GMO Sapiens by Knoepfler, Paul -- Read -- Imperial Library of Trantor

Index

Cover Page Title Copyright Contents Preface Chapter 1 An Introduction to Playing God

Genetically modified (GM) human embryos You’re only human … but your kids could be more On the menu: IVF meets GMO Cutting edge technology: CRISPR-Cas9 Your better baby GMO genesis The stem cell and cloning connections References

Chapter 2 The Birth and Explosive Growth of GMOs

GM plants sprout Where did GMOs come from? The race for GM crops Democratizing creation GM pets and novelties GM mosquitoes as good “weapons” to fight disease Defining human genetic modification Gene therapy References

Chapter 3 Human Cloning

A student and the first clone Cloning culture The birth of cloning The two kinds of cloning Phony cloning Cloning myths The politics of cloning De-extinction: resurrecting the extinct Cloning meets GMOs? Cloners and friends Who will be the first human clones? References

Chapter 4 Messing with Mother Nature: The First GMO Sapiens

The birth of IVF and a devilish dilemma The “cowboys of medicine” make first GM babies Would it be legal to make a GMO sapiens? Monkeying around with primate eggs and genomes The future of three-person IVF References

Chapter 5 Build-a-Baby Better via Genetics

The genesis of commercial human genetic testing Genetics dating and mating service: I prefer a child with … Changing the genetic equation via designer babies? Preimplantation genetic diagnosis (PGD) CRISPR versus PGD Sex selection Savior siblings Human GMO economics OvaScience Mitogenome therapeutics Genetics and human choices Genetic tourism Are designer babies the next step on the GM timeline? References

Chapter 6 DIY Guide to Creating GMO Sapiens

Why make a GMO sapiens and what is your target? The CRISPR connection CRISPR as a laboratory tool In the laboratory, begin at the beginning A la carte genetic modifications A potential role for stem cells Build a better mouse and they will come: the experience of making a GMO What if you make a mistake? What could go wrong Could we correct a mistake? Practical challenges to making a GMO sapiens References

Chapter 7 Eugenics and Transhumanism

Eugenics takes root in California “Better babies” through eugenics IVF and eugenics What is a “better” or “perfect” person? Should we try to make “better babies” via genetic modification? Transhumanism: Getting from point ACGT to H+ George Church, genetics pioneer and transhumanist Forced genetic change: gene drive, and weapons References

Chapter 8 Cultural Views on Human Genetic Modification

Public perceptions of human modification American views on creating GM humans Global views on human genetic modification Frankenstein revisited The Brothers Huxley GATTACA DNA Dreams and reality Orphan Black An artist’s view of human cloning Genetic discrimination or celebrity Gender issues in human modification Letting your GMO imagination run wild How will culture view real GMO sapiens? References

Chapter 9 GMO Sapiens Today and Tomorrow

Creation of the first gene-edited human embryos “Don’t edit the human germline” “Prudent path forward” ABCD plan Stanford Law meeting on human genetic modification George Church on human genetic modification Oxford ethicists: don’t worry, just do it! The human genome as ever-changing mashup? The future of human genetic modification References

Glossary Index