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Index
Cover
Title Page
Copyright
Dedication
Acknowledgements
Contents
FOREWORD
Introduction to the First Edition
Psychedelic Renaissance
Profiles
Pharmacology
Themes and Trends
Notes on Ketamine
Organizations and Publications
MDMA Update
MDMA’s Historic Advance
Chemistry
Physical Effects
Mental Effects
Forms, Sources and Preparation
Psychedelic Obituaries
Index to new material in the Third Edition
PREVIEW
Cultural Context
Origin of the World Psychedelic
Other Terms Proposed
Varieties of “Psychedelics”
What are the Common Effects?
What are the Benefits to Humanity?
Countercultural Influences
Questions about Purity and Other Complications
Use and Misuse
Dealing with Difficulties
Drawbacks of Psychedelic Usage
Future Directions
Chapter One: The LSD Family (the archetype)
History
The First LSD Experiences
Early Distribution of LSD
A Decade of Clinical Use
A Decade and a Half of Covert Use
The Big Wave Hits
LSD Becomes Illegal
Ebb and Resurgence
Chemistry
Resemblances and Differences Between LSD and Other Substances
Other Psychoactive Lysergic Acid Derivatives
Physical Effects
Distribution of LSD Throughout the Body
Measurable Effects on the Brain
Effects upon Chromosomes
LSD and Physical Health
Pain Reduction
Mental Effects
General Effects
Dosage Considerations
Therapy and Everyday Problems
Creative Stimulus
Religious Considerations
Botanical Sources of Lysergic Acid Amides
Rye and Other Grasses
Morning Glories
Hawaiian Woodroses
Forms and Preparations
Chapter Two: Peyote, Mescaline and San Pedro
History
Mesoamerican Accounts
Peyote Passes to the U.S.
Scientific Scrutiny and Diffusion among Non-Indians
A Decade Opening the “Psychedelic Doors”
Discovery of Mescaline in Other Cacti
Mescaline and Peyote Go “Underground”
Native and Non-native Use under The Bill of Rights
Trekking Back to Peyote Country
Botany
The Lophophora Genus
Trichoceri
Chemistry
β-phenethylamines and Tetrahydroisoquinolines
Escaline, Proscaline and Similar Synthetic Compounds
Physical Effects
Taste and Nausea
Coursing through the Body
Medical and Health Aspects
Mental Effects
Similarities and Differences with LSD
Dosage and Timing
Sacramental Aspects
Visual Effects
Auditory Effects
Dimensions Outside Time and Space
Creative Potential
Psychological Safety
Psychotherapeutic Potential
Forms and Preparations
Chapter Three: Marijuana and Hashish
History
Ancient Forms and Distinctions about Usage
The Spread to Europe and Africa
Early American Experience with Cannabis
The Anslinger Era
Governmental Investigations and Other Reports
Moves toward Decriminalization
Smuggling and Cash Crops
Other Developments
Botany
Uniqueness
Life Cycle
Chemistry
Cracking the THC molecule
Analogues and Mixtures
Physical Effects
Coursing through the Body
Medical Safety
Medical Use
Mental Effects
Strength of Cannabis Preparations
The Tart Study
Old Myths Dispelled
Other Aspects of Pot
Inspiration
Forms and Preparations
Distinguishing among Marijuana Samples
Hashish and Hash Oil
THC and Analogues
Smoking
Eating Marijuana
Chapter Four: Psilocybian Mushrooms
History
From Antiquity until June 29, 1955
The Wassons Mobilize Others
Sandoz Synthesizes Analogues and Distributes Psilocybin to Researchers
The Harvard Psilocybin Research Project
Use of Psilocybian Mushrooms Increases
Botany
Field Identification, Bluing Reaction, Spore Prints and Preparation
Stropharia (Psilocybe) cubensis (San Isidro)
Psilocybe semilanceata (Liberty Caps)
Panaeolus subbalteatus (benanosis)
Psilocybe cyanescens (Wavy Caps, Blue Halos)
Psilocybe baeocystis
Pilocybe stuntzii
Chemistry
Psilocybin and Psilocin
Related Psychoactive Derivatives
Physical Effects
Mental Effects
Leo Hollister’s Observations
R. Gordon Wasson’s Observations
Dosage Considerations
Gentleness
Auditory Effects
The Great Oracle
Andrew Weil’s Observations
Forms and Preparations
Chapter Five: Nutmeg and MDA
History
Introduction to the MDA “Cluster”
Nutmeg and Mace
Calamus, or “Sweet Flag”
Alles Discovers MDA’s Psychoactivity
Synthesis and Testing of Related Compounds
Chemistry
Physical Effects
Nutmeg
The MDA-like and STP-like Subclusters
Mental Effects
Nutmeg
STP
Zinberg’s Evaluation of MDA
MDA and MMDA Compared
Naranjo’s Psychiatric Distinctions
Forms and Preparations
Chapter Six: DMT, DET, DPT and Other Short-Acting Tryptamines
History
Observations of New World Use of Psychoactive Snuffs
Identification of Botanical and Other Sources
Testing and Use of Synthetics
Botany
Anadenanthera Species and Other Members of the Pea Family
Virolas
Chemistry
Tryptamine Constituents of the Psychedelic Snuffs
Altering the Side Chains
Physical Effects
Native Use of Enormous Amounts
Use and Safety of Synthetics in Ordinary Amounts
Tolerance, Potentiation and MAO-Inhibition
Cerebrospinal Tryptamines
Mental Effects
Effects from Cohoba and Epená Snuffs
DMT Effects
DET Effects
DPT Effects
Forms and Preparations
Chapter Seven: Ayahuasca, Yagé and Harmaline
History
Records from South American Explorers
Identification of the Active Principles
Developments over the Last Twenty Years
Botany
Ayahuasca and Yagé
The Admixtures of Yagé
Syrian Rue
Chemistry
Harmalas (β-Carbolines)
Natural Harmalas in Humans
Admixtures
Physical Effects
Purgative Aspects
Other Physical Side-Effects
Healing Qualities
Mental Effects
Dosage Considerations
Yagé Visions and their Stages
Specificity of Yagé’s Visions
Auditory Component
Telepathic Element
Sexual Component
Psychotherapeutic Potential
Forms and Preparations
Chapter Eight: Iboga and Ibogaine
History
Early Reports and Synthesis of Ibogaine
Recent Usage
Botany
Chemistry
Physical Effects
Mental Effects
Native Accounts
Modern American Experiences
Naranjo’s Psychotherapeutic Findings
Forms and Preparations
Chapter Nine: Fly Agaric, Panther Caps and “Soma”
History
“Soma” Identified as the Fly Agaric Mushroom
Discovery of Long-Time Use of Fly Agaric in North America
Use of Fly Agaric in Siberia
Botany
Poisonous Amanitas
Fly Agaric and Panther Caps
Chemistry
Physical Effects
Mental Effects
The Importance of Drying
Dosage
The Importance of Mental Set
The Question of “Soma”
Chapter Ten: Contrasting Profiles
Belladonna-like Substances
Yohimbe
Kava-Kava
Ketamine
Nitrous Oxide
Appendices
Notes on Purity Tests and Precursors
Thoughts on Increasing Intelligence (by Francis Jeffrey)
Other Literature
Index to the Second Edition Text
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