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Index
Cover Title page Copyright page Acknowledgments Introduction CHAPTER 1: Anatomy and Physiology
Introduction Mammalian Cell Components Tissue Groups Tissue Growth Organs and Organ Systems Homeostasis Summary Questions
CHAPTER 2: The Cell
Introduction Cell Structure Cell Membranes Membrane Transport Cellular Junctions Cell Cycle Cellular Division Cell Death Summary Questions
CHAPTER 3: Radiation Characteristics and Units
Introduction Types of Ionizing Radiation EM Radiation Atoms and Isotopes Particulate Radiation Radiation Units: Traditional and Modern Summary Questions
CHAPTER 4: Radiation Interactions with Tissue
Introduction Charged Particle Interactions EM Radiation Interactions Neutrons Specific Ionization Linear Energy Transfer (LET) Path and Range of Charged Particles Half-Value Layer (HVL) (Photons) Effects on Tissue The Relative Biological Effectiveness (RBE) of High- versus Low-LET Radiations Summary Questions
CHAPTER 5: Cell Survival Curves
Introduction The In Vitro Survival Curve Cell Survival Curves: Description of Experimental Method Cell Survival Curves: Quantification Surviving Fraction versus Dose: The Cell Survival Curve Modeling the Shape of the Survival Curve Single-Target/Single-Hit Model Multitarget Model (also “Two-Component Model” or “Dq, D0, and n Model”) LQ or α/β Model Application of the Multitarget and LQ Models in Radiobiology Factors Affecting the Shape of Survival Curves Survival Curve Shape and LET Chemicals Summary Questions
CHAPTER 6: DNA and Genetics
Introduction History DNA Structure DNA Functions DNA Replication and Repair Genome Summary Questions
CHAPTER 7: Radiation Damage and Repair of Cells
Introduction DNA Strand Breaks DNA Damage versus Mutation Chromosomes and Cell Division The Bystander Effect Radiosensitivity and the Mitotic Cycle Classifications of Radiation Damage and Repair Evidence of Repair from Split Doses and Fractionation Summary Questions
CHAPTER 8: Normal and Malignant Cells
Introduction Normal Cells Cancer Cells and Their Characteristics The Characteristics of Cancer Cells Cancer Grade Traditional Hypothesis of Cancer Development Predictions Regarding Treatment Radiation and Cancer Summary and Important Points Questions
CHAPTER 9: Radiation Effects on Tissues and Organs
Latent Period Deterministic and Stochastic Radiation Damage Stochastic Effects Radiation Effects on Tissues Summary Questions
CHAPTER 10: Whole Body Radiation Effects
Introduction Acute Radiation Syndrome (ARS) Mean Lethal Dose (LD50) Clinical Syndromes of ARS Stages of ARS Bystander Effect Summary Questions
CHAPTER 11: Radiation Treatment of Cancer
The Four Rs of Radiation Oncology Cell Survival Curves and Fractionation Fractionation Hyperfractionation Hypofractionation or Continuous Radiation Complications from Radiation Therapy Techniques Used to Treat Cancer External Beam Treatment Brachytherapy or Implant Therapy Summary Questions
CHAPTER 12: Radiation Biology of Diagnostic Imaging
Diagnostic Procedures Fluoroscopy Mammography Computerized Tomography (CT) Radiobiology of Radiographic Imaging Patient Concerns and Questions Summary of Diagnostic X-ray Radiation Effects Questions
CHAPTER 13: Nuclear Medicine Radiation Biology
Introduction Isotopes and Radiopharmaceuticals Radioactive Decay External Dosimetry Internal Dosimetry Half-Life and Cumulated Activity The Biological Half-Life and Effective Half-Life Medical Internal Radiation Dosimetry (MIRD) Fetal Dose Conclusion Questions
CHAPTER 14: Environmental Radiation
Introduction Natural Background Radiation Sources Inhalation Sources Internal Sources Cosmic Radiation Primordial and Terrestrial Man-Made Radiation Occupational Exposure Smokers Medical Radiation Exposure Benefits of Radiation Risk of Typical Radiation Exposures Summary Questions
CHAPTER 15: Regulations and Risk
Introduction Expressions of Risk Organizations Sources of Data Dose–Response Models Sunk Cost Bias Radiation Protection Recommendations and Regulations Conclusions Questions
CHAPTER 16: Biological Effects of Ultrasound
Introduction Ultrasound Properties and Procedures Properties of Ultrasound Waves Ultrasound Imaging Equipment Biological Effects of Ultrasound Waves Ultrasound Regulations Other Types of Medical Ultrasound Procedures Summary of Radiation Effects of Ultrasound Safety Statement Questions
CHAPTER 17: Biological Effects of Magnetic Resonance Imaging
Topics Introduction Basic Principles of MRI Biological Effects of MRI Conclusions Summary Questions
Answers to Odd-Numbered Questions Index
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