB, et al: Identification and assay of serotonin in brain. J Pharmacol Exp Ther 117(1):82–88, 1956 13320304
Booker SA, Pires N, Cobb S, et al: Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors. Neuropharmacology 93:103–115, 2015 25656478
Bortolato M, Pivac N, Muck Seler D, et al: The role of the serotonergic system at the interface of aggression and suicide. Neuroscience 236:160–185, 2013 23333677
Bourne HR, Nicoll R: Molecular machines integrate coincident synaptic signals. Cell 72 (suppl):65–75, 1993 8094038
Bouvier M: Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2(4):274–286, 2001 11283750
Brambilla D, Chapman D, Greene R: Adenosine mediation of presynaptic feedback inhibition of glutamate release. Neuron 46(2):275–283, 2005 15848805
Brodie TG: The immediate action of an intravenous injection of blood-serum. J Physiol 26(1–2):48–71, 1900 16992567
Bruinvels AT, Palacios JM, Hoyer D: 5-hydroxytryptamine1 recognition sites in rat brain: heterogeneity of non-5-hydroxytryptamine1A/1C binding sites revealed by quantitative receptor autoradiography. Neuroscience 53(2):465–473, 1993 8492913
Bruno V, Battaglia G, Copani A, et al: An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. Eur J Neurosci 13(8):1469–1478, 2001 11328342
Brüss M, Pörzgen P, Bryan-Lluka LJ, et al: The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression. Brain Res Mol Brain Res 52(2):257–262, 1997 9495547
Brüss M, Bönisch H, Bühlen M, et al: Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor. Pharmacogenetics 9(1):95–102, 1999 10208648
Bylund DB, Eikenberg DC, Hieble JP, et al: International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 46(2):121–136, 1994 7938162
Cahill L, Prins B, Weber M, et al: Beta-adrenergic activation and memory for emotional events. Nature 371(6499):702–704, 1994 7935815
Camardese G, De Risio L, Di Nicola M, et al: Changes of dopamine transporter availability in depressed patients with and without anhedonia: a 123I-N-ω-fluoropropyl-carbomethoxy-3β-(4-Iodophenyl)tropane SPECT study. Neuropsychobiology 70(4):235–243, 2014a 25613182
Camardese G, Di Giuda D, Di Nicola M, et al: Imaging studies on dopamine transporter and depression: a review of literature and suggestions for future research. J Psychiatr Res 51:7–18, 2014b 24433847
Cannon DM, Klaver JK, Gandhi SK, et al: Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder. Mol Psychiatry 16(4):407–418, 2011 20351719
Carlezon WA Jr, Nestler EJ: Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci 25(12):610–615, 2002 12446127
Carman CV, Benovic JL: G-protein-coupled receptors: turn-ons and turn-offs. Curr Opin Neurobiol 8(3):335–344, 1998 9687355
Carter CS: Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 23(8):779–818, 1998 9924738
Casado M, Bendahan A, Zafra F, et al: Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J Biol Chem 268(36):27313–27317, 1993 7903307
Caspi A, Sugden K, Moffitt TE, et al: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301(5631):386–389, 2003 12869766
Catapano LA, Manji HK: G protein-coupled receptors in major psychiatric disorders. Biochim Biophys Acta 1768(4):976–993, 2007 17078926
Chan E, Fogler JM, Hammerness PG: Treatment of attention-deficit/hyperactivity disorder in adolescents: a systematic review. JAMA 315(18):1997–2008, 2016 27163988
Chandley MJ, Szebeni A, Szebeni K, et al: Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression. Int J Neuropsychopharmacol 17(10):1569–1578, 2014 24925192
Chávez AE, Singer JH, Diamond JS: Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors. Nature 443(7112):705–708, 2006 17036006
Chen G, Hasanat KA, Bebchuk JM, et al: Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosom Med 61(5):599–617, 1999 10511011
Chen R, Lewis KA, Perrin MH, Vale WW: Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci U S A 90(19):8967–8971, 1993 7692441
Chiuccariello L, Houle S, Miler L, et al: Elevated monoamine oxidase a binding during major depressive episodes is associated with greater severity and reversed neurovegetative symptoms. Neuropsychopharmacology 39(4):973–980, 2014 24154665
Clark D, White FJ: D1 dopamine receptor—the search for a function: a critical evaluation of the D1/D2 dopamine receptor classification and its functional implications. Synapse 1(4):347–388, 1987 2971273
Conn PJ, Pin JP: Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205–237, 1997 9131252
Conn PJ, Sanders-Bush E: Central serotonin receptors: effector systems, physiological roles and regulation. Psychopharmacology (Berl) 92(3):267–277, 1987 2819915
Conradt M, Stoffel W: Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation. J Neurochem 68(3):1244–1251, 1997 9048771
Cooper JR, Bloom FE, Roth RH: The Biochemical Basis of Neuropharmacology, 8th Edition. New York, Oxford University Press, 2003
Costa A, Riedel M, Müller U, et al: Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies. Synapse 65(10):998–1005, 2011 21404331
Coupland N, Zedkova L, Sanghera G, et al: Response to pentagastrin after acute phenylalanine and tyrosine depletion in healthy men: a pilot study. J Psychiatry Neurosci 26(3):247–251, 2001 11394194
Coyle JT, Tsai G, Goff DC: Ionotropic glutamate receptors as therapeutic targets in schizophrenia. Curr Drug Targets CNS Neurol Disord 1(2):183–189, 2002 12769626
Dahlström A: Regional distribution of brain catecholamines and serotonin. Neurosci Res Program Bull 9(2):197–205, 1971 5164695
D’Amato RJ, Largent BL, Snowman AM, et al: Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine. J Pharmacol Exp Ther 242(1):364–371, 1987 3475452
Darcet F, Gardier AM, David DJ, et al: Chronic 5-HT4 receptor agonist treatment restores learning and memory deficits in a neuroendocrine mouse model of anxiety/depression. Neurosci Lett 616:197–203, 2016 26850572
David SP, Murthy NV, Rabiner EA, et al: A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 25(10):2586–2590, 2005 15758168
De Vivo M, Maayani S: Stimulation and inhibition of adenylyl cyclase by distinct 5-hydroxytryptamine receptors. Biochem Pharmacol 40(7):1551–1558, 1990 2222510
Descarries L, Watkins KC, Garcia S, et al: The serotonin neurons in nucleus raphe dorsalis of adult rat: a light and electron microscope radioautographic study. J Comp Neurol 207(3):239–254, 1982 7107985
Deschwanden A, Karolewicz B, Feyissa AM, et al: Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am J Psychiatry 168(7):727–734, 2011 21498461
Diazgranados N, Ibrahim L, Brutsche NE, et al: A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry 67(8):793–802, 2010 20679587
Ding YS, Naganawa M, Gallezot JD, et al: Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: implications on treatment of depression and ADHD. Neuroimage 86:164–171, 2014 23933039
Donaldson ZR, le Francois B, Santos TL, et al: The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Transl Psychiatry 6:e746, 2016 26926882
Drevets WC, Bogers W, Raichle ME: Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 12(6):527–544, 2002 12468016
Drevets WC, Zarate CA Jr, Furey ML: Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review. Biol Psychiatry 73(12):1156–1163, 2013 23200525
Drury AN, Szent-Györgyi A: The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol 68(3):213–237, 1929 16994064
Du J, Gould T, Manji H: Neurotrophic signaling in mood disorders, in Signal Transduction and Human Disease. Edited by Finkel T, Gutkind JS. Hoboken, NJ, Wiley-Interscience, 2003, pp 411–445
Du J, Suzuki K, Wei Y, et al: The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders. Neuropsychopharmacology 32(4):793–802, 2007 16936714
Duman RS: Synaptic plasticity and mood disorders. Mol Psychiatry 7 (suppl 1): S29–S34, 2002 11986993
Dunlop BW, Nemeroff CB: The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 64(3):327–337, 2007 17339521
Ebstein RP, Knafo A, Mankuta D, et al: The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav 61(3):359–379, 2012 22245314
Emeson RB, Morabito MV: Food fight: the NPY-serotonin link between aggression and feeding behavior. Sci STKE 2005(277): pe12, 2005 15798100
Encinas JM, Vaahtokari A, Enikolopov G: Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A 103(21):8233–8238, 2006 16702546
Faden AI, Demediuk P, Panter SS, et al: The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244(4906):798–800, 1989 2567056
Farber NB, Kim SH, Dikranian K, et al: Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity. Mol Psychiatry 7(1):32–43, 2002 11803444
Feyissa AM, Chandran A, Stockmeier CA, et al: Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 33(1):70–75, 2009 18992785
Feyissa AM, Woolverton WL, Miguel-Hidalgo JJ, et al: Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 34(2):279–283, 2010 19945495
Fields RD, Stevens-Graham B: New insights into neuron-glia communication. Science 298(5593):556–562, 2002 12386325
Foote SL, Bloom FE, Aston-Jones G: Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol Rev 63(3):844–914, 1983 6308694
Fountoulakis KN, Gazouli M, Kelsoe J, et al: The pharmacodynamic properties of lurasidone and their role in its antidepressant efficacy in bipolar disorder. Eur Neuropsychopharmacol 25(3):335–342, 2015 25596883
Frankle WG, Cho RY, Prasad KM, et al: In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients. Am J Psychiatry 172(11):1148–1159, 2015 26133962
Freedman R, Coon H, Myles-Worsley M, et al: Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A 94(2):587–592, 1997 9012828
Gaddum JH, Picarelli ZP: Two kinds of tryptamine receptor. Br Pharmacol Chemother 12(3):323–328, 1957 13460238
Galli A, DeFelice LJ, Duke BJ, et al: Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. J Exp Biol 198(pt 10):2197–2212, 1995 7500004
Galli A, Blakely RD, DeFelice LJ: Norepinephrine transporters have channel modes of conduction. Proc Natl Acad Sci U S A 93(16):8671–8676, 1996 8710929
Gardner AJ, Griffiths J: Propranolol, post-traumatic stress disorder, and intensive care: incorporating new advances in psychiatry into the ICU. Crit Care 18(6):698, 2014 25673425
Gimpl G, Fahrenholz F: The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81(2):629–683, 2001 11274341
Glykys J, Peng Z, Chandra D, et al: A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. Nat Neurosci 10(1):40–48, 2007 17159992
González-Maeso J, Weisstaub NV, Zhou M, et al: Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron 53(3):439–452, 2007 17270739
Goodwin FK, Jamison KR, Ghaemi SN: Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd Edition. New York, Oxford University Press, 2007
Gould TD, Chen G, Manji HK: Mood stabilizer psychopharmacology. Clin Neurosci Res 2(3–4):193–212, 2002 22707923
Gould T, Gray N, Manji H: Cellular neurobiology of severe mood and anxiety disorders: implications for the development of novel therapeutics, in Molecular Neurobiology for the Clinician. Edited by Charney D (Review of Psychiatry Series, Vol 22; Oldham JM and Riba MB, series editors). Washington, DC, American Psychiatric Publishing, 2003, pp 123–228
Grailhe R, Grabtree GW, Hen R: Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. Eur J Pharmacol 418(3):157–167, 2001 11343685
Grammatopoulos DK, Randeva HS, Levine MA, et al: Rat cerebral cortex corticotropin-releasing hormone receptors: evidence for receptor coupling to multiple G-proteins. J Neurochem 76(2):509–519, 2001 11208914
Gross C, Zhuang X, Stark K, et al: Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416(6879):396–400, 2002 11919622
Gu S, Wang W, Wang F, et al: Neuromodulator and emotion biomarker for stress induced mental disorders. Neural Plast 2016:2609128, 2016 27051536
Guillin O, Diaz J, Carroll P, et al: BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature 411(6833):86–89, 2001 11333982
Haass-Koffler CL, Leggio L, Kenna GA: Pharmacological approaches to reducing craving in patients with alcohol use disorders. CNS Drugs 28(4):343–360, 2014 24573997
Habert E, Graham D, Tahraoui L, et al: Characterization of [3H]paroxetine binding to rat cortical membranes. Eur J Pharmacol 118(1–2):107–114, 1985 2935409
Hammer H, Bader BM, Ehnert C, et al: A multifaceted GABAA receptor modulator: functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude). Mol Pharmacol 88(2):401–420, 2015 26056160
Harder R, Bönisch H: Effects of monovalent ions on the transport of noradrenaline across the plasma membrane of neuronal cells (PC-12 cells). J Neurochem 45(4):1154–1162, 1985 4031884
Henley JM, Wilkinson KA: Synaptic AMPA receptor composition in development, plasticity and disease. Nat Rev Neurosci 17(6):337–350, 2016 27080385
Henry LK, DeFelice LJ, Blakely RD: Getting the message across: a recent transporter structure shows the way. Neuron 49(6): 791–796, 2006 16543127
Heurteaux C, Lucas G, Guy N, et al: Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nat Neurosci 9(9):1134–1141, 2006 16906152
Hillhouse EW, Grammatopoulos DK: The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev 27(3):260–286, 2006 16484629
Hoffman BJ, Mezey E: Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain. FEBS Lett 247(2):453–462, 1989 2714444
Hollmann M, Maron C, Heinemann S: N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13(6):1331–1343, 1994 7993626
Horti AG, Kuwabara H, Holt DP, et al: Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors. J Labelled Comp Radiopharm 56(3–4):159–166, 2013 24285321
Hoyer D, Bartfai T: Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach. Chem Biodivers 9(11):2367–2387, 2012 23161624
Hoyer D, Pazos A, Probst A, et al: Serotonin receptors in the human brain, II: characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites. Brain Res 376(1):97–107, 1986 2941113
Hoyer D, Hannon JP, Martin GR: Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71(4):533–554, 2002 11888546
Hrdina PD, Pappas BA, Roberts DC, et al: Relationship between levels and uptake of serotonin and high affinity [3H]imipramine recognition sites in the rat brain. Can J Physiol Pharmacol 63(10):1239–1244, 1985 3000552
Humphrey PP, Hartig P, Hoyer D: A proposed new nomenclature for 5-HT receptors. Trends Pharmacol Sci 14(6):233–236, 1993 8372403
Innocenti B, Parpura V, Haydon PG: Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes. J Neurosci 20(5):1800–1808, 2000 10684881
Inoue E, Mochida S, Takagi H, et al: SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Neuron 50(2):261–275, 2006 16630837
Iwata Y, Nakajima S, Suzuki T, et al: Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials. Mol Psychiatry 20(10):1151–1160, 2015 26077694
Jacobs BL, Abercrombie ED, Fornal CA, et al: Single-unit and physiological analyses of brain norepinephrine function in behaving animals. Prog Brain Res 88:159–165, 1991 1813921
Jacobs BL, van Praag H, Gage FH: Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry 5(3):262–269, 2000 10889528
Kandel ER: Principles of Neural Science, 5th Edition. New York, McGraw-Hill, 2013
Kaupmann K, Huggel K, Heid J, et al: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386(6622):239–246, 1997 9069281
Kellendonk C, Simpson EH, Polan HJ, et al: Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49(4):603–615, 2006 16476668
Kim SF, Huang AS, Snowman AM, et al: From the cover: antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A 104(9):3456–3459, 2007 17360666
Kimelberg HK, Katz DM: High-affinity uptake of serotonin into immunocytochemically identified astrocytes. Science 228(4701):889–891, 1985 3890180
Kish SJ, Furukawa Y, Chang LJ, et al: Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region? Nucl Med Biol 32(2):123–128, 2005 15721757
Klimek V, Schenck JE, Han H, et al: Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study. Biol Psychiatry 52(7):740–748, 2002 12372665
Krügel U: Purinergic receptors in psychiatric disorders. Neuropharmacology 104:212–225, 2016 26518371
Krystal JH, Anand A, Moghaddam B: Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Arch Gen Psychiatry 59(7):663–664, 2002 12090822
Kumar JS, Mann JJ: PET tracers for serotonin receptors and their applications. Cent Nerv Syst Agents Med Chem 14(2):96–112, 2014 25360773
Labrie V, Roder JC: The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia. Neurosci Biobehav Rev 34(3):351–372, 2010 19695284
Lacerda-Pinheiro SF, Pinheiro Junior RF, Pereira de Lima MA, et al: Are there depression and anxiety genetic markers and mutations? A systematic review. J Affect Disord 168:387–398, 2014 25106036
Laeng P, Pitts RL, Lemire AL, et al: The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. J Neurochem 91(1):238–251, 2004 15379904
Lambert GA: Preclinical neuropharmacology of naratriptan. CNS Drug Rev 11(3):289–316, 2005 16389295
Langer SZ, Moret C, Raisman R, et al: High-affinity [3H]imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine. Science 210(4474):1133–1135, 1980 7444441
Laporte AM, Koscielniak T, Ponchant M, et al: Quantitative autoradiographic mapping of 5-HT3 receptors in the rat CNS using [125I]iodo-zacopride and [3H]zacopride as radioligands. Synapse 10(4):271–281, 1992 1585260
Lawrence JA, Charters AR, Butcher SP, et al: 5-HT transporter antibodies as a tool in serotonergic synaptosomal isolation. Biochem Soc Trans 23(1):115S, 1995a 7758676
Lawrence JA, Charters AR, Butcher SP, et al: Recognition of 5-HT transporter by antipeptide antibodies. Biochem Soc Trans 23(3):473S, 1995b 8566369
Lee BH, Kim YK: Potential peripheral biological predictors of suicidal behavior in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 35(4):842–847, 2011 20708058
Lee JL, Di Ciano P, Thomas KL, et al: Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior. Neuron 47(6):795–801, 2005 16157275
Leung LY, Baillie TA: Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J Med Chem 29(11):2396–2399, 1986 3783598
Lewis DA, Hashimoto T, Volk DW: Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6(4):312–324, 2005 15803162
Liaw CW, Lovenberg TW, Barry G, et al: Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology 137(1):72–77, 1996 8536644
Lilley BN, Krishnaswamy A, Wang Z, et al: SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems. Proc Natl Acad Sci U S A 111(3):1138–1143, 2014 24395778
Lisman JE, McIntyre CC: Synaptic plasticity: a molecular memory switch. Curr Biol 11(19):R788–R791, 2001 11591339
Liu QS, Pu L, Poo MM: Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. Nature 437(7061):1027–1031, 2005 16222299
Liu YF, Albert PR: Cell-specific signaling of the 5-HT1A receptor: modulation by protein kinases C and A. J Biol Chem 266(35):23689–23697, 1991 1660881
López-Giménez JF, Mengod G, Palacios JM, et al: Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100,907. Naunyn Schmiedebergs Arch Pharmacol 356(4):446–454, 1997 9349630
Lothe A, Boni C, Costes N, et al: 5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study. Behav Brain Funct 6:37, 2010 20609217
Lovejoy DA, Chang BS, Lovejoy NR, et al: Molecular evolution of GPCRs: CRH/CRH receptors. J Mol Endocrinol 52(3):T43–T60, 2014 24711645
Lummis SC, Beene DL, Lee LW, et al: Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature 438(7065):248–252, 2005 16281040
Maciag D, Hughes J, O’Dwyer G, et al: Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studies. Biol Psychiatry 67(5):465–470, 2010 20004363
Madden DR: The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 3(2):91–101, 2002 11836517
Maeng S, Zarate CA Jr, Du J, et al: Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry 63(4):349–352, 2008 17643398
Malberg JE, Eisch AJ, Nestler EJ, et al: Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20(24):9104–9110, 2000 11124987
Malenka RC, Nicoll RA: Long-term potentiation—a decade of progress? Science 285(5435):1870–1874, 1999 10489359
Malinow R, Malenka RC: AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 25:103–126, 2002 12052905
Mangelsdorf DJ, Thummel C, Beato M, et al: The nuclear receptor superfamily: the second decade. Cell 83(6):835–839, 1995 8521507
Manji HK, Lenox RH: Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biol Psychiatry 46(10):1328–1351, 1999 10578449
Manji HK, Drevets WC, Charney DS: The cellular neurobiology of depression. Nat Med 7(5):541–547, 2001 11329053
Manto M, Dalmau J, Didelot A, et al: In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction. Orphanet J Rare Dis 5:31, 2010 21110857
Masdeu JC, Dalmau J, Berman KF: NMDA receptor internalization by autoantibodies: a reversible mechanism underlying psychosis? Trends Neurosci March 22, 2016 [Epub ahead of print] 27130657
McCann UD, Thorne D, Hall M, et al: The effects of L-dihydroxyphenylalanine on alertness and mood in alpha-methyl-para-tyrosine-treated healthy humans: further evidence for the role of catecholamines in arousal and anxiety. Neuropsychopharmacology 13(1):41–52, 1995 8526970
McKeon A: Autoimmune encephalopathies and dementias. Continuum (Minneap Minn) 22(2 Dementia):538–558, 2016 27042907
McMahon FJ, Buervenich S, Charney D, et al: Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet 78(5):804–814, 2006 16642436
Meltzer HY: Action of atypical antipsychotics. Am J Psychiatry 159(1):153–154, author reply 154–155, 2002 11772718
Meyer JH, Krüger S, Wilson AA, et al: Lower dopamine transporter binding potential in striatum during depression. Neuroreport 12(18):4121–4125, 2001 11742250
Meyer JH, Goulding VS, Wilson AA, et al: Bupropion occupancy of the dopamine transporter is low during clinical treatment. Psychopharmacology (Berl) 163(1): 102–105, 2002 12185406
Meyer JH, McNeely HE, Sagrati S, et al: Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study. Am J Psychiatry 163(9):1594–1602, 2006 16946186
Millar RP, Newton CL: The year in G protein-coupled receptor research. Mol Endocrinol 24(1):261–274, 2010 20019124
Miller JM, Hesselgrave N, Ogden RT, et al: Positron emission tomography quantification of serotonin transporter in suicide attempters with major depressive disorder. Biol Psychiatry 74(4):287–295, 2013 23453288
Mishina M, Ishiwata K: Adenosine receptor PET imaging in human brain. Int Rev Neurobiol 119:51–69, 2014 25175960
Miwa JM, Stevens TR, King SL, et al: The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron 51(5):587–600, 2006 16950157
Moberg T, Nordström P, Forslund K, et al: CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters. J Affect Disord 132(1–2):173–178, 2011 21356560
Moghaddam B, Krystal JH: Capturing the angel in “angel dust”: twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Schizophr Bull 38(5):942–949, 2012 22899397
Möhler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther 300(1):2–8, 2002 11752090
Møllerud S, Frydenvang K, Pickering DS, et al: Lessons from crystal structures of kainate receptors. Neuropharmacology 112(Pt A):16–28, 2017 27236079
Montecucchi PC, Anastasi A, de Castiglione R, et al: Isolation and amino acid composition of sauvagine: an active polypeptide from methanol extracts of the skin of the South American frog Phyllomedusa sauvagei. Int J Pept Protein Res 16(3):191–199, 1980 7461901
Moses-Kolko EL, Price JC, Shah N, et al: Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population. Neuropsychopharmacology 36(13):2729–2740, 2011 21849982
Mukherjee J, Baranwal A, Schade KN: Classification of therapeutic and experimental drugs for brown adipose tissue activation: potential treatment strategies for diabetes and obesity. Curr Diabetes Rev 12(4):414–428, 2016 27183844
Mulligan SJ, MacVicar BA: VRACs CARVe a path for novel mechanisms of communication in the CNS. Sci STKE 2006(357): pe42, 2006 17047222
Murase S, Mathé JM, Grenhoff J, et al: Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization. J Neural Transm 91(1):13–25, 1993 8452684
Navarria A, Wohleb ES, Voleti B, et al: Rapid antidepressant actions of scopolamine: role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors. Neurobiol Dis 82:254–261, 2015 26102021
Nestler EJ, Hyman SE, Malenka RC: Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. New York, McGraw-Hill, 2001
Nestler EJ, Hyman SE, Holtzman DM, et al: Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 3rd Edition. New York, McGraw-Hill, 2015
Neumann ID, Landgraf R: Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 35(11):649–659, 2012 22974560
Newport DJ, Carpenter LL, McDonald WM, et al; APA Council of Research Task Force on Novel Biomarkers and Treatments: Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression. Am J Psychiatry 172(10):950–966, 2015 26423481
Niswender CM, Sanders-Bush E, Emeson RB: Identification and characterization of RNA editing events within the 5-HT2C receptor. Ann N Y Acad Sci 861:38–48, 1998 9928237
Nutt D, Wilson S, Lingford-Hughes A, et al: Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers. Neuropharmacology 88:155–163, 2015 25195191
Oo KZ, Aung YK, Jenkins MA, Win AK: Associations of 5HTTLPR polymorphism with major depressive disorder and alcohol dependence: a systematic review and meta-analysis. Aust N Z J Psychiatry 50(9):842–857, 2016 26979101
Ortiz R, Ulrich H, Zarate CA Jr, et al: Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics. Prog Neuropsychopharmacol Biol Psychiatry 57:117–131, 2015 25445063
Owens MJ, Nemeroff CB: The serotonin transporter and depression. Depress Anxiety 8 (suppl 1):5–12, 1998 9809208
Pacholczyk T, Blakely RD, Amara SG: Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 350(6316):350–354, 1991 2008212
Panatier A, Theodosis DT, Mothet JP, et al: Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell 125(4):775–784, 2006 16713567
Papageorgiou A, Denef C: Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Endocrinology 148(3):1384–1395, 2007 17122082
Parker CA, Rabiner EA, Gunn RN, et al: Human kinetic modeling of the 5HT6 PET radioligand 11C-GSK215083 and its utility for determining occupancy at both 5HT6 and 5HT2A receptors by SB742457 as a potential therapeutic mechanism of action in Alzheimer disease. J Nucl Med 56(12):1901–1909, 2015 26383152
Patapoutian A, Reichardt LF: Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11(3):272–280, 2001 11399424
Paterson NE, Vocci F, Sevak RJ, et al: Dopamine D3 receptors as a therapeutic target for methamphetamine dependence. Am J Drug Alcohol Abuse 40(1):1–9, 2014 24359505
Pazos A, Cortés R, Palacios JM: Quantitative autoradiographic mapping of serotonin receptors in the rat brain, II: serotonin-2 receptors. Brain Res 346(2):231–249, 1985 4052777
Pessiglione M, Seymour B, Flandin G, et al: Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442(7106):1042–1045, 2006 16929307
Piñeyro G, Blier P: Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51(3):533–591, 1999 10471417
Pisano P, Samuel D, Nieoullon A, et al: Activation of the adenylate cyclase-dependent protein kinase pathway increases high affinity glutamate uptake into rat striatal synaptosomes. Neuropharmacology 35(5):541–547, 1996 8887962
Pollak TA, McCormack R, Peakman M, et al: Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor [corrected] antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis. Psychol Med 44(12):2475–2487, 2014 24330811
Prabhakaran J, Underwood MD, Kumar JS, et al: Synthesis and in vitro evaluation of [18F]FECIMBI-36: a potential agonist PET ligand for 5-HT2A/2C receptors. Bioorg Med Chem Lett 25(18):3933–3936, 2015 26253634
Przybyslawski J, Roullet P, Sara SJ: Attenuation of emotional and nonemotional memories after their reactivation: role of beta adrenergic receptors. J Neurosci 19(15):6623–6628, 1999 10414990
Purselle DC, Nemeroff CB: Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology 28(4):613–619, 2003 12655305
Rajkowska G: Cell pathology in mood disorders. Semin Clin Neuropsychiatry 7(4): 281–292, 2002 12382210
Rapport MM, Green AA, Page IH: Serum vasoconstrictor, serotonin; isolation and characterization. J Biol Chem 176(3): 1243–1251, 1948 18100415
Rashid AJ, So CH, Kong MM, et al: D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104(2): 654–659, 2007 17194762
Rasmussen K, Jacobs BL: Single unit activity of locus coeruleus neurons in the freely moving cat, II: conditioning and pharmacologic studies. Brain Res 371(2):335–344, 1986 3697762
Rasmussen K, Strecker RE, Jacobs BL: Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli. Brain Res 369(1–2):336–340, 1986 3697750
Ravid R, Van Zwieten EJ, Swaab DF: Brain banking and the human hypothalamus—factors to match for, pitfalls and potentials. Prog Brain Res 93:83–95, 1992 1480765
Reader TA: Microiontophoresis of biogenic amines on cortical neurons: amounts of NA, DA and 5-HT ejected, compared with tissue content. Acta Physiol Lat Am 30(4):291–304, 1980 6152846
Ressler KJ, Bradley B, Mercer KB, et al: Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet 153B(3):812–824, 2010 20029939
Risinger R, Bhagwagar Z, Luo F, et al: Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study. Psychopharmacology (Berl) 231(11):2299–2310, 2014 24337079
Robinson MB, Jackson JG: Astroglial glutamate transporters coordinate excitatory signaling and brain energetics. Neurochem Int 98:56–71, 2016 27013346
Roman T, Schmitz M, Polanczyk G, et al: Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet 105(5):471–478, 2001 11449401
Roth BL, McLean S, Zhu XZ, et al: Characterization of two [3H]ketanserin recognition sites in rat striatum. J Neurochem 49(6):1833–1838, 1987 2960784
Roth BL, Craigo SC, Choudhary MS, et al: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 268(3):1403–1410, 1994 7908055
Roybal K, Theobold D, Graham A, et al: Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A 104(15):6406–6411, 2007 17379666
Ruljancic N, Mihanovic M, Cepelak I: Thrombocyte serotonin and serum cholesterol concentration in suicidal and non-suicidal depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 35(5):1261–1267, 2011 21338651
Ruljancic N, Mihanovic M, Cepelak I, et al: Platelet serotonin and magnesium concentrations in suicidal and non-suicidal depressed patients. Magnes Res 26(1):9–17, 2013 23614979
Sakaba T, Stein A, Jahn R, et al: Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage. Science 309(5733):491–494, 2005 16020741
Salerno S, Da Settimo F, Taliani S, et al: Medicinal chemistry of indolylglyoxylamide GABAA/BzR high affinity ligands: identification of novel anxiolytic/non sedative agents. Curr Top Med Chem 12(4): 286–311, 2012 22204484
Sanchez C, Asin KE, Artigas F: Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther 145:43–57, 2015 25016186
Sanders J, Nemeroff C: The CRF system as a therapeutic target for neuropsychiatric disorders. Trends Pharmacol Sci 37(12): 1045–1054, 2016 27717506
Savitz JB, Drevets WC: Neuroreceptor imaging in depression. Neurobiol Dis 52:49–65, 2013 22691454
Savitz J, Lucki I, Drevets WC: 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 88(1):17–31, 2009 19428959
Saxena PR, De Vries P, Villalón CM: 5-HT1-like receptors: a time to bid goodbye. Trends Pharmacol Sci 19(8):311–316, 1998 9745358
Schoeffter P, Bobirnac I: 5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells. Naunyn Schmiedebergs Arch Pharmacol 352(3):256–262, 1995 8584040
Schoepp DD: Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299(1):12–20, 2001 11561058
Scott JA, Crews FT: Down-regulation of serotonin2, but not of beta-adrenergic receptors during chronic treatment with amitriptyline is independent of stimulation of serotonin2 and beta-adrenergic receptors. Neuropharmacology 25(12): 1301–1306, 1986 3031528
Scott MM, Marcus JN, Elmquist JK: Orexin neurons and the TASK of glucosensing. Neuron 50(5):665–667, 2006 16731504
Shaltiel G, Chen G, Manji HK: Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr Opin Pharmacol 7(1):22–26, 2007 17055337
Sihra TS, Rodríguez-Moreno A: Presynaptic kainate receptor-mediated bidirectional modulatory actions: mechanisms. Neurochem Int 62(7):982–987, 2013 23538266
Sleight AJ, Carolo C, Petit N, et al: Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Mol Pharmacol 47(1):99–103, 1995 7838138
Smith DF, Jakobsen S: Molecular tools for assessing human depression by positron emission tomography. Eur Neuropsychopharmacol 19(9):611–628, 2009 19502013
Smith RC, Amiaz R, Si TM, et al: Varenicline effects on smoking, cognition, and psychiatric symptoms in schizophrenia: a double-blind randomized trial. PLoS One 11(1):e0143490, 2016 26730716
Sobczak S, Schruers K: Can formulation affect tryptophan depletion results? Hints from studies in experimental panic. J Psychopharmacol 28(5):486–490, 2014 24429220
Soltesz I, Staley K: High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci 9(12):1461–1463, 2006 17128279
Spreux-Varoquaux O, Alvarez JC, Berlin I, et al: Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. Life Sci 69(6):647–657, 2001 11476186
Squire LR: Fundamental Neuroscience, 4th Edition. Boston, MA, Elsevier/Academic Press, 2013
Stoof JC, Kebabian JW: Two dopamine receptors: biochemistry, physiology and pharmacology. Life Sci 35(23):2281–2296, 1984 6390056
Szabo ST, Blier P: Response of the norepinephrine system to antidepressant drugs. CNS Spectr 6(8):679–684, 2001 15520619
Szabo S, Machado-Vieira R, Yuan P, et al: Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology 56(1):47–55, 2009 18789340
Taber MT, Fibiger HC: Electrical stimulation of the medial prefrontal cortex increases dopamine release in the striatum. Neuropsychopharmacology 9(4):271–275, 1993 8305127
Taliani S, Cosimelli B, Da Settimo F, et al: Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem 52(12):3723–3734, 2009 19469479
Tatsch K, Poepperl G: Nigrostriatal dopamine terminal imaging with dopamine transporter SPECT: an update. J Nucl Med 54(8):1331–1338, 2013 23864718
Tejani-Butt SM, Ordway GA: Effect of age on [3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans. Brain Res 583(1–2):312–315, 1992 1504838
Tejani-Butt SM, Brunswick DJ, Frazer A: [3H] Nisoxetine: a new radioligand for norepinephrine uptake sites in brain. Eur J Pharmacol 191(2):239–243, 1990 2086242
Truss M, Beato M: Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 14(4):459–479, 1993 8223341
Tsao P, von Zastrow M: Downregulation of G protein-coupled receptors. Curr Opin Neurobiol 10(3):365–369, 2000 10851176
Ungerstedt U: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl 367:1–48, 1971 4109331
van Donkelaar EL, Blokland A, Ferrington L, et al: Mechanism of acute tryptophan depletion: is it only serotonin? Mol Psychiatry 16(7):695–713, 2011 21339754
Van Sickle MD, Duncan M, Kingsley PJ, et al: Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310(5746):329–332, 2005 16224028
Van Tol HH, Wu CM, Guan HC, et al: Multiple dopamine D4 receptor variants in the human population. Nature 358(6382):149–152, 1992 1319557
Vo L, Drummond PD: Involvement of α2-adrenoceptors in inhibitory and facilitatory pain modulation processes. Eur J Pain 20(3):386–398, 2016 26032281
Voineskos AN, Wilson AA, Boovariwala A, et al: Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography. Psychopharmacology (Berl) 193(4):539–545, 2007 17497139
Volkow ND, Morales M: The brain on drugs: from reward to addiction. Cell 162(4):712–725, 2015 26276628
Weinshenker D, Holmes PV: Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin. Brain Res 1641(pt B):320–337, 2016 26607256
Weisstaub NV, Zhou M, Lira A, et al: Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313(5786):536–540, 2006 16873667
Wentworth BA, Stein MB, Redwine LS, et al: Post-traumatic stress disorder: a fast track to premature cardiovascular disease? Cardiol Rev 21(1):16–22, 2013 22717656
Westphal RS, Sanders-Bush E: Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists. Mol Pharmacol 46(5):937–942, 1994 7969083
Whitaker-Azmitia PM, Shemer AV, Caruso J, et al: Role of high affinity serotonin receptors in neuronal growth. Ann N Y Acad Sci 600:315–330, 1990 2252318
Wiklund L, Björklund A: Mechanisms of regrowth in the bulbospinal serotonin system following 5,6-dihydroxytryptamine induced axotomy, II: fluorescence histochemical observations. Brain Res 191(1): 109–127, 1980 7378747
Wisner A, Dufour E, Messaoudi M, et al: Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc Natl Acad Sci U S A 103(47):17979–17984, 2006 17101991
Wiste AK, Arango V, Ellis SP, et al: Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorder. Bipolar Disord 10(3):349–359, 2008 18402623
Wolf WA, Bobik A: Effects of 5,6-dihydroxytryptamine on the release, synthesis, and storage of serotonin: studies using rat brain synaptosomes. J Neurochem 50(2):534–542, 1988 2447243
Xia Y, Zheng MQ, Holden D, et al: Measurement of Bmax and Kd with the glycine transporter 1 radiotracer18F-MK6577 using a novel multi-infusion paradigm. J Cereb Blood Flow Metab 35(12):2001–2009, 2015 26198176
Yamashita A, Singh SK, Kawate T, et al: Crystal structure of a bacterial homologue of Na+/Cl–dependent neurotransmitter transporters. Nature 437(7056):215–223, 2005 16041361
Yau JL, Noble J, Seckl JR: Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus. Neurosci Lett 309(3):141–144, 2001 11514061
Ye ZC, Oberheim N, Kettenmann H, Ransom BR: Pharmacological “cross-inhibition” of connexin hemichannels and swelling activated anion channels. Glia 57(3):258–269, 2009 18837047
Yun HM, Rhim H: The serotonin-6 receptor as a novel therapeutic target. Exp Neurobiol 20(4):159–168, 2011 22355260
Zanos P, Moaddel R, Morris PJ, et al: NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533(7604):481–486, 2016 27144355
Zarate CA Jr, Singh JB, Carlson PJ, et al: A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63(8):856–864, 2006a 16894061
Zarate CA Jr, Singh J, Manji HK: Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Biol Psychiatry 59(11):1006–1020, 2006b 16487491
Zhang J, McDonald AJ: Light and electron microscopic analysis of enkephalin-like immunoreactivity in the basolateral amygdala, including evidence for convergence of enkephalin-containing axon terminals and norepinephrine transporter-containing axon terminals onto common targets. Brain Res 1636:62–73, 2016 26835559
Zuckerman M: Sensation seeking, mania, and monoamines. Neuropsychobiology 13(3):121–128, 1985 4047373