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Index
Cover image Title page Table of Contents Copyright Frontispiece Dedication List of Contributors Preface Chapter 1. An Overview of Toxicologic Pathology
Introduction What is Toxicologic Pathology? The Basis of Toxicologic Pathology The Challenges Facing Toxicologic Pathology Training and Certification in Toxicologic Pathology The “Practitioner” of Toxicologic Pathology Summary Further Reading
Part I: Principles of Toxicologic Pathology
Chapter 2. Biochemical and Molecular Basis of Toxicity
Abstract Introduction General Principles of Xenobiotic Disposition Interactions of Toxicants With Cellular and Molecular Targets Protective Mechanisms, Repair Mechanisms, and Adaptation Summary Further Reading
Chapter 3. Pharmacokinetics and Toxicokinetics
Abstract Introduction Pharmacokinetics: Processes and Determinants Pharmacokinetic (Time-Course) Data and Derivation of Dose Metrics Pharmacokinetic Models and Computation of Dose Metrics Pharmacokinetics and Its Use in Designing Toxicity Studies Concluding Remarks Further Reading
Chapter 4. Principles of Pharmacodynamics and Toxicodynamics
Abstract Introduction: Pharmacodynamics and Toxicodynamics Defined Relevance to Toxicological Pathology Drug/Toxin–Receptor Interactions Lead to Signal Transduction and Effect Selectivity and Safety: Therapeutic Versus Toxic Effect of Drugs Quantal Dose–Effect Curves Forms of Antagonism at the Tissue or Organism Level Dynamic Receptor Phenomena Resulting in Altered Efficacy Following Chronic Dosing Variation in Drug/Toxin Responsiveness Nonmonotonic Dose–Effect Curves Principles of Pharmacokinetic/Pharmacodynamic Modeling Further Reading
Chapter 5. Morphologic Manifestations of Toxic Cell Injury
Abstract Introduction Irreversible versus Reversible Cell Injury Irreversible Cell Injury Summary Further Readings
Chapter 6. Carcinogenesis: Manifestation and Mechanisms
Abstract Overview of Carcinogenesis Mechanisms of Carcinogenesis Summary Identifying Carcinogens Overall Summary Acknowledgments Further Reading
Chapter 7. Design of Studies and Risk Management in Toxicologic Pathology: Addressing Risks in Product Discovery and Development
Abstract Introduction Risk Assessment: The Process Risk Assessment: The Elements Toxicologic Pathology Issues in Risk Assessment Risk Perception and Acceptability Risk Communication Risk Management Financial Risk and Toxicologic Pathology Summary Acknowledgments Further Reading
Part II: Systems Toxicologic Pathology
Chapter 8. Liver and Gall Bladder
Abstract Introduction Structure, Function, and Cell Biology Evaluation of Liver Toxicity Response to Injury Mechanisms of Toxicity in Liver Summary Further Reading
Chapter 9. Cardiovascular System
Abstract Introduction Heart Blood Vessels Summary Further Reading
Chapter 10. Skeletal Muscle System
Abstract Structure and Function Evaluation of Skeletal Muscle Toxicity Response to Injury Mechanisms of Toxicity Summary Further Reading
Chapter 11. Urinary System
Abstract Part 1: Kidney Part 2: Lower Urinary Tract Acknowledgments Further Reading
Chapter 12. Immune System
Abstract Introduction Mechanisms and Evaluation of Toxicity Response to Injury Summary Further Reading
Chapter 13. Hematopoietic System
Abstract Introduction Phylogenesis and Ontogenesis Structure, Function, and Cell Biology Evaluation of Hematotoxicity Mechanisms of Toxicity Responses of Hematopoietic Tissues to Injury Summary Further Reading
Chapter 14. Respiratory System
Abstract Introduction Structure, Function, and Cell Biology Testing for Toxicity Response to Injury Mechanisms of Toxicity Summary Acknowledgment Further Reading
Chapter 15. Digestive System
Abstract Introduction Structure and Function of the Gastrointestinal Tract Evaluation of Gastrointestinal Toxicity Response of the Gastrointestinal Tract to Injury Mechanisms of Gastrointestinal Toxicity Summary Further Reading
Chapter 16. Exocrine Pancreas
Abstract Introduction Normal Structure and Function of the Exocrine Pancreas Evaluation of Toxicity Responses of Exocrine Pancreas to Injury Mechanisms of Exocrine Pancreatic Toxicity Summary Further Reading
Chapter 17. Male Reproductive System
Abstract Introduction Structure, Function, and Cell Biology Evaluation of Toxicity Response to Injury Mechanisms of Toxicity Further Reading
Chapter 18. Female Reproductive System
Abstract Introduction Structure, Function, and Cell Biology Evaluation of Female Reproductive System Toxicity Mechanisms of Toxicity in the Female Reproductive System Carcinogenesis in the Female Reproductive System Further Reading
Chapter 19. The Mammary Gland
Abstract Introduction Mammary Gland Structure and Function Morphologic Evaluation Evaluation of Toxicity Response to Injury Mechanisms of Toxicity Summary Further Reading
Chapter 20. Endocrine System
Abstract Introduction Part 1: Adrenal Cortex Part 2: Adrenal Medulla Part 3: Pituitary Gland Part 4: Thyroid C Cells Part 5: Thyroid Follicular Cells Part 6: Parathyroid Gland Part 7: Endocrine Pancreas Summary Acknowledgments Further Reading
Chapter 21. Nervous System
Abstract Introduction Neuroanatomic Considerations in Toxicologic Neuropathology Evaluation of Neurotoxicity Nervous System Responses to Neurotoxic Injury Mechanisms of Nervous System Injury Summary Further Reading
Chapter 22. Special Senses
Chapter 22a. Special Senses—Eye
Introduction Structure and Function Evaluation of Toxicity Response to Injury by Specific Ocular Tissues Mechanisms of Ocular Toxicity Summary Further Reading
Chapter 22b. Special Senses—Ear
Introduction Structure and Function Testing for Otic Toxicity Responses to Injury and Mechanisms of Injury Summary Further Reading
Chapter 23. Bone and Joints
Abstract Introduction Structure, Function, and Cell Biology of Bone and Cartilage Evaluation of Toxicity Responses to Injury Mechanisms of Toxicity Summary Further Reading
Chapter 24. The Integumentary System
Abstract Introduction Structure and Function Response to Injury Mechanisms of Toxicity Summary Further Reading
Chapter 25. Embryo, Fetus, and Placenta
Abstract Introduction Normal Morphologic Development Developmental Toxicity Testing and Risk Assessment Responses to Injury Principles of Developmental Toxicity Mechanisms of Developmental Toxicity Summary Further Reading
Index
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