Abelson, Herbert, 53
Acute leukemia, 4, 7, 11, 16, 22, 26, 34, 36, 43, 48, 53, 57, 59, 76–77, 82, 84, 88, 90, 95, 100, 119, 259, 263, 272
Acute lymphocytic (lymphoblastic) leukemia (ALL), 11, 13, 15–16, 32, 246, 268, 274
Acute myeloid leukemia (AML), 11–15, 17, 23, 32, 62, 64, 77–78, 93, 145–146, 187–188, 209, 246, 257, 273–274, 276
Acute promyelocytic leukemia (APL), 13, 95–101, 114–121, 124, 130, 186, 189
All-trans retinoic acid (ATRA), 13, 97–101, 115, 117, 118, 120–121, 137–138, 184, 189, 210, 217, 253
American Society of Hematology, 120
Angelou, Maya, 107
Apheresis, 222
Apperley, Jane, 158
Arsenic and Old Lace (Kesselring), 204
Arsenic compounds, 13, 60, 117–122, 189, 196–197, 203–204, 217–219
Artificial intelligence, 277
Atomic (nuclear) bomb, 42, 44–45
Atomic Bomb Disease Institute, 44–45
Atomic Energy Commission, 223
Auer rods, 96
Auer, John, 96
BCR-ABL chromosome translocation, 51, 53, 58, 95–96, 239–241, 249–250, 274–275
Be The Match program, 228, 230–231, 235, 247, 263
Begum, Rana, 110
Bennett, John, 5
Benzene, 43
Birth defects, 32, 66–67, 105, 160–161
Bone marrow, 5, 7, 10–17, 21–23, 26, 32, 34, 36–38, 43, 46, 50–52, 54, 59–60, 76, 92–93, 99, 131, 143, 146, 183, 187–188, 203, 206–207, 209, 211, 219–230, 232, 234, 240, 243, 256, 259, 265–266, 269–271, 277
Bone marrow biopsy, 11, 23, 34, 38, 50, 76–77, 89, 92, 129–130, 143–144, 186, 189, 191, 196, 202–207, 259
Bone marrow transplant/transplantation, 12–14, 60, 65, 87, 90, 93, 152, 210–211, 220–235, 243, 262, 272–274
allogeneic, 222
autologous, 221–222
haploidentical, 227
reduced intensity, 227
syngeneic, 224
Book of David, 145, 147, 202, 207
Buffalo, New York, 246
Bunts, Frank E., 108
Canton, Ohio, 264
Carrey, Jim, 268
Carver, Raymond, 1
Castel del Monte, 23–24
Center for International Blood and Marrow Research, 244
Centers for Disease Control and Prevention (CDC), 161, 256
Cetus Corporation, 239
Chemotherapy (chemo), 8–9, 12–15, 21, 23, 26–33, 41, 46, 59–60, 63–64, 67, 76–86, 92, 94, 97–98, 100–104, 111, 117–134, 137, 139, 143–146, 154, 156, 158, 160–161, 185–189, 192, 196, 201, 203, 206–208, 211, 213–214, 217, 219–222, 226, 238, 244, 248–252, 254, 257–259, 262–263, 267–268, 272–274, 277, 280–281
Chimera, 266–267
Chimeric antigen receptor (CAR) T-cells, 274
Chromosomes, 23–24, 53–65, 95–98, 114, 119, 156, 160, 196, 219, 225, 232, 239–241, 246–247, 275
Chronic lymphocytic leukemia (CLL), 11, 15
Chronic myeloid leukemia (CML), 11, 15, 36, 41, 44–46, 51–57, 60–66, 95–96, 98–99, 117, 152–153, 156–160, 238–241, 249–250, 275
Cleveland Browns, 262
Cleveland Clinic, 3, 77, 107–110, 164, 271
Cleveland Heights, 229
Cleveland Indians, 129, 132, 251, 258, 262, 276
Cleveland Museum of Art, 229
Complete blood cell count (CBC), 34
Computerized tomography (CT) scan, 4, 82, 91, 129, 166, 191
Confucian philosophy, rehabilitation of criminals, 99
Cooperstown, New York, 223
Crash cart, 138
Crile, George Washington, 108
Crosby, Bing, 252
Cuban Missile Crisis, 43
cummings, e e, 149
Cuyahoga Community College (Tri-C), 40
Cytarabine (Ara-C), 23–25, 32, 36, 64, 103, 119, 131, 146–147, 188–189, 240
Dana-Farber Cancer Institute, 61, 86, 111, 181
Daunorubicin, 23–25, 36, 97, 103, 119, 131, 146–147
Didion, Joan, 141
Differentiation syndrome, 135–137, 162, 183, 186, 189, 210, 253, 256
Disseminated intravascular coagulopathy (DIC), 88–89, 94–95, 101, 115, 191
DMSO preservative, 265
Doctors interrupt patients, 40–41
Doyle, Arthur Conan, 60
Eastern Cooperative Oncology Group (ECOG) performance status, 198–200
Eliot, T. S., 69
Entsminger, Scott, 262
Estey, Elihu, 120
Eternal Sunshine of the Spotless Mind, 268
Family cancer risk, 47–48
Fellow (fellowship), 8, 32, 34, 84, 88, 94, 103, 163–164, 181, 210, 268
Fibrosis, bone marrow, 37
Finch, Spencer, 110
Fluorescence in-situ hybridization (FISH), 114, 117
Fowler, Thomas, 60
Fowler’s solution, 60, 117–118
Fred Hutchinson Cancer Research Center, 226
Genetic mutations
germline, 48
IDH1, 273
somatic, 48
SF3B1, 273
T315I, 275
TP53, 273
Golem, 77, 186–187, 203, 218–219, 251, 272
Good, Robert, 225
Graft versus host disease (GVHD), 226
Greensburg, Pennsylvania, 113
Groundhog Day, 190
Guthrie cards, 245–247
Guthrie, Robert, 246
Hammersmith Hospital, 157
Harbin Medical University, 118
Hemoglobin (a measure of red blood cells), 4, 7, 10, 34, 126, 187, 196, 217
Hickman catheter, 264
Hillestad, L. K., 95
Hippocratic path, 168
Human leukocyte antigen (HLA) complex, 225
Hungerford, David, 54–55
I Got Burned Once (IGBO), 89
Imatinib (Gleevec), 15, 61, 62, 64–67, 149, 152–161, 184, 238, 240–242, 247, 249–250, 274–275
stopping treatment, 249–250
Intensive care unit (ICU) outcomes, leukemia, 90
Intensive chemotherapy, 12–13, 23, 29, 77, 143, 201, 208, 219, 268
Intern/internship, 8, 9, 18, 20, 22, 34, 74, 112, 163–181, 229
Jamshidi, Khosrow, 34
Jernigan, Amanda, 31
Johns Hopkins University, 96–97
Kaplan, Henry, 45–46
Karnofsky scale, 199
Karnofsky, David, 199
Kesselring, Joseph, 204
Kubler-Ross, Elizabeth, 128, 163, 192
Langer-Safer, Pennina, 114
Levine, M., 114
Livedo, 33
Lo-Coco, Francesco, 120
Lower, William, 108
Lyden, Nick, 62
Lymphocytes, white blood cell, 11, 36
Mackinaw instrument for intubation, 175–176
Massachusetts General Hospital, 164
Mayo Clinic, 108
Mayo, William Benson, 108
McCrae, Thomas, 96
MD Anderson Cancer Center, 77, 120
Medication adherence, 156–159
Memorial Sloan Kettering Cancer Center, 199
Meyer, Urban, 136
Minimal residual disease, 93
Misattributed paternity/Paternal discrepency, 232–235
Mucositis, 189
Mullis, Kary, 239–240
Murray, Bill, 190
Myeloblasts (Blasts), 11–17, 22, 36–37, 51–52, 76, 95, 116, 143–146, 183–184, 205, 207, 217–219
Myelodysplastic syndromes (MDS), 11, 14, 21, 42, 45, 48, 57, 77, 152, 256, 272, 277
Myeloproliferative disorders (myeloproliferative neoplasms), 36–37
National Cancer Institute (NCI), 145–146, 198, 256
National Institutes of Health, 62, 160
National Toxicology Program, 160
Nausea, anticipatory, 127–128
Neutropenic enterocolitis, 189
New York Yankees, 132
Newport Creamery, 18
Novartis, 62–63
Nowell, Peter, 54–55
The Office, 213
Ohio State University, 20, 79–80, 139, 198, 260
The Old Man and the Sea (Hemingway), 205
Olds, Sharon, 237
On Death and Dying (Kübler-Ross), 128–131
Oregon Health Sciences University, 62
Packard automobile dealership, 50
Phenylketonuria (PKU), 246
Philadelphia chromosome, 54–56, 58, 61, 63–65, 156, 160, 239–241, 275
Phillips, John, 108–109
The Plain Dealer, 116
Platelets, 4, 5, 7, 10, 22, 26, 28, 34, 37, 76, 88, 94, 120–121, 139, 155, 184, 187, 190–191, 193–194, 198, 202, 204, 217–218, 220–221, 254–256, 258, 263
Platzbecker, Uwe, 120–121
PML-RAR alpha chromosome translocation, 96, 98
Polymerase chain reaction (PCR), 239–240, 275
Radiation therapy, 44–46
Red blood cells (erythrocytes), 5, 7, 17, 22, 26, 37, 51–52, 115, 126, 139, 190, 220, 255
Religion and medicine, 190–193
Remission (from leukemia), 27, 29, 60, 62, 77, 83–84, 91–93, 97, 100–101, 115, 118–123, 129, 143, 146, 158, 161, 186, 188, 192, 196, 208–211, 220, 240, 249–250, 262, 271–272, 274
Resident/Residency, 8, 9, 11, 18–20, 30, 31, 34, 38, 42, 71, 101, 125–126, 163–181, 183, 215, 224, 229
Respiratory syncytial virus (RSV), 271
Reticuloendothelial system, 37
Retrospective studies, 29
Rochester, New York, 223
Roswell park cancer Institute, 246
Rothschild, Eva, 110
Rui-Jin Hospital, 97
Sasaki, Sadako, 44
Schistocytes, 115
Seattle, Washington, 226
Seinfeld, 213
Selection bias, 29
“7+3” chemotherapy, 23, 26, 131, 201, 207
Severance Hall, 229
Shaker Heights, 229
Shuster, Joe, 136
Siegel, Jerry, 136
Slyman’s Deli, 185
Southwest Oncology Group (SWOG), 145
Springsteen, Bruce, 70
Steinbrenner family, 132
STI-571, 62
Storb, Ranier, 226
Surveillance, Epidemiology and End results (SEER) program, 256
Theil, Karl, 50–53, 76, 114–115, 144–145, 205–206, 277
Thomas, E. Donnall, 223–225
Tillamook, Oregon, 63
Topoisomerase, 23–25
Translocation of chromosomes 15, 17, 95–96, 98, 196, 219
Treatment benefits, exaggerated, 81–87
Treatment decisions, influences, 103–104
Treatment time/delays, 76–78
Tyrosine kinase inhibitors (TKIs), 15, 153, 241
Umbilical cord blood banking, 243–247
Umbilical cord transplant, 227
University of Florida, 136
US Food and Drug Administration (FDA), 23, 61, 64, 155, 209–210
Vertical cancer transmission, 49, 238
von Furstenberg, Diane, 20, 89
Wang, Zhen-Yi, 97–100
Ward, David, 114
White blood cells, 3, 5, 7, 10, 16–17, 22, 34–37, 51, 76, 95, 97, 99, 117, 119–122, 134, 137, 139, 155, 183, 193, 217–218, 253
basophils, 36–37
differential, 35–37
monocytes, 36
neutrophils, 17, 36–37, 51–52, 183–184, 188, 193, 198, 203
promyelocytes, 13, 36–37, 95–99
White Christmas, 252
William Rawn Associates, 110
Winslet, Kate, 268
Wooster, OH, 1
Workstation on wheels (WOW), 8, 36, 43, 115, 125, 134, 152, 165, 170, 187, 229
X-ray, 22, 43, 74, 108, 134, 166–167, 170, 176, 213
The Year of Magical Thinking (Didion), 141
Yeats, William Butler, 195