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Index
Cover Series Page Title Page Copyright Contributors Preface Chapter 1: Development of the Epidemic
Development of the epidemic (Boxes 1.1 and 1.2) Acknowledgement Further reading
Chapter 2: Immunology of HIV-1 Infection
Introduction Primary infection Antiviral host immune responses HIV-1 evasion of host immunity Immunodeficiency The response to cART Further reading
Chapter 3: Viral Assays Used in the Diagnosis and Management of HIV Infection
The diagnosis of HIV infection The window period Laboratory-based HIV screening tests Western blot and line immunoassay Rapid point-of-care HIV screening tests Serology tests to detect recent HIV-1 infection Virology tests for HIV detection and characterization Viral load HIV proviral DNA testing Antiretroviral drug resistance HIV-1 tropism Further reading
Chapter 4: HIV Testing: Strategies to Prevent Late Diagnosis
Introduction Who to test for HIV Frequency of HIV testing Which test to use Pre-test discussion (Box 4.3) Giving HIV test results Summary Further reading
Chapter 5: Clinical Staging and Natural History of Untreated HIV Infection
Introduction Primary HIV infection (PHI) Asymptomatic infection Symptomatic HIV infection before the development of AIDS Constitutional symptoms HIV and haematological problems Non-AIDS diagnoses for which cART has treatment benefit irrespective of CD4 count Risk of progression and the value of surrogate markers Further reading
Chapter 6: Routine Assessment and Follow-up of the Newly Diagnosed HIV-positive Individual
Introduction Interventions and discussion Follow-up Further reading
Chapter 7: Tumours in HIV
Introduction AIDS-defining malignancies Non-AIDS-defining malignancies Further reading
Chapter 8: The Lung and HIV
Infections Malignant conditions Non-malignant, non-infectious conditions Further reading
Chapter 9: HIV and Tuberculosis Co-infection
Background and epidemiology Presentation and diagnosis of active disease Treatment Immune reconstitution inflammatory syndrome TB control Further reading
Chapter 10: The Gut and HIV
Introduction Dysphagia and odynophagia Nausea and vomiting Diarrhoea Further reading
Chapter 11: Viral Hepatitis and Liver Disease
Introduction Hepatitis B co-infection Hepatitis C co-infection Immune reconstitution Liver disease in an HIV-infected patient Management of end-stage liver disease Conclusions Further reading
Chapter 12: Neurological Manifestations
Introduction Primary HIV seroconversion illness Asymptomatic HIV disease Advanced HIV disease Peripheral nerve disorders in HIV infection Neurological IRIS syndromes Further reading
Chapter 13: The Eye and HIV
Introduction Non-infectious HIV retinopathy Ocular infection associated with HIV Malignancy associated with HIV Drug-induced ocular disease Further reading
Chapter 14: The Skin and HIV
Introduction Seborrhoeic dermatitis Kaposi sarcoma Pruritic papular eruption/eosinophilic folliculitis Nodular prurigo Drug rashes Human papillomavirus (HPV) Molluscum contagiosum Herpes simplex virus Candidiasis Tinea infections Scabies Syphilis Penicillium marneffei, Cryptococcus neoformans, Histoplasma capsulatum Conclusions Further reading
Chapter 15: The Kidney and HIV
Introduction Evaluating renal disease in HIV Acute renal failure HIV-associated nephropathy Immune complex kidney disease Antiretroviral drugs and the kidney Renal monitoring in HIV infection Renal replacement therapy Further reading
Chapter 16: Sexually Transmitted Infections and HIV
HIV as an STI STIs as a cofactor in HIV transmission HIV and STI co-infection Diagnosis and management of STIs Further reading
Chapter 17: Women and HIV
Psycho-social issues Natural history Pregnancy management in the developed world Pregnancy management in the developing world Gynaecological care Further reading
Chapter 18: HIV Infection in Children
Epidemiology Prevention of mother-to-child transmission Management Supportive care Further reading
Chapter 19: Antiretroviral Drugs
Reverse transcriptase inhibitors Protease inhibitors Integrase inhibitors Chemokine receptor antagonists Fusion inhibitors Other treatment modalities Treatment of chronic adult infection When to start therapy (Table 19.2) Choice of therapy Antiretroviral regimens Further reading
Chapter 20: Pharmacopoeia of Treatments
The role of cART after diagnosis of an opportunistic infection Further reading and resources
Chapter 21: Psychological and Mental Health Issues
Psychological wellbeing Psychological sequelae Adjustment to diagnosis Physical health Treatment regimens Changes to body shape HIV-associated neurocognitive disorders Recognition of psychological symptomatology Psychological Interventions Factors impacting on living with HIV Prevention Further reading
Chapter 22: Strategies for Preventing HIV Transmission
Introduction Targeted HIV education Sexual transmission Behavioural Interventions Biomedical and treatment interventions Risk compensation Inclusion of people with HIV High-quality sexual health services HIV testing Conclusion Further reading
Chapter 23: Patient and Community Perspective
Garry Brough Namatovu Lubega Late diagnosis Care and treatment outside of the HIV setting and its implications for HIV patients and their doctors HIV testing for children Social and psychological impact: examples of good practice
Chapter 24: The Role of Patient Engagement
Introduction How can services engage patients? (Box 24.1) What are the advantages for patients and care providers? Care providers Peer support Representation at management meetings Workshops Forums Newly diagnosed courses Social events Conclusions
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