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Index
Half title Title Copyright Contents Preface to the Second Edition Part I. Clinical Aspects of Depression
1. The Definition of Depression
Paradoxes of Depression Prevalence of Depression
Prevalence and Severity by Types and Age at Onset
Descriptive Concepts of Depression Semantics of Depression Depression and Normal Moods
2. Symptomatology of Depression
Previous Systematic Studies Chief Complaint Symptoms
Emotional Manifestations
Dejected Mood Negative Feelings Toward Self Reduction in Gratification Loss of Emotional Attachments Crying Spells Loss of Mirth Response
Cognitive Manifestations
Low Self-Evaluation Negative Expectations Self-Blame and Self-Criticism Indecisiveness Distortion of Body Image
Motivational Manifestations
Paralysis of the Will Avoidance, Escapist, and Withdrawal Wishes Suicidal Wishes Increased Dependency
Vegetative and Physical Manifestations
Loss of Appetite Sleep Disturbance Loss of Libido Fatigability
Delusions
Worthlessness Crime and Punishment Nihilistic Delusions Somatic Delusions Poverty
Hallucinations
Clinical Examination
Appearance Retardation Agitation
Variations in Symptoms
Children and Adolescents Cultural Variations
3. Course and Prognosis
Depression as a Clinical Entity Importance of Course and Outcome Systematic Studies
Onset of Episodes Remission and Chronicity
Remission from Dysthymic Disorder Remission from Functional Impairments
Duration
Brief Attacks of Manic-Depressive Psychosis (Bipolar Disorder)
Recurrence Intervals between Attacks Outcome for “Endogenous” Versus “Neurotic” Depression Schizophrenic Outcome Suicide
Suicide Risk in Bipolar Disorder
Predictors of Chronic Depression
Developmental Factors Personality Disorders Psychological Stressors Comorbid Disorders Biological Factors Cognitive Factors
Conclusions
4. Classifying Mood Disorders
The Official Nomenclature Derivation of System of Classification Reliability and Validity of Classification Dichotomies and Dualisms: Past and Present
Endogenus Versus Exogenous Autonomous Versus Reactive Agitated Versus Retarded Psychotic Versus Neurotic
Endogenous and Exogenous Depressions
Origin of Endogenous-Exogenous Model “The Great Debates” Distinction between Endogenous and Reactive Depressions Systematic Studies
Methodological Problems Studies of Symptomatology Physiological Responses and Tests Body Build Response to Treatment
Depressive Equivalents Depressions Secondary to Somatic Disorders
5. Psychotic Versus Nonpsychotic Depression
“Psychoneurotic” Depressive Reaction
Definition Evolution of the Concept
Severe Depression with Psychotic Features (Psychotic Depressive Reaction)
Case 1 Case 2 Case 3
Contemporary Diagnosis
6. Bipolar Disorders
History and Definition Current Criteria for Bipolar Disorder Relationship of Manic to Depressive Episodes Symptomatology of Manic Phase
Emotional Manifestations
Elation Increased Gratification Self-Love Increased Attachment to People and Activities Increased Mirth Response
Cognitive Manifestations
Positive Self-Image Positive Expectations Assignment of Blame Denial Arbitrariness Delusions
Motivational Manifestations
Impulse-Driven Action-Oriented Drive for Independence Drive for Self-Enhancement
Physical and Vegetative Manifestations
Hyperactivity High Tolerance for Fatigue Appetite Increased Libido Insomnia
Behavioral Observations of Manic Phase Periodicity of Manic-Depressive Behavior Premorbid Personality of Manic-Depressive Patients Issues for Further Study
Classification Problems Goal Achievement and Manic Symptoms
7. Involutional Depression
History of the Concept Etiology Age Symptomatology Premorbid Personality Conclusion
8. Schizoaffective Disorder
Definition Evolution of the Concept
Catatonia and Manic-Depressive Psychosis Benign Stupor
Inactivity Negativism Affect Catalepsy Intellectual Processes Ideational Content Follow-up Studies
Acute Schizoaffective Psychosis Acute Remitting Schizophrenia Studies of Revised Diagnoses
Differentiation of Depression and Schizophrenia Prognosis
Affective Factors and Prognosis in Schizophrenia
Manifest Affect Content of Delusions Hallucinations Manic-Depressive Heredity and Outcome in Schizophrenia Presence of Depression Patterns of Aggression in Overt Behavior
Present Classification of Schizoaffective Disorder Unresolved Issues for Continuing Research
Course of Illness Symptom and Cognitive Profiles Family and Genetic Studies Bertelsen and Gottesman’s Review
Conclusion
Part II. Experimental Aspects of Depression
9. Biological Studies of Depression
Early studies Manic-Depressive Disorder and Constitution Heredity in Manic-Depressive Disorder
Identical Twin Studies Identical Twins Reared Separately Pedigree Studies Summary
Bipolar Disorder Unipolar Depression
Biochemical Studies of Depression
Early Studies
Blood Glucose Glucose Tolerance Acidity and Alkaline Reserve Serum Calcium and Phosphorus Nitrogenous Substances Lipoidal Substances Chlorides Critique of Studies
More Recent Studies
Differences Between Manic and Depressive Phases Studies of Continued Cycles Studies During Depressive Episodes An Experimental Test of Biological Markers Responses of Normal Subjects to Stress
Endocrine Studies
Steroid Metabolism Thyroid Function
Autonomic Function
Blood Pressure Responses to Mecholyl Salivation Studies
Critique of Salivation Studies
Neurophysiological Studies
Sedation Threshold
Anatomical Studies
Frodl’s Study
Neurotropic and Neurogenesis Theories
Electromyograph (EMG) Studies Electroencephalogram (EEG) Sleep Studies EEG Arousal Response
Recent Studies of Children and Adolescents Neuropsychological Studies Conclusions
10. Psychological Studies: Tests of Psychoanalytic Theory
Early Tests of Psychological Functioning
Psychomotor Performance Conceptual Performance Perceptual Threshold Distortion of Time Judgment Distortion of Spatial Judgment
Early Experimental Studies Family Background and Personality Self-Concept Beck’s Systematic Investigation of Depression
Psychodynamic Factors History of the Investigation Testing the Hypothesis
Definition of Negative Dream Study Early Memories Focused Fantasy Test Negative Inventory Self-Concept Test Experimental Studies
Collateral Studies
Cognitive Patterns in Verbal Material Longitudinal Studies Patterns in Dreams of Depressed Patients
Preliminary Study Principal Study
Childhood Bereavement and Adult Depression
Childhood Bereavement Study
Cognitive Distortions in Depression
Thematic Content of Cognitions Typology of Cognitive Distortions Formal Characteristics of Depressive Cognitions Relationship of Depressive Thoughts to Affect Discussion
Afterword
Part III. Theoretical Aspects of Depression
11. Theories of Depression
Behavioral Theories Cognitive and Evolutionary Theories Psychoanalytic Theories
Aggression in Depression Orality in Depression
Psychodynamic and Psychological Theories Existential Theories Neurological Theory Neuropsychological Theories Biochemical Theory Animal Models Expressed Emotion
12. Cognition and Psychopathology
The Primary Triad in Depression
Negative Interpretation of Experience
Thwarting or Defeat Deprivation Deprecation
Negative View of Self Negative Expectations
The Affective Response Cognitive Primacy Changes in Motivation Physical Symptoms Cognition in Mania and Other Disorders A Cognitive Classification of Psychiatric Disorders
Neuroses
Depressive Hypomanic Anxious Phobic Somatization Paranoid Obsessive and Compulsive
Psychoses
Conclusions
13. Development of Depression
Predisposition to Depression
Formation of Permanent Concepts Value Judgments and Affect Specific Vulnerability
Precipitation of Depression
Specific Stress Genetic Moderation of the Stress-Depression Link Nonspecific Stress Other Contributing Factors
Developmental Studies on Effects of Chronic Stress
Genetic Risk, Previous Episodes, and Chronic Stress
Personality Organization in Depression
Literature on Cognitive Organizations Definition of Schemas Identification of Schemas Schemas in Depression
Modes and Psychopathology
Distortion and Misinterpretation Perseveration (Rumination) Loss of Objectivity
Affects and Cognition A Feedback Model
Part IV: Treatment of Depression
14. Somatic Therapies
Pharmacotherapy
The Tricyclic Drugs
Early Studies
MAO Inhibitors Selective Serotonin-Reuptake Inhibitors (SSRIS) Antidepressant Prescribing Patterns Side Effects Stimulants Lithium Current Use of Tricyclics and Maois Treatment Resistance
Augmenting Versus Switching Antidepressants Placebo-Controlled Studies of Drug Combinations Medication, Psychotherapy, and Prescriptive Indices Clinical Considerations
Treatment after Age 60 Research Problems and Controversies
Rater Bias Placebo Response Nonrandom Distribution of Variables Variability of Measures Other Problems
Issues of Risk Versus Benefit Controversy about Placebo Effect Adverse Effects of Antidepressant Drugs
SSRIs Tricyclic Drugs MAO Inhibitors
Electroconvulsive Therapy
Physiological Effects Biochemical Effects Psychological Effects Complications Mechanism of Action Efficacy
Future Directions
Transcranial Magnetic Stimulation Pharmacogenomics
15. Psychotherapy
Early Approaches Supportive Psychotherapy
Reassurance Ventilation and Catharsis Guidance and Environmental Change
Psychoanalysis and Psychoanalytic Psychotherapy Depression-Focused Psychotherapies Interpersonal Therapy (IPT)
IPT for Chronic Depression IPT for Elderly Populations
Cognitive Therapy
Formulation and Conceptualization Structure and Strategy
Basic Elements Structure of Sessions Behavioral Aspects
Interpersonal Aspects of Change
Maintaining a Therapeutic Relationship A Collaborative Context Teaching Independent Problem-solving Modification of Interpersonal Dysfunctions Behavioral Activation
Cognitive Techniques
Delineating the Major Maladaptive Patterns Neutralizing Automatic Thoughts Pinpointing Depressive Cognitions Identifying Idiosyncratic Content Recognizing Formal Characteristics of Cognitions Distinguishing “Ideas” from “Facts” Checking Observations Responding to Depressive Cognitions Weighing Alternative Explanations Validating Basic Premises Modifying Mood by Induced Fantasies Case Illustration Case Illustration: Relapse Prevention
Treating Bipolar Disorder: Drugs and Psychotherapy Prevention of Suicide Prevention of Relapse Psychotherapy Change Processes
16. Evaluating Depression Treatments: Randomized Controlled Trials
Outcome and Follow-Up Data
Randomized Clinical Trials Ecological Validity and Randomized Clinical Trials Relapse Prevention
Overall Conclusions Issues for Further Study Afterword The New Developmental Cognitive Model
Cognitive Vulnerability Genetic Links to Cognitive Vulnerability Physiological Hyperreactivity Cognitive Neurobiology
Appendix: Scoring Instructions for Negative Dreams Definition Scoring
Negative Representation of the Self Physical Discomfort and Injury Thwarting Deprivation Physical Attack Nonphysical Attack Excluded, Superseded, or Abandoned Lost Punishment Failure
Exclusions
Threat Dreams
References Name Index Subject Index
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