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Index
List of Figures
Preface
1 Genetic Variation
1.1 DNA variation in Drosophila
1.2 Loci and alleles
1.3 Genotype and allele frequencies
1.4 The Hardy-Weinberg law
1.5 Answers to problems
2 Genetic Drift
2.1 A first look at genetic drift
2.2 The decay of heterozygosity
2.3 Mutation and drift
2.4 Molecular evolution
2.5 The neutral theory
2.6 The coalescent
2.7 The effective size of a population
2.8 Another model of genetic drift
2.9 The stationary distribution
2.10 Is genetic drift important in evolution?
2.11 Answers to problems
3 Natural Selection
3.1 The fundamental model
3.2 Relative fitness
3.3 Three kinds of selection
3.4 Mutation-selection balance
3.5 Genetic load
3.6 The heterozygous effects of alleles
3.7 Changing environments
3.8 The stationary distribution
3.9 Selection and drift
3.10 Molecular evolution
3.11 Answers to problems
4 Two-Locus Dynamics
4.1 Linkage disequilibrium
4.2 Two-locus selection
4.3 Genetic draft
4.4 Answers to problems
5 Nonrandom Mating
5.1 Generalized Hardy-Weinberg
5.2 Identity by descent
5.3 Inbreeding
5.4 The evolution of selfing
5.5 Subdivision
5.6 Answers to problems
6 Quantitative Genetics
6.1 Correlation between relatives
6.2 Response to selection
6.3 Evolutionary quantitative genetics
6.4 Dominance
6.5 The intensity of selection
6.6 Answers to problems
7 The Evolutionary Advantage of Sex
7.1 Genetic segregation
7.2 Crossing-over
7.3 Muller’s ratchet
7.4 Kondrashov’s hatchet
7.5 Answers to problems
Appendix A Mathematical Necessities
Appendix B Probability
Bibliography
Index
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