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Index
COVER TITLE PAGE COPYRIGHT PAGE CONTRIBUTORS PREFACE
PURPOSE OF THIS BOOK INTENDED AUDIENCE ORGANIZATION OF THE BOOK FEATURES
1 GENERAL PRINCIPLES OF TOXICOLOGY
1.1 BASIC DEFINITIONS AND TERMINOLOGY 1.2 TOXICOLOGY: A DIVERSE SCIENCE WITH TWO BASIC GOALS 1.3 HAZARD IDENTIFICATION FUNCTION 1.4 DOSE–RESPONSE/RISK ASSESSMENT FUNCTION 1.5 HOW DOSE–RESPONSE DATA CAN BE USED 1.6 AVOIDING INCORRECT CONCLUSIONS FROM DOSE–RESPONSE AND HAZARD IDENTIFICATION DATA 1.7 ADDITIONAL FACTORS INFLUENCING HAZARD IDENTIFICATION AND DOSE–RESPONSE DATA 1.8 DESCRIPTIVE TOXICOLOGY: TESTING ADVERSE EFFECTS OF CHEMICALS AND GENERATING DOSE–RESPONSE DATA 1.9 EVIDENCE-BASED TOXICOLOGY 1.10 SUMMARY SUGGESTED READING
2 XENOBIOTIC ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
2.1 XENOBIOTIC INTERACTIONS WITH THE BIOLOGICAL (CELL) MEMBRANE 2.2 ABSORPTION 2.3 DISTRIBUTION 2.4 METABOLISM 2.5 EXCRETION (ELIMINATION) 2.6 SUMMARY SUGGESTED READING
3 TOXICOKINETICS
3.1 INTRODUCTION 3.2 TOXICOKINETIC MODELING FUNDAMENTALS 3.3 APPLICATIONS OF TOXICOKINETICS 3.4 CASE STUDY: TOXICOKINETICS OF DIBUTYL PHTHALATE 3.5 TOXICOKINETICS IN THE FUTURE 3.6 SUMMARY REFERENCES AND SUGGESTED READING
4 OMICS TECHNOLOGIES IN TOXICOLOGY
4.1 INTRODUCTION TO OMICS 4.2 GENOMICS 4.3 PROTEOMICS 4.4 METABOLOMICS 4.5 PHARMACOGENOMICS 4.6 SYSTEMS BIOLOGY 4.7 SUMMARY SUGGESTED READING
5 TOXICITY OF THE HEMATOPOIETIC SYSTEM
5.1 HEMATOPOIESIS: ORIGINS OF HEMATOPOIETIC CELLS 5.2 HEMATOTOXICITY: ASSAYS USED FOR ANALYSIS 5.3 DISEASES OF THE HEMATOPOIETIC SYSTEM 5.4 HEMATOTOXINS: KNOWN HEMATOTOXIC AGENTS REFERENCES AND SUGGESTED READING
6 HEPATOTOXICITY: TOXIC EFFECTS ON THE LIVER
6.1 PHYSIOLOGICAL AND MORPHOLOGICAL BASES OF LIVER INJURY 6.2 TYPES OF LIVER INJURY 6.3 EVALUATION OF LIVER INJURY 6.4 SUMMARY REFERENCES AND SUGGESTED READING
7 NEPHROTOXICITY: TOXIC RESPONSES OF THE KIDNEY
7.1 RENAL STRUCTURE AND PHYSIOLOGY 7.2 CLASSIFICATIONS OF RENAL INJURY 7.3 ASSESSMENT OF RENAL FUNCTION AND INJURY IN THE CLINIC AND IN IN VIVO ANIMAL MODELS 7.4 IN VITRO MODELS TO STUDY RENAL FUNCTION AND INJURY 7.5 EXAMPLES OF ENVIRONMENTAL, INDUSTRIAL, AND THERAPEUTIC CHEMICALS THAT PRODUCE NEPHROTOXICITY 7.6 SUMMARY SUGGESTED READING
8 NEUROTOXICITY: TOXIC EFFECTS ON THE NERVOUS SYSTEM
8.1 NERVOUS SYSTEM 8.2 NEUROTOXICOLOGICAL AGENTS 8.3 NEUROTOXICANTS THAT INDUCE NEURONOPATHY 8.4 NEUROTOXICANTS THAT INDUCE AXONOPATHY 8.5 NEUROTOXICANTS THAT INDUCE MYELINOPATHY 8.6 NEUROTOXICANTS THAT INDUCE ALTERATIONS OF NEUROTRANSMISSION AT THE SYNAPSE 8.7 ROLE FOR GLIA IN NEUROTOXICITY 8.8 EVALUATION OF NEUROTOXIC INJURY 8.9 SUMMARY SUGGESTED READING
9 DERMATOTOXICITY: TOXIC EFFECTS ON THE SKIN
9.1 HISTOLOGY 9.2 FUNCTIONS 9.3 TYPES OF DERMAL TOXICITY 9.4 SUMMARY SUGGESTED READING
10 PULMONOTOXICITY: TOXIC EFFECTS IN THE LUNG
10.1 ANATOMY AND PHYSIOLOGY OF RESPIRATORY SYSTEM 10.2 GENERAL PRINCIPLES OF INHALATION TOXICOLOGY 10.3 ACUTE RESPONSES OF THE RESPIRATORY SYSTEM TO INJURY 10.4 CHRONIC RESPONSE OF THE RESPIRATORY SYSTEM TO INJURY 10.5 EVALUATION OF TOXIC DAMAGE IN THE RESPIRATORY SYSTEM 10.6 SUMMARY REFERENCES AND SUGGESTED READING
11 IMMUNOTOXICITY: TOXIC EFFECTS ON THE IMMUNE SYSTEM
11.1 BIOLOGY OF THE IMMUNE RESPONSE 11.2 TYPES OF IMMUNE REACTIONS AND DISORDERS 11.3 CLINICAL TESTS FOR DETECTING IMMUNOTOXICITY 11.4 TESTS FOR DETECTING IMMUNOTOXICITY IN ANIMAL MODELS 11.5 SPECIFIC CHEMICALS THAT ADVERSELY AFFECT THE IMMUNE SYSTEM 11.6 SUMMARY SUGGESTED READING
12 TOXIC EFFECTS ON REPRODUCTION
12.1 GENERAL PHYSIOLOGY OF THE MALE AND FEMALE REPRODUCTIVE SYSTEM 12.2 GENERAL METHODS TO ANALYZE REPRODUCTIVE TOXICANTS 12.3 REPRODUCTIVE TOXICANTS REFERENCES AND SUGGESTED READING
13 DEVELOPMENTAL TOXICOLOGY
13.1 BIRTH AND DEVELOPMENTAL ANOMALIES: TERATOLOGY 13.2 PHYSIOLOGY OF PREGNANCY 13.3 WORKPLACE, OCCUPATION, AND ADVERSE REPRODUCTIVE EFFECTS 13.4 GENERAL TESTING METHODS FOR TERATOGENIC EFFECTS IN EXPERIMENTAL ANIMALS 13.5 NEURODEVELOPMENTAL TOXICITY 13.6 THE ROLE OF EPIGENETICS IN ENVIRONMENTAL EFFECTS 13.7 SUMMARY SUGGESTED READING
14 MUTAGENESIS AND GENETIC TOXICOLOGY
14.1 FUNDAMENTALS OF CHEMICALLY INDUCED GENETIC DAMAGE 14.2 GENETIC DAMANGE AND ITS IMPACT ON HUMAN DISEASE 14.3 GENETIC TOXICOLOGY TESTS 14.4 CHROMOSOME TRANSLOCATIONS IN GERM CELLS 14.5 THE MOUSE-SPECIFIC LOCUS TEST 14.6 THE DOMINANT LETHAL ASSAY IN MALE MICE (OECD TG 478) 14.7 REGULATORY USE OF GENETIC TOXICOLOGY DATA 14.8 PROMISING ASSAYS UNDER DEVELOPMENT 14.9 SUMMARY SUGGESTED READING
15 CHEMICAL CARCINOGENESIS
15.1 BACKGROUND 15.2 NOMENCLATURE AND DEFINITIONS OF NEOPLASIA 15.3 CLASSFICATION OF CARCINOGENS 15.4 MULTISTAGE CARCINOGENESIS 15.5 CAUSES OF CANCER 15.6 TEST SYSTEMS FOR CARCINOGENECITY ASSESSMENT 15.7 CARCINOGEN CLASSIFICATION 15.8 SUMMARY SUGGESTED READING
16 PROPERTIES AND EFFECTS OF METALS
16.1 GENERAL CHARACTERISTICS OF METALS 16.2 ENVIRONMENTAL AND OCCUPATIONAL EXPOSURE 16.3 GENERAL PROPERTIES OF ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION OF METALS 16.4 BIOMARKERS 16.5 GENERAL MECHANISMS OF TOXICITY 16.6 ESSENTIALITY VERSUS TOXIC EFFECTS 16.7 TOXICOLOGY OF SPECIFIC METALS 16.8 SUMMARY ACKNOWLEDGMENTS REFERENCES AND SUGGESTED READING
17 PROPERTIES AND EFFECTS OF PESTICIDES
17.1 ORGANOPHOSPHATE AND CARBAMATE INSECTICIDES 17.2 ORGANOCHLORINE INSECTICIDES 17.3 INSECTICIDES OF BIOLOGICAL ORIGIN 17.4 HERBICIDES 17.5 FUNGICIDES 17.6 RODENTICIDES 17.7 FUMIGANTS 17.8 SUMMARY REFERENCES AND SUGGESTED READING
18 PROPERTIES AND EFFECTS OF SOLVENTS AND SOLVENT-LIKE CHEMICALS
18.1 GENERAL CONSIDERATIONS 18.2 EXPOSURE POTENTIAL, MONITORING, AND RISK CONSIDERATIONS 18.3 BASIC PRINCIPLES AND REVIEW OF TARGET ORGAN SYSTEMS 18.4 TOXIC PROPERTIES OF REPRESENTATIVE ALIPHATIC AND ALICYCLIC HYDROCARBON SOLVENTS 18.5 TOXIC PROPERTIES OF REPRESENTATIVE AROMATIC HYDROCARBON SOLVENTS 18.6 TOXIC PROPERTIES OF HALOGENATED ALIPHATIC AND AROMATIC SOLVENTS 18.7 TOXIC PROPERTIES OF ALCOHOLS 18.8 TOXIC PROPERTIES OF ALDEHYDES, KETONES, AND CARBOXYLIC ACIDS 18.9 TOXIC PROPERTIES OF REPRESENTATIVE ESTERS, ETHERS, AND EPOXIDES 18.10 TOXIC PROPERTIES OF REPRESENTATIVE NITROGEN-CONTAINING SOLVENTS 18.11 TOXIC PROPERTIES OF SULFUR-CONTAINING SOLVENTS 18.12 SUMMARY SUGGESTED READING
19 NANOTOXICOLOGY
19.1 CLASSIFICATION OF NANOMATERIALS AND THEIR POTENTIAL APPLICATIONS 19.2 HOW IS NANOTOXICOLOGY DIFFERENT? 19.3 HUMAN NANOTOXICOLOGY 19.4 ENVIRONMENTAL NANOTOXICOLOGY 19.5 MECHANISMS OF TOXICITY (MODES OF ACTION) 19.6 CHALLENGES AND FUTURE DIRECTIONS 19.7 SUMMARY SUGGESTED READING
20 COMPUTATIONAL TOXICOLOGY
20.1 DATA RELEVANT TO CT APPLICATIONS 20.2 DATA, DATABASES, KNOWLEDGE BASES, AND ONTOLOGIES 20.3 EXAMPLE CT APPLICATIONS 20.4 SUMMARY SUGGESTED READING
21 EPIDEMIOLOGICAL ISSUES IN OCCUPATIONAL AND ENVIRONMENTAL HEALTH
21.1 ENVIRONMENTAL AND OCCUPATIONAL EPIDEMIOLOGIC STUDIES 21.2 WHAT EPIDEMIOLOGY IS 21.3 EPIDEMIOLOGIC METRICS AND MEASURES OF ASSOCIATION 21.4 EPIDEMIOLOGIC STUDY DESIGNS 21.5 EPIDEMIOLOGIC EXPOSURE ASSESSMENT 21.6 BIOMARKERS IN EPIDEMIOLOGIC STUDIES 21.7 HOW EPIDEMIOLOGISTS INFER CAUSALITY 21.8 SUMMARY SUGGESTED READING
22 OCCUPATIONAL AND ENVIRONMENTAL HEALTH
22.1 HISTORY OF OCCUPATIONAL HEALTH 22.2 DEFINITION AND SCOPE 22.3 DATA SOURCES AND THE BURDEN OF OCCUPATIONAL AND ENVIRONMENTAL ILLNESS AND INJURY 22.4 CHARACTERISTICS OF OCCUPATIONAL ILLNESS 22.5 THREE PREVENTION GOALS 22.6 ACTIVITIES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH PROVIDERS 22.7 THE MULTIDISCIPLINARY APPROACH TO WORKERS’ HEALTH 22.8 LEGAL AND REGULATORY ISSUES PERTINENT TO OCCUPATIONAL AND ENVIRONMENTAL HEALTH 22.9 ETHICAL CONSIDERATIONS FOR THE OCCUPATIONAL AND ENVIRONMENTAL HEALTH PROFESSIONAL 22.10 SUMMARY AND CONCLUSION ACKNOWLEDGMENT SUGGESTED READING
23 HUMAN HEALTH RISK ASSESSMENT
23.1 RISK ASSESSMENT BASICS 23.2 HAZARD IDENTIFICATION 23.3 DOSE–RESPONSE ASSESSMENT 23.4 EXPOSURE ASSESSMENT: EXPOSURE PATHWAYS AND RESULTING DOSAGES 23.5 RISK CHARACTERIZATION 23.6 PROBABILISTIC VERSUS DETERMINISTIC RISK ASSESSMENTS 23.7 EVALUATING RISK FROM CHEMICAL MIXTURES 23.8 COMPARATIVE RISK ANALYSIS 23.9 RISK COMMUNICATION 23.10 SUMMARY SUGGESTED READING
GLOSSARY INDEX END USER LICENSE AGREEMENT
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