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Index
Cover Page
Goodman and Gilman’s The Pharmacological Basis of Therapeutics
Copyright Page
Contents
Contributors
Preface
Preface to the First Edition
Acknowledgements
SECTION I General Principles
1. Drug Invention and the Pharmaceutical Industry
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination
3. Pharmacodynamics: Molecular Mechanisms of Drug Action
4. Drug Toxicity and Poisoning
5. Membrane Transporters and Drug Response
6. Drug Metabolism
7. Pharmacogenetics
SECTION II Neuropharmacology 169
8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
9. Muscarinic Receptor Agonists and Antagonists
10. Anticholinesterase Agents
11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
12. Adrenergic Agonists and Antagonists
13. 5-Hydroxytryptamine (Serotonin) and Dopamine
14. Neurotransmission and the Central Nervous System
15. Drug Therapy of Depression and Anxiety Disorders
16. Pharmacotherapy of Psychosis and Mania
17. Hypnotics and Sedatives
18. Opioids, Analgesia, and Pain Management
19. General Anesthetics and Therapeutic Gases
20. Local Anesthetics
21. Pharmacotherapy of the Epilepsies
22. Treatment of Central Nervous System Degenerative Disorders
23. Ethanol and Methanol
24. Drug Addiction
SECTION III Modulation of Cardiovascular Function
25. Regulation of Renal Function and Vascular Volume
26. Renin and Angiotensin
27. Treatment of Myocardial Ischemia and Hypertension
28. Pharmacotherapy of Congestive Heart Failure
29. Anti-Arrhythmic Drugs
30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
31. Drug Therapy for Hypercholesterolemia and Dyslipidemia
SECTION IV Inflammation, Immunomodulation, and Hematopoiesis
32. Histamine, Bradykinin, and Their Antagonists
33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout
35. Immunosuppressants, Tolerogens, and Immunostimulants
36. Pulmonary Pharmacology
37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
SECTION V Hormones and Hormone Antagonists
38. Introduction To Endocrinology: The Hypothalamic-Pituitary Axis
39. Thyroid and Anti-Thyroid Drugs
40. Estrogens and Progestins
41. Androgens
42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex
43. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia
44. Agents Affecting Mineral Ion Homeostasis and Bone Turnover
SECTION VI Drugs Affecting Gastrointestinal Function
45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
46. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease
47. Pharmacotherapy of Inflammatory Bowel Disease
SECTION VII Chemotherapy of Microbial Diseases
48. General Principles of Antimicrobial Therapy
49. Chemotherapy of Malaria
50. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections
51. Chemotherapy of Helminth Infections
52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections
53. Penicillins, Cephalosporins, and Other β-Lactam Antibiotics
54. Aminoglycosides
55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents
56. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy
57. Antifungal Agents
58. Antiviral Agents (Nonretroviral)
59. Antiretroviral Agents and Treatment of HIV Infection
SECTION VIII Chemotherapy of Neoplastic Diseases
60. General Principles of Cancer Chemotherapy
61. Cytotoxic Agents
62. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines
63. Natural Products in Cancer Chemotherapy: Hormones and Related Agents
SECTION IX Special Systems Pharmacology
64. Ocular Pharmacology
65. Dermatological Pharmacology
66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders
67. Environmental Toxicology; Carcinogens and Heavy Metals
I. Principles of Prescription Order Writing and Patient Compliance
II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data
Index
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