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Index
Cover image Title page Table of Contents Dedication Copyright Preface Chapter 1. Introduction
Abstract 1.1 Prokaryote Cell Membranes 1.2 Eukaryote Cell Membranes 1.3 Plasma Membranes 1.4 Intracellular Membranes 1.5 Viral Membranes 1.6 Membrane Motifs 1.7 The Hydrophobic Effect 1.8 Structure of Water 1.9 Nonpolar Molecules and Water 1.10 Highlights References
Chapter 2. The Lipids of Biological Membranes
Abstract 2.1 Phospholipids 2.2 Sphingolipids 2.3 Glycolipids 2.4 Sterols 2.5 Two-Headed Lipids 2.6 Lipopolysaccharide 2.7 Lipid Identification 2.8 Highlights References
Chapter 3. Biogenesis of Membrane Lipids
Abstract 3.1 Desaturation of Fatty Acids 3.2 Biosynthesis of Phospholipids 3.3 Biosynthesis of Sphingolipids 3.4 Cholesterol Biosynthesis 3.5 Assembly of Newly Synthesized Lipids into Membranes 3.6 Highlights References
Chapter 4. Detergents
Abstract 4.1 Nonionic Detergents 4.2 Ionic Detergents 4.3 Detergent Properties 4.4 Detergents and Membrane Rafts References
Chapter 5. Membrane Models
Abstract 5.1 The Evidence for the Lipid Bilayer 5.2 The Singer Nicholson Model for Membranes 5.3 Current Model for Biological Membranes 5.4 Highlights References
Chapter 6. Laboratory Membrane Systems
Abstract 6.1 Structure of Laboratory Membrane Systems 6.2 Properties Derived from Laboratory Membrane Systems 6.3 Hydration 6.4 Ion Binding 6.5 Highlights References
Chapter 7. Structures of Lipid Assemblies
Abstract 7.1 Lamellar (Bilayer) Structure 7.2 Interdigitated Bilayers 7.3 Micellar Phase 7.4 Hexagonal I Phase (HI) 7.5 Hexagonal II Phase (HII) 7.6 Cubic Phase 7.7 Subphase for Phospholipid Bilayers 7.8 Solution Phase 7.9 Lipid Phase Transitions 7.10 Phase Transitions in Cell Membranes 7.11 Lamellar to HII Phase Transition 7.12 Lipid Microdomains in Membranes 7.13 Lipid Conformation in Membranes 7.14 Water in the Lipid Bilayer 7.15 Highlights References
Chapter 8. Lipid Dynamics in Membranes
Abstract 8.1 Introduction 8.2 ESR 8.3 2H NMR 8.4 Motional Order 8.5 Motional Rates 8.6 Integrated View of Motional Order and Dynamics 8.7 Membrane Fluidity 8.8 Free Volume within a Membrane Bilayer 8.9 Lateral Diffusion of Membrane Components 8.10 Lateral Phase Separation 8.11 Transmembrane Movement of Lipids 8.12 Movement of Phospholipids Between Membranes 8.13 Transmembrane Lipid Asymmetry 8.14 Highlights References
Chapter 9. Cholesterol and Related Sterols: Roles in Membrane Structure and Function
Abstract 9.1 Structure and Properties of the Cholesterol Molecule 9.2 Cholesterol Location in Cells 9.3 Cholesterol Modulates Membrane Physical Properties 9.4 Role of Sterols in Sterol-Requiring Cells 9.5 Essential Role of Cholesterol in Mammalian and Other Sterol-Requiring Cells 9.6 Hypothesis for a Specific Sterol Requirement 9.7 Highlights References
Chapter 10. Membrane Proteins
Abstract 10.1 Classification of Membrane Proteins 10.2 Peripheral Membrane Proteins 10.3 Integral Membrane Proteins 10.4 Primary Structure of Membrane Proteins 10.5 Secondary Structure of Integral Membrane Proteins 10.6 Tertiary Structure of Membrane Proteins 10.7 Quaternary Structure of Membrane Proteins 10.8 Three-Dimensional Structure of Integral Membrane Proteins—Experimental Approaches 10.9 Principles of Membrane Protein Structure 10.10 Domain Structure of Membrane Proteins 10.11 Membrane Protein Stability 10.12 Dynamics of Membrane Proteins in Membranes 10.13 Membrane Protein Asymmetry in Membranes 10.14 Posttranslational Modification of Membrane Proteins 10.15 Highlights References
Chapter 11. Membrane Biogenesis
Abstract 11.1 Assembly of Newly Synthesized Lipids into Membranes 11.2 Transport of Lipids to Target Membranes 11.3 Membrane Protein Biosynthesis 11.4 Biosynthesis and Insertion of Integral Membrane Proteins into Endoplasmic Reticulum 11.5 Posttranslational Modifications of Membrane Proteins 11.6 Degradation of Membrane Proteins 11.7 Highlights References
Chapter 12. Lipid–Protein Interactions in Membranes
Abstract 12.1 Influence of Membrane Proteins on Bulk Membrane Lipid Properties in a Bilayer 12.2 Specific Lipid Influence on Membrane Protein Function 12.3 Tight Noncovalent Binding of Lipids to Membrane Proteins 12.4 Pleckstrin Homology Domains 12.5 Phospholipase Binding to Phospholipid Substrate 12.6 Boundary Lipids in Membranes Containing Transmembrane Proteins 12.7 Dynamics of Lipids Interacting with Membrane Proteins 12.8 Membrane Proteins and Rafts 12.9 Proteins That Bend Bilayers 12.10 Lipids Covalently Bonded to Proteins 12.11 Reconstitution 12.12 Highlights References
Chapter 13. Membrane Transport
Abstract 13.1 Passive Diffusion 13.2 Facilitated Diffusion 13.3 Active Transport 13.4 Highlights References
Chapter 14. Membrane Fusion
Summary 14.1 Fundamentals of the Membrane Fusion Process 14.2 Measurement of Membrane Fusion 14.3 Fusion of Phospholipid Vesicles 14.4 Virus Fusion 14.5 Sendai Virus 14.6 Influenza Virus 14.7 Intracellular Membrane Fusion 14.8 Highlights References
Chapter 15. Membrane Receptors
Abstract 15.1 LDL Receptor 15.2 Receptor-Mediated Endocytosis 15.3 Transferrin Receptor 15.4 Receptor Tyrosine Kinases—Insulin Receptor 15.5 Receptor Tyrosine Kinases—Epidermal Growth Factor Receptor 15.6 Nicotinic Acetylcholine Receptor 15.7 Integrins, Adhesion Receptors 15.8 Guanylyl Cyclase Receptors 15.9 G-Protein Coupled Receptors 15.10 Highlights References
Index
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