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Index
Preface Acknowledgements Author biographies Section I Introduction to Microbiology Infection Immunity and Molecular Diagnostic Methods 1 Microbiology microbial pathogens and infectious disease
Further reading
2 Subdivisions classification and morphological characterization of infectious agents
Microscopical techniques Pathogenic microorganisms Biological classification and nomenclature References Further reading
3 Infection and immunity
Normal flora Comparative aspects of innate and adaptive immunity Recognition of pathogens Cells involved in innate immune responses Complement Adaptive immunity Immunity to bacteria Immunity to fungi Immunity to viruses Concluding comments References Further reading
4 Immunodeficiency diseases
Severe combined immunodeficiency diseases Thymic aplasia or hypoplasia Wiskott-Aldrich syndrome Primary immunodeficiency diseases involving B lymphocytes Secondary immunodeficiency Further reading
5 Vaccines and vaccination
Vaccination Inactivated vaccines Live attenuated vaccines Vaccines produced by recombinant nucleic acid technology Synthetic peptide vaccines DNA vaccines Reverse vaccinology Adjuvants Administration of vaccines Adverse reactions following vaccination Vaccination failure References Further reading
6 Molecular diagnostic methods
Analytical properties of nucleic acid Molecular hybridization DNA sequencing Polymerase chain reaction (PCR) Real-time PCR Diagnostic approaches to surveillance and subtyping of bacteria a comparison of phenotyping and genotyping methods Molecular subtyping for definitive identification of bacteria Plasmid profiling Restriction endonuclease analysis (REA) Ribotyping Pulsed-field gel electrophoresis (PFGE) PCR-based subtyping methods Multilocus sequence typing (MLST) DNA microarray technology Whole bacterial genome sequencing References Further reading
Section II Introductory Bacteriology 7 The structure of bacterial cells
Capsule Cell wall Cytoplasmic membrane Cytoplasm Ribosomes Nuclear material Flagella Pili Biofilms Protein secretion systems Endospores Reference Further reading
8 Cultivation preservation and inactivation of bacteria
Bacterial growth Bacterial nutrition Physical and chemical factors which influence growth Preservation of microorganisms Physical methods for inactivating microorganisms Biosafety cabinets Reference Further reading
9 Bacterial genetics mechanisms of genetic variation and gene databases
Replication of bacterial DNA Transcription and translation the expression of genetic information Mechanisms contributing to genetic variation Examples of mobile genetic elements Genetic engineering of bacteria in the laboratory Genetic databases and bioinformatics Further reading
10 Laboratory diagnosis of bacterial disease
Selection collection and transportation of specimens Identification of pathogenic bacteria Serology Further reading
11 Antibacterial agents
Development of chemotherapy for bacterial infections Mode and site of action Combined antibacterial therapy Factors influencing a ntibacterial activity Further reading
12 Antibacterial resistance
Resistance mechanisms Multiple drug resistance Strategies for limiting a ntibacterial resistance Antibacterial susceptibility testing References Further reading
13 Bacterial colonization tissue invasion and clinical disease
Commensals Pathogens Colonization and growth Pathogen-host interactions Virulence factors Responses of the host to bacterial pathogens The clinical spectrum of bacterial disease References
Section III Pathogenic Bacteria 14 Staphylococcus species
Usual habitat Differentiation of Staphylococcus species Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
15 Streptococci
Usual habitat Differentiation of the streptococci Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
16 Actinobacteria
Actinomyces Arcanobacterium and Actinobaculum species Nocardia species Dermatophilus congolensis Crossiella equi References Further reading
17 Corynebacterium species
Usual habitat Differentiation of the corynebacteria Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
18 Rhodococcus equi
Usual habitat Clinical infections References Further reading
19 Listeria species
Usual habitat Differentiation of Listeria species Pathogenesis and pathogenicity Clinical infections References Further reading
20 Erysipelothrix rhusiopathiae
Usual habitat Definitive identification of Erysipelothrix rhusiopathiae Pathogenesis and pathogenicity Clinical infections References Further reading
21 Bacillus species
Usual habitat Differentiation of Bacillus species Clinical infections Infections with Bacillus licheniformis References Further reading
22 Clostridium species
Usual habitat Specimen collection and cultural requirements Detection and differentiation of clostridia Clinical conditions caused by neurotoxic clostridia Clinical conditions caused by histotoxic clostridia Enteropathogenic and enterotoxaemia-producing clostridia References Further reading
23 Mycobacterium species
Usual habitat Differentiation of pathogenic mycobacteria Clinical infections References Further reading
24 Enterobacteriaceae
Usual habitat Differentiation of the Enterobacteriaceae Escherichia coli Salmonella serotypes Yersinia species Opportunistic pathogens References Further reading
25 Pseudomonas aeruginosa and Burkholderia species
Usual habitat Differentiation of Pseudomonas and Burkholderia species Clinical infections References Further reading
26 Actinobacillus species
Usual habitat Differentiation of Actinobacillus species Pathogenesis and pathogenicity Clinical infections References Further reading
27 Pasteurella species Mannheimia haemolytica and Bibersteinia trehalosi
Usual habitat Differentiation of Pasteurella Bibersteinia and Mannheimia species Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
28 Francisella tularensis
Usual habitat Epidemiology Clinical infections References
29 Histophilus somni Haemophilus parasuis and Avibacterium paragallinarum
Usual habitat Differentiation of Histophilus somni Haemophilus parasuis and Avibacterium paragallinarum Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
30 Taylorella species
Usual habitat Clinical infections References Further reading
31 Bordetella species
Usual habitat Differentiation of Bordetella bronchiseptica and B. avium Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
32 Moraxella species
Moraxella bovis References
33 Brucella species
Usual habitat Differentiation of Brucella species Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
34 Campylobacter and Helicobacter species
Campylobacter species Helicobacter species References Further reading
35 Lawsonia intracellularis
Usual habitat Pathogenesis and pathogenicity Clinical signs Diagnosis Treatment and control References Further reading
36 Spirochaetes
Leptospira species Borrelia species Brachyspira and Treponema species References Further reading
37 Pathogenic anaerobic non-spore-forming Gram-negative bacteria
Usual habitat Diagnostic procedures Differentiation of the non-spore-forming Gram-negative anaerobes Pathogenesis and pathogenicity Clinical infections References Further reading
38 Mycoplasmas
Usual habitat Differentiation of the mycoplasmas Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
39 Chlamydia and Chlamydophila species
Usual habitat Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
40 Rickettsiales and Coxiella burnetii
Epidemiology Pathogenesis and pathogenicity Recognition and differentiation of members of the Rickettsiales Clinical infections References Further reading
41 Bacterial species of limited pathogenic significance
Acinetobacter species Bartonella species Aeromonas species Plesiomonas shigelloides and Vibrio species Chromobacterium violaceum Ornithobacterium rhinotracheale Riemerella anatipestifer Streptobacillus moniliformis References
Section IV Mycology 42 General features of fungi associated with disease in animals
Structure Growth reproduction and colonial formation General features of fungal disease Diagnosis of fungal diseases Differentiation of fungal species Antifungal chemotherapy References Further reading
43 Dermatophytes
Usual habitat Laboratory recognition and differentiation Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
44 Aspergillus species
Usual habitat Recognition of Aspergillus species Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
45 Yeasts and disease production
Candida species Cryptococcus species Malassezia pachydermatis ‘Megabacteria’ (Macrorhabdus ornithogaster) Trichosporon beigelii Geotrichum candidum References Further reading
46 Dimorphic fungi
Blastomyces dermatitidis Histoplasma capsulatum Coccidioides species Sporothrix schenckii References Further reading
47 Zygomycetes of veterinary importance
Mucorales and Mortierellales Entomophthorales References Further reading
48 Fungus-like organisms of veterinary importance
Pythium insidiosum Rhinosporidium seeberi Lacazia loboi References Further reading
49 Pneumocystis carinii
Usual habitat Pathogenesis and pathogenicity Diagnostic procedures Clinical infections References Further reading
50 Opportunistic infections caused predominantly by phaeoid fungi
Usual habitat Clinical infections Diagnosis Treatment References Further reading
51 Mycotoxins and mycotoxicoses
Aflatoxicosis Citrinin toxicosis Cyclopiazonic acid toxicosis Diplodiosis Ergotism Facial eczema Fescue toxicosis Fumonisin toxicoses Mouldy sweet potato toxicity Mycotoxic lupinosis Ochratoxicosis Mycotoxic oestrogenism Patulin toxicosis Slaframine toxicosis Sterigmatocystin toxicosis Tremorgen intoxications Trichothecene toxicoses References Further reading
52 Pathogenic algae and cyanobacteria
Prototheca species Chlorella species The cyanobacteria References Further reading
53 Antifungal chemotherapy
Antifungal drugs Resistance to antifungal drugs References Further reading
Section V Introductory Virology 54 Nature structure and taxonomy of viruses
The origin of viruses Structure of viruses Taxonomy of viruses References Further reading
55 Replication of viruses
Replication of DNA viruses Replication of RNA viruses Protein synthesis Assembly and release of virions References Further reading
56 Genetics and evolution of viruses
Mutation Viral recombination Viral genomic sequence analysis Evolution of viruses References Further reading
57 Propagation of viruses and virus-cell interactions
Propagation of viruses Determination of virus concentration Virus-host cell interactions Further reading
58 Pathogenesis of viral diseases
Routes of infection Dissemination in the host Clinical signs Virus shedding and patterns of infection Further reading
59 Laboratory diagnosis of viral infections
Collection preservation and transportation of samples Detection of virus viral antigens or nucleic acid Diagnostic serology Interpretation of test results Further reading
60 Antiviral chemotherapy
Introduction Development of antiviral drugs Viral infections and strategies for interrupting virus replication Immunomodulators Ion channel blocking compounds Neuraminidase inhibitors Antiviral drugs which inhibit viral genome replication Antiretroviral drugs Resistance to antiviral drugs Future developments References Further reading
Section VI Viruses and Prions 61 Herpesviridae
Clinical infections References Further reading
62 Papillomaviridae
Clinical infections References Further reading
63 Adenoviridae
Clinical infections References Further reading
64 Poxviridae
Clinical infections References Further reading
65 Asfarviridae
Africans wine fever References Further reading
66 Parvoviridae
Clinical infections References Further reading
67 Circoviridae
Clinical infections References Further reading
68 Retroviridae
Clinical infections References Further reading
69 Reoviridae
Clinical infections References Further reading
70 Birnaviridae
Clinical infections Further reading
71 Orthomyxoviridae
Clinical infections References Further reading
72 Paramyxoviridae
Clinical infections References Further reading
73 Rhabdoviridae
Clinical infections References Further reading
74 Bornaviridae
Clinical infections References Further reading
75 Bunyaviridae
Clinical infections References Further reading
76 Picornaviridae
Clinical infections References
77 Caliciviridae
Clinical infections References Further reading
78 Astroviridae
Clinical infections References
79 Coronaviridae
Clinical infections References Further reading
80 Arteriviridae
Clinical infections References Further reading
81 Flaviviridae
Clinical infections References Further reading
82 Togaviridae
Clinical infections References Further reading
83 Prions: unconventional infectious agents
Clinical infections References Further reading
Section VII Microbial Agents and Disease Production 84 Tissue and system preferences of bacterial fungal and viral pathogens and the nature of the diseases caused by these infectious agents
References Further reading
85 Interactions of microbial pathogens with the nervous system
Haematogenous bacterial infections Haematogenous viral infections Infection via peripheral nerves Infections with lentiviruses Viral infections which cause developmental anomalies Transmissible spongiform encephalopathies (TSEs) Algal bacterial and fungal neurotoxicity Algal and fungal infections Further reading
86 Interactions of microbial pathogens with the male and female reproductive systems
Infections of the male reproductive system Infections of the non pregnant uterus Infections of the pregnant uterus Further reading
87 The role of microbial pathogens in intestinal disease
Intestinal structure and function Normal flora Pathogenetic mechanisms in enteritis Further reading
88 The role of microbial pathogens in respiratory disease
Defence mechanisms in the conducting airways Defence mechanisms in the lungs Microbial diseases of the conducting airways Microbial diseases of the lungs References Further reading
89 Interactions of microbial pathogens with the renal system
Ascending infection of the excretory pathway Structure and function of the excretory passages Virulence factors of uropathogens Responses of the host to ascending bacterial infection of the excretory pathway Infectious diseases of the kidneys References
90 Microbial diseases of the cardiovascular system
The heart: structural and functional relationships Infections of the heart Infections of the vascular channels References
91 Interactions of microbial pathogens with the musculoskeletal system
Responses of muscle to microbial pathogens Distinctive structural features of skeletal muscle Responses of muscle to injury Responses of muscle to bacterial infection Responses of bone to microbial pathogens Responses of joints to microbial pathogens Foot infections of cattle sheep and pigs associated with microbial agents References
92 The role of microbial pathogens in diseases of the integumentary system
Structural and functional perspectives Responses of the skin to microorganisms Bacterial diseases of skin Viral diseases of skin Fungal diseases of skin References
93 Bacterial causes of bovine mastitis
Mammary gland defence mechanisms Contagious mastitis Environmental mastitis Diagnosis Treatment Prevention and control References
94 Disinfection biosecurity and other aspects of disease control
Survival of infectious agents in the environment Transmission of infectious agents Biosecurity Animals Feed Water Environment of domestic animals Vehicular and pedestrian traffic Equipment Animal waste Wild mammals and birds Cleaning and disinfection of farm buildings Thermal inactivation of microbial pathogens Disinfection antisepsis and sterilization Characteristics modes of action and selection of chemical disinfectants Chemical inactivation of microbial pathogens Bacteria Fungal pathogens Viruses Prions Chemicals used as disinfectants in veterinary medicine Microbial resistance to disinfection Disinfection procedures References Further reading Appendix: Relevant websites General topics Genomic analysis Bacteriology Mycology Virology Infectious diseases
Index
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