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Index
Cover
Table of Contents
Series page
Title page
Copyright page
Contributors
Preface
Introduction
PART I: Engineering Bio-inspired Material Microenvironments
CHAPTER 1: ECM-Inspired Chemical Cues: Biomimetic Molecules and Techniques of Immobilization
1.1 Introduction
1.2 Development and Immobilization of Biomimetic Cues in 3-D Biomaterials
1.3 Spatial Orientation and Dynamic Display
1.4 Future Perspectives
References
CHAPTER 2: Dynamic Materials Mimic Developmental and Disease Changes in Tissues
2.1 Introduction
2.2 Cell Scaffolds, Their Intrinsic Properties, and Their Effects on Cells
2.3 ECM is a Dynamic Tissue
2.4 Dynamic Scaffolds
2.5 Conclusion
References
CHAPTER 3: The Role of Mechanical Cues in Regulating Cellular Activities and Guiding Tissue Development
3.1 Introduction
3.2 Mechanotransduction
3.3 Mechanotransduction from Cytoplasm to Nucleus
3.4 Role of Mechanical Cues in Developmental Biology
3.5 Applications of Mechanical Stimulation in Regenerative Medicine
3.6 Summary
References
CHAPTER 4: Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes
4.1 Introduction
4.2 Physical Forces
4.3 Conclusion
References
CHAPTER 5: Cellular Responses to Bio-Inspired Engineered Topography
5.1 Introduction
5.2 Definition of Engineered Topography
5.3 Surface Fabrication Techniques
5.4 Cellular Responses to 2-D Engineered Topographies
5.5 Cellular Responses to Dynamic, Engineered 2-D Topographies
5.6 Conclusions and Future Directions
References
CHAPTER 6: Engineering the Mechanical and Growth Factor Signaling Roles of Fibronectin Fibrils
6.1 Introduction
6.2 Structure of Fibronectin
6.3 Assembly of Fibronectin Fibrils
6.4 Mechanics of Fibronectin Fibrils
6.5 Role of Fibronectin Fibrils in Cell Attachment
6.6 Role of Fibronectin Fibrils in Growth Factor Signaling
6.7 Cell-Free Mechanisms of Fibril Formation
6.8 Cell-Derived Fibronectin Matrices
6.9 Use of Fibronectin in Tissue Engineering Applications
6.10 Conclusions
References
CHAPTER 7: Biologic Scaffolds Composed of Extracellular Matrix as a Natural Material for Wound Healing
7.1 Introduction
7.2 Products and Clinical Use of ECM
7.3 Mechanisms of ECM Remodeling
7.4 Summary
References
CHAPTER 8: Bio-Inspired Integration of Natural Materials
8.1 Introduction
8.2 Naturally Derived Materials
8.3 Conclusions
References
PART II: Bio-Inspired Tissue Engineering
CHAPTER 9: Bio-Inspired Design of Skin Replacement Therapies
9.1 Introduction
9.2 Bio-Inspiration of Skin Replacement Therapy
9.3 Biomimetic Solutions
9.4 Discussion
References
CHAPTER 10: Epithelial Engineering: From Sheets to Branched Tubes
10.1 Introduction
10.2 Inspiration from the Biology of Epithelial Morphogenesis
10.3 Engineering Approaches to Mimic Epithelial Morphogenesis
10.4 Conclusion
References
CHAPTER 11: A Biomimetic Approach toward the Fabrication of Epithelial-like Tissue
11.1 Introduction
11.2 Skin ECM and Its Function
11.3 Skin Tissue Engineering and Scaffold Design
11.4 Biomimetic Approach toward the Formation of Epithelial-Like Tissue Using Electrospun Nanofibers
11.5 Future Perspective and Challenge
11.6 Conclusion
References
CHAPTER 12: Nano- and Microstructured ECM and Biomimetic Scaffolds for Cardiac Tissue Engineering
12.1 Introduction
12.2 Structure and Function of the Myocardium
12.3 Bio-inspired Design Requirements of Cardiac Tissue Engineering Scaffolds
12.4 Approaches to Fabricating ECM Biomimetic Scaffolds
12.5 Persistent Challenges
12.6 The Future of Cardiac Tissue Engineering
References
CHAPTER 13: Strategies and Challenges for Bio-inspired Cardiovascular Biomaterials
13.1 Need for Cardiovascular Biomaterials
13.2 Structure Equals Function: Focus on Strategies that Introduce Hierarchical Organization
13.3 Tissue Engineering Approaches to Cardiovascular Biomaterials
13.4 Scaffold-Free Tissue Engineering: 3-D Tissues Without Exogenous Material Complications
13.5 Conclusion
References
CHAPTER 14: Evaluation of Bio-inspired Materials for Mineralized Tissue Regeneration Using Type I Collagen Reporter Cells
14.1 Introduction
14.2 Collagen 1 Promoter/GFP Reporter Technology
14.3 Primary Cell Harvest and Image Analysis of the Collagen Reporter Cells from Transgenic Mice
14.4 Type I Collagen/GFP Reporter System with Human Cells
14.5 Evaluation of Biomimetic cHA Thin Films by Collagen/GFP Reporter Cells
14.6 Evaluation of Fibrillar Collagen Thin Films by Primary Type I Collagen/GFP Reporter Cells
14.7 In vivo Use of Type I Collagen/GFP Reporter Mice to Screen Biomimetic Collagen/Hydroxyapatite Scaffolds
14.8 Conclusions and Future Directions
References
CHAPTER 15: Learning from Tissue Equivalents: Biomechanics and Mechanobiology
15.1 Introduction
15.2 Background
15.3 Prior Experiments
15.4 Prior Mechanical Analyses
15.5 Growth and Remodeling (G&R) Models
15.6 Summary
References
CHAPTER 16: Mimicking the Hematopoietic Stem Cell Niche by Biomaterials
16.1 Introduction
16.2 Concepts of HSC Niches
16.3 Biomaterial Approaches to Create Biomimetic HSC Niches
16.4 HSC Control Ex Vivo: From HSC Expansion to Biomimetic Niches
16.5 Outlook
References
CHAPTER 17: Engineering Immune Responses to Allografts
17.1 Introduction
17.2 Engineering Strategies forImmune Acceptance
17.3 Conclusion
References
CHAPTER 18: Immunomimetic Materials
18.1 Introduction
18.2 Surface Motifs
18.3 Morphogenic Factor-Related Materials
18.4 Stimuli-Responsive Materials
18.5 Self-Assembly Motifs
18.6 Conclusions and Outlook
References
Supplemental Images
Index
End User License Agreement
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