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Contributors Preface Acknowledgments SECTION 1 Fundamentals of Pediatrics 1 . Role of the Pediatrician 2 . Decision Making: Use of Evidence-Based Medicine 3 . Communication 4 . Interviewing Techniques 5 . Systems of Practice and Office Management 6 . Core Competencies 7 . Patient and Family-Centered Care 8 . Disaster Preparedness 9 . Law, Ethics, and Clinical Judgment SECTION 2 Health Promotion and Disease Prevention PART 1: Health Maintenance Issues 10 . Well-Child Care 11 . Child Development 12 . Screening 13 . Oral Health Supervision 14 . Complementary and Alternative Medicine (CAM) 15 . Culture and Pediatric Practice 16 . Gay and Lesbian Parents 17 . Environmental Pediatrics 18 . Travel Medicine PART 2: Managing Family Transition 19 . Family Function and Birth of a Child 20 . Foster Care and Adoption 21 . Family Discord and Divorce 22 . Supporting the Grieving Child and Family SECTION 3 Nutrition 23 . Normal Nutritional Requirements 24 . Breast-Feeding 25 . Infant Formula and Complementary Foods 26 . Postdischarge Nutritional Management of the Premature Infant 27 . Nutritional Issues: Toddler to Adolescent 28 . Assessment of Nutritional Adequacy 29 . Malnutrition and Refeeding 30 . Poor Weight Gain 31 . Approach to the Infant and Child with Feeding Difficulty 32 . The Overweight or Obese Child 33 . Specialized Nutrition Support 34 . Nutritional Access Devices SECTION 4 Abuse, Neglect, Violence 35 . Child Maltreatment: Neglect to Abuse 36 . Family and Community Violence 37 . Child Abuse Prevention: What Pediatricians Can Do SECTION 5 Newborn PART 1: Care of the Newborn 38 . Historical Perspectives 39 . Care of the Fetus 40 . Fetal Disorders 41 . Neonatal Mortality and Morbidity 42 . Delivery Room Resuscitation 43 . Transitional Changes in the Newborn 44 . Examination of the Newborn Infant 45 . Postnatal Care and Observation PART 2: Infants at Risk 46 . Multiple Births 47 . The Small-for-Gestational-Age Infant 48 . Infant of a Diabetic Mother PART 3: Specific Neonatal Conditions 49 . Approach to the Cyanotic Infant 50 . Abnormalities of the Lungs 51 . Metabolic Abnormalities 52 . Brain Abnormalities and Injuries 53 . Hematologic Abnormalities and Jaundice PART 4: Disorders Specifically Related to Preterm Birth 54 . Respiratory Distress Syndrome 55 . Patent Ductus Arteriosus and Ductus Venosus 56 . Hemodynamics 57 . Necrotizing Enterocolitis 58 . Intraventricular Hemorrhage 59 . Bronchopulmonary Dysplasia 60 . Emergencies 61 . Special Intensive Care 62 . Outcomes of Preterm and Term Infants SECTION 6 Principles of Adolescent Care PART 1: Growth and Development 63 . Somatic Growth and Development 64 . Reproductive Growth and Development in the Female Adolescent 65 . Reproductive Growth and Development in the Male Adolescent 66 . Psychological Development 67 . The Adolescent Visit PART 2: Health Problems of Adolescents 68 . Mortality 69 . Morbidity 70 . Sexual Behavior 71 . Substance Use and Abuse PART 3: Mental Health Disorders in the Adolescent 72 . Depression, Anxiety, and Other Disorders 73 . Disorders of Eating PART 4: Reproductive Health Problems 74 . Breast Masses 75 . Scrotal Masses 76 . Menstrual Problems 77 . Intrauterine and Ectopic Pregnancy 78 . Contraception SECTION 7 Developmental and Behavioral Pediatrics PART 1: General Concepts 79 . Introduction to Developmental and Behavioral Pediatrics 80 . Fundamental Concepts of Child Development 81 . Brain Development and Behavior 82 . Standardized Developmental Screening and Assessment Instruments PART 2: Developmental Variation to Disorder 83 . Crying in Infants 84 . Hyperactivity and Inattention 85 . Learning Problems 86 . Language Delay 87 . Difficult Behavior 88 . Anxiety 89 . Repetitive Behaviors 90 . Gender Identity and Sexual Behavior 91 . Developmental Delay PART 3: Major Psychopathologic Disorders 92 . Autistic Spectrum Disorders 93 . Affective Disorders and Suicide 94 . Pediatric Condition Falsification 95 . Childhood Schizophrenia PART 4: Psychosocial Context of Development and Behavior 96 . Families in the 21st Century: An Introduction to Families 97 . Nonparental Childcare 98 . Vulnerable Child Syndrome 99 . Adaptation to Illness 100 . Poverty, Homelessness, and Social Disorganization 101 . Resiliency in Children and Adolescents SECTION 8 The Acutely Ill Infant and Child PART 1: Assessment of the Acutely Ill Infant and Child 102 . Respiratory Distress and Failure 103 . Decreased Perfusion and Circulatory Shock 104 . Acute Neurological Dysfunction 105 . The Febrile Child PART 2: Stabilization and Management of the Acutely Ill Infant and Child 106 . Monitoring of Vital Function 107 . Vascular Access 108 . Cardiopulmonary Resuscitation 109 . Life Support Systems 110 . Stabilization and Transport 111 . Management of Cerebral Edema and Elevated Intracranial Pressure 112 . Perioperative Care 113 . Pain Management and Sedation 114 . Acute Metabolic Dysfunction PART 3: Injuries and Untoward Events 115 . Acute Inflammation 116 . Trauma, Burns, and Bites 117 . Submersion Injury 118 . Foreign-Body Aspiration 119 . Apparent Life-Threatening Events and SIDS 120 . Toxic Ingestions and Exposures 121 . Heat Stress 122 . Poisonous Bites and Stings SECTION 9 The Chronically Ill Infant and Child PART 1: The Changing Outlook of Chronic Illness in Childhood 123 . Psychological and Behavioral Responses 124 . The Technology-Dependent Child PART 2: Death and Dying in Childhood 125 . Caring for Children Dying from Chronic Disease 126 . Hospice and Palliative Care 127 . Law, Ethics, and Caring Near the End of Life SECTION 10 Transplantation 128 . Pediatric Transplantation 129 . Kidney Transplantation 130 . Liver Transplantation 131 . Intestinal and Multivisceral Transplant 132 . Heart Transplant 133 . Hematopoietic Cell Transplantation SECTION 11 Inherited Disorders of Metabolism PART 1: Inborn Errors of Metabolism 134 . Principles of Inborn Errors of Metabolism PART 2: Disorders of Amino Acid (AA) and Organic Acid (OA) Metabolism 135 . Hyperphenylalaninemias 136 . Disorders of Tyrosine Metabolism 137 . Disorders of Branched Chain Amino and Organic Acid Metabolism 138 . Disorders of Sulfur-Containing Amino Acid Metabolism 139 . Disorders of Glycine, Serine, and Proline Metabolism 140 . Disorders of Metabolism of Lysine, Hydroxylysine, and Related Compounds 141 . Disorders of Metabolism of Neurotransmitter Amino Acids 142 . Disorders of Creatine and Ornithine Metabolism 143 . Disorders of Amino Acid Transport Across Cell Membranes 144 . Other Disorders of Amino Acid Metabolism 145 . Urea Cycle and Related Disorders PART 3: Inborn Errors of Water Soluble Vitamins 146 . Introduction 147 . Vitamin B 12 and Folic Acid 148 . Biotin Responsive Disorders 149 . Vitamin B 6 and Vitamin B 1 Responsive Disorders PART 4: Disorders of Fatty Acid Oxidation, Ketogenesis, and Ketolysis 150 . Disorders of Fatty Acid Oxidation 151 . Disorders of Ketogenesis 152 . Disorders of Ketolysis 153 . Disorders of Leukotriene Synthesis and Fatty Aldehyde Dehydrogenase PART 5: Carbohydrate Metabolism 154 . Disorders of Glycogen Metabolism 155 . Disorders of Galactose and Fructose Metabolism and Gluconeogenesis 156 . Disorders of Pentose Phosphate Pathway 157 . Disorders of Glucose Transporters PART 6: Disorders of Oxidative Phosphorylation and Pyruvate Oxidation 158 . Respiratory Chain Disorders 159 . Disorders of Energy Metabolism PART 7: Organelle-Related Disorders 160 . Mucopolysaccharidosis, Glycoproteinosis, and Mucolipidosis 161 . Sphingolipidoses 162 . Peroxisomal Disorders 163 . Congenital Disorders of Glycosylation PART 8: Disorders of Lipid and Bile Acid Metabolism 164 . Disorders of Cholesterol Synthesis 165 . Disorders of Bile Acid Synthesis 166 . Disorders of Lipid and Lipoprotein Metabolism PART 9: Disorders of Nucleic Acids, Heme Metabolism, and Metals Transport 167 . Disorders of Heme Biosynthesis: The Porphyrias 168 . Disorders of Purine and Pyrimidine Metabolism 169 . Disorders of Metal Metabolism SECTION 12 Clinical Genetics and Dysmorphology PART 1: The Genetic Approach to Disorders of Children 170 . Key Principles in Human Genetics 171 . Multifactorial Inheritance 172 . Principles of Care PART 2: Chromosomal Disorders 173 . Human Cytogenetics 174 . Chromosome Disorders PART 3: Birth Defects, Malformations, and Syndromes 175 . Birth Defects, Malformations, and Syndromes 176 . Syndromes of Multiple Congenital Anomalies/Dysplasias 177 . Craniofacial Disorders 178 . Approach to the Child with Birth Defects 179 . Genetic Skeletal Disorders 180 . Congenital Contractures 181 . Connective Tissue Dysplasias 182 . Neurocutaneous Disorders 183 . Environmental Causes of Birth Defects 184 . Disorders of Accelerated Aging 185 . Genetic Evaluation of Developmental Delay/Mental Retardation SECTION 13 Immunologic Disorders 186 . Overview of the Immune System 187 . Undue Susceptibility to Infection 188 . Primary Immunodeficiencies 189 . Complement Disorders SECTION 14 Allergic Disorders 190 . Allergic Disease and Atopy 191 . Clinical Aspects of Allergic Diseases 192 . Allergic Rhinitis and Conjunctivitis 193 . Anaphylaxis, Urticaria, and Angioedema 194 . Food Allergy 195 . Insect Allergy 196 . Latex Allergy 197 . Adverse Reactions to Drugs SECTION 15 Rheumatology PART 1: General Principles in Rheumatology 198 . Pathogenesis of Inflammatory and Autoimmune Disorders 199 . History and Physical Examination in Rheumatology 200 . Diagnostic Testing in Rheumatology PART 2: Specific Rheumatologic Disorders 201 . Juvenile Idiopathic Arthritis 202 . Spondyloarthropathies 203 . Vasculitides 204 . Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease 205 . Juvenile Dermatomyositis 206 . Scleroderma PART 3: Systemic Syndromes in Rheumatology 207 . Musculoskeletal Pain Syndromes 208 . Chronic Fatigue Syndrome 209 . Autoinflammatory Disorders SECTION 16 The Musculoskeletal System 210 . Growth and Development 211 . The Limping Child 212 . Torsional and Angular Deformities 213 . Disorders of the Foot 214 . Disorders of the Knee 215 . Developmental Dysplasia of the Hip 216 . Disorders of the Neck and Spine 217 . Disorders of the Upper Extremity 218 . Injuries 219 . Tumors 220 . Neuromuscular Disorders 221 . Common Orthopedic Misses SECTION 17 Infectious Diseases PART 1: Principles of Infectious Disease 222 . Bacterial Pathogenesis 223 . Bacteremia, Sepsis, and Septic Shock 224 . Viral Pathogenesis 225 . Infection Control 226 . Diagnostic Approaches for Infectious Diseases 227 . Acute Fever without a Focus 228 . Fever of Unknown Origin 229 . Fever and Infection in the Immunocompromised Patient 230 . Therapy for Perinatal and Neonatal Infections PART 2: Infections of Organ Systems 231 . Bacterial Infections of the Central Nervous System 232 . Viral Infections of the Central Nervous System 233 . Sexually Transmitted Infections 234 . Bone, Joint, Soft Tissue Infections 235 . Cardiac Infections 236 . Gastrointestinal Infections 237 . Infections of the Liver 238 . Urinary Tract Infections 239 . Catheter-Associated Infections PART 3: Infections of the Respiratory System 240 . Community-Acquired and Bacterial Pneumonia in Children 241 . Viral Respiratory Infections Including Influenza 242 . Fungal Respiratory Infections 243 . Infections of the Ear PART 4: Treatment and Prevention of Infectious Diseases 244 . Immunizations 245 . Antiviral Therapy 246 . Antibacterial Therapy 247 . Antifungal Therapy PART 5: Bacterial Infections 248 . Actinomycosis 249 . Anaerobic Infections 250 . Clostridial Infections 251 . Anthrax ( Bacillus anthracis ) 252 . Arcanobacterium 253 . Bacillus cereus 254 . Brucellosis 255 . Burkholderia and Pseudomonas 256 . Campylobacter 257 . Cat Scratch Disease ( Bartonella henselae ) 258 . Chancroid ( Hemophilus ducreyi ) 259 . Chlamydia 260 . Cholera 261 . Diphtheria 262 . Enterococcus 263 . Haemophilus influenzae 264 . Legionella Pneumonia 265 . Leptospirosis 266 . Listeriosis 267 . Lyme Disease 268 . Moraxella catarrhalis 269 . Tuberculosis ( Mycobacteria tuberculosis ) 270 . Nontuberculous Mycobacterial Infections 271 . Leprosy 272 . Buruli Ulcer ( Mycobacterium ulcerans Infection) 273 . Mycoplasma Infections 274 . Neisseria gonorrhoeae 275 . Neisseria meningitidis 276 . Nocardiosis 277 . Pasteurella multocida 278 . Pertussis 279 . Plague 280 . Pneumococcal Infections 281 . Rat-Bite Fever 282 . Relapsing Fever 283 . Salmonella , Shigella , and Escherichia coli 284 . Staphylococcus Infections 285 . Streptococcus Group A Infections 286 . Group B Streptococcus Infections 287 . Nongroup A or B Streptococcus 288 . Syphilis 289 . Tetanus 290 . Q Fever 291 . Tularemia 292 . Ureaplasma urealyticum Infections 293 . Yersinia enterocolitica Infections 294 . Rickettsial Infections PART 6: Fungal Infections 295 . Aspergillosis 296 . Blastomycosis 297 . Candida 298 . Coccidioidomycosis 299 . Cryptococcosis 300 . Histoplasmosis 301 . Malassezia furfur 302 . Microsporidiosis 303 . Sporotrichosis 304 . Zygomycosis (Mucormycosis) PART 7: Viral Infections 305 . Arboviruses 306 . Enterovirus Infections 307 . Hemorrhagic Fevers 308 . Viral Hepatitis 309 . Herpes Simplex Virus Infections 310 . Cytomegalovirus 311 . Epstein-Barr Virus Mononucleosis 312 . Human Herpesviruses 6 and 7 313 . Human Herpesvirus 8 314 . Varicella-Zoster Virus Infections 315 . Human Immunodeficiency Virus Type 1 Infection 316 . Measles 317 . Molluscum Contagiosum 318 . Mumps 319 . Human Parvovirus 320 . Rubella 321 . Rabies 322 . Smallpox PART 8: Parasitic Infections—Nematodes 323 . Antiparasitic Therapy 324 . Ascariasis 325 . Baylisascariasis 326 . Dracunculiasis 327 . Enterobiasis (Pinworm) 328 . Lymphatic Filariasis and Onchocerciasis 329 . Hookworm 330 . Strongyloidiasis 331 . Toxocariasis (Visceral and Ocular Larva Migrans) 332 . Trichinosis 333 . Trichuriasis 334 . Anasakiasis and Angiostrongyliasis PART 9: Parasitic Infections—Trematodes 335 . Foodborne Trematodiasis and Schistosomiasis 336 . Diphyllobothriasis 337 . Dipylidiasis 338 . Echinococcosis 339 . Hymenolepiasis 340 . Taeniasis and Cysticercosis PART 10: Parasitic Infections—Protozoa 341 . Amebiasis 342 . Babesiosis 343 . Balantidiasis 344 . Blastocystis hominis 345 . Cryptosporidiosis 346 . Cyclosporiasis 347 . Dientamoebiasis 348 . Free-Living Amebic Infections 349 . Giardiasis 350 . Isosporiasis 351 . Leishmaniasis 352 . Malaria 353 . Pneumocystis Pneumonia 354 . Toxoplasmosis 355 . Trypanosomiases SECTION 18 Disorders of the Skin 356 . Functional Overview 357 . Neonatal Dermatology 358 . Disorders of the Epidermis 359 . Disorders of the Dermis and Subcutaneous Tissue 360 . Genetic Disorders of the Skin 361 . Melanocytic Lesions and Disorders of Pigmentation 362 . Immunologic Diseases 363 . Neoplastic and Proliferative Disorders 364 . Vascular Tumors and Malformations 365 . Acne and Other Disorders of the Pilosebaceous Unit 366 . Disorders of Nails 367 . Skin Infections and Exanthems 368 . Infestations SECTION 19 Disorders of the Ear, Nose, and Throat 369 . The Ear 370 . Nose and Sinus 371 . The Pharynx and Upper Airway 372 . The Head, Face, and Neck 373 . Head and Neck Masses SECTION 20 Disorders of the Oral Cavity 374 . Dental Caries 375 . Dental Emergency Care 376 . Dental Occlusion and Its Management 377 . Periodontal and Gingival Health and Diseases 378 . Oral Pathology 379 . Temporomandibular Joint Disorders 380 . Behavioral Treatment Options in Pediatric Dentistry SECTION 21 Disorders of the Gastrointestinal System PART 1: Presenting Signs and Symptoms 381 . Normal Structure and Function of the Gastrointestinal Tract 382 . Approach to the Child with Acute, Chronic, or Cyclic Vomiting 383 . Acute Abdominal Pain 384 . Chronic Abdominal Pain 385 . Diarrhea 386 . Constipation and Fecal Incontinence 387 . Upper and Lower Gastrointestinal Bleeding 388 . Abdominal Masses 389 . Gastrointestinal Obstruction 390 . Protein-Losing Enteropathy 391 . Gastrointestinal Disorders Associated with Immunodeficiency PART 2: Esophageal Disorders 392 . Anatomic Disorders of the Esophagus 393 . Disorders of Esophageal Motility 394 . Gastroesophageal Reflux and Other Causes of Esophageal Inflammation 395 . Other Esophageal Disorders PART 3: Congenital and Anatomic Disorders of the Stomach and Intestine 396 . Abdominal Wall Defects 397 . Malrotation and Volvulus 398 . Infantile Hypertrophic Pyloric Stenosis 399 . Congenital Atresias, Stenosis, and Webs 400 . Microgastria and Gastric Perforation 401 . Duplications and Cysts 402 . Omphalo-Mesenteric Duct Remnants 403 . Meconium Diseases of Infancy and Distal Intestinal Obstruction Syndrome 404 . Intussusception 405 . Inguinal and Other Hernias 406 . Superior Mesenteric Artery Syndrome 407 . Motor Disorders of the Stomach, Small Bowel, and Colon PART 4: Disorders of Digestion and Absorption 408 . Disorders of Digestion and Absorption PART 5: Disorders of the Stomach and Intestine 409 . Inflammatory Disorders of the Stomach 410 . Inflammatory Bowel Disease 411 . Allergic and Eosinophilic Gastroenteropathies 412 . Vascular, Systemic, and Other Disorders Affecting the Gastrointestinal Tract 413 . Acute Appendicitis, Typhlitis, and Chronic Appendicitis 414 . Polyps and Tumors of the Gastrointestinal Tract 415 . Congenital Anomalies of the Anorectum 416 . Other Anorectal Disorders PART 6: The Exocrine Pancreas 417 . Disorders of the Exocrine Pancreas SECTION 22 Disorders of the Liver and Biliary Tract 418 . Structure and Function of the Liver 419 . Evaluation of the Infant and Child with Liver Disease 420 . Autoimmune Disorders of the Liver 421 . Metabolic and Genetic Disorders of the Liver 422 . Drug, Toxin, and TPN Liver Disease 423 . The Liver in Systemic Disease 424 . Acute Liver Failure 425 . End-Stage Liver Disease 426 . Other Disorders of the Liver 427 . The Biliary Tract SECTION 23 Disorders of the Blood PART 1: Principles of Blood Disorders 428 . Approach to Suspected Hematologic Disorders 429 . Hematopoeisis PART 2: Disorders of Red Blood Cells and Anemia 430 . Anemia 431 . Iron Deficiency 432 . Anemia Due to Diminished Red Blood Cell Production 433 . Hemolytic Anemia 434 . Hemoglobinopathies PART 3: Disorders of Coagulation and Platelets 435 . Normal and Abnormal Hemostasis 436 . Inherited Bleeding Disorders 437 . Acquired Coagulation Disorders 438 . Diagnosis and Management of Thrombosis 439 . Disorders of Platelets PART 4: Disorders of the Spleen and Lymph Nodes 440 . The Spleen and Lymph Nodes PART 5: Disorders of White Blood Cells 441 . Disorders of Granulocytes PART 6: Principles of Transfusion 442 . Transfusion Medicine SECTION 24 Neoplastic Disorders PART 1: Principles of Oncology 443 . Cancer Genetics and Biology 444 . Epidemiology of Childhood Cancer 445 . Chemotherapy and Radiation Therapy 446 . Clinical Trials in Pediatric Oncology 447 . Neonatal Oncology 448 . Cancer Survivorship and Recommendations for Follow-Up PART 2: Hematologic Malignancies 449 . Acute Lymphoblastic Leukemia 450 . Myeloid Malignancies 451 . Non-Hodgkin Lymphoma 452 . Hodgkin Lymphoma PART 3: Solid Tumors 453 . Osteosarcoma 454 . Ewing Sarcoma and Primitive Neuroectodermal Tumor 455 . Rhabdomyosarcoma 456 . Renal Tumors 457 . Neuroblastoma 458 . Malignant Liver Tumors 459 . Germ Cell Tumors 460 . Brain Tumors and Spinal Tumors 461 . Retinoblastoma 462 . Vascular Neoplasms PART 4: Mononuclear Phagocytic System Disorders 463 . Histiocytic Disorders SECTION 25 Disorders of the Kidney and Urinary Tract PART 1: Principles of Nephrology 464 . Renal Morphogenesis 465 . Development of Renal Function 466 . Fluid, Electrolyte, and Acid-Base Disorders 467 . Diagnostic Approach to Renal Disease PART 2: Abnormalities of the Kidney and Urinary Tract 468 . Kidney or Urinary Tract Disorders 469 . Renal Malformations 470 . Cystic Diseases of the Kidney 471 . Acute Renal Failure 472 . Glomerular Diseases 473 . Hereditary Glomerulopathies 474 . Renal Tubular Disorders 475 . Urinary Tract Stone Diseases 476 . Urologic Abnormalities of the Genitourinary Tract PART 3: Chronic Kidney Disease 477 . Chronic Kidney Disease 478 . Chronic Dialysis 479 . Systemic Hypertension SECTION 26 Disorders of the Cardiovascular System PART 1: Principles of Cardiology 480 . Development of the Cardiovascular System 481 . Genetics of Heart Disease PART 2: Approach to the Patient with Cardiovascular Disease 482 . Fetal Cardiology 483 . Neonate and Infant with Cardiovascular Disease 484 . Congenital Heart Disease 485 . Arrhythmias 486 . Child and Adolescent with Cardiovascular Disease PART 3: Acquired Cardiovascular Disease 487 . Cardiac Tumors 488 . Kawasaki Disease 489 . Diseases of Myocardium 490 . Infective Endocarditis 491 . Pericardial Diseases 492 . Pulmonary Hypertension PART 4: Diagnostic Tools in Heart Disease 493 . Electrocardiography 494 . Radiologic Imaging 495 . Echocardiography 496 . Cardiac Catherization PART 5: Management of Patients with Cardiovascular Disease 497 . Heart Failure 498 . The Patient with Single Ventricle 499 . Interventional Cardiology 500 . Health Care Management for the Child with Cardiovascular Disease 501 . Sports Screening for Cardiovascular Risk SECTION 27 Disorders of the Respiratory System PART 1: Principles of Pulmonology 502 . Lung Growth in Infancy and Childhood 503 . Physiologic Basis of Pulmonary Function 504 . Global Burden of Respiratory Infections and Mucosal Immunology of the Respiratory Tract 505 . Clinical Presentation of Respiratory Illness 506 . Tools for Diagnosis and Management of Respiratory Disease PART 2: Disorders of the Respiratory System 507 . Congenital Disorders of the Lower Airways and Mediastinum 508 . Disorders of Respiratory Control and Sleep-Disordered Breathing 509 . Sleep Disorders 510 . Disorders Causing Airway Obstruction 511 . Aspiration Syndromes 512 . Asthma 513 . Bronchopulmonary Dysplasia 514 . Cystic Fibrosis 515 . Interstitial Lung Disease 516 . Alpha-1 Antitrypsin Deficiency Lung Disease 517 . Pulmonary Vasculitis Syndromes 518 . Pulmonary Alveolar Proteinosis 519 . Chest Wall and Respiratory Muscle Disorders SECTION 28 Disorders of the Endocrine System 520 . Mechanisms of Hormone Action 521 . Disorders of the Anterior Pituitary Gland 522 . Growth and Growth Impairment 523 . Endocrine Abnormalities Causing Growth Impairment 524 . Tall Stature 525 . Primary Disturbances in Water Homeostasis 526 . The Thyroid 527 . Hypothyroidism in the Infant 528 . Acquired Hypothyroidism 529 . Hyperthyroidism 530 . Other Disorders of the Thyroid 531 . The Adrenal Cortex 532 . Evaluation of Adrenal Function 533 . Genetic Lesions in Steroidogenesis 534 . Adrenal Insufficiency 535 . Adrenal Excess 536 . Glucocorticoid Therapy and Withdrawal 537 . Endocrine Neoplasia Syndromes 538 . Normal Human Sex Differentiation 539 . Disorders of Sexual Development (DSD) 540 . Normal Pubertal Development 541 . Abnormal Pubertal Development 542 . Calcium, Phosphorus, and Magnesium Metabolism 543 . Disorders of Bone Formation 544 . Diabetes Mellitus 545 . Endocrine Causes of Hypoglycemia SECTION 29 Disorders of the Nervous System PART 1: Principles of Neurology 546 . Introduction to Neurology 547 . Clinical Approach to Neurologic Disease PART 2: Abnormal Development of the Nervous System 548 . Cranial Developmental Abnormalities 549 . Disturbances of the Neural Tube and Spine Closure 550 . Macrocephaly and Microcephaly PART 3: Acute Deterioration of Neurologic Function 551 . Trauma to the Nervous System 552 . Stroke and Cerebrovascular Disease 553 . Hydrocephalus and Pseudotumor Cerebri 554 . Cerebral Palsy and Static Encephalopathies 555 . Infections of the Central Nervous System 556 . Immune- and Inflammatory-Mediated Central Nervous System Syndromes PART 4: Epilepsy 557 . Epidemiology of Epilepsy, Seizure Classification, Epilepsy Syndromes 558 . Etiologies of Epilepsies 559 . Febrile Seizures 560 . Evaluation of New Onset Seizures 561 . Status Epilepticus 562 . Epilepsy Treatment: Antiepileptic Drug Therapy 563 . Epilepsy Treatment: Ketogenic Diet and Neurostimulation 564 . Epilepsy Treatment: Surgery PART 5: Paroxysmal Disorders 565 . Migraine and Headache Disorders 566 . Movement Disorders, Tics, and Tourette Syndrome 567 . Other Paroxysmal Disorders PART 6: Disorders of Strength, Tone, and Sensation 568 . General Evaluation of Strength, Tone, and Sensation 569 . The Hypotonic Infant 570 . Peripheral Nerve Disorders and Anterior Horn Cell Diseases 571 . Diseases of the Neuromuscular Junction 572 . Myopathies PART 7: Developmental Delay and Regression 573 . Neurologic Aspects of Disorders of Metal Metabolism 574 . Lysosomal Storage Disorders 575 . Rett Syndrome ( MECP2 -Related Disorders) 576 . Leukoencephalopathies 577 . Neurotransmitter Disorders 578 . Phakomatoses SECTION 30 Disorders of the Eyes PART 1: General Principles 579 . Anatomy and Physiology of the Eye and Ocular System 580 . Office Evaluation of the Eyes 581 . Special Tests of the Eyes 582 . International Pediatric Ophthalmology PART 2: Disorders of the Eye 583 . Eye Emergencies and Trauma 584 . Visual Impairment in Childhood 585 . Amblyopia 586 . Strabismus 587 . The Eye in Child Abuse 588 . Red Eye 589 . Lid and Lacrimal System Disorders 590 . Anterior Segment Disorders 591 . Retinopathy of Prematurity 592 . Genetic Eye Diseases 593 . Optic Nerve Disorders

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