Targeting a Cure for Type 1 Diabetes by Rotenstein, Lisa S. -- Read -- Imperial Library of Trantor

Index

Cover Title Page Copyright Page Table of Contents Foreword Preface How To Use This Book Introduction

Cures Treatments Summary

Chapter 1: The Basics

1.1 Where Are We Today? 1.2 Glucose and Insulin 1.3 The Course of Type 1 Diabetes 1.4 Targeting a Cure 1.5 Cure-Targeted Therapies

Immune Therapeutics Islet and Pancreas Transplantation Beta Cell Regeneration and Survival The Artificial Pancreas

1.6 The Drug Development Process

Preclinical Studies Human Studies Submission and Approval

1.7 Where To Learn More

Chapter 2: Immune Therapeutics

2.1 Background 2.2 The Immune System and Type 1 Diabetes 2.3 Diabetes Vaccines

Glutamic Acid Decarboxylase (GAD65) Immunization Insulin Immunization

2.4 Other ‘Immune Modulating’ Strategies

Anti-CD3 Therapies Anti-CD20 Therapies Abatacept IL-1 Therapies

2.5 The Interface of Vaccines and Immune Modulation

DiaPep277 BCG Administration

2.6 Mesenchymal Stem Cells 2.7 Overall Potential 2.8 Where To Learn More

Chapter 3: Islet and Pancreas Transplantation

3.1 Current Techniques 3.2 Immune Suppression in Transplantation 3.3 The Intended Population for Islet Transplantation 3.4 New Sources of Islets

Creating Beta Cells From Stem Cells Pig Islet Transplants

3.5 The Bioartificial Pancreas

Encapsulation Scaffolding Improving Blood Supply Additional Strategies

3.6 Overall Potential 3.7 Where To Learn More

Chapter 4: Beta Cell Regeneration and Survival Agents

4.1 Background 4.2 Beta Cell Regeneration and Survival Factors 4.3 Current Trials 4.4 Where To Learn More

Chapter 5: The Artificial Pancreas

5.1 Background 5.2 Current State of Closed Loop Components

Insulin Pumps Continuous Glucose Monitors Control Algorithms

5.3 The Path Ahead

Better and More Accurate CGM Technology Faster Insulin A Cautious Regulatory Environment Increasing Use of Other Hormones Important Upcoming Trials

5.4 Overall Potential 5.5 Where To Learn More

Conclusion: From Kelly Close Acknowledgments Appendices

Glossary References Footnotes