Kidney Transplantation · Principles and Practice by Morris, Peter -- Read -- Imperial Library of Trantor

Index

Cover image Title page Table of Contents Copyright Video Table of Contents Preface to the First Edition Preface to the Seventh Edition List of Contributors Chapter 1: Kidney Transplantation: A History

EARLY EXPERIMENTS HUMAN KIDNEY TRANSPLANTS THE MIDDLE YEARS POST WORLD WAR II IMMUNOSUPPRESSION AND THE MODERN ERA CHEMICAL IMMUNOSUPPRESSION A TIME OF OPTIMISM TISSUE TYPING THE 1970s PLATEAU WAITING FOR XENOGRAFTS CONCLUSION

Chapter 2: Immunology of Graft Rejection

INITIATION OF ALLOIMMUNITY BY THE INNATE IMMUNE SYSTEM STIMULATION OF ADAPTIVE ALLOIMMUNITY ACTIVATION OF CELLULAR IMMUNITY MECHANISMS OF GRAFT INJURY SUMMARY

Chapter 3: Chronic Kidney Failure: Renal Replacement Therapy

INTRODUCTION DEFINITION AND TIMING REFERRAL PREVALENCE AND INCIDENCE ETIOLOGY TREATMENT OF CKD5 CHOICE AND PLANNING FOR THE INDIVIDUAL PATIENT DIALYSIS POSTTRANSPLANT RETURN TO DIALYSIS AFTER TRANSPLANT FAILURE RRT MODALITY AND SURVIVAL QUALITY OF LIFE

Chapter 4: The Recipient of a Kidney Transplant

THE PATIENT WITH CHRONIC KIDNEY DISEASE GENERAL CONCEPTS COUNSELING SPECIFIC MEDICAL CONSIDERATIONS PREPARATION FOR TRANSPLANTATION

Chapter 5: Access for Renal Replacement Therapy

INTRODUCTION VASCULAR ACCESS CATHETERS FISTULAS AND SYNTHETIC GRAFTS PERITONEAL DIALYSIS RENAL TRANSPLANT ISSUES WITH PERITONEAL DIALYSIS CONCLUSION

Chapter 6: Brain Death and Cardiac Death: Donor Criteria and Care of Deceased Donor

INTRODUCTION BRAIN DEATH CARDIAC DEATH DONOR MANAGEMENT OTHER TOPICS IN DONOR MANAGEMENT CONCLUSION

Chapter 7: Medical Evaluation of the Living Donor

INTRODUCTION HISTORICAL PERSPECTIVE AND CURRENT STATUS RATIONALE FOR LIVE KIDNEY DONATION RISKS OF LIVE KIDNEY DONATION THE EVALUATION PROCESS SUMMARY

Chapter 8: Donor Nephrectomy

DECEASED DONOR NEPHRECTOMY DONATION AFTER BRAIN DEATH DONATION AFTER CARDIAC DEATH LIVING DONOR NEPHRECTOMY ANESTHETIC MANAGEMENT OPEN DONOR NEPHRECTOMY LAPAROSCOPIC DONOR NEPHRECTOMY RIGHT DONOR NEPHRECTOMY SINGLE-PORT DONOR NEPHRECTOMY ROBOTIC DONOR NEPHRECTOMY COMPLICATIONS SUMMARY

Chapter 9: Kidney Preservation

TOWARDS “TAILORED” PRESERVATION STRATEGIES PRINCIPLES OF COLD STORAGE PRESERVATION COMPOSITION OF CLINICALLY USED SOLUTIONS HYPOTHERMIC MACHINE PERFUSION REVISITED NORMOTHERMIC PERFUSION FUTURE OUTLOOK

Chapter 10: Histocompatibility in Kidney Transplantation

HISTORICAL BACKGROUND THE HLA SYSTEM HLA MATCHING HLA-SPECIFIC ALLOSENSITIZATION DONOR CROSSMATCH STRATEGIES FOR TRANSPLANTING SENSITIZED AND HIGHLY SENSITIZED PATIENTS POSTTRANSPLANT MONITORING CONCLUDING REMARKS

Chapter 11: Surgical Techniques of Kidney Transplantation

PREPARATION OF RECIPIENT SITE INCISION PREPARATION OF OPERATIVE BED PREPARATION OF KIDNEY REVASCULARIZATION RECONSTRUCTION OF THE URINARY TRACT CLOSURE PEDIATRIC RECIPIENT PEDIATRIC DONOR DOUBLE KIDNEY TRANSPLANT TRANSPLANT NEPHRECTOMY

Chapter 12: Transplantation and the Abnormal Bladder

ASSESSMENT OF BLADDER FUNCTION GENERAL CONCEPTS OF MANAGEMENT OF BLADDER DYSFUNCTION CONCLUSION

Chapter 13: Perioperative Care of Patients Undergoing Kidney Transplantation

COMORBIDITIES IN END-STAGE RENAL DISEASE PREOPERATIVE CONSIDERATIONS INTRAOPERATIVE CONSIDERATIONS POSTOPERATIVE CARE ANESTHESIA FOR PATIENTS AFTER KIDNEY TRANSPLANTATION KIDNEY–PANCREAS TRANSPLANTATION

Chapter 14: Early Course of the Patient with a Kidney Transplant

OVERVIEW SURGICAL COMPLICATIONS REJECTION DURING THE EARLY POSTOPERATIVE PERIOD MEDICAL COMPLICATIONS SUMMARY

Chapter 15: Azathioprine

INTRODUCTION MECHANISM OF ACTION DOSAGE SIDE EFFECTS MONITORING OF AZATHIOPRINE THERAPY AZATHIOPRINE AND MYCOPHENOLATE MOFETIL CYCLOSPORINE CONVERSION TO AZATHIOPRINE AZATHIOPRINE CONVERSION TO MYCOPHENOLATE MOFETIL TACROLIMUS AND AZATHIOPRINE CONCLUSION

Chapter 16: Steroids

INTRODUCTION MECHANISM OF ACTION STEROID RESISTANCE DOSAGE TREATMENT OF ACUTE REJECTION SIDE EFFECTS STEROID WITHDRAWAL AND AVOIDANCE CONCLUSIONS

Chapter 17: Calcineurin Inhibitors

MECHANISM OF ACTION PHARMACOKINETIC PROPERTIES PHARMACOGENETICS ABSORPTION AND DISTRIBUTION METABOLISM AND ELIMINATION SPECIAL PATIENT POPULATIONS CLINICAL STUDIES IN KIDNEY TRANSPLANTATION CLINICAL STUDIES IN KIDNEY–PANCREAS TRANSPLANTATION (SEE CHAPTER 36) SIDE EFFECTS AND TOLERABILITY OF CALCINEURIN INHIBITORS CONCLUSION

Chapter 18: Mycophenolates

INTRODUCTION HISTORY OF MYCOPHENOLATES MECHANISM OF ACTION CLINICAL PHARMACOLOGY AND BLOOD MONITORING CLINICAL TOXICITIES EARLY CLINICAL TRIALS OF MYCOPHENOLATES IN KIDNEY TRANSPLANTATION COMBINATION THERAPY UTILIZING MMF IN KIDNEY TRANSPLANTATION USE OF MYCOPHENOLATES TO MINIMIZE OR AVOID OTHER IMMUNOSUPPRESSANTS THERAPEUTIC DRUG MONITORING

Chapter 19: mTor Inhibitors: Sirolimus and Everolimus

DISCOVERY MECHANISM OF ACTION PHARMACOKINETICS THERAPEUTIC BLOOD MONITORING PHARMACOGENETICS DRUG INTERACTIONS USE OF mTOR INHIBITORS mTOR INHIBITORS AND MALIGNANCY SAFETY AND SIDE EFFECTS OF mTOR INHIBITORS CONCENTRATION-CONTROLLED DOSING SUMMARY AND CONCLUSIONS

Chapter 20: Antilymphocyte Globulin, Monoclonal Antibodies, and Fusion Proteins

HISTORICAL PERSPECTIVE ANTIBODY STRUCTURE AND FUNCTION GENERAL CLINICAL CONSIDERATIONS FOR THE USE OF ANTIBODY PREPARATIONS POLYCLONAL ANTIBODY PREPARATIONS SPECIFIC CLINICAL APPLICATIONS OF POLYCLONAL ANTIBODY PREPARATIONS MONOCLONAL ANTIBODY PREPARATIONS MONOCLONAL ANTIBODIES IN CURRENT CLINICAL TRANSPLANTATION PRACTICE FUSION PROTEINS CONCLUSION

Chapter 21: Belatacept

INTRODUCTION: TWO SIGNALS COSTIMULATORY PATHWAYS COSTIMULATION BLOCKADE CLINICAL APPLICATION OF BELATACEPT CONCLUSIONS

Chapter 22: Other Forms of Immunosuppression

SMALL MOLECULES TOTAL LYMPHOID IRRADIATION PHOTOPHERESIS SPLENECTOMY PLASMAPHERESIS

Chapter 23: Approaches to the Induction of Tolerance

INTRODUCTION UNDERSTANDING THE IMMUNOLOGIC MECHANISMS BEHIND TOLERANCE INDUCTION STRATEGIES WITH THE POTENTIAL TO INDUCE IMMUNOLOGIC TOLERANCE TO AN ALLOGRAFT LEUKOCYTE DEPLETION AT THE TIME OF TRANSPLANTATION CELL THERAPY

Chapter 24: Transplantation in the Sensitized Recipient and Across ABO Blood Groups

SENSITIZED PATIENTS ALLOANTIBODY DETECTION IMMUNOLOGICAL RISK CLINICAL APPROACHES TO SENSITIZED PATIENTS CHRONIC ANTIBODY-MEDIATED INJURY ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION MECHANISTIC VIEW OF ANTIBODY PRODUCTION AND INJURY CONCLUSION

Chapter 25: Kidney Paired Donation Programs for Living Donors

BEGINNINGS OF KIDNEY PAIRED DONATION THE ROLE OF HLA MATCHING LEGAL RESTRICTIONS ANONYMITY DONOR TRAVEL AND ORGAN TRANSPORT FINANCIAL ISSUES EXPANSIONS BEYOND INCOMPATIBLE PAIRS THE ROLE OF NON-DIRECTED DONORS GOALS OF MATCHING MATCHING ALGORITHMS REGISTRY SIZE BEYOND NATIONAL LINES FUTURE OF KIDNEY PAIRED DONATION

Chapter 26: Pathology of Kidney Transplantation

RENAL ALLOGRAFT BIOPSY DONOR KIDNEY BIOPSY HYPERACUTE REJECTION ACUTE RENAL ALLOGRAFT REJECTION LATE GRAFT DISEASES ACUTE TUBULAR INJURY CALCINEURIN INHIBITOR NEPHROTOXICITY TARGET OF RAPAMYCIN INHIBITOR TOXICITY DRUG-INDUCED ACUTE TUBULOINTERSTITIAL NEPHRITIS INFECTIONS MAJOR RENAL VASCULAR DISEASE DE NOVO GLOMERULAR DISEASE RECURRENT RENAL DISEASE PROTOCOL BIOPSIES FUTURE DIRECTIONS IN BIOPSY ASSESSMENT

Chapter 27: Chronic Allograft Failure

INTRODUCTION: THE PROBLEM OF GRAFT LOSS PATHOPHYSIOLOGY OF CHRONIC ALLOGRAFT DAMAGE TIME COURSE OF HISTOLOGICAL DAMAGE APPROACH TO A FAILING ALLOGRAFT TREATMENT OF A FAILING ALLOGRAFT SUMMARY

Chapter 28: Vascular and Lymphatic Complications after Kidney Transplantation

INTRODUCTION TECHNICAL COMPLICATIONS AND THEIR PREVENTION HEMATOMA VASCULAR THROMBOSIS AND THROMBOPHILIA TORSION VASCULAR ACCESS THROMBOSIS DEEP VEIN THROMBOSIS VASCULAR CAUSES OF URETERIC COMPLICATIONS MYCOTIC ANEURYSM BIOPSY-RELATED VASCULAR COMPLICATIONS TRANSPLANT RENAL ARTERY STENOSIS LYMPHOCELE CONCLUSIONS

Chapter 29: Urological Complications After Kidney Transplantation

URETERAL COMPLICATIONS USE OF PROPHYLACTIC URETERAL STENTS URINARY CALCULI IN TRANSPLANT RECIPIENTS URINARY RETENTION ERECTILE DYSFUNCTION UROLOGIC MALIGNANCIES

Chapter 30: Cardiovascular Disease in Renal Transplantation

INTRODUCTION BACKGROUND: CVD IN CKD EPIDEMIOLOGY AND NATURE OF POSTTRANSPLANT CVD NOVEL AND TRANSPLANT-SPECIFIC RISK FACTORS SPECIFIC RISK FACTORS AND MANAGEMENT HYPERTENSION AND UREMIC CARDIOMYOPATHY OTHER SURROGATES: VASCULAR STIFFNESS AND CALCIFICATION CHOICE OF ANTIHYPERTENSIVE AGENT GUIDELINES AND OBSERVED PATTERNS OF USAGE DYSLIPIDEMIA RENAL FUNCTION SMOKING NEW-ONSET DIABETES AFTER TRANSPLANTATION OBESITY AND THE METABOLIC SYNDROME OTHER RISK FACTORS AND INTERVENTIONS SCREENING INTERVENTION AND SECONDARY PREVENTION OTHER CARDIOVASCULAR CONDITIONS PREDICTING CARDIOVASCULAR RISK TRIAL END-POINTS CONCLUSION

Chapter 31: Infection in Kidney Transplant Recipients

OVERVIEW RISK OF INFECTION TIMELINE OF INFECTION ASSESSMENT OF INFECTIOUS DISEASES IN RECIPIENTS AND POTENTIAL DONORS BEFORE TRANSPLANTATION SELECTED INFECTIONS OF IMPORTANCE CONCLUSIONS

Chapter 32: Liver Disease among Renal Transplant Recipients

OVERVIEW OF INCIDENCE AND CLINICOPATHOLOGICAL ASSOCIATIONS COMBINED LIVER AND KIDNEY DISEASES SPECIFIC IMMUNOSUPPRESSIVE AGENTS IN RENAL TRANSPLANTATION AND HEPATOTOXICITY HEPATITIS VIRUSES ASSOCIATED WITH RENAL TRANSPLANTATION HEPATOCELLULAR CARCINOMA AFTER RENAL TRANSPLANTATION SYSTEMIC INFECTIONS RESULTING IN HEPATITIS AND LIVER DISEASE

Chapter 33: Neurological Complications after Kidney Transplantation

NEUROLOGICAL DISEASE PRECEDING RENAL TRANSPLANTATION APPROACH TO THE RENAL TRANSPLANT PATIENT WITH NEUROLOGICAL DISEASE IMMEDIATE NEUROLOGICAL COMPLICATIONS SUBACUTE NEUROLOGICAL COMPLICATIONS CHRONIC NEUROLOGICAL COMPLICATIONS SUMMARY

Chapter 34: Non-Malignant and Malignant Skin Lesions in Kidney Transplant Patients

INTRODUCTION DRUG SIDE EFFECTS INFECTIONS INFLAMMATORY AND NON-INFLAMMATORY CUTANEOUS FINDINGS PREMALIGNANT AND MALIGNANT SKIN CONDITIONS SUMMARY

Chapter 35: Cancer in Dialysis and Kidney Transplant Patients

CANCER IN DIALYSIS PATIENTS CANCER IN KIDNEY TRANSPLANT RECIPIENTS TRANSPLANTATION IN PATIENTS WITH A HISTORY OF CANCER PREVENTION AND EARLY DETECTION OF CANCER IN KIDNEY TRANSPLANT RECIPIENTS SURVIVAL IN KIDNEY TRANSPLANT RECIPIENTS WHO DEVELOP CANCER CONCLUSIONS

Chapter 36: Pancreas and Kidney Transplantation for Diabetic Nephropathy

HISTORY INDICATIONS AND CATEGORIES ALLOCATION SPECIFIC RISK FACTORS PROCEDURE MANAGEMENT PANCREAS TRANSPLANT OUTCOMES PANCREAS RETRANSPLANTS LIVING DONOR PANCREAS TRANSPLANTS QUALITY-OF-LIFE STUDY LONG-TERM QUALITY OF LIFE METABOLIC STUDIES STUDIES OF DIABETIC SECONDARY COMPLICATIONS SUMMARY

Chapter 37: Renal Transplantation in Children

INTRODUCTION EPIDEMIOLOGY OF END-STAGE RENAL DISEASE IN CHILDREN ACCESS TO TRANSPLANTATION TIMING OF TRANSPLANTATION PATIENT AND GRAFT SURVIVAL CONTRAINDICATIONS TO TRANSPLANTATION RECURRENCE OF ORIGINAL DISEASE PRETRANSPLANT EVALUATION PERIOPERATIVE MANAGEMENT OF PEDIATRIC RENAL TRANSPLANT RECIPIENTS IMMUNOSUPPRESSIVE PROTOCOLS AND DRUGS ACUTE REJECTION IN PEDIATRIC TRANSPLANTATION LONG-TERM MANAGEMENT POSTTRANSPLANT

Chapter 38: Kidney Transplantation in Developing Countries

PREAMBLE END-STAGE KIDNEY DISEASE IN DEVELOPING COUNTRIES DIALYSIS IN DEVELOPING COUNTRIES (Figure 38-6) KIDNEY TRANSPLANTATION TRANSPLANT ACTIVITY IN DIFFERENT DEVELOPING REGIONS OF THE WORLD IMMUNOSUPPRESSION TRANSPLANT OUTCOMES (Table 38-3) POSTTRANSPLANT COMPLICATIONS SPECIAL CONSIDERATIONS IN TRANSPLANTATION

Chapter 39: Results of Renal Transplantation

INTRODUCTION RENAL FAILURE TREATMENTS – DIALYSIS VERSUS TRANSPLANTATION KIDNEY DONATION GRAFT SURVIVAL KIDNEY-ALONE VERSUS KIDNEY–PANCREAS TRANSPLANTATION FOR DIABETES CANCER RISK PREGNANCY AFTER RENAL TRANSPLANTATION RENAL TRANSPLANTATION IN HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS PREVALENCE OF PEOPLE LIVING WITH A FUNCTIONING KIDNEY TRANSPLANT LONG-TERM OUTCOMES OF RENAL TRANSPLANTATION QUALITY OF LIFE CONCLUSION

Chapter 40: Psychological Aspects of Kidney Transplantation and Organ Donation

INTRODUCTION QUALITY OF LIFE AND PSYCHOLOGICAL WELLBEING FOR RENAL TRANSPLANT PATIENTS RENAL DISEASE – DIALYSIS AND PREOPERATIVE ADJUSTMENTS HOPE OF A TRANSPLANT IMMEDIATE POSTOPERATIVE PSYCHOLOGICAL ISSUES IMMUNOSUPPRESSION REGIMENS AND PSYCHOLOGICAL REACTIONS FAMILY INTERACTIONS GRAFT FUNCTION PSYCHOLOGICAL ASPECTS OF LIVING DONATION LIVING UNRELATED DONORS PRE-EMPTIVE TRANSPLANTATION PSYCHOLOGICAL ISSUES AND IMPLICATIONS FOR PRACTICE FOR LIVING DONOR PROGRAMS PSYCHOLOGICAL ASPECTS OF CADAVER ORGAN DONATION CONCLUSION

Chapter 41: Ethical and Legal Aspects of Kidney Donation

INTRODUCTION DECEASED DONOR ORGAN ALLOCATION EXPANSION AND ENCOURAGEMENT OF LIVING KIDNEY DONATION COMMERCIALIZATION OF ORGANS CONCLUSION

Chapter 42: Evidence in Transplantation

INTRODUCTION SEARCHING THE LITERATURE RANDOMIZED CONTROLLED TRIALS SYSTEMATIC REVIEWS META-ANALYSIS BIOMEDICAL/INDUSTRIAL SPONSORSHIP CONCLUSION

Index

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