How the Immune System Works by Sompayrac, Lauren M. -- Read -- Imperial Library of Trantor

Index

Cover Dedication Title page Copyright page Acknowledgments How to Use This Book The Anytime, Anywhere Textbook LECTURE 1: An Overview

PHYSICAL BARRIERS THE INNATE IMMUNE SYSTEM THE ADAPTIVE IMMUNE SYSTEM A COMPARISON OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS THE INNATE SYSTEM RULES! EPILOGUE

LECTURE 2: The Innate Immune System

THE COMPLEMENT SYSTEM PROFESSIONAL PHAGOCYTES NATURAL KILLER CELLS THE INNATE IMMUNE SYSTEM – A COOPERATIVE EFFORT A PROPORTIONAL RESPONSE HOW THE INNATE SYSTEM DEALS WITH VIRUSES SUMMARY FIGURE

LECTURE 3: B Cells and Antibodies

THE B CELL RECEPTOR HOW THE BCR SIGNALS HOW B CELLS ARE ACTIVATED CLASS SWITCHING ANTIBODY CLASSES AND THEIR FUNCTIONS SOMATIC HYPERMUTATION B CELLS MAKE A CAREER CHOICE SUMMARY FIGURE

LECTURE 4: The Magic of Antigen Presentation

CLASS I MHC MOLECULES CLASS II MHC MOLECULES ANTIGEN PRESENTATION BY CLASS I MHC MOLECULES ANTIGEN PRESENTATION BY CLASS II MHC MOLECULES ANTIGEN PRESENTING CELLS NON-CLASSICAL MHC MOLECULES AND LIPID PRESENTATION THE LOGIC OF CLASS I MHC PRESENTATION THE LOGIC OF CLASS II MHC PRESENTATION MHC PROTEINS AND ORGAN TRANSPLANTS SUMMARY SUMMARY FIGURE

LECTURE 5: T Cell Activation

T CELL RECEPTORS TRADITIONAL T CELLS NON-TRADITIONAL T CELLS HOW A T CELL’S RECEPTORS SIGNAL CD4 AND CD8 CO-RECEPTORS CO-STIMULATION A TIME-LAPSE PHOTO OF HELPER T CELL ACTIVATION HOW KILLER T CELLS ARE ACTIVATED

LECTURE 6: T Cells at Work

THE DENDRITIC CELL AS “COACH” OF THE IMMUNE SYSTEM TEAM Th1 HELPER T CELLS Th2 HELPER T CELLS Th17 HELPER T CELLS Th0 HELPER T CELLS LOCKING IN THE HELPER T CELL PROFILE SUMMARY DELAYED TYPE HYPERSENSITIVITY HOW CTLs KILL EPILOGUE SUMMARY FIGURE

LECTURE 7: Secondary Lymphoid Organs and Lymphocyte Trafficking

LYMPHOID FOLLICLES HIGH ENDOTHELIAL VENULES A TOUR OF THE SECONDARY LYMPHOID ORGANS THE LOGIC OF SECONDARY LYMPHOID ORGANS LYMPHOCYTE TRAFFICKING WHY MOTHERS KISS THEIR BABIES

LECTURE 8: Restraining the Immune System

AVOIDING OVERREACTION ATTENUATING THE IMMUNE RESPONSE DEACTIVATING THE SYSTEM LIFE IS SHORT EXHAUSTION

LECTURE 9: Tolerance Induction and MHC Restriction

THE THYMUS MHC RESTRICTION THE LOGIC OF MHC RESTRICTION TESTING FOR TOLERANCE OF SELF GRADUATION THE RIDDLE OF MHC RESTRICTION AND TOLERANCE INDUCTION TOLERANCE BY IGNORANCE TOLERANCE INDUCTION IN SECONDARY LYMPHOID ORGANS PERIPHERAL TOLERANCE TOLERANCE DUE TO ACTIVATION-INDUCED DEATH B CELL TOLERANCE MAINTENANCE OF B CELL TOLERANCE IN GERMINAL CENTERS SUMMARY FIGURE

LECTURE 10: Immunological Memory

INNATE MEMORY ADAPTIVE MEMORY INNATE VERSUS ADAPTIVE MEMORY

LECTURE 11: Vaccines

GENERATING MEMORY HELPER T AND B CELLS GENERATING MEMORY KILLER T CELLS STRATEGIES FOR VACCINE DEVELOPMENT WILL THERE BE AN AIDS VACCINE?

LECTURE 12: The Immune System Gone Wrong

PATHOLOGICAL CONDITIONS CAUSED BY A NORMAL IMMUNE RESPONSE DISEASES CAUSED BY DEFECTS IN IMMUNE REGULATION AUTOIMMUNE DISEASE

LECTURE 13: Immunodeficiency

GENETIC DEFECTS LEADING TO IMMUNODEFICIENCY AIDS

LECTURE 14: Cancer and the Immune System

CANCER IS A CONTROL SYSTEM PROBLEM CLASSIFICATION OF CANCER CELLS IMMUNE SURVEILLANCE AGAINST CANCER VACCINATION TO PREVENT VIRUS-ASSOCIATED CANCER

LECTURE 15: A Critique of the Immune System

WE ARE UNDER ATTACK! CRITIQUING THE IMMUNE DEFENSE WEAKNESSES OF THE IMMUNE SYSTEM BAD DESIGN?

Glossary Index