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Index
Instructions for online access Title page Table of Contents Copyright Dedication Contributors Preface: A New Chapter Acknowledgments General Pathology
Chapter 1 The Cell as a Unit of Health and Disease
The Genome Cellular Housekeeping Cellular Metabolism and Mitochondrial Function Cellular Activation Signal Transduction Pathways Growth Factors and Receptors Interaction with the Extracellular Matrix Maintaining Cell Populations Suggested Readings
Chapter 2 Cellular Responses to Stress and Toxic Insults
Introduction to Pathology Overview: Cellular Responses to Stress and Noxious Stimuli Adaptations of Cellular Growth and Differentiation Overview of Cell Injury and Cell Death Causes of Cell Injury Morphologic Alterations in Cell Injury Mechanisms of Cell Injury Clinicopathologic Correlations: Selected Examples of Cell Injury and Necrosis Apoptosis Autophagy Intracellular Accumulations Pathologic Calcification Cellular Aging Suggested Readings
Chapter 3 Inflammation and Repair
Overview of Inflammation: Definitions and General Features Acute Inflammation Chronic Inflammation Systemic Effects of Inflammation Tissue Repair Cell and Tissue Regeneration Repair by Connective Tissue Deposition Factors That Influence Tissue Repair Selected Clinical Examples of Tissue Repair and Fibrosis Abnormalities in Tissue Repair Suggested Readings
Chapter 4 Hemodynamic Disorders, Thromboembolic Disease, and Shock
Edema and Effusions Hyperemia and Congestion Hemostasis, Hemorrhagic Disorders, and Thrombosis Embolism Infarction Shock Suggested Readings
Chapter 5 Genetic Disorders
Genes and Human Diseases Mendelian Disorders Complex Multigenic Disorders Chromosomal Disorders Single-Gene Disorders with Nonclassic Inheritance Molecular Genetic Diagnosis Acknowledgment Suggested Reading
Chapter 6 Diseases of the Immune System
The Normal Immune Response Hypersensitivity: Immunologically Mediated Tissue Injury Autoimmune Diseases Rejection of Tissue Transplants Immunodeficiency Syndromes Amyloidosis Suggested Readings
Chapter 7 Neoplasia
Nomenclature Characteristics of Benign and Malignant Neoplasms Epidemiology of Cancer Molecular Basis of Cancer: Role of Genetic and Epigenetic Alterations Carcinogenic Agents and Their Cellular Interactions Suggested Readings
Chapter 8 Infectious Diseases
General Principles of Microbial Pathogenesis Special Techniques for Diagnosing Infectious Agents Viral Infections Bacterial Infections Fungal Infections Parasitic Infections Emerging Infectious Diseases Suggested Readings
Chapter 9 Environmental and Nutritional Diseases
Environmental Effects on Global Disease Burden Health Effects of Climate Change Toxicity of Chemical and Physical Agents Environmental Pollution Occupational Health Risks: Industrial and Agricultural Exposures Effects of Alcohol Injury by Therapeutic Drugs and Drugs of Abuse Injury by Physical Agents Nutritional Diseases Suggested Readings
Chapter 10 Diseases of Infancy and Childhood
Congenital Anomalies Prematurity and Fetal Growth Restriction Perinatal Infections Fetal Hydrops Inborn Errors of Metabolism and Other Genetic Disorders Sudden Infant Death Syndrome (SIDS) Tumors and Tumor-like Lesions of Infancy and Childhood Suggested Readings
Systemic Pathology: Diseases of Organ Systems
Chapter 11 Blood Vessels
Vascular Structure and Function Vascular Anomalies Vascular Wall Response to Injury Hypertensive Vascular Disease Arteriosclerosis Atherosclerosis Aneurysms and Dissection Vasculitis Disorders of Blood Vessel Hyperreactivity Veins and Lymphatics Vascular Tumors Pathology of Vascular Intervention Suggested Readings
Chapter 12 The Heart
Cardiac Structure and Specializations Effects of Aging on the Heart Overview of Cardiac Pathophysiology Heart Failure Congenital Heart Disease Ischemic Heart Disease Arrhythmias Hypertensive Heart Disease Valvular Heart Disease Cardiomyopathies Pericardial Disease Heart Disease Associated with Rheumatologic Disorders Tumors of the Heart Cardiac Transplantation Suggested Readings
Chapter 13 Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus
Disorders of White Cells Spleen Thymus Suggested Readings
Chapter 14 Red Blood Cell and Bleeding Disorders
Anemias Polycythemia Bleeding Disorders: Hemorrhagic Diatheses Suggested Readings
Chapter 15 The Lung
Congenital Anomalies Atelectasis (Collapse) Pulmonary Edema Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage) Obstructive and Restrictive Lung Diseases Obstructive Lung Diseases Chronic Diffuse Interstitial (Restrictive) Diseases Diseases of Vascular Origin Pulmonary Infections Lung Transplantation Tumors Pleura Suggested Readings
Chapter 16 Head and Neck
Oral Cavity Upper Airways Ears Neck Salivary Glands Suggested Readings
Chapter 17 The Gastrointestinal Tract
Congenital Abnormalities Esophagus Stomach Small Intestine and Colon Peritoneal Cavity Tumors Suggested Readings
Chapter 18 Liver and Gallbladder
The Liver and Bile Ducts Gallbladder Suggested Readings
Chapter 19 The Pancreas
Congenital Anomalies Pancreatitis Nonneoplastic Cysts Neoplasms Suggested Readings
Chapter 20 The Kidney
Clinical Manifestations of Renal Diseases Glomerular Diseases Tubular and Interstitial Diseases Vascular Diseases Congenital and Developmental Anomalies Cystic Diseases of the Kidney Urinary Tract Obstruction (Obstructive Uropathy) Neoplasms of the Kidney Suggested Readings
Chapter 21 The Lower Urinary Tract and Male Genital System
The Lower Urinary Tract The Male Genital Tract Suggested Readings
Chapter 22 The Female Genital Tract
Vulva Vagina Cervix Body of Uterus and Endometrium Fallopian Tubes Ovaries Gestational and Placental Disorders Suggested Readings
Chapter 23 The Breast
Disorders of Development Clinical Presentations of Breast Disease Inflammatory Disorders Benign Epithelial Lesions Carcinoma of the Breast Types of Breast Carcinoma Stromal Tumors Other Malignant Tumors of the Breast Suggested Readings
Chapter 24 The Endocrine System
Pituitary Gland Thyroid Gland Parathyroid Glands The Endocrine Pancreas Adrenal Glands Multiple Endocrine Neoplasia Syndromes Pineal Gland Suggested Readings
Chapter 25 The Skin
The Skin: More Than a Mechanical Barrier Disorders of Pigmentation and Melanocytes Benign Epithelial Tumors Adnexal (Appendage) Tumors Premalignant and Malignant Epidermal Tumors Tumors of the Dermis Tumors of Cellular Migrants to the Skin Disorders of Epidermal Maturation Acute Inflammatory Dermatoses Chronic Inflammatory Dermatoses Blistering (Bullous) Diseases Disorders of Epidermal Appendages Panniculitis Infection Suggested Readings
Chapter 26 Bones, Joints, and Soft Tissue Tumors
Bone Joints Soft Tissue Suggested Readings
Chapter 27 Peripheral Nerves and Skeletal Muscles
Diseases of Peripheral Nerves Diseases of the Neuromuscular Junction Diseases of Skeletal Muscle Peripheral Nerve Sheath Tumors Suggested Readings
Chapter 28 The Central Nervous System
Cellular Pathology of the Central Nervous System Cerebral Edema, Hydrocephalus, and Raised Intracranial Pressure and Herniation Malformations and Developmental Disorders Perinatal Brain Injury Trauma Cerebrovascular Disease Infections Prion Diseases Demyelinating Diseases Neurodegenerative Diseases Genetic Metabolic Diseases Toxic and Acquired Metabolic Diseases Tumors Suggested Readings
Chapter 29 The Eye
Orbit Eyelid Conjunctiva Sclera Cornea Anterior Segment Uvea Retina and Vitreous Optic Nerve The End-Stage Eye: Phthisis Bulbi Suggested Readings
Index
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