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Index
Cover Titlepage Copyright List of Contributors Preface Introduction: Interactions between the Immune and Central Nervous Systems
Origins By invitation only Cross-talk between the immune system and CNS Of mice and men Immune responses and neurodegenerative disorders Acknowledgements References
About the Companion Website 1 Immune Privilege of the Brain
Introduction The original experiment Mechanisms of the brain's immune privilege Concluding remarks Acknowledgements References
2 Innate Immunity in the CNS – A Focus on the Myeloid Cell
Introduction to concepts of innate immunity Cells of the innate immune system Innate immune cell receptors Innate immune responses in the CNS Summary Conflict of interests References
3 Adaptive Immune Responses in the CNS
Introduction to concepts of adaptive immunity Leukocyte populations in the CNS T cell populations T lymphocyte subsets Mediators of the adaptive immune response MHC expression on cells of the CNS Antigen presentation in the CNS Suppression of immune responses in the CNS Allografts and cytotoxic T cell responses Summary References
4 Ageing and the Immune Response in the CNS
Gene expression in the ageing brain Inflammation as a hallmark of the ageing brain Microglia Microglia in the ageing brain Microglia in the neurogenic niche Changes in regulation of microglial activation with ageing Neural contribution to age-associated brain inflammation Role of astrocytes in age-associated neuroinflammation Immune cells in the aged brain Implications of altered neuroinflammation for the ageing brain References
5 Brain Repair: The Role of Endogenous and Transplanted Neural Stem Cells
Introduction The homeostatic regulatory role of endogenous NPCs NPC transplantation as a therapeutic tool to promote brain repair The bystander effect of transplanted NPCs Immunomodulatory effects of transplanted NPCs Neurotrophic effects of transplanted NPCs Conclusions and perspectives Acknowledgements References
6 Neuroinflammation in Alzheimer's, Parkinson's and Huntington's Diseases
General introduction Alzheimer's disease Neuroinflammation in Parkinson's disease Neuroinflammation in Huntington's disease Conclusions References
7 CNS Infections
Introduction Herpes viruses Picornaviruses Retroviruses JC polyoma virus Prion diseases Conclusions References
8 Neuroimmunology of Amyotrophic Lateral Sclerosis
Overview of amyotrophic lateral sclerosis Mutant superoxide dismutase animal model of ALS TDP43 animal model of ALS Proposed mechanisms of motoneuron injury in ALS Neuroinflammation and mSOD1 mice Immunologic aspects of ALS: part 1 – microglia Immunologic aspects of ALS: part 2 – T cells Immunologic aspects of ALS: part 3 – B cells Immunologic aspects of ALS: part 4 – astrocytes Immunologic aspects of ALS: part 5 – cytokines, chemokines and other markers of inflammation in ALS Immunologic aspects of ALS: part 6 – dendritic cells Conclusions References
9 Demyelinating Disorders of the CNS
Introduction Specific diseases Conclusion Conflict of interest Acknowledgements References
10 Other Autoimmune Disorders: Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, Gluten-related Neurological Dysfunction and Paraneoplastic Neurological Syndromes
Systemic lupus erythematosus Primary Sjögren's syndrome Gluten-related neurological dysfunction Paraneoplastic neurological syndromes References
11 Inflammation in the Pathogenesis of Depression
Introduction A role for the immune system in depressive illness – what is the evidence? Evidence for activation of the immune system in depressed patients Stress as a trigger for activating the immune system in depressed patients Conclusion Acknowledgements References
12 Immune Responses in the CNS in Epilepsy
Introduction Innate immunity in epilepsy Adaptive immunity in epilepsy Conclusions References
13 Inflammatory Mediators and Dysfunction of the Neurovascular Unit following Ischaemia Reperfusion
Focal ischaemia and early mechanisms of injury Calcium ion homeostasis Free radical formation The ischaemic inflammatory response The neurovascular unit Blood–brain barrier permeability References
14 Spinal Cord Injury
Overview of neuroinflammation and spinal cord injury Role of the innate immune response: neutrophils Role of the innate immune response: astrocytes Role of the innate immune response: macrophages Role of the adaptive immune response: T and B cells Current clinical approaches Conclusion References
15 Immune Responses to Tumours in the CNS
Tumours of the CNS The inflammatory infiltrate in CNS tumours Biology of immune responses to CNS tumours Immunotherapy of CNS tumours Conclusions Acknowledgements References
Index End User License Agreement
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