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Index
Cover page
Halftitle page
Series page
Title page
Copyright page
Contents
Acknowledgements
List of illustrations
List of abbreviations
1 What is the immune system?
The immune system and immunity
Immune systems in different organisms
The human immune system
Specific structures in the immune system
2 First responders: the innate immune response
Sensing danger
Responding to danger
The acute phase response
3 Adaptive immunity: a voyage of (non-)self-discovery
B cells and antibodies
T cells: turning cells inside out
Helpers and killers
Unconventional T cells
Distribution and recirculation
4 Making memories
Priming the immune response
Laying down immunological memory
T cell memory and its distribution
Harnessing B and T cell memories for immune protection
5 Too little immunity: immunological failure
Redundancy, polymorphisms, and knockouts
Inborn errors of the immune system
Malnutrition and immunodeficiency
HIV and Acquired Immunodeficiency Syndrome (AIDS)
6 Too much immunity: auto-immunity and allergic diseases
Tolerance in the thymus
Peripheral tolerance
Tolerance in specific organs: the liver and the placenta
Auto-immunity and inflammation
7 The immune system v2.0: biological and immune therapies
Boosting immunity and vaccines
Harnessing immunity and cancer immunotherapy
Blocking immunity and biological therapies
Inflammation and ageing (‘inflammageing’)
The future of the immune system
Further reading
Index
Social media
Cancer
HIV/AIDS
Epidemiology
Autism
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