Kumar and Clark's Clinical Medicine by Edited By Parveen Kumar, Michael Clark. -- Read -- Imperial Library of Trantor

Index

Cover image Title Page Table of Contents Copyright Acknowledgements Online Special Topics Contributors Online contributors International Advisory Board Preface to the Ninth Edition

How to Use This Book

Section 1 Good medical practice

1 Ethics, law and communication

Ethics and the Law Communication

2 Clinical pharmacology

Introduction Why Do Patients Need Drugs? The Choice of Drug The Dose Pharmacokinetics Pharmacodynamics Affordability and Cost-Effectiveness Prescribing in Special Populations Monitoring Drug Therapy Adverse Drug Reactions Drug Interactions Inter-Individual Variability in Drug Response Evidence-Based Medicine Statistical Analyses Information Sources Significant websites

3 Palliative medicine and symptom control

Introduction and General Aspects Symptom Control Extending Palliative Care to People with Non-Malignant Disease Palliative Care of the Frail Elderly Care of the Dying Further reading Bibliography Significant websites

4 Global health

Introduction Millennium Development Goals Global Burden of Disease Poverty Water and Sanitation Organizations and the Global Health Agenda Education Maternal Health and Child Health Mental Health Accidents and Trauma Conflict and Catastrophe Economics and Politics in Global Health Social Determinants of Health Human Rights and the Value of Engagement in Global Health Bibliography

5 Environmental medicine

Disease and the Environment Environmental Temperature Heat Injury Cold Injury High Altitude Diving Drowning Air Pollution Ionizing Radiation Electric Shock Lightning Strike Smoke Noise Bioterrorism/Biowarfare Travel Building-Related Illnesses

6 Poisoning

Introduction Clinical approach to the poisoned patient Principles of Management of Poisoning Specific Poisons Significant websites

Section 2 Clinical sciences

7 Molecular cell biology and human genetics

Cell Biology Human Genetics Bibliography Significant websites

8 The immune system and disease

Anatomy and Principles of the Immune System Innate Immune System Adaptive Immune System Cell Migration HLA Molecules and Antigen Presentation The Immune System in Concert Laboratory Investigations of the Immune System Clinical Immunodeficiency Type I (Immediate) Hypersensitivity and Allergic Disease Autoimmune Disease Organ Rejection in Clinical Transplantation Immune-Based Therapies

9 Water, electrolytes and acid–base balance

Water and Electrolytes Acid–Base Disorders Further reading Bibliography

10 Nutrition

Introduction Water and Electrolyte Balance Dietary Requirements Protein–Energy Malnutrition Vitamins Minerals Nutrition and Ageing Obesity Nutritional Support Food Allergy and Food Intolerance Alcohol Bibliography Significant websites

Section 3 Clinical practice

11 Infectious diseases and tropical medicine

Infection and Infectious Disease Viral Infections Transmissible Spongiform Encephalopathies (Prion Diseases) Bacterial Infections Fungal Infections Protozoal Infections Helminthic Infections Arthropod Ectoparasites

12 Sexually transmitted infections and human immunodeficiency virus

Sexually Transmitted Infections Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome Bibliography

13 Gastrointestinal disease

Introduction Clinical Approach to the Patient with Gastrointestinal Disease The Mouth The Salivary Glands The Pharynx and Oesophagus The Stomach and Duodenum Acute and Chronic Gastrointestinal Bleeding The Small Intestine Inflammatory Bowel Disease The Colon and Rectum Diarrhoea Functional Gastrointestinal Disorders The Acute Abdomen The Peritoneum Bibliography Significant websites

14 Liver disease

Introduction Anatomy of the Liver and Biliary System Functions of the Liver Clinical Approach to the Patient with Liver Disease Jaundice Hepatitis Acute Hepatic Failure Autoimmune Hepatitis Drug-Induced Chronic Hepatitis Chronic Hepatitis of Unknown Cause Non-Alcoholic Fatty Liver Disease Cirrhosis Alcoholic Liver Disease Budd–Chiari Syndrome Hepatic Sinusoidal Obstruction Syndrome Fibropolycystic Diseases Liver Abscess Other Infections of the Liver Liver Disease in Pregnancy Liver Tumours Miscellaneous Conditions of the Liver Drugs and the Liver Bibliography

15 Biliary tract and pancreatic disease

The Gall Bladder and Biliary System The Pancreas

16 Haematological disease

The Red Cell The Spleen Blood Transfusion The White Cell Haemostasis and Thrombosis Bibliography Significant websites

17 Malignant disease

Cancer Treatment Acute Oncology Haematological Malignancies Common Solid Tumour Treatment

18 Rheumatic disease

Introduction Anatomy and Physiology of the Normal Joint Clinical Approach to the Patient with Rheumatic Disease Common Regional Musculoskeletal Problems Chronic Pain Syndromes Analgesic and Anti-Inflammatory Drugs for Musculoskeletal Problems Disorders of collagen Osteoarthritis Inflammatory Arthritis Rheumatoid arthritis Infections of Joints Autoimmune Rheumatic Diseases Systemic Inflammatory Vasculitis Arthritis in Children Rheumatological Problems Seen in Other Diseases Miscellaneous Arthropathies

19 Bone disease

Anatomy and Physiology of Bone Clinical Approach to the Patient with Bone Disease Osteoporosis Osteonecrosis Paget's Disease of Bone Rickets and Osteomalacia Bone Infections Neoplastic Disease Of Bone Other Bone Disorders Bibliography Significant websites

20 Kidney and urinary tract disease

Anatomy and Physiology of the Kidney and Urinary Tract Clinical Approach to the Patient with Kidney and Urinary Tract Disease The Glomerulus and Glomerular Disease Kidney Involvement in Other Diseases Hypertension and the Kidney Other Vascular Disorders of the Kidney Renal Calculi and Nephrocalcinosis Urinary Tract Obstruction Drugs and the Kidney Urinary Tract Infection Tubulointerstitial Nephritis Acute Kidney Injury Chronic Kidney Disease Cystic Renal Disease Tumours of the Kidney and Genitourinary Tract Diseases of the Prostate Gland The Urinary Tract in the Elderly Bibliography Significant websites

21 Neurological disease

Introduction Clinical Approach to the Patient with Neurological Disease Functional Neuroanatomy Cranial Nerves Motor Control Systems Lower Motor Neurone Lesions Sensory Pathways and Pain Bladder Control and Sexual Dysfunction Investigation of Neurological Disease Unconsciousness and Coma Stroke Intracranial haemorrhage Headache, Migraine and Facial Pain Epilepsy and Loss of Consciousness Movement Disorders Neuroinflammatory Disorders Nervous System Infection Brain Tumours Hydrocephalus Traumatic Brain Injury Spinal Cord Disease Neurodegenerative Diseases Congenital Disorders Neurogenetic Disorders Paraneoplastic Syndromes Peripheral Nerve Disease Muscle Diseases Bibliography Significant websites

22 Psychological medicine

Introduction Clinical Approach to the Patient with a Psychiatric Disorder Classification of Psychiatric Disorders Aetiology of Psychiatric Disorders Psychiatric Aspects of Physical Diseases The Sick Role and Illness Behaviour Functional Somatic Syndromes Somatoform Disorders Dissociative/Conversion Disorders Sleep Difficulties Mood (Affective) Disorders Suicide and Self-Harm Anxiety Disorders Alcohol Misuse and Dependence Drug Misuse and Dependence Schizophrenia Organic Mental Disorders Eating Disorders Sexual Disorders Personality Disorders Involuntary Detention or Commitment Mental Capacity Act Further reading Significant websites

23 Cardiovascular disease

Cardiac Arrhythmias Heart Failure Coronary Artery Disease Valvular Heart Disease Infective Endocarditis Congenital Heart Disease Marfan Syndrome Pulmonary Heart Disease Myocardial and Endocardial Disease Pericardial Disease Systemic Hypertension Peripheral Vascular Disease Significant websites

24 Respiratory disease

Introduction Anatomy of the Respiratory System Physiology of the Respiratory System Clinical Approach to the Patient with Respiratory Disease Smoking Diseases of the Upper Respiratory Tract Diseases of the Lower Respiratory Tract Asthma Pneumonia Tuberculosis Diffuse Parenchymal Lung Diseases Occupational Lung Disease Lung Cysts Tumours of the Respiratory Tract Disorders of the Chest Wall and Pleura Disorders of the Diaphragm Mediastinal Lesions Significant websites

25 Critical care medicine

Introduction Clinical Approach to the Critically Ill Patient Applied Cardiorespiratory Physiology Disturbances of Acid–Base Balance Shock, Sepsis and Acute Disturbances of Haemodynamic Function Respiratory Failure Acute Respiratory Distress Syndrome Acute Kidney Injury Neurocritical Care Outcomes Bibliography Significant websites

26 Endocrine disease

Introduction Clinical Approach to the Patient with Endocrine Disease The Pituitary Gland and Hypothalamus The Thyroid Axis Reproduction and Sex The Adrenal Axis The Thirst Axis Disorders of Calcium Metabolism Other Endocrine Disorders Bibliography Significant websites

27 Diabetes mellitus

Introduction Classification of Diabetes Clinical Approach to the Patient with Diabetes Management of Diabetes Diabetic Metabolic Emergencies Complications of Diabetes Special Situations in Diabetes Hypoglycaemia in the Non-Diabetic Patient Significant websites

28 Lipid and metabolic disorders

Disorders of Lipid Metabolism Inborn Errors of Carbohydrate Metabolism Inborn Errors of Amino Acid Metabolism Lysosomal Storage Diseases Amyloidosis The Porphyrias Bibliography Significant websites

29 Women's health

Introduction The Life Course Approach Miscarriage Heavy Menstrual Bleeding Abortion/Termination of Pregnancy Urinary Incontinence Domestic Abuse and Violence Medical Problems in Pregnancy Prescribing in Pregnancy

30 Ear, nose and throat and eye disease

Disorders of the Ear Disorders of the Nose Disorders of the Throat Disorders of the Eye

31 Skin disease

Introduction Structure and Function of the Skin Clinical Approach to the Patient with Skin Disease Infections Papulo-Squamous/Inflammatory Rashes Facial Rashes Photodermatology Erythroderma Cutaneous Signs of Systemic Disease Bullous Disease Skin Tumours Disorders of Blood Vessels and Lymphatics Disorders of Collagen and Elastic Tissue Disorders of Pigmentation Disorders of the Nails Disorders of Hair Birth Marks/Neonatal Rashes Drug Eruptions Human Immunodeficiency Virus and the Skin Principles of Topical Therapy Bibliography Significant Websites

Index

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