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Index
Cover Page Title Page Copyright Dedication Contributors Preface Preface To The Second Edition Preface To The First Edition Acknowledgments Origins Of Chapters Introduction SECTION I: Broad Concepts And Analytic Techniques
CHAPTER 1: Statistical Concepts Fundamental To Investigations
OPERATIONAL DEFINITION THE INFINITE-DATA CASE PROBABILISTIC THINKING INDUCTION STUDY DESIGN STATISTICAL REPORTING REFERENCES
CHAPTER 2: Some Uses Of Statistical Thinking
THE NEED FOR GOOD DATA UNCERTAINTY FROM UNRECOGNIZED ERROR IN A CRITICAL ASSUMPTION THE HEALTH EFFECTS OF AUTOMOTIVE EMISSIONS USING STATISTICAL CONCEPTS LESSONS FROM THE EXAMPLES ACKNOWLEDGMENTS REFERENCES
CHAPTER 3: Use Of Statistical Analysis In The New England Journal Of Medicine
METHODS RESULTS DISCUSSION REFERENCES
SECTION II: Design
CHAPTER 4: Randomized Trials And Other Parallel Comparisons Of Treatment
WHAT IS THE QUESTION? ASSIGNING SUBJECTS TO GROUPS WHAT IS THE OUTCOME? WEIGHING IN ON POWER RECOGNIZING A NEED TO END A STUDY EARLY REFERENCES
CHAPTER 5: Crossover And Self-Controlled Designs In Clinical Research
PARALLEL VERSUS CROSSOVER DESIGN KEY FACTORS FURTHER COMPARISONS WITH PARALLEL DESIGNS PATIENTS AS THEIR OWN CONTROLS REFERENCES
CHAPTER 6: The Series Of Consecutive Cases As A Device For Assessing Outcomes Of Interventions
WHAT IS A SERIES? INTERPRETING A SERIES THE “CLEAR-CUT” SERIES ADDITIONAL ISSUES IN INTERPRETATION CONCLUSIONS REFERENCES
CHAPTER 7: Biostatistics In Epidemiology: Design And Basic Analysis
ARE THE OBJECTIVES OF THE STUDY STATED PRECISELY AND CLEARLY? IS THE STUDY DESIGN APPROPRIATE FOR THE PURPOSE? SUMMARY AND CONCLUSIONS REFERENCES
SECTION III: Analysis
CHAPTER 8: P-Values
WHAT ARE P-VALUES? THE 0.05 AND 0.0L SIGNIFICANCE LEVELS P-VALUES AND SIGNIFICANCE TESTS ISSUES IN REPORTING AND INTERPRETING P-VALUES STATISTICAL POWER AND SAMPLE SIZE STATISTICAL AND MEDICAL SIGNIFICANCE RECOMMENDATIONS REFERENCES
CHAPTER 9: Understanding Analyses Of Randomized Trials
INTENTION-TO-TREAT PARADIGM STUDIES WITH MULTIPLE ENDPOINTS MULTIPLE TIMES STUDIES WITH MISSING DATA ADJUSTING FOR COVARIATES MATCHING THE ANALYSIS TO THE MEASUREMENT SCALE OF THE KEY VARIABLES INTERPRETATION OF RESULTS SUMMARY OF PRINCIPAL ANALYTICAL CHALLENGES IN RCTS REFERENCES
CHAPTER 10: Linear Regression In Medical Research
SIMPLE LINEAR REGRESSION CORRELATION VERSUS REGRESSION ASSOCIATION AND CAUSATION CAREFUL USE OF LINEAR REGRESSION MULTIPLE LINEAR REGRESSION SUMMARIZATION, ADJUSTMENT, AND PREDICTION REVISITED REPORTING REGRESSION RESULTS ADDITIONAL READING ACKNOWLEDGMENTS REFERENCES
CHAPTER 11: Statistical Analysis Of Survival Data
SURVIVAL AND HAZARD FUNCTIONS CENSORING ESTIMATING S(T): THE KAPLAN-MEIER ESTIMATOR COMPARISON OF TWO GROUPS: THE LOG-RANK TEST ASSESSING MULTIPLE EXPLANATORY VARIABLES: COX’S MODEL COMPETING RISKS ACKNOWLEDGMENT REFERENCES
CHAPTER 12: Analysis Of Categorical Data In Medical Studies
MEASURES OF ASSOCIATION TESTING FOR AN ASSOCIATION SAMPLE SIZE AND POWER FOR TESTING ASSOCIATION COLLAPSING TABLES: SIMPSON’S PARADOX SIMPLE STRATIFIED ANALYSES REGRESSION METHODS FOR CATEGORICAL DATA REFERENCES
CHAPTER 13: Analyzing Data From Ordered Categories
A SUITABLE METHOD OF ANALYSIS APPROXIMATE METHODS OF ANALYSIS ORDERED INPUT VARIABLES SUMMARY AND RECOMMENDATIONS ACKNOWLEDGMENTS REFERENCES
SECTION IV: Communicating Results
CHAPTER 14: Guidelines For Statistical Reporting In Articles For Medical Journals: Amplifications And Explanations
CONCLUSION REFERENCES
CHAPTER 15: Reporting Of Subgroup Analyses In Clinical Trials
SUBGROUP ANALYSES AND RELATED CONCEPTS SUBGROUP ANALYSES IN THE JOURNAL — ASSESSMENT OF REPORTING PRACTICES ANALYSIS OF OUR FINDINGS AND GUIDELINES FOR REPORTING SUBGROUPS ACKNOWLEDGMENTS REFERENCES
CHAPTER 16: Writing About Numbers
NUMBERS IN TABLES OR TEXT? NUMBERS IN THE TEXT NUMBERS IN TABLES SYMBOLS ACKNOWLEDGMENTS REFERENCES
SECTION V: Specialized Methods
CHAPTER 17: Combining Results From Independent Studies: Systematic Reviews And Meta-Analysis In Clinical Research
SYSTEMATIC REVIEWS IN THE NEW ENGLAND JOURNAL OF MEDICINE THE PRACTICE OF RESEARCH SYNTHESIS SYNTHESIZING THE RESULTS OF MULTIPLE STUDIES CONTROVERSIAL ISSUES IN SYSTEMATIC REVIEWS CONCLUSIONS REFERENCES
CHAPTER 18: Biostatistics In Epidemiology: Advanced Methods Of Regression Analysis
REGRESSION MODELS INCIDENCE COHORT STUDIES MATCHING IN COHORT STUDIES TO CONTROL FOR CONFOUNDING NESTED CASE-CONTROL STUDIES LONGITUDINAL COHORT STUDIES INCIDENCE CASE-CONTROL STUDIES CROSS-SECTIONAL STUDIES SOME GENERAL ISSUES IN REGRESSION MODELING OVERALL CONSIDERATIONS REFERENCES
CHAPTER 19: Genetic Inference
ESTIMATING GENETIC CONTRIBUTIONS TO DISEASE LOCALIZING DISEASE GENES THROUGH LINKAGE STUDIES CONCLUSIONS ACKNOWLEDGMENTS REFERENCES
CHAPTER 20: Identifying Disease Genes In Association Studies
CASE-CONTROL ASSOCIATION STUDIES FAMILY-BASED ASSOCIATION STUDIES LINKAGE DISEQUILIBRIUM, HAPLOTYPE BLOCKS, AND MULTILOCUS METHODS AN ASSOCIATION STUDY OF DRUG RESISTANCE TYPE I ERRORS IN ASSOCIATION STUDIES AN ASSOCIATION STUDY OF MYOCARDIAL INFARCTION REPLICATION OF ASSOCIATION STUDIES ACKNOWLEDGMENTS REFERENCES
CHAPTER 21: Risk Assessment
A CLINICAL EXAMPLE WITH RISK-MOTIVATED INTERVENTION RISKS, HAZARDS, AND HEALTH CARE COMPONENTS OF A RISK ASSESSMENT REFLECTIONS ON RISK STATISTICAL CONCEPTS IMPORTANT FOR RISK QUANTITATIVE RISK ESTIMATION ISSUES (EXPOSURE-RESPONSE RELATIONSHIPS REVISITED) UNCERTAINTY NEXT STEPS HOW MIGHT MEDICAL PROFESSIONALS BE INVOLVED IN THE RISK ASSESSMENT PROCESS? ACKNOWLEDGMENTS REFERENCES
INDEX
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