Conquering Lyme Disease, Science Bridges the Great Divide by Fallon, Brian -- Read -- Imperial Library of Trantor

Index

Cover Title Page Copyright Dedication Epigraph Contents Acknowledgments Preface Basic Terminology 1. What Is Lyme disease?

Basic Facts A Bird’s Eye View

2. The Early History and Epidemiologic Surveillance

3. What Are the Symptoms and Signs of Lyme Disease?

Early Localized Stage Early Disseminated Stage Late Disseminated Stage Post-Treatment Lyme Disease Syndrome

4. What Do the Diagnostic Tests Tell Us?

Blood Tests Urine-Based Tests Spinal Fluid and Brain Tests Other Tests Summary

5. The Great Divide and the Lyme Wars

What Is the Great Divide? What Are the Lyme Wars? Concluding Comments Regarding the Great Divide and the Lyme Wars

6. Why Would Symptoms Persist After Antibiotic Treatment for Lyme Disease?

Persistent Infection Hypothesis Residual Damage Hypothesis Persistent Immune Activation and Inflammation Hypothesis Neural Network Dysregulation Hypothesis The Relationship Between Immune Activation and Depression The Connection Between the Gut Microbiome and Mood Somatization, Anxiety, and Chronic Symptoms

7. What Are the Treatments for Lyme Disease?

Treatment of Early Lyme Disease Treatment of Later-Stage Disseminated Lyme Disease Treatment Failures and Borrelia Persisters Risks and Benefits of Antibiotics Treatment of Post-Treatment Lyme Disease Syndrome Other Therapeutic Strategies

8. Other Tick-Borne Infections

9. What Other Noninfectious Diseases Cause Lyme-Like symptoms?

Celiac Disease Chronic Fatigue Syndrome Chronic Heavy Metal Poisoning Chronic Inflammatory Demyelinating Polyneuropathy Fibromyalgia Lupus Major Depressive Disorder Malignancy (Cancer) Multiple Sclerosis Panic Disorder Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Postural Orthostatic Tachycardia Syndrome Sleep Disorders Somatic Symptom Disorder Vitamin B12 Deficiency

10. Lyme Disease Prevention and Transmission

The Ticks Prevention Recommendations Transmission Lyme Disease and Pregnancy The Lyme Disease Vaccines New Developments in Prevention

11. Suggestions to the Patient Seeking Evaluation or Treatment

How to Approach the Visit What to Bring to the Appointment Seeking a Second Opinion Tips for Navigating Online Health Information

12. The Experience of the Patient with Chronic Symptoms

13. Frequently Asked Questions

Signs, Symptoms, and Diagnosis Overlap of Lyme Disease with Other Diseases Testing and Treatment for Lyme Disease Ticks Miscellaneous

14. The Good News Emerging from Lyme Disease Research

Generic (Brand) Drug Names Glossary of Terms References Index