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Index
Cover
Table of Contents
Dedication
Title page
Copyright page
List of Contributors
Preface
SECTION 1: Malignant Hematology and Hematopoietic Cell Transplantation
PART 1: Acute Lymphoblastic Leukemia in Adults
CHAPTER 1: Diagnosis of Acute Lymphoblastic Leukemia
Case Study Answers
Selected Readings
CHAPTER 2: Prognostic Markers and Models in Acute Lymphoblastic Leukemia
Pretherapeutic Prognostic Markers
Response Parameters
Stratification into Risk Groups
Selected Reading
CHAPTER 3: Management of B-Cell Acute Lymphoblastic Leukemia
Selected Reading
CHAPTER 4: Management of T-Cell Acute Lymphoblastic Leukemia
Selected Reading
CHAPTER 5: Minimal Residual Disease in Acute Lymphoblastic Leukemia
Case Study Answers
Selected Reading
CHAPTER 6: Hematopoietic Cell Transplantation in Adult Acute Lymphoblastic Leukemia
Multiple Choice and Discussion Questions
Mutiple Choice Answer
Case Study Answer
Selected Reading
PART 2: Acute Myeloid Leukemia in Adults
CHAPTER 7: Prognosis in Acute Myeloid Leukemia: Cytogenetics and Beyond
Case Study Answers
Selected Reading
CHAPTER 8: Induction Therapy in Acute Myeloid Leukemia
Case Study Answers
Selected Reading
CHAPTER 9: Consolidation Therapy in Acute Myeloid Leukemia
Selected Reading
CHAPTER 10: Management of Acute Promyelocytic Leukemia
Selected Reading
CHAPTER 11: Minimal Residual Disease in Acute Myeloid Leukemia
Selected Reading
CHAPTER 12: Relapsed and Refractory Acute Myeloid Leukemia
Multiple Choice Questions
Case Study Answers
Mutiple Choise Answers
Selected Reading
CHAPTER 13: Hematopoietic Cell Transplantation in Acute Myeloid Leukemia
Multiple choice question
Case Study Answers
Mutiple choice answer
Selected reading
PART 3: Myelodysplastic Syndromes and Related Disorders
CHAPTER 14: Pitfalls in the Diagnosis of Myelodysplastic Syndromes
Case Study Answers
Selected Reading
CHAPTER 15: Cytogenetics and Prognostic Models in Myelodysplastic Syndromes
MDS Cytogenetics and Prognosis
Conclusion
Selected Reading
CHAPTER 16: Management of Myelodysplastic Syndromes
Selected Reading
CHAPTER 17: Management of Therapy-Related Myeloid Neoplasms
Introduction
Multiple Choice Questions
Multiple Choice Answers
Note
Selected Reading
CHAPTER 18: Hematopoietic Cell Transplantation in Myelodysplastic Syndromes
Notes
Selected Reading
CHAPTER 19: Acquired Aplastic Anemia
Case Study Answers
Selected Reading
PART 4: Myeloproliferative Neoplasms
CHAPTER 20: Diagnostic Approach in Myeloproliferative Neoplasms
Introduction
Selected Reading
CHAPTER 21: Chronic Myeloid Leukemia: Chronic Phase
Introduction
Multiple Choice and Discussion Questions
Multiple Choice Answer
Selected Reading
Selected Websites
CHAPTER 22: Blast Crisis of Chronic Myeloid Leukemia
Selected Reading
CHAPTER 23: Chronic Myeloid Leukemia and Pregnancy
Selected Reading
CHAPTER 24: Polycythemia Vera
Selected Reading
CHAPTER 25: Essential Thrombocytosis
Note
Case Study Answers
Selected Reading
CHAPTER 26: Primary Myelofibrosis
Introduction
Selected Reading
CHAPTER 27: Eosinophilic Myeloproliferative Disorders
Case Study Answers
Selected Reading
CHAPTER 28: Chronic Myelomonocytic Leukemia
Selected Reading
CHAPTER 29: Hematopoietic Cell Transplantation in Chronic Myeloid Leukemia
Case Study Answers
Selected Reading
CHAPTER 30: Hematopoietic Cell Transplantation in Primary Myelofibrosis
Conclusion
Selected Reading
PART 5: Chronic Lymphocytic and Other Leukemias
CHAPTER 31: Prognostic Markers and Management of Chronic Lymphocytic Leukemia
Multiple Choice Questions
Multiple Choice Answers
Selected reading
CHAPTER 32: Hematopoietic Cell Transplantation in Chronic Lymphocytic Leukemia
Selected Reading
CHAPTER 33: Prolymphocytic Leukemia
Summary
Case Study Answers
Selected Reading
CHAPTER 34: Hairy Cell Leukemia
Multiple Choice and Discussion Questions
Selected Reading
Case Study Answers
Multiple Choice Answer
PART 6: Hodgkin Lymphoma
CHAPTER 35: Management of Classical Hodgkin Lymphoma
Case Study Answers
Selected Reading
CHAPTER 36: Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Multiple Choice Questions
Multiple Choice Answers
Seleced Reading
CHAPTER 37: Hematopoietic Cell Transplantation in Hodgkin Lymphoma
Selected Reading
PART 7: Non-Hodgkin's Lymphomas
CHAPTER 38: Pitfalls in the Diagnosis of Non-Hodgkin's Lymphomas
Case Study Answers
Selected Reading
CHAPTER 39: Follicular Lymphoma
Case Study Answers
Selected Reading
CHAPTER 40: Diffuse Large B-Cell Lymphoma
Introduction
Multiple Choice and Discussion Questions
Conclusion
Multiple Choice Answers
Selected Reading
CHAPTER 41: Mantle Cell Lymphoma
Case Study Answers
Selected Reading
CHAPTER 42: Marginal Zone Lymphoma
Treatment Controversies
Selected Reading
CHAPTER 43: Primary Mediastinal Large B-Cell Lymphoma
Clinical Features
Primary Management
Selected reading
CHAPTER 44: Burkitt Lymphoma
Selected Reading
CHAPTER 45: Gray Zone Lymphoma
Selected Reading
CHAPTER 46: Transformed Lymphoma
Multiple Choice Question
Multiple Choice Question
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 47: HIV-Associated Lymphoma
Selected Reading
CHAPTER 48: Primary CNS Lymphoma
Case Study Answers
Selected Reading
CHAPTER 49: Primary Cutaneous Lymphoma
Introduction
Topical Approaches
Ultraviolet B Phototherapy and Ultraviolet A Photochemotherapy
Total Skin Electron Beam Therapy
Treatment of Advanced-Stage Disease
Extracorporeal Photochemotherapy
Recombinant Interferon
Bexarotene
Denileukin Difitox
Histone Deacetylase (HDAC) Inhibitors
Purine Nucleoside Analogs
Pegylated Liposomal Doxorubicin
Pralatrexate
Monoclonal Antibodies
Combined-Modality Systemic Chemotherapy
High-Dose Chemotherapy and Hematopoietic Stem Cell Transplantation
Treatment Summary
Survivorship Issues in Cutaneous T-Cell Lymphoma
Conclusion
Suggested Reading
CHAPTER 50: Mycosis Fungoides and Sézary Syndrome
Selected Reading
CHAPTER 51: Hematopoietic Cell Transplantation in Indolent Non-Hodgkin's Lymphoma
Selected Reading
CHAPTER 52: Hematopoietic Cell Transplantation in Diffuse Large B-cell Lymphoma
Case Study Answers
Selected Reading
CHAPTER 53: Hematopoietic Cell Transplantation in T-Cell Non-Hodgkin's Lymphomas
Introduction
Summary
Selected Reading
PART 8: Plasma Cell Neoplasms and Related Disorders
CHAPTER 54: Smoldering Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance
Mutiple Choice and Discussion Questions
Smoldering (Asymptomatic) Multiple Myeloma (SMM)
Mutiple Choice Answers
Selected Reading
CHAPTER 55: Risk Stratification and Response Assessment in Multiple Myeloma and Waldenström's Macroglobulinemia
Case Study Answers
Selected Reading
CHAPTER 56: Treatment of Multiple Myeloma
Prognostic Markers
Mutiple Choice Questions
Front-Line Therapy in Symptomatic Multiple Myeloma
Treatment Strategies
Case Study Answers
Mutiple Choice Ansewrs
Selected Reading
CHAPTER 57: Light-Chain Amyloidosis
Case Study Answers
Selected Reading
CHAPTER 58: Waldenström's Macroglobulinemia
Mutiple Choice and Discussion Questions
Cryoglobulinemia and Related Autoimmune Disorders in WM
Risk of Amyloid Light-Chain (AL) Amyloidosis
IgM-Related Neurologic Manifestations
Survivorship Issues in W4M
Mutiple Choice Answer
Case Study Answers
Selected Reading
CHAPTER 59: Autologous Hematopoietic Cell Transplantation in Multiple Myeloma
Selected Reading
CHAPTER 60: Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma
Introduction
The Evolution of the Allogeneic Approach in MM
Randomized Trials
Lenalidomide
Bortezomib
Measuring the Efficacy of Allo-HCT and Defining Deeper Remissions After Allo-HCT
The Future of Allo-HCT for MM
Selected Reading
PART 9: Special Issues in Hematology
CHAPTER 61: Role of PET Scan in Lymphomas
Mutiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 62: Radioimmunotherapy in Lymphomas
Multiple Choice Questions
Mutiple Choice Answers
Selected Reading
CHAPTER 63: Radiation Oncology Consultation for Hematologic Malignancies
Selected Reading
PART 10: Special Issues in Hematopoietic Cell Transplantation
CHAPTER 64: Donor and Graft Selection in Allogeneic Hematopoietic Cell Transplantation
Introduction
Case Study Answers
Selected Reading
CHAPTER 65: Preparative Regimens in Allogeneic Hematopoietic Cell Transplantation for Malignant Hematological Diseases
Multiple Choice Questions
Multiple Choice Answers
Selected Reading
CHAPTER 66: T-Cell Depletion in Allogeneic Hematopoietic Cell Transplantation
Introduction
Conclusions
Selected Reading
CHAPTER 67: Prevention and Treatment of Relapse Following Hematopoietic Cell Transplantation
Introduction
Selected Reading
CHAPTER 68: Acute Graft-Versus-Host Disease
Case Study Answers
Selected Reading
CHAPTER 69: Chronic Graft-Versus-Host Disease
Case Study Answers
Selected Reading
SECTION 2: Oncology
PART 1: Central Nervous System Tumors
CHAPTER 70: Primary Brain Tumors
Epidemiology, Tumor Classification, and Prognostic and Predictive Markers
Treatment Questions
Selected Reading
CHAPTER 71: Secondary Brain and Spinal Cord Tumors
Case Study Answers
Selected Reading
PART 2: Head and Neck Cancers and Thoracic Malignancies
CHAPTER 72: Medical Management of Head and Neck Cancers
Case Study Answers
Selected Reading
CHAPTER 73: Endocrine Malignancies
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 74: Methodological and Practical Challenges for Personalized Therapies in Non-Small-Cell Lung Cancer
Introduction
Conclusion
Selected Reading
CHAPTER 75: Screening, Staging, and Stage I Non-Small-Cell Lung Cancer
Randomized Controlled Trials
False-Positive Results
Radiation Exposure
Conclusion
Case Study Answers
Selected Reading
CHAPTER 76: Stage II and III Non-Small-Cell Lung Cancer
Case Study Answer
Selected Reading
CHAPTER 77: Recurrent and Metastatic Non-Small-Cell Lung Cancer and Novel Targets
Case Study Answers
Suggested Reading
CHAPTER 78: Small-Cell Lung Cancer
Multiple Choice Questions
Multiple Choice Answers
Case Study Answers
Selected Reading
CHAPTER 79: Mesothelioma
Selected Reading
PART 3: Breast Cancer
CHAPTER 80: Immunohistochemistry Testing and Beyond in Breast Cancer
Conclusion
Selected Reading
CHAPTER 81: Prevention and Adjuvant Therapy in Breast Cancer
Selected Reading
CHAPTER 82: Preoperative Systemic Therapy for Breast Cancer
Selected Reading
CHAPTER 83: Recurrent and Metastatic Breast Cancer
Case Study Answers
Suggested Reading
CHAPTER 84: Special Issues in the Young and Pregnant Patient with Breast Cancer
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
PART 4: Gastrointestinal Oncology
CHAPTER 85: Early-Stage Esophageal and Stomach Cancers
CHAPTER 86: Metastatic Esophagogastric Cancer: Controversies, Consensus, and New Targets
Selected Reading
CHAPTER 87: Early-Stage Colorectal Cancer
Multiple Choice and Discussion Questions
Multiple Choice Answers
Selected Reading
CHAPTER 88: Recurrent and Metastatic Colorectal Cancer: Controversies, Consensus, and New Targets
Case Study Answers
Selected Reading
CHAPTER 89: Pancreatic Cancer
Case Study Answers
Selected Reading
CHAPTER 90: Hepatobiliary Cancer
Selected Reading
CHAPTER 91: Neuroendocrine Tumors
Case Study Answers
Selected Reading
CHAPTER 92: Transarterial Liver-Directed Therapies in Oncology
Selected Reading
CHAPTER 93: Anal Cancer
Introduction
Macroscopic Disease
Microscopic Disease
Conclusion
Selected Reading
PART 5: Genitourinary Oncology
CHAPTER 94: Renal Cancer: Tumor Diversity, Molecular Taxonomy, and Prognostic Algorithms
Case Study Answers
Selected Reading
CHAPTER 95: Medical Management of Renal Cancer
Case Study Answers
Selected Reading
CHAPTER 96: Medical Management of Bladder Cancer
Case Study Answers
Selected Reading
CHAPTER 97: Prostate Cancer: Screening, Surveillance, Prognostic Algorithms and Independent Pathologic Predictive Parameters
Case Study Answers
Selected Reading
CHAPTER 98: Medical Management of Prostate Cancer
Multiple Choice and Discussion Questions
Multiple Choice Answers
Selected Reading
CHAPTER 99: Germ Cell Tumors
Multiple Choice and Discussion Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
PART 6: Skin Malignancies
CHAPTER 100: Medical Management of Melanoma
Introduction
Systemic Therapy of Melanoma in the Adjuvant Setting and for Metastatic Disease
Case Study Answers
Selected Reading
CHAPTER 101: Nonmelanoma Skin Cancers
Case Study Answers
Selected Reading
PART 7: Gynecological Malignancies
CHAPTER 102: Ovarian Cancer: Neoadjuvant, Adjuvant, and Surgical Issues
Case Study Answers
Selected Reading
CHAPTER 103: Ovarian Cancer: Second-Line Treatment Strategies
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 104: Endometrial and Cervical Cancers
Cervical Cancer
Multiple Choice Questions
Endometrial Cancer
Case Study Answers
Multiple Choice Answers
Selected Reading
PART 8: Sarcomas
CHAPTER 105: Bone Sarcomas
Case Study Answers
Selected Reading
CHAPTER 106: Soft Tissue Sarcomas
Case Study Answers
Selected Reading
PART 9: Multidisciplinary Approach: Consultation with Surgical Oncology Team
CHAPTER 107: Surgical Aspects of Head and Neck Cancers
Case Study Answers
Selected Reading
CHAPTER 108: Surgical Aspects of Thoracic Malignancies
Case Study Answers
CHAPTER 109: Surgical Aspects of Upper Gastrointestinal Cancers
Selected Reading
CHAPTER 110: Surgical Aspects of Pancreatic Cancer
Selected Reading
CHAPTER 111: Surgical Aspects of Hepatobiliary Tumors
Multiple Choice and Discussion Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 112: Surgical Aspects of Lower Gastrointestinal Cancers
Case Study Answers
Suggested Reading
CHAPTER 113: Surgical Aspects of Renal Cancer
Selected Reading
CHAPTER 114: Surgical Aspects of Bladder Cancer
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 115: Surgical Aspects of Prostate Cancer
Case Study Answers
Selected Reading
CHAPTER 116: Surgical Aspects of Melanoma
Introduction
Histologic Subtypes of Melanoma
Melanoma Staging
Primary Management
Surgical Intervention
Sentinel Lymph Node Biopsy
Case Study Answers
Selected Reading
PART 10: Multidisciplinary Approach: Consultation with Radiation Oncology Team
CHAPTER 117: Radiotherapy for Head and Neck Cancers
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 118: Radiotherapy for Ductal Carcinoma in Situ (DCIS)
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 119: Radiotherapy for Early-Stage Invasive Breast Cancer
Selected Reading
CHAPTER 120: Radiotherapy for Thoracic Malignancies
Selected Reading
CHAPTER 121: Radiotherapy for Gastrointestinal Malignancies
Case Study Answers
Selected Reading
CHAPTER 122: Radiotherapy for Genitourinary Malignancies
Bladder Cancer
Testicular Cancer
Renal Cell Carcinoma
Selected Reading
PART 11: Hereditary Cancer Syndromes and Genetic Testing in Oncology
CHAPTER 123: When to Suspect Hereditary Cancer Syndromes
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 124: Hereditary Breast Cancer Syndromes
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 125: Genetic Testing in Gastrointestinal Tumors
Case Study Answers
Selected Reading
CHAPTER 126: Hereditary Urogenital Cancer Syndromes
Case Study Answers
Selected Reading
PART 12: Special Issues in Hematology and Oncology
CHAPTER 127: Carcinoma of Unknown Primary (CUP)
Multiple Choice Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 128: Geriatric Oncology
Selected Reading
CHAPTER 129: Nuts and Bolts of Cancer Immunotherapy
Note
Case Study Answers
Selected Reading
CHAPTER 130: Controversies Related to Oncology Clinical Trial Development
Selected Reading
CHAPTER 131: PET Scan in Oncology
Selected Reading
CHAPTER 132: Hematopoietic Growth Factors
Selected Reading
CHAPTER 133: Anticoagulation Issues in Oncology
Case Study Answers
Selected Readings
CHAPTER 134: Symptom Management and Palliative Care
Case Study Answers
Selected Reading
CHAPTER 135: Metabolic and Nutritional Issues in Oncology
Introduction
Multiple Choice Question
Multiple Choice Answer
Case Study Answers
Selected Reading
CHAPTER 136: Bone-Related Issues in Oncology
Introduction
Note
Selected Reading
CHAPTER 137: Integrative Medicine in Oncology
Multiple Choice and Discussion Questions
Case Study Answers
Multiple Choice Answers
Selected Reading
CHAPTER 138: Naturopathic Medicine in Oncology
Case Study Answers
Selected Reading
CHAPTER 139: Anesthesiology Consultation for Localized Cancer Pain
Case Study Answers
Selected Reading
CHAPTER 140: Musculoskeletal Care in Oncology
Selected Readings
CHAPTER 141: Cancer Survivorship and Psychosocial Issues in Oncology
Case Study Answers
Selected Readings
Supplemental Images
Index
End User License Agreement
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