Schizophrenia and Genetics : The End of an Illusion (9781483598185) by Joseph, Jay -- Read -- Imperial Library of Trantor

Index

Cover Title Copyright Dedication Preface Chapter 1: Introduction

Differing Concepts of "Schizophrenia" Evidence in Support of Environmental Causes Problems with Genetic Explanations of Schizophrenia

Most Diagnosed People Have No Family History of Psychosis Low Reproduction Rates Is "Schizophrenia" a Valid Disorder that Can Be Reliably Identified?

Genetic and Brain Disease Claims Do Not Cross-Validate Each Other

Chapter 2: The "Nonreplication Curse" in Schizophrenia Molecular Genetic Research

"Finding and Losing" Schizophrenia Genes

Gene Discovery Claims by Authoritative Experts The Schizophrenia "Gene Pond" is Empty The APA Contradicts Itself New Molecular Genetic Methods Will Not Uncover Genes if They Do Not Exist

The "Heritability" of Schizophrenia is "Missing"

Heritability: "One of the Most Misleading Terms in the History of Science" "Variation Explained by" Is Not the Same as "Strength"

Chapter 3: Schizphrenia Family Studies

“Runs in the Family” ≠ Genetic Ernst Rüdin and the “Munich School” of Psychiatric Genetics Kallmann's Study Conclusion

Chapter 4: Schizophrenia Twin Studies

The Twin Method and Its Assumptions The MZ-DZ Equal Environment Assumption: The Achilles' Heel of the Twin Method

Two Defenses of the EEA That Fail Same-Sex vs. Opposite-Sex DZ Twin Concordance Rates DZ Twin vs. Non-Twin Sibling Concordance Rates A 2015 Twin Study "Cathedral" A Pulitzer Prize Winner Gets the Basic Facts Wrong

Other Twin Study Designs

The Offspring of Discordant MZ Pairs Design Twins Reared Apart

Conclusion: Genetic Interpretations of Schizophrenia Twin Studies Must Be Rejected Outright

Chapter 5: Schizophrenia Adoption Studies

Complete Separation of Genes and Environment?

Abandoned Children Prenatal Environment Range Restriction and Representativeness

Bias and Deception in Behavioral Research

P-Hacking, HARKing, and Data Dredging The Preregistration of Research

The Individual Studies

Heston's U.S. Oregon Study The Kety-Led Danish-American Studies The Rosenthal-Led Danish-American Study The Wender-Led Danish-American Study The Tienari-Led Finnish Study The Lichtenstein-Led Swedish Study

Major Problem Areas of the Danish-American Adoption Studies

The Schizophrenia Spectrum Concept Index Group Dianostic Rates Must Be Significantly Higher than the General Population Rate The "Inadequate Personality" Diagnosis "Uncertain" Diagnoses in the Kety-Led Copenhagen Study Homophobic and Non-Psychotic Diagnostic Criteria No Significant Elevation of B1 Chronic Schizophrenia in 1968 or 1971 Interviews and "Pseudointerviews" in the Kety-Led 1975 Study Chronic B1 Schizophrenia in the 1975 Kety-Led Study The Necessity of "Broadening the Concept of Schizophrenia Disorder as Widely as it May Have Ever Been Reasonably Conceived Before" "Necessarily Vague" Diagnostic Boundaries The Arbitrary Inclusion of "Borderline Schizophrenia" in the Spectrum The Arbitrary Exclusion of "Acute Schizophrenia" from the Spectrum High Rate of Spectrum Diagnoses Among Control Biological Relatives Attachment Rupture: The Use of Late-Separated and Late-Placed Adoptees Violation of the Statistical Assumption of Independent Observations Counting "Manic-Depression" as a Schizophrenia Spectrum Disorder The Kety-Led Studies: Changing the Research Design After the Results Came In The Rosenthal-Led Study: Assuming the Genetic Basis of Schizophrenia in the Process of Testing for It Diagnoses Among Biological Half-Siblings Were Not Consistent with Genetic Predictions The "Compelling" Biological Paternal Half-Sibiling Comparison Was Not Statistically Significant The Final Results of the Rosenthal-Led Study: Negative Inconsistencies in Counting and Diagnosing Relatives Problem Areas in the 1974 Crossfostering Study "Uncertain" Diagnoses in the Kety-Led Provincial Study Reduction of the Control Group in the Kety-Led Provincial Study Additional Problem Areas in the 1994 Kety-Led Provincial Study

Summary of the Danish-American Adoption Studies Critique Selective Placement: The Achilles' Heel of Schizophrenia Adoption Research

Denmark Oregon Finland and Sweden Conclusion

Misleading Textbook Accounts of Schizophrenia Adoption Research

Citing Non-Existent Studies in Support of Genetics Incorrect Descriptions of the Comparison Groups Used in the Kety-Lef Studies A Past President of the APA Gets It Wrong

Schizophrenia Adoption Research: Summary and Conclusions

Chapter 6: Schizophrenia and Genetics: General Conclusions Acknowledgements Notes

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