Phytocannabinoids Unraveling the Complex Chemistry and Pharmacology of Cannabis sativa by Gibbons, Simon -- Read -- Imperial Library of Trantor

Index

Preface Contents Phytochemistry of Cannabis sativa L.

1 Introduction 2 Nomenclature

2.1 Botanical Nomenclature 2.2 Common Names 2.3 Definition of Cannabis

3 Cultivation of Cannabis sativa

3.1 Outdoor Cultivation 3.2 Indoor Cultivation

3.2.1 Propagation Through Seeds 3.2.2 Propagation Through Vegetative Cuttings 3.2.3 Micropropagation

3.3 Harvesting, Processing, and Storage of Cannabis sativa Biomass

4 Chemotaxonomy of Cannabis sativa 5 Biosynthesis of Phytocannabinoids 6 Constituents of Cannabis sativa

6.1 Cannabinoids

6.1.1 (-)-Delta9-trans-Tetrahydrocannabinol (Delta9-THC) Type 6.1.2 (-)-Delta8-trans-Tetrahydrocannabinol (Delta8-THC) Type 6.1.3 Cannabigerol (CBG) Type 6.1.4 Cannabichromene (CBC) Type 6.1.5 Cannabidiol (CBD) Type 6.1.6 Cannabinodiol (CBND) Type 6.1.7 Cannabielsoin (CBE) Type 6.1.8 Cannabicyclol (CBL) Type 6.1.9 Cannabinol (CBN) Type 6.1.10 Cannabitriol (CBT) Type 6.1.11 Miscellaneous Types

6.2 Non-Cannabinoid Constituents

7 Analysis of Cannabinoids in Cannabis sativa and Its Preparations References

Synthesis of Phytocannabinoids

1 Introduction 2 Early Approaches 3 Stereospecific Approaches 4 Enantioselective Approaches 5 Conclusion References

Molecular Pharmacology of Phytocannabinoids

1 Introduction 2 Delta9-trans-Tetrahydrocannabinol

2.1 Activity at Cannabinoid Receptors 2.2 Cannabinoid Receptor Independent Activity

3 Delta9-Tetrahydrocannabivarin

3.1 Activity at Cannabinoid Receptors 3.2 Cannabinoid Receptor Independent Activity

4 Cannabinol

4.1 Activity at Cannabinoid Receptors 4.2 Cannabinoid Receptor Independent Activity

5 Cannabidiol

5.1 Activity at Cannabinoid Receptors 5.2 Cannabinoid Receptor Independent Activity

6 Cannabidivarin

6.1 Activity at Cannabinoid Receptors 6.2 Cannabinoid Receptor Independent Activity

7 Cannabigerol

7.1 Activity at Cannabinoid Receptors 7.2 Cannabinoid Receptor Independent Activity

8 Cannabichromene

8.1 Activity at Cannabinoid Receptors 8.2 Cannabinoid Receptor Independent Activity

9 Conclusions References

Molecular Targets of the Phytocannabinoids: A Complex Picture

1 Introduction 2 Pharmacology of Selected Phytocannabinoids

2.1 Abundant Cannabinoid Constituents of Cannabis sativa

2.1.1 Delta9-Tetrahydrocannabinol (Delta9-THC) 2.1.2 Delta8-Tetrahydrocannabinol (Delta8-THC) 2.1.3 Cannabinol (CBN) 2.1.4 Cannabidiol (CBD) 2.1.5 Cannabigerol (CBG) 2.1.6 Cannabichromene (CBC) 2.1.7 Delta9-Tetrahydrocannabivarin (Delta9-THCV) 2.1.8 Cannabivarin (CBV) 2.1.9 Cannabidivarin (CBDV)

2.2 Less Abundant Cannabinoid Constituents of Cannabis sativa

2.2.1 Cannabinodiol (CBND) 2.2.2 Cannabielsoin (CBE) 2.2.3 Cannabicyclol (CBL) 2.2.4 Cannabitriol (CBT)

3 Molecular Targets of Phytocannabinoids

3.1 G-Protein Coupled Receptors 3.2 Beyond GPCRs: PPARs, GlyR, and TRP Channels

3.2.1 Peroxisome Proliferator-Activated Receptors (PPARs) 3.2.2 Glycine Receptors (GlyR) 3.2.3 Transient Receptor Potential Channels

References