The Biology of Human Longevity, Inflammation, Nutrition, and Aging in the Evolution of Life Spans by Finch, Caleb E. -- Read -- Imperial Library of Trantor

Index

Cover image Title page Table of Contents PREFACE ACKNOWLEDGMENTS Chapter 1: Inflammation and Oxidation in Aging and Chronic Diseases

Publisher Summary PART I 1.1 OVERVIEW 1.2 EXPERIMENTAL MODELS FOR AGING 1.3 OUTLINE OF INFLAMMATION 1.4 BYSTANDER DAMAGE AND DEPENDENT VARIABLES IN SENESCENCE PART II 1.5 ARTERIAL AGING AND ATHEROSCLEROSIS 1.6 ALZHEIMER DISEASE AND VASCULAR-RELATED DEMENTIAS 1.7 INFLAMMATION IN OBESITY 1.8 PROCESSES OF NORMAL AGING IN THE ABSENCE OF SPECIFIC DISEASES 1.9 SUMMARY

Chapter 2: Infections, Inflammogens, and Drugs

Publisher Summary 2.1 INTRODUCTION 2.2 VASCULAR DISEASE 2.3 INFECTIONS FROM THE CENTRAL TUBE: METCHNIKOFF REVISITED 2.4 AEROSOLS AND DIETARY INFLAMMOGENS 2.5 INFECTIONS, INFLAMMATION, AND LIFE SPAN 2.6 ARE INFECTIONS A CAUSE OF OBESITY? 2.7 INFLAMMATION, DEMENTIA, AND COGNITIVE DECLINE 2.8 IMMUNOSENESCENCE AND STEM CELLS 2.9 CANCER, INFECTION, AND INFLAMMATION 2.10 PHARMACOPLEIOTROPIES IN VASCULAR DISEASE, DEMENTIA, AND CANCER 2.11 SUMMARY

Chapter 3: Energy Balance, Inflammation, and Aging

Publisher Summary 3.1 INTRODUCTION 3.2 DIET RESTRICTION AND AGING 3.3 ENERGY SENSING IN DIET RESTRICTION AND SATIETY 3.4 EXERCISE, CARDIOVASCULAR HEALTH, AND LONGEVITY 3.5 DIET, EXERCISE, AND NEURODEGENERATION 3.6 LABORATORY RODENTS AS MODELS FOR THE ‘COUCH POTATO’ 3.7 ENERGY BALANCE IN THE LIFE HISTORY 3.8 SUMMARY

Chapter 4: Nutrition and Infection in the Developmental Influences on Aging

Publisher Summary 4.1 INTRODUCTION 4.2 SYNOPSIS OF THE FETAL ORIGINS THEORY 4.3 THE BARKER STUDIES OF INFECTIONS AND VASCULAR DISEASE 4.4 SIZE, HEALTH, AND LONGEVITY 4.5 INFECTION AND UNDERNUTRITION ON BIRTH WEIGHT AND LATER DISEASE 4.6 INFECTION AND NUTRITION IN POSTNATAL DEVELOPMENT AND LATER DISEASE 4.7 FAMINE 4.8 MATERNAL PHYSIOLOGY, FETAL GROWTH, AND LATER CHRONIC DISEASE 4.9 GROWTH IN ADAPTIVE RESPONSES TO THE ENVIRONMENT 4.10 GENOMICS OF FETAL GROWTH REGULATION 4.11 SUMMARY

Chapter 5: Genetics

Publisher Summary 5.1 INTRODUCTION 5.2 SOURCES OF INDIVIDUAL VARIATIONS IN AGING AND LIFE SPAN 5.3 SEX DIFFERENCES IN LONGEVITY 5.4 METABOLISM AND HOST-DEFENSE IN WORM AND FLY 5.5 THE WORM 5.6 FLY 5.7 MAMMALS 5.8 SUMMARY

Chapter 6: The Human Life Span: Present, Past, and Future

Publisher Summary 6.1 INTRODUCTION 6.2 FROM GREAT APE TO HUMAN 6.3 FOUR MAJOR SHIFTS IN HUMAN LIFE HISTORY FROM GENETIC AND CULTURAL EVOLUTION 6.4 THE INSTABILITY OF LIFE SPANS 6.5 SUMMARY OF CHAPTERS 1–6: MECHANISMS IN AGING AND LIFE HISTORY EVOLUTION

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