Contents

List of Figures

List of Tables

Preface

Share Cancer Pharmacology and Pharmacotherapy Review: Study Guide for Oncology Boards and MOC Exams

I. Traditional Chemotherapy

1.     Microtubule Inhibitors

             Taxanes and Related Agents

             Vinca Alkaloids

2.     Alkylating Agents

             Nitrogen Mustards

             Non-Nitrogen Mustards

             Platinums

             Antitumor Antibiotics

3.     Enzyme Inhibitors—Topoisomerase I Inhibitors

             Camptothecans

4.     Enzyme Inhibitors—Topoisomerase II Inhibitors

             Epipodophyllotoxins

             Anthracyclines

5.     Antimetabolites

             Antifolates

             Purine Antagonists

             Purine Analogues

             Pyrimidine Analogues/Fluoropyrimidines

             Pyrimidine Analogues/Deoxycytidine Analogues

II. Next-Generation Antineoplastics

6.     Monoclonal Antibodies

7.     VEGF Trap

             Ziv-Aflibercept (Zaltrap^®)

8.     Tyrosine Kinase Inhibitors

             Angiogenesis Inhibitors and Multi-Kinase Inhibitors

             Breakpoint Cluster Region-Abelson Murine Leukemia Viral Oncogene Homolog 1 (BCR-ABL) Inhibitors

             B-Cell Receptor (BCR) Pathway Inhibitors

             EGFR-Ras-Raf-MEK-ERK (MAPK) Pathway Inhibitors

             Miscellaneous Oral Targeted Therapies

9.       Antiandrogen Therapies

10.     Mammalian Target of Rapamycin (mTOR) Inhibitors

11.     Histone Deacetylase (HDAC) Inhibitors

12.     Hypomethylating Agents

13.     Proteasome Inhibitors

14.     Immunomodulatory Agents

15.     L-Asparaginase Enzymes

16.   Promyelocytic Leukemia Gene Retinoic Acid Receptor-Alpha (PML-RARα) Translocation Inhibitors

III. Miscellaneous Oncolytics

17. Sipuleucel-T (Provenge^®)

18. Omacetaxine (Synribo^®)

19. Estramustine (Emcyt^®)

Appendix A: Agents Requiring Renal and/or Hepatic Dose Adjustments

Appendix B: Extravasation Risk of Chemotherapeutic Agents

Index