Bipolar Disorder by Maj, Mario, Yatham, Lakshmi N. -- Read -- Imperial Library of Trantor

Index

Cover Title Copyright Preface List of Contributors CHAPTER 1: From Mania to Bipolar Disorder

From Pinel to Kraepelin Manic-depressive illness The reception of manic-depressive illness – the academic response The reception of manic-depressive illness: a typical asylum The emergence of bipolar disorder References

CHAPTER 2: Clinical Features and Subtypes of Bipolar Disorder

Introduction: the phenomenology of cyclicity and polarity Clinical features of affective episodes Mania Depression Mixed states of bipolar disorder Diagnostic subgroups of bipolar disorder Cyclothymia Conclusion References

CHAPTER 3: The Long-Term Course and Clinical Management of Bipolar I and Bipolar II Disorders

Introduction Methods of the NIMH CDS Characteristics of the long-term course of bipolar illness Conclusions about the long-term course of bipolar illness Implications for the long-term clinical management of BP-I and BP-II disorders References

CHAPTER 4: Comorbidity in Bipolar Disorder: A Focus on Addiction and Anxiety Disorders

Introduction Alcohol abuse and dependence Comorbid alcoholism and bipolar course of illness Treatment implications for dual diagnosis bipolar disorder and alcoholism Nicotine dependence Bipolar disorder course of illness and nicotine dependence Treatment considerations in bipolar disorder with nicotine dependence Anxiety disorders Epidemiological and clinical data Comorbid ADs and clinical presentation of bipolar disorder Treatment implications of anxious comorbidity Conclusion References

CHAPTER 5: DSM-V Perspectives on Classification of Bipolar Disorder

An overall view of the DSM-V process Ongoing work on bipolar disorder for DSM-V Criteria for recommending a change in DSM-IV Bipolar disorder Bipolar spectrum Mixed episodes Rapid cycling bipolar disorder Bipolar depression Schizoaffective disorder Paediatric bipolar disorder Behavioural dimensions References

CHAPTER 6: Update on the Epidemiology of Bipolar Disorder

Introduction Background on epidemiology Epidemiology of bipolar disorder in adults Epidemiology of bipolar disorder in youth Age of onset and treatment rates in both adults and youth with bipolar disorder Risk factors Family history/genetics Summary References

CHAPTER 7: Suicide and Bipolar Disorder

Introduction Suicide and attempted suicide in major mood disorders Suicide risk and protective factors in bipolar disorders References

CHAPTER 8: Neurocognition in Bipolar Disorder

Introduction Brief overview of neuropsychological assessment Nature of cognitive impairment in bipolar disorder Cognitive deficits associated with mood symptoms Cognitive deficits in euthymic patients Cognitive deficits in subsets of patients Effects of medication Neuroimaging bipolar disorder cognition Aetiology of cognitive impairment Genetic vulnerability Progressive cognitive decline Clinical significance of cognitive impairments Cognition and functional outcome Neuropsychological assessment in bipolar disorder Treatment strategies for cognitive deficits Conclusions References

CHAPTER 9: The Genius-Insanity Debate: Focus on Bipolarity, Temperament, Creativity and Leadership

History Methodologic issues Is psychosis relevant to creative genius? Affective temperaments and achievement Toward a synthesis Implications for clinical practice References

CHAPTER 10: Economics of Bipolar Disorder

Introduction Economic cost of bipolar disorder Economic evaluations of interventions for bipolar disorder Conclusions References

CHAPTER 11: An Introduction to the Neurobiology of Bipolar Illness Onset, Recurrence and Progression

Introduction Clinical evidence for bipolar illness progression Potential neurobiological mechanisms for illness progression Overview of the neurobiology of bipolar disorder Clinical implications for illness progression Neurobiology informing clinical therapeutics An evolving neurobiology of bipolar disorder References

CHAPTER 12: Genetics of Bipolar Disorder

Introduction Genetic epidemiology of bipolar disorders Linkage studies of bipolar disorders Candidate gene studies of bipolar disorder Genome-wide association studies Conclusions and future directions References

CHAPTER 13: Structural Brain Imaging in Bipolar Disorder

Prefrontal cortex Ventricles Limbic structures Subcortical structures Corpus callosum Cerebellum and vermis Conclusions Acknowledgements References

CHAPTER 14: Functional Magnetic Resonance Imaging, Diffusion Tensor Imaging, and Magnetic Resonance Spectroscopy in Bipolar Disorder

Introduction Magnetic resonance spectroscopy in bipolar disorder Diffusion tensor imaging in bipolar disorder Functional magnetic resonance imaging in bipolar disorder Acknowledgements References

CHAPTER 15: Functional Brain Imaging Studies in Bipolar Disorder: Focus on Cerebral Metabolism and Blood Flow

Introduction Overall organization Cerebral blood flow and metabolism across affective states Conclusions References

CHAPTER 16: Neurotransmitter Systems in Bipolar Disorder

The role of monoamines and acetylcholine in the pathophysiology of bipolar disorder Amino acids and the pathophysiology of bipolar disorder Neuroendocrine systems and neuropeptides Conclusions References

CHAPTER 17: Molecular Biology of Bipolar Disorder

Introduction Signal transduction pathways References

CHAPTER 18: Mitochondrial Dysfunction and Oxidative Stress

Introduction Cellular vulnerability in bipolar disorder Phosphorous magnetic resonance spectroscopy in bipolar disorder Role of mitochondrial DNA deletion in bipolar disorder Gene expression analysis Genetics Animal models Consequence of mitochondrial dysfunction Calcium signalling Progressive cell loss Oxidative stress and mitochondrial dysfunction: a vicious cycle propelled by dopaminergic hyperactivity? Oxidative stress markers in bipolar disorder Treatment studies Effects of known treatment on oxidative systems Glutathione precursors Conclusion References

CHAPTER 19: Neuroendocrinology of Bipolar Illness

HPA regulation Basal HPA activity in bipolar disorder Dexamethasone suppression test (DST) Dexamethasone/CRH test DEX/vasopressin test CRH receptor studies Corticoid receptors Thyroid hormones Thyroid status in patients with affective disorders Rapid cycling bipolar disorder Conclusions and future directions References

CHAPTER 20: Circadian Rhythms and Sleep in Bipolar Disorder

Introduction and overview Circadian rhythms and sleep Sleep, circadian function and affect Sleep, circadian function and mood symptoms in BD Mechanisms underpinning biological rhythm involvement in BD Psychosocial interventions targeting biological rhythms in BD Summary and conclusions References

CHAPTER 21: Treatment Adherence in Bipolar Disorder

Introduction Adherence Therapeutic relationships Developing a shared understanding and agreeing treatment goals Three questions to aid effective prescribing Monitoring and enhancing adherence Future directions – using a necessities-concerns framework References

CHAPTER 22: Acute Mania

Introduction Lithium Valproic acid Carbamazepine First-generation (typical) antipsychotics Second-generation (atypical) antipsychotics Electroconvulsive therapy New potential antimanic agents Agents without demonstrated antimanic efficacy Clinical recommendations Summary References

CHAPTER 23: Pharmacological Treatment of Bipolar Depression

Introduction Treatments for the management of bipolar I depression Pharmacological treatment of bipolar II depression Conclusions Financial disclosures References

CHAPTER 24: Practical Pharmacological Maintenance Treatment of Bipolar Disorder

Introduction Goals of long-term treatment Adherence to and participation in treatment Nature of evidence: relationship to the goals of treatment Transition to maintenance treatment Maintenance treatment: evidence from controlled trials Treatments for severe illness without evidence from randomized clinical trials Treatment targets other than affective episodes Using major treatments Summary: practical maintenance pharmacological treatment References

CHAPTER 25: Rapid Cycling Bipolar Disorder: Phenomenology and Treatment

Controversies regarding the definition of rapid cycling Phenomenology Antidepressants and rapid cycling Treatment of rapid cycling Lithium and divalproex Carbamazepine Lamotrigine Thyroid hormone Calcium channel blockers Second-generation antipsychotics Is there a role for antidepressants? Electroconvulsive therapy Other novel treatments Chronobiological treatments Psychotherapy Summary and conclusions References

CHAPTER 26: Management of Bipolar II Disorder

Introduction An overall management model Medication Education Psychological interventions Well-being plans Summary Acknowledgement References

CHAPTER 27: Management of Comorbidity in Bipolar Disorder

Introduction Faces of comorbidity in bipolar disorder Management issues Diagnostic considerations The role of systematic screening General treatment considerations Treatment phases Pharmacotherapy Issues related to specific medications Conclusion References

CHAPTER 28: Bipolar Disorder and Safety Monitoring for Clinicians: A Review of the Evidence and the Implications

Introduction Metabolism and bipolar disorder Monitoring requirements for bipolar patients Topical debates for years to come Can safety monitoring for CVD risk factors improve? Can wellness programmes in bipolar illness decrease CVD risk? Implications for future monitoring and clinical research Summary Declaration of interest Disclosure References

CHAPTER 29: Somatic Treatments for Bipolar Disorder: ECT, VNS and TMS

Introduction to the technologies Electroconvulsive therapy (ECT) Vagus nerve stimulation (VNS) Transcranial magnetic stimulation (TMS) Overall conclusions about brain stimulation methods for BD Acknowledgement Conflicts References

CHAPTER 30: Novel Therapeutic Strategies for Bipolar Disorder

Introduction Intracellular pathways and targets worthy of further study in BPD Conclusion Acknowledgements References

CHAPTER 31: Psychoeducation as a Core Element of Psychological Approaches for Bipolar Disorders

Psychoeducation in bipolar disorders: state of the art What is psychoeducation? Growth of evidence-based psychoeducational approaches Ingredients of psychoeducation Practical considerations when implementing a psychoeducation group Conclusions References

CHAPTER 32: Cognitive-Behavioural Therapy for Bipolar Disorder

Overview of key CBT manuals for bipolar disorder Theoretical underpinnings for a model of CBT for bipolar disorder Review of CBT trials Summary of CBT trials with ‘treatmentas-usual’ controls References

CHAPTER 33: Interpersonal and Social Rhythm Therapy for Bipolar Disorder

Introduction Overview of interpersonal and social rhythm therapy Treatment strategies IPSRT for adolescents Research findings Conclusion Acknowledgement References

CHAPTER 34: Family Therapy Approaches to Bipolar Disorder

Introduction Theoretical background Family-focused treatment Communication enhancement training Problem solving Multifamily group approaches Cognitive-behavioural family models Conclusions Directions for future research References

CHAPTER 35: Collaborative Care for Bipolar Disorder

Integrated care for bipolar disorder: current evidence Bridging the divide: treatment models to integrate patient care A collaborative care model for bipolar disorder Conclusion References

CHAPTER 36: Bipolar Disorder in Women

Introduction The reproductive life cycle in women with bipolar disorder The postpartum in women with bipolar disorder Menopause and menopausal transition Conclusions References

CHAPTER 37: Phenomenology and Treatment of Bipolar I Disorder in Children: A Critical Review

Introduction The ‘bipolar controversy’ Clinical phenomenology Comorbidities Course Offspring studies Assessment Treatment Conclusion References

CHAPTER 38: Bipolar Disorder in the Elderly

Introduction Epidemiology Clinical presentation Course of illness Comorbidity Cognitive function Treatment effects Adherence to treatment Attitudes and beliefs/satisfaction with treatment Clinical recommendations Conclusions and areas for future research References

Index Color plate

← Prev
Back
Next →

← Prev
Back
Next →