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Index
Title page Table of Contents Copyright Preface List of Contributors Chapter 1: General Principles of Pharmacology
HOW DO DRUGS ACT? THE BLOOD–BRAIN BARRIER AND PLACENTA PLASMA PROTEIN BINDING METABOLISM DRUG EXCRETION PHARMACOKINETIC PRINCIPLES PHARMACOGENETICS METHODS OF DRUG ADMINISTRATION DRUG INTERACTIONS VOLATILE ANAESTHETIC AGENTS
Chapter 2: Inhalational Anaesthetic Agents
PROPERTIES OF THE IDEAL INHALATIONAL ANAESTHETIC AGENT AGENTS IN COMMON CLINICAL USE AGENTS IN OCCASIONAL USE ANAESTHETIC GASES
Chapter 3: Intravenous Anaesthetic Agents
BARBITURATES NON-BARBITURATE INTRAVENOUS ANAESTHETIC AGENTS INTRAVENOUS MAINTENANCE OF ANAESTHESIA
Chapter 4: Local Anaesthetic Agents
MECHANISM OF ACTION OF LOCAL ANAESTHETICS THE VOLTAGE-ACTIVATED Na+ CHANNEL PAIN FIBRES LOCAL ANAESTHETIC STRUCTURE PHARMACOLOGICAL PROPERTIES OF LOCAL ANAESTHETICS DIFFERENTIAL SENSORY AND MOTOR BLOCKADE PHARMACOKINETICS CLINICAL PREPARATION OF LOCAL ANAESTHETICS ENANTIOMER PHARMACOLOGY INDIVIDUAL LOCAL ANAESTHETIC PHARMACOLOGY LOCAL ANAESTHETIC TOXICITY MANAGEMENT OF SEVERE LOCAL ANAESTHETIC TOXICITY EMERGING LOCAL ANAESTHETIC APPROACHES
Chapter 5: Analgesic Drugs
OPIOIDS PARACETAMOL NON-STEROIDAL ANTI-INFLAMMATORY DRUGS COX-2-SPECIFIC INHIBITORS KETAMINE
Chapter 6: Muscle Function and Neuromuscular Blockade
PHYSIOLOGY OF NEUROMUSCULAR TRANSMISSION PHARMACOLOGY OF NEUROMUSCULAR TRANSMISSION REVERSAL AGENTS NEUROMUSCULAR MONITORING
Chapter 7: Sedative and Anxiolytic Drugs
INDICATIONS FOR THE USE OF SEDATIVE DRUGS BENZODIAZEPINES NEUROLEPTICS α2-ADRENOCEPTOR AGONISTS OTHER DRUGS
Chapter 8: Drugs Acting on the Cardiovascular System
THE AUTONOMIC NERVOUS SYSTEM DRUGS ACTING ON THE SYMPATHETIC NERVOUS SYSTEM DRUGS ACTING ON THE PARASYMPATHETIC NERVOUS SYSTEM VASODILATORS CALCIUM CHANNEL BLOCKERS DRUGS ACTING VIA THE RENIN–ANGIOTENSIN–ALDOSTERONE SYSTEM ANTIARRHYTHMIC DRUGS
Chapter 9: Drugs Acting on the Respiratory System
DRUGS AFFECTING AIRWAY CALIBRE DRUGS ACTING ON THE PULMONARY VASCULATURE DRUGS MODERATING VENTILATORY CONTROL OXYGEN THERAPY DRUGS AFFECTING MUCOCILIARY FUNCTION
Chapter 10: Drugs Used in Renal Disease
DRUG CONSIDERATIONS IN PATIENTS WITH RENAL DYSFUNCTION VASOACTIVE DRUGS USED IN RENAL DYSFUNCTION DIURETICS ACUTE RENAL FAILURE, SEPSIS AND THE INTENSIVE CARE UNIT ACUTE KIDNEY INJURY AFTER CARDIAC OR MAJOR VASCULAR SURGERY DRUGS AND RENAL TRANSPLANTATION
Chapter 11: Metabolism, the Stress Response to Surgery and Perioperative Thermoregulation
METABOLISM CARBOHYDRATE METABOLISM PROTEIN METABOLISM LIPID METABOLISM THE STRESS RESPONSE TO SURGERY THERMOREGULATION AND ANAESTHESIA
Chapter 12: Fluid, Electrolyte and Acid–Base Balance
BASIC DEFINITIONS COMPARTMENTAL DISTRIBUTION OF TOTAL BODY WATER SOLUTE COMPOSITION OF BODY FLUID COMPARTMENTS WATER HOMEOSTASIS PRACTICAL FLUID BALANCE SODIUM AND POTASSIUM ACID–BASE BALANCE
Chapter 13: Haematological Disorders and Blood Transfusion
THE PHYSIOLOGY OF BLOOD HAEMATOLOGICAL DISORDERS AND THEIR IMPACT ON ANAESTHESIA INTERVENTIONAL PROCEDURES AND REGIONAL ANAESTHESIA IN COAGULOPATHIC PATIENTS THROMBOSIS AND ACUTE ISCHAEMIC EVENTS PATIENTS WITH HAEMATOLOGICAL MALIGNANCY BLOOD PRODUCTS AND BLOOD TRANSFUSION MAJOR HAEMORRHAGE
Chapter 14: Basic Physics for the Anaesthetist
BASIC DEFINITIONS FLUIDS GAS REGULATORS THE VENTURI, THE INJECTOR AND BERNOULLI HEAT VAPORIZATION AND VAPORIZERS HUMIDITY AND HUMIDIFICATION SOLUBILITY OF GASES ELECTRICITY ISOTOPES AND RADIATION MAGNETIC RESONANCE IMAGING ULTRASOUND LASERS OPTICAL FIBRES FIRES AND EXPLOSIONS
Chapter 15: Anaesthetic Apparatus
GAS SUPPLIES CYLINDERS THE ANAESTHETIC MACHINE SAFETY FEATURES OF MODERN ANAESTHETIC MACHINES BREATHING SYSTEMS VENTILATORS SCAVENGING RESERVOIR BAGS LARYNGOSCOPES TRACHEAL TUBES PROTECTING THE BREATHING SYSTEM IN ANAESTHESIA SUPRAGLOTTIC AIRWAY DEVICES (SADs) OTHER APPARATUS DECONTAMINATION OF ANAESTHETIC EQUIPMENT
Chapter 16: Clinical Measurement and Monitoring
PROCESS OF CLINICAL MEASUREMENT BIOLOGICAL ELECTRICAL SIGNALS BIOLOGICAL MECHANICAL SIGNALS THE CARDIOVASCULAR SYSTEM THE RESPIRATORY SYSTEM GAS AND VAPOUR ANALYSIS BLOOD GAS ANALYSIS THE NERVOUS SYSTEM TEMPERATURE BLOOD LOSS AND TRANSFUSION MONITORING STANDARDS ALARMS GENERAL GUIDELINES FOR MONITORING DURING ANAESTHESIA ANAESTHETIC RECORD-KEEPING
Chapter 17: Preoperative Assessment and Premedication
THE PROCESS OF PREOPERATIVE ASSESSMENT PREDICTION OF PERIOPERATIVE MORBIDITY OR MORTALITY POSSUM PREOPERATIVE PREPARATION PREMEDICATION AND OTHER PROPHYLACTIC MEASURES
Chapter 18: Intercurrent Disease and Anaesthesia
CARDIOVASCULAR DISEASE RESPIRATORY DISEASE ASTHMA GASTROINTESTINAL DISEASE LIVER DISEASE RENAL DISEASE DIABETES MELLITUS OTHER ENDOCRINE DISORDERS NEUROLOGICAL DISEASE PSYCHIATRIC DISEASE CONNECTIVE TISSUE DISORDERS NUTRITIONAL PROBLEMS ANAESTHETIC CONSIDERATIONS IN THE ELDERLY ANAESTHETIC CONSIDERATIONS HUMAN IMMUNODEFICIENCY VIRUS MYELOMA PORPHYRIA
Chapter 19: Consent and Information for Patients
TYPES OF CONSENT CONSENT AS AN ACTIVE PROCESS SUMMARY
Chapter 20: The Operating Theatre Environment
THE OPERATING THEATRE SUITE
Chapter 21: The Practical Conduct of Anaesthesia
PREPARATION FOR ANAESTHESIA INDUCTION OF ANAESTHESIA POSITION OF PATIENT FOR SURGERY MAINTENANCE OF ANAESTHESIA OTHER TECHNIQUES CONDUCT OF EXTUBATION EMERGENCE AND RECOVERY
Chapter 22: Management of the Difficult Airway
BEFORE MANAGING THE DIFFICULT AIRWAY MANAGEMENT OF THE DIFFICULT AIRWAY DIFFICULT AIRWAYS AND THEIR MANAGEMENT MANAGEMENT OF UNPREDICTED DIFFICULT INTUBATION EMERGENCY SURGICAL AIRWAY TECHNIQUES MANAGEMENT OF THE PREDICTED DIFFICULT AIRWAY MANAGEMENT OF THE OBSTRUCTED AIRWAY SPECIFIC TECHNIQUES EXTUBATION AND RECOVERY THE DIFFICULT AIRWAY IN OTHER LOCATIONS MANAGEMENT OF THE DIFFICULT AIRWAY IN CHILDREN AFTER DIFFICULT AIRWAY MANAGEMENT
Chapter 23: Management of the High-Risk Surgical Patient
WHAT MAKES AN OPERATION HIGH-RISK? IDENTIFYING THE HIGH-RISK SURGICAL PATIENT RISK PREDICTION SCORING SYSTEMS Revised Cardiac Risk Index POSTOPERATIVE PULMONARY COMPLICATION RISK PREDICTORS LABORATORY INVESTIGATIONS FOR RISK ASSESSMENT REDUCING RISK BEFORE SURGERY ALTERNATIVES TO MAJOR SURGERY PREOPERATIVE INTERVENTIONS TO REDUCE RISK IDENTIFYING PATIENTS IN NEED OF POSTOPERATIVE CRITICAL CARE PERIOPERATIVE MANAGEMENT OF THE HIGH-RISK PATIENT POSTOPERATIVE MANAGEMENT INOTROPIC SUPPORT FOR THE HIGH-RISK SURGICAL PATIENT
Chapter 24: Local Anaesthetic Techniques
FEATURES OF LOCAL ANAESTHESIA COMPLICATIONS OF LOCAL ANAESTHESIA GENERAL MANAGEMENT INTRAVENOUS REGIONAL ANAESTHESIA CENTRAL NERVE BLOCKS PERIPHERAL BLOCKS SPECIAL SITUATIONS
Chapter 25: Anaesthesia for the Bariatric Patient
INTRODUCTION MEASURING OBESITY OBESITY PATHOPHYSIOLOGY, COMORBIDITY AND THE METABOLIC SYNDROME COMORBIDITY AND ANAESTHETIC MANAGEMENT CLINICAL RESPIRATORY COMORBIDITY ANAESTHETIC MANAGEMENT POINTS CARDIOVASCULAR PATHOPHYSIOLOGY VASCULAR DISEASE LIVER PHARMACOLOGY BARIATRIC OPERATIONS POSTOPERATIVE CARE OF THE OBESITY SURGERY PATIENT
Chapter 26: Day-Case Anaesthesia
PATIENT SELECTION ORGANIZATION OF THE DAY-CASE UNIT ANAESTHESIA POSTOPERATIVE CARE
Chapter 27: Anaesthesia for Gynaecological and Genitourinary Surgery
GENERAL CONSIDERATIONS TRANSURETHRAL RESECTION (TUR) SYNDROME REGIONAL ANAESTHESIA PERIOPERATIVE INFECTIONS OTHER CONSIDERATIONS ANAESTHETIC IMPLICATIONS OF SPECIFIC SURGICAL TECHNIQUES
Chapter 28: Anaesthesia for Orthopaedic Surgery
THE PATIENT POPULATION TECHNIQUES OF ANAESTHESIA POSTOPERATIVE ANALGESIA SURGICAL CONSIDERATIONS SPECIFIC SURGICAL PROCEDURES
Chapter 29: Anaesthesia for ENT, Maxillofacial and Dental Surgery
ENT SURGERY ORAL AND MAXILLOFACIAL SURGERY ANAESTHESIA FOR HEAD & NECK CANCER SURGERY DENTAL ANAESTHESIA
Chapter 30: Ophthalmic Anaesthesia
PHYSIOLOGY OF THE EYE OCULAR BLOOD FLOW OCULOCARDIAC REFLEX CONDITIONS FOR INTRAOCULAR SURGERY CHOICE OF ANAESTHESIA NOMENCLATURE OF BLOCKS OPHTHALMIC REGIONAL BLOCKS OPHTHALMIC DRUGS RELEVANT TO THE ANAESTHETIST ANAESTHESIA FOR SPECIFIC OPHTHALMIC PROCEDURES REQUIRING GENERAL ANAESTHESIA CONCLUSION
Chapter 31: Anaesthesia for Vascular, Endocrine and Plastic Surgery
MAJOR VASCULAR SURGERY SURGERY FOR TUMOURS OF THE ENDOCRINE SYSTEM PLASTIC SURGERY BURNS
Chapter 32: Neurosurgical Anaesthesia
APPLIED ANATOMY AND PHYSIOLOGY GENERAL PRINCIPLES OF NEUROSURGICAL ANAESTHESIA POSTOPERATIVE CARE ANAESTHESIA FOR ELECTIVE INTRACRANIAL SURGERY ANAESTHESIA FOR SURGERY OF THE SPINE AND SPINAL CORD ANAESTHESIA FOR EMERGENCY INTRACRANIAL SURGERY MANAGEMENT OF THE HEAD-INJURED PATIENT INTENSIVE CARE MANAGEMENT OF HEAD-INJURED PATIENTS ANAESTHESIA FOR CT AND MRI SCANNING
Chapter 33: Anaesthesia for Thoracic Surgery
PREOPERATIVE ASSESSMENT ANATOMY INDUCTION AND MAINTENANCE OF ANAESTHESIA ANAESTHESIA FOR THORACIC SURGERY PROCEDURES POSTOPERATIVE CARE OUTCOME
Chapter 34: Anaesthesia for Cardiac Surgery
TRENDS IN SURGICAL PRACTICE PREOPERATIVE ASSESSMENT RISK ASSESSMENT MONITORING PATHOPHYSIOLOGY ANAESTHETIC TECHNIQUE HAEMODYNAMICS AFTER CPB POSTOPERATIVE CARE
Chapter 35: Obstetric Anaesthesia and Analgesia
ANATOMY AND PHYSIOLOGY OF PREGNANCY PHARMACOLOGY OF RELEVANT DRUGS BASIC OBSTETRICS FEEDING AND ANTACID PROPHYLAXIS IN LABOUR PAIN AND PAIN RELIEF IN LABOUR EPIDURAL AND SUBARACHNOID ANALGESIA REGIONAL ANAESTHESIA FOR THE PARTURIENT GENERAL ANAESTHESIA FOR THE PARTURIENT ASSESSMENT OF THE PREGNANT WOMAN PRESENTING FOR ANAESTHESIA AND ANALGESIA EMERGENCIES IN OBSTETRIC ANAESTHESIA ANAESTHESIA FOR INTERVENTIONS OTHER THAN DELIVERY OR EXTRACTION OF RETAINED PRODUCTS OF CONCEPTION ACKNOWLEDGEMENT
Chapter 36: Paediatric Anaesthesia
PHYSIOLOGY IN THE NEONATE PHARMACOLOGY IN THE NEONATE ANAESTHETIC MANAGEMENT SPECIFIC OPERATIONS IN THE NEONATE
Chapter 37: Emergency Anaesthesia
PREOPERATIVE ASSESSMENT THE FULL STOMACH TECHNIQUES OF ANAESTHESIA THE ANAESTHETIST AND MAJOR TRAUMA ACKNOWLEDGEMENT
Chapter 38: Anaesthesia Outside the Operating Theatre
ANAESTHESIA IN REMOTE HOSPITAL LOCATIONS ANAESTHESIA IN THE PRE-HOSPITAL ENVIRONMENT
Chapter 39: Anaesthesia for the Patient with a Transplanted Organ
INTRODUCTION GENERAL CONSIDERATIONS ANAESTHETIC CONSIDERATIONS SPECIFIC ISSUES SUMMARY
Chapter 40: Postoperative Care
THE EARLY RECOVERY PERIOD CENTRAL NERVOUS SYSTEM RESPIRATORY SYSTEM CARDIOVASCULAR SYSTEM OTHER MAJOR POSTOPERATIVE COMPLICATIONS OTHER COMPLICATIONS (TABLE 40.10)
Chapter 41: Postoperative Pain
PHYSIOLOGY EFFECTS OF NOXIOUS SURGICAL STIMULATION INPATIENT PAIN TEAMS CAUSES OF VARIATION IN ANALGESIC REQUIREMENTS MEASUREMENT OF PAIN TREATMENT OF POSTOPERATIVE PAIN METHODS OF TREATING POSTOPERATIVE PAIN REGIONAL ANAESTHESIA AND PAIN MANAGEMENT PRE-EMPTIVE ANALGESIA BALANCED (MULTIMODAL) ANALGESIA NEUROPATHIC PAIN IN THE POSTOPERATIVE PERIOD
Chapter 42: Postoperative Nausea and Vomiting
DEFINITIONS MECHANISMS OF NAUSEA AND VOMITING ADVERSE EFFECTS IDENTIFYING PATIENTS AT RISK MANAGEMENT PHARMACOLOGY
Chapter 43: Complications During Anaesthesia
CAUSES OF COMPLICATIONS
Chapter 44: Quality and Safety in Anaesthesia
QUALITY CULTURE OF QUALITY AND SAFETY MEASURING SAFETY AND QUALITY DESIGNING PROBLEMS OUT OF THE SYSTEM SUMMARY
Chapter 45: The Intensive Care Unit
STAFFING AN INTENSIVE CARE UNIT OUTREACH/FOLLOW-UP ADMISSION TO THE INTENSIVE CARE UNIT MONITORING IN ICU INSTITUTION OF INTENSIVE CARE OTHER ASPECTS OF INTENSIVE CARE ETHICAL ISSUES IN ICU OUTCOME AFTER INTENSIVE CARE DEATH IN THE ICU ORGAN DONATION DISCHARGE FROM INTENSIVE CARE FUTURE DEVELOPMENTS
Chapter 46: Management of Chronic Pain
DEFINITIONS OF PAIN AND RELATED TERMS THE PARADIGM OF PAIN EPIDEMIOLOGY OF CHRONIC PAIN CLASSIFICATION OF PAIN MANAGEMENT OF CHRONIC PAIN EVIDENCE-BASED PRACTICE COSTS OF PAIN MANAGEMENT SERVICES
Chapter 47: Resuscitation
INTRODUCTION SCIENCE AND GUIDELINES EPIDEMIOLOGY PREVENTION CARDIOPULMONARY RESUSCITATION ADVANCED LIFE SUPPORT PERI-ARREST ARRHYTHMIAS POST-RESUSCITATION CARE DECISIONS RELATING TO CARDIOPULMONARY RESUSCITATION NATIONAL CARDIAC ARREST AUDIT ACKNOWLEDGEMENT
Appendix A: Training and Assessment in Anaesthesia Appendix B: Data, Statistics and Clinical Trials Appendix C: Clinical Data Index
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