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Index
Cover
Front Matter
Part I. Basic Science of Pulmonary Development and Pulmonary Arterial Disease
1. Perspective for Part I
2. The Alveolar Stem Cell Niche of the Mammalian Lung
3. Lung Development and Notch Signaling
4. Specialized Smooth Muscle Cell Progenitors in Pulmonary Hypertension
5. Diverse Pharmacology of Prostacyclin Mimetics: Implications for Pulmonary Hypertension
6. Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension
7. Extracellular Vesicles, MicroRNAs, and Pulmonary Hypertension
8. Roles of Tbx4 in the Lung Mesenchyme for Airway and Vascular Development
9. A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery
10. Roles of Stem Cell Antigen-1 in the Pulmonary Endothelium
11. Morphological Characterization of Pulmonary Microvascular Disease in Bronchopulmonary Dysplasia Caused by Hyperoxia in Newborn Mice
12. Involvement of CXCR4 and Stem Cells in a Rat Model of Pulmonary Arterial Hypertension
13. Ca2+ Signal Through Inositol Trisphosphate Receptors for Cardiovascular Development and Pathophysiology of Pulmonary Arterial Hypertension
Part II. Abnormal Pulmonary Circulation in the Developing Lung and Heart
14. Perspective for Part II
15. Pathophysiology of Pulmonary Circulation in Congenital Heart Disease
16. Development of Novel Therapies for Pulmonary Hypertension by Clinical Application of Basic Research
17. Using Patient-Specific Induced Pluripotent Stem Cells to Understand and Treat Pulmonary Arterial Hypertension
18. Modeling Pulmonary Arterial Hypertension Using Induced Pluripotent Stem Cells
19. Dysfunction and Restoration of Endothelial Cell Communications in Pulmonary Arterial Hypertension: Therapeutic Implications
20. Inflammatory Cytokines in the Pathogenesis of Pulmonary Arterial Hypertension
21. Genotypes and Phenotypes of Chinese Pediatric Patients with Idiopathic and Heritable Pulmonary Arterial Hypertension: Experiences from a Single Center
22. Fundamental Insight into Pulmonary Vascular Disease: Perspectives from Pediatric PAH in Japan
23. Risk Stratification in Paediatric Pulmonary Arterial Hypertension
24. The Adaptive Right Ventricle in Eisenmenger Syndrome: Potential Therapeutic Targets for Pulmonary Hypertension?
25. Impaired Right Coronary Vasodilator Function in Pulmonary Hypertensive Rats Assessed by In Vivo Synchrotron Microangiography
26. Relationship Between Mutations in ENG and ALK1 Genes and the Affected Organs in Hereditary Hemorrhagic Telangiectasia
27. A Genetic Analysis for Patients with Pulmonary Arterial Hypertension
28. Evaluation and Visualization of the Right Ventricle Using Three-Dimensional Echocardiography
29. Pulmonary Hypertension Associated with Postoperative Tetralogy of Fallot
30. Microscopic Lung Airway Abnormality and Pulmonary Vascular Disease Associated with Congenital Systemic-to-Pulmonary Shunt
31. Respiratory Syncytial Virus Infection in Infants with Heart and Lung Diseases
Part III. Ductus Arteriosus: Bridge Over Troubled Vessels
32. Perspective for Part III
33. The Ductus Arteriosus, a Vascular Outsider, in Relation to the Pulmonary Circulation
34. Molecular, Genetic, and Pharmacological Modulation of the Ductus Arteriosus: KATP Channels as Novel Drug Targets
35. New Mediators in the Biology of the Ductus Arteriosus: Lessons from the Chicken Embryo
36. Constriction of the Ductus Arteriosus with KATP Channel Inhibitors
37. New Insights on How to Treat Patent Ductus Arteriosus
38. Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Ductus Arteriosus
39. Prostaglandin E-EP4-Mediated Fibulin-1 Up-regulation Plays a Role in Intimal Thickening of the Ductus Arteriosus
40. Transcriptional Profiles in the Chicken Ductus Arteriosus During Hatching
41. Inhibition of Cyclooxygenase Contracts Chicken Ductus Arteriosus
42. Prostaglandin E2 Receptor EP4 Inhibition Constricts the Rat Ductus Arteriosus
43. Dilatation of the Ductus Arteriosus by Diazoxide in Fetal and Neonatal Rats
44. The Effect of Long-term Administration of Prostaglandin E1 on Morphological Changes in Ductus Arteriosus
45. Significance of SGK1 as a Protein Kinase Transcriptionally Regulated by ALK1 Signaling in Vascular Endothelial Cells
46. Fabrication of Implantable Human Arterial Graft by Periodic Hydrostatic Pressure
47. Optimum Preparation of Candida albicans Cell Wall Extra (CAWE) for the Mouse Model of Kawasaki Disease
Part IV. Development and Regeneration of the Cardiovascular System
48. Perspective for Part IV
49. Advances in the Second Heart Field
50. Novel Cardiac Progenitors for All Components of the Heart Except for the Right Ventricle
51. Regional and TBX5-Dependent Gene Expression in the Atria: Implications for Pulmonary Vein Development and Atrial Fibrillation
52. The Endocardium as a Master Regulator of Ventricular Trabeculation
53. The Role of Alternative mRNA Splicing in Heart Development
54. Progress in the Generation of Multiple Lineage Human-iPSC-Derived 3D-Engineered Cardiac Tissues for Cardiac Repair
55. Quantification of Contractility in Stem Cell-Derived Cardiomyocytes
56. A Neurotrophic Factor Receptor GFRA2, a Specific Surface Antigen for Cardiac Progenitor Cells, Regulates the Process of Myocardial Compaction
57. Cardiac Cell Specification by Defined Factors
58. A Temporo-Spatial Regulation of Sema3c Is Essential for Interaction of Progenitor Cells during Cardiac Outflow Tract Development
59. Spatiotemporally Restricted Developmental Alterations in the Anterior and Secondary Heart Fields Cause Distinct Conotruncal Heart Defects
60. Significance of Transcription Factors in the Mechanisms of Great Artery Malformations
61. The Different c-kit Expression in Human Induced Pluripotent Stem (iPS) Cells Between With Feeder Cells and Without Feeder Cells
62. Establishment of Induced Pluripotent Stem Cells from Immortalized B Cell Lines and Their Differentiation into Cardiomyocytes
63. Establishment of an In Vitro LQT3 model Using Induced Pluripotent Stem Cells from LQT3 Patient-Derived Cardiomyocytes
64. Genetic Assessments for Clinical Courses of Left Ventricle Noncompaction
65. Elucidating the Pathogenesis of Congenital Heart Disease in the Era of Next-Generation Sequencing
Back Matter
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