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Index
Cover
Frontmatter
1. Physiology of HDL
Structure of HDL: Particle Subclasses and Molecular Components
HDL Biogenesis, Remodeling, and Catabolism
Regulation of HDL Genes: Transcriptional, Posttranscriptional, and Posttranslational
Cholesterol Efflux and Reverse Cholesterol Transport
Functionality of HDL: Antioxidation and Detoxifying Effects
Signal Transduction by HDL: Agonists, Receptors, and Signaling Cascades
2. Pathology of HDL
Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers
Beyond the Genetics of HDL: Why Is HDL Cholesterol Inversely Related to Cardiovascular Disease?
Mouse Models of Disturbed HDL Metabolism
Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers
3. Possible Indications and Target Mechanisms of HDL Therapy
HDL and Atherothrombotic Vascular Disease
HDLs, Diabetes, and Metabolic Syndrome
High-Density Lipoprotein: Structural and Functional Changes Under Uremic Conditions and the Therapeutic Consequences
Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions
HDL in Infectious Diseases and Sepsis
High-Density Lipoproteins in Stroke
Therapeutic Potential of HDL in Cardioprotection and Tissue Repair
4. Treatments for Dyslipidemias and Dysfunction of HDL
HDL and Lifestyle Interventions
Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function
Emerging Small Molecule Drugs
ApoA-I Mimetics
Antisense Oligonucleotides, microRNAs, and Antibodies
Backmatter
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