FITZPATRICK'S COLOR ATLAS AND SYNOPSIS OF CLINICAL DERMATOLOGY · 7th EDITION by Wolff, Klaus -- Read -- Imperial Library of Trantor

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FITZPATRICK’S COLOR ATLAS AND SYNOPSIS OF CLINICAL DERMATOLOGY, SEVENTH EDITION Copyright Page Dedication Contents Preface Acknowledgment Introduction

Approach to Dermatologic Diagnosis Outline of Dermatologic Diagnosis Special Clinical and Laboratory Aids to Dermatologic Diagnosis

PART I DISORDERS PRESENTING IN THE SKIN AND MUCOUS MEMBRANES SECTION 1 DISORDERS OF SEBACEOUS AND APOCRINE GLANDS

Acne Vulgaris (Common Acne) and Cystic Acne Rosacea Perioral Dermatitis Hidradenitis Suppurativa Fox Fordyce Disease

SECTION 2 ECZEMA/DERMATITIS

Contact Dermatitis Irritant Contact Dermatitis (ICD) Acute Irritant Contact Dermatitis Chronic Irritant Contact Dermatitis Special Forms of ICD Allergic Contact Dermatitis Special Forms of ACD Allergic Contact Dermatitis Due to Plants Systemic ACD Airborne ACD Atopic Dermatitis Suggested Algorithm of AD Management Lichen Simplex Chronicus (LSC) Prurigo Nodularis (PN) Dyshidrotic Eczematous Dermatitis Nummular Eczema Autosensitization Dermatitis Seborrheic Dermatitis Asteatotic Dermatitis

SECTION 3 PSORIASIS AND PSORIASIFORM DERMATOSES

Psoriasis Psoriasis Vulgaris Pustular Psoriasis Palmoplantar Pustulosis Generalized Acute Pustular Psoriasis (Von Zumbusch) Psoriatic Erythroderma Psoriatic Arthritis Management of Psoriasis Pityriasis Rubra Pilaris (PRP) Pityriasis Rosea Parapsoriasis en Plaques (PP) Pityriasis Lichenoides (Acute and Chronic) (PL)

SECTION 4 ICHTHYOSES

Dominant Ichthyosis Vulgaris (DIV) X-Linked Ichthyosis (XLI) Lamellar Ichthyosis (LI) Epidermolytic Hyperkertosis (EH) Ichthyosis in the Newborn Collodion Baby Harlequin Fetus Syndromic Ichthyoses Acquired Ichthyoses Inherited Keratodermas of Palms and Soles

SECTION 5 MISCELLANEOUS EPIDERMAL DISORDERS

Acanthosis Nigricans (AN) Darier Disease (DD) Grover Disease (GD) Hailey–Hailey Disease (Familial Benign Pemphigus) Disseminated Superficial Actinic Porokeratosis (DSAP)

SECTION 6 GENETIC AND ACQUIRED BULLOUS DISEASES

Hereditary Epidermolysis Bullosa (EB) Pemphigus Bullous Pemphigoid (BP) Cicatricial Pemphigoid Pemphigoid Gestationis (PG) Dermatitis Herpetiformis (DH) Linear IgA Dermatosis (LAD) Epidermolysis Bullosa Acquisita (EBA)

SECTION 7 NEUTROPHIL-MEDIATED DISEASES

Pyoderma Gangrenosum (PG) Sweet Syndrome (SS) Granuloma Faciale (GF) Erythema Nodosum (EN) Syndrome Other Panniculitides

SECTION 8 SEVERE AND LIFE-THREATENING SKIN ERUPTIONS IN THE ACUTELY ILL PATIENT

Exfoliative Erythroderma Syndrome (EES) Rashes in the Acutely III Febrile Patient Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

SECTION 9 BENIGN NEOPLASMS AND HYPERPLASIAS

Disorders of Melanocytes Acquired Nevomelanocytic Nevi (NMN) Halo Nevomelanocytic Nevus Blue Nevus Nevus Spilus Spitz Nevus Mongolian Spot Nevus of Ota Vascular Tumors and Malformations Vascular Tumors Hemangioma of Infancy (HI) Pyogenic Granuloma Glomus Tumor Angiosarcoma Vascular Malformations Capillary Malformations Port-Wine Stain Spider Angioma Venous Lake Cherry Angioma Angiokeratoma Lymphatic Malformation “Lymphangioma” Capillary/Venous Malformations (CVMs) Miscellaneous Cysts and Pseudocysts Epidermoid Cyst Trichilemmal Cyst Epidermal Inclusion Cyst Milium Digital Myxoid Cyst Miscellaneous Benign Neoplasms and Hyperplasias Seborrheic Keratosis Becker Nevus (BN) Trichoepithelioma Syringoma Sebaceous Hyperplasia Nevus Sebaceous Epidermal Nevus Benign Dermal and Subcutaneous Neoplasms and Hyperplasias Lipoma Dermatofibroma Hypertrophic Scars and Keloids Infantile Digital Fibromatosis Skin Tag

SECTION 10 PHOTOSENSITIVITY, PHOTO-INDUCED DISORDERS, AND DISORDERS BY IONIZING RADIATION

Skin Reactions to Sunlight Acute Sun Damage (Sunburn) Drug-/Chemical-Induced Photosensitivity Phototoxic Drug-/Chemical-Induced Photosensitivity Systemic Phototoxic Dermatitis Topical Phototoxic Dematitis Phytophotodermatitis (PPD) Photoallergic Drug/Chemical-Induced Photosensitivity Polymorphous Light Eruption (PMLE) Solar Urticaria Photo-Exacerbated Dermatoses Metabolic Photosensitivity—the Porphyrias Porphyria Cutanea Tarda Variegate Porphyria Erythropoietic Protoporphyria Chronic Photodamage Dermatoheliosis (“Photoaging”) Solar Lentigo Chondrodermatitis Nodularis Helicis Actinic Keratosis Skin Reactions to Ionizing Radiation Radiation Dermatitis

SECTION 11 PRECANCEROUS LESIONS AND CUTANEOUS CARCINOMAS

Epidermal Precancers and Cancers Cutaneous Horn Arsenical Keratoses Squamous Cell Carcinoma In Situ Invasive Squamous Cell Carcinoma Keratoacanthoma Basal Cell Carcinoma (BCC) Basal Cell Nevus Syndrome (BCNS) Malignant Appendage Tumors Merkel Cell Carcinoma Dermatofibrosarcoma Protuberans (DFSP) Atypical Fibrosarcoma (AFX)

SECTION 12 MELANOMA PRECURSORS AND PRIMARY CUTANEOUS MELANOMA

Precursors of Cutaneous Melanoma Dysplastic Melanocytic Nevus Congenital Nevomelanocytic Nevus (CNMN) Cutaneous Melanoma Melanoma in Situ (MIS) Lentigo Maligna Melanoma (LMM) Superficial Spreading Melanoma Nodular Melanoma Desmoplastic Melanoma (DM) Acral Lentiginous Melanoma Amelanotic Melanoma Malignant Melanoma of the Mucosa Metastatic Melanoma Staging of Melanoma Prognosis of Melanoma Management of Melanoma

SECTION 13 PIGMENTARY DISORDERS

Vitiligo Oculocutaneous Albinism Melasma Pigmentary Changes Following Inflammation of the Skin Hyperpigmentation Hypopigmentation PART II DERMATOLOGY AND INTERNAL MEDICINE

SECTION 14 THE SKIN IN IMMUNE, AUTOIMMUNE, AND RHEUMATIC DISORDERS

Systemic Amyloidosis Systemic AL Amyloidosis Systemic AA Amyloidosis Localized Cutaneous Amyloidosis Urticaria and Angioedema Erythema Multiforme (EM) Syndrome Cryopyrinopathies (CAPS) Lichen Planus (LP) Behçet Disease Dermatomyositis Lupus Erythematosus (LE) Systemic Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus (SCLE) Chronic Cutaneous Lupus Erythematosus (CCLE) Chronic Lupus Panniculitis Livedo Reticularis Raynaud Phenomenon Scleroderma Scleroderma-Like Conditions Morphea Lichen Sclerosus et Atrophicus (LSA) Vasculitis Hypersensitivity Vasculitis Henoch–Schönlein Purpura Polyarteritis Nodosa Wegener Granulomatosis Giant Cell Arteritis Urticarial Vasculitis Nodular Vasculitis Pigmented Purpuric Dermatoses (PPD) Kawasaki Disease Reactive Arthritis (Reiter Syndrome) Sarcoidosis Granuloma Annulare (GA)

SECTION 15 ENDOCRINE, METABOLIC AND NUTRITIONAL DISEASES

Skin Diseases in Pregnancy Cholestasis of Pregnancy (CP) Pemphigoid Gestationis Polymorphic Eruption of Pregnancy (PEP) Prurigo of Pregnancy and Atopic Eruption of Pregnancy (AEP) Pustular Psoriasis in Pregnancy Skin Manifestations of Obesity Skin Diseases Associated with Diabetes Mellitus Diabetic Bullae “Diabetic Foot” and Diabetic Neuropathy Diabetic Dermopathy Necrobiosis Lipoidica Cushing Syndrome and Hypercorticism Graves Disease and Hyperthyroidism Hypothyroidism and Myxedema Addison Disease Metabolic and Nutritional Conditions Xanthomas Xanthelasma Xanthoma Tendineum Xanthoma Tuberosum Eruptive Xanthoma Xanthoma Striatum Palmare Normolipemic Plane Xanthoma Scurvy Acquired Zinc Deficiency and Acrodermatitis Enteropathica Pellagra Gout

SECTION 16 GENETIC DISEASES

Pseudoxanthoma Elasticum Tuberous Sclerosis (TS) Neurofibromatosis (NF) Hereditary Hemorrhagic Telangiectasia

SECTION 17 SKIN SIGNS OF VASCULAR INSUFFICIENCY

Atherosclerosis, Arterial Insuffficiency, and Atheroembolization Thromboangiitis Obliterans (TO) Thrombophlebitis and Deep Venous Thrombosis Chronic Venous Insufficiency Most Common Leg/Foot Ulcers Livedoid Vasculitis (LV) Chronic Lymphatic Insufficiency Pressure ulcers

SECTION 18 SKIN SIGNS OF RENAL INSUFFICIENCY

Classification of Skin Changes Calciphylaxis Nephrogenic Fibrosing Dermopathy (NFD) Acquired Perforating Dermatosis

SECTION 19 SKIN SIGNS OF SYSTEMIC CANCERS

Mucocutaneous Signs of Systemic Cancers Classification of Skin Signs of Systemic Cancer Metastatic Cancer to the Skin Mammary Paget Disease Extramammary Paget Disease Cowden Syndrome (Multiple Hamartoma Syndrome) Peutz–Jeghers Syndrome Glucagonoma Syndrome Malignant Acanthosis Nigricans Paraneoplastic Pemphigus (PNP)

SECTION 20 SKIN SIGNS OF HEMATOLOGIC DISEASE

Thrombocytopenic Purpura Disseminated Intravascular Coagulation Cryoglobulinemia Leukemia Cutis Langerhans Cell Histiocytosis Mastocytosis Syndromes

SECTION 21 CUTANEOUS LYMPHOMAS AND SARCOMA

Adult T Cell Leukemia/Lymphoma Cutaneous T Cell Lymphoma Mycosis Fungoides (MF) Mycosis Fungoides Variants Sézary Syndrome Lymphomatoid Papulosis Cutaneous Anaplastic Large Cell Lymphomas (CALCLs) Cutaneous B Cell Lymphoma Kaposi Sarcoma (KS)

SECTION 22 SKIN DISEASES IN ORGAN AND BONE MARROW TRANSPLANTATION

Most Common Infections Associated with Organ Transplantation Skin Cancers Associated with Organ Transplantation Graft-Versus-host Disease Acute Cutaneous GVHR Chronic Cutaneous GVHR

SECTION 23 ADVERSE CUTANEOUS DRUG REACTIONS

Adverse Cutaneous Drug Reactions Exanthematous Drug Reactions Pustular Eruptions Drug-Induced Acute Urticaria, Angioedema, Edema, and Anaphylaxis Fixed Drug Eruption Drug Hypersensitivity Syndrome Drug-Induced Pigmentation Pseudoporphyria ACDR-Related Necrosis ACDR-Related to Chemotherapy

SECTION 24 DISORDERS OF PSYCHIATRIC ETIOLOGY

Body Dysmorphic Syndrome (BDS) Delusions of Parasitosis Neurotic Excoriations and Trichotillomania Factitious Syndromes (Münchhausen Syndrome) Cutaneous Signs of Injecting Drug Use PART III DISEASES DUE TO MICROBIAL AGENTS

SECTION 25 BACTERIAL COLONIZATIONS AND INFECTIONS OF SKIN AND SOFT TISSUES

Erythrasma Pitted Keratolysis Trichomycosis Intertrigo Impetigo Abscess, Furuncle, Carbuncle Soft-Tissue Infection Cellulitis Necrotizing Soft-Tissue Infections Lymphangitis Wound Infection Disorders Caused by Toxin-Producing Bacteria Staphylococcal Scalded-Skin Syndrome Toxic Shock Syndrome Scarlet Fever Cutaneous Anthrax Cutaneous Diphtheria Tetanus Cutaneous Nocardia Infections Rickettsial Disorders Tick Spotted Fevers Rocky Mountain Spotted Fever Rickettsialpox Infective Endocarditis Sepsis Meningococcal Infection Bartonella Infections Cat-Scratch Disease (CSD) Bacillary Angiomatosis Tularemia Cutaneous Pseudomonas Aeruginosa Infections Mycobacterial Infections Hansen Disease (Leprosy) Cutaneous Tuberculosis Nontuberculous Mycobacterial Infections Mycobacterium Marinum Infection Mycobacterium Ulcerans Infection Mycobacterium Fortuitum Complex Infections Lyme Disease

SECTION 26 FUNGAL INFECTIONS OF THE SKIN, HAIR, AND NAILS

Introduction Superficial Fungal Infections Candidiasis Cutaneous Candidiasis Oropharyngeal Candidiasis Genital Candidiasis Chronic Mucocutaneous Candidiasis Disseminated Candidiasis Tinea Versicolor Trichosporon Infections Tinea Nigra Dermatophytoses Tinea Pedis Tinea Manuum Tinea Cruris Tinea Corporis Tinea Facialis Tinea Incognito Dermatophytoses of Hair Tinea Capitis Tinea Barbae Majocchi granuloma Invasive and Disseminated Fungal Infections

SECTION 27 VIRAL DISEASES OF SKIN AND MUCOSA

Introduction Poxvirus Diseases Molluscum Contagiosum Human Orf Milkers’ Nodules Smallpox Smallpox Vaccination Human Papillomavirus Infections Human Papillomavirus: Cutaneous Diseases Systemic Viral Infections with Exanthems Rubella Measles Enteroviral Infections Hand-Foot-and-Mouth Disease Herpangina Erythema Infectiosum Gianotti–Crosti Syndrome Dengue Herpes Simplex Virus Disease Nongenital Herpes Simplex Neonatal Herpes Simplex Eczema Herpeticum Herpes Simplex with Host Defense Defects Varicella Zoster Virus Disease VZV: Varicella VZV: Herpes Zoster VZV: Host Defense Defects Human Herpesvirus-6 and -7 Disease Human Immunodeficiency Virus Disease Acute HIV Syndrome Eosinophilc Folliculitis Papular Pruritic Eruption of HIV Photosensitivity in HIV Disease Oral Hairy Leukoplakia Adverse Cutaneous Drug Eruptions in HIV Disease Variations in Common Mucocutaneous Disorders in HIV Disease

SECTION 28 ARTHROPOD BITES, STINGS, AND CUTANEOUS INFECTIONS

Cutaneous Reactions to Arthropod Bites Pediculosis Capitis Pediculosis Corporis Pediculosis Pubis Demodicidosis Scabies Cutaneous Larva Migrans Water-Associated Diseases Schistosome Cercarial Dermatitis Seabather’s Eruption Cnidaria Envenomations

SECTION 29 SYSTEMIC PARASITIC INFECTIONS

Leishmaniasis Human American Trypanosomiasis Human African Trypanosomiasis Cutaneous Amebiasis Cutaneous Acanthamebiasis

SECTION 30 SEXUALLY TRANSMITTED DISEASES

Human Papillomavirus: Anogenital Infections Genital Warts HPV: Squamous Cell Carcinoma in Situ (SCCIS) and Invasive SCC of Anogenital Skin Herpes Simplex Virus: Genital Disease Neisseria Gonorrhoeae Disease Neisseria Gonorrhoeae: Gonorrhea Syphilis Primary Syphilis Secondary Syphilis Latent Syphilis Tertiary/Late Syphilis Congenital Syphilis Lymphogranuloma Venereum Chancroid Donovanosis PART IV SKIN SIGNS OF HAIR, NAIL, AND MUCOSAL DISORDERS

SECTION 31 DISORDERS OF HAIR FOLLICLES AND RELATED DISORDERS

Biology of Hair Growth Cycles Hair Loss: Alopecia Pattern Hair Loss Alopecia Areata Telogen Effuvium Anagen Effuvium Cicatricial or Scarring Alopecia Excess Hair Growth Hirsutism Hypertrichosis Infectious Folliculitis

SECTION 32 DISORDERS OF THE NAIL APPARATUS

Normal Nail Apparatus Components of the Normal Nail Apparatus Local Disorders of Nail Apparatus Chronic Paronychia Onycholysis Green Nail Syndrome Onychauxis and Onychogryphosis Psychiatric Disorders Nail Apparatus Involvement of Cutaneous Diseases Psoriasis Lichen Planus (LP) Alopecia Areata (AA) Darier Disease (Darier–White Disease, Keratosis Follicularis) Chemical Irritant or Allergic Damage or Dermatitis Neoplasms of the Nail Apparatus Myxoid Cysts of Digits Longitudinal Melanonychia Nail Matrix Nevi Acrolentiginous Melanoma (ALM) Squamous Cell Carcinoma Infections of the Nail Apparatus Acute Paronychia Felon Candida Onychia Tinea Unguium/Onychomycosis Nail Signs of Multisystem Diseases Transverse or Beau Lines Leukonychia Yellow Nail Syndrome Periungual Fibroma Splinter hemorrhages Nail Fold/Periungual Erythema and Telangiectasia Koilonychia Clubbed Nails Drug-Induced Nail Changes

SECTION 33 DISORDERS OF THE MOUTH

Diseases of the Lips Angular Cheilitis (Perlèche) Actinic Cheilitis Conditions of the Tongue, Palate, and Mandible Fissured Tongue Black or White Hairy Tongue Oral Hairy Leukoplakia Migratory Glossitis Palate and Mandibular Torus Diseases of the Gingiva, Periodontium, and Mucous Membranes Gingivitis and Periodontitis Lichen Planus Acute Necrotizing Ulcerative Gingivitis Gingival Hyperplasia Aphthous ulceration Leukoplakia Erythematous Lesions and/or Leukoplakia Premalignant and Malignant Neoplasms Dysplasia and Squamous Cell Carcinoma In Situ (SCCIS) Oral Invasive Squamous Cell Carcinoma Oral Verrucous Carcinoma Oropharyngeal Melanoma Submucosal Nodules Mucocele Irritation Fibroma Cutaneous Odontogenic (Dental) Abscess Cutaneous Disorders Involving the Mouth Pemphigus Vulgaris (PV) Paraneoplastic Pemphigus Bullous Pemphigoid Cicatricial Pemphigoid Systemic Diseases Involving the Mouth Lupus Erythematosus Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

SECTION 34 DISORDERS OF THE GENITALIA, PERINEUM, AND ANUS

Pearly Penile Papules Sebaceous Gland Prominence Angiokeratoma Sclerosing Lymphangitis of Penis Lymphedema of the Genitalia Plasma Cell Balanitis and Vulvitis Phimosis, Paraphimosis, Balanitis Xerotica Obliterans Mucocutaneous Disorders Genital (Penile/Vulvar/Anal) Lentiginoses Vitiligo and Leukoderma Psoriasis Vulgaris Lichen Planus Lichen Nitidus Lichen Sclerosus Migratory Necrolytic Erythema Genital Aphthous Ulcerations Eczematous Dermatitis Allergic Contact Dermatitis Atopic Dermatitis, Lichen Simplex Chronicus, Pruritus Ani Fixed Drug Eruption Premalignant and Malignant Lesions Squamous Cell Carcinoma in Situ HPV-Induced Intraepithelial Neoplasia (IN) and Squamous Cell Carcinoma In Situ Invasive Anogenital Squamous Cell Carcinoma Invasive SCC of Penis Invasive SCC of Vulva Invasive SCC of Cutaneous Anus Genital Verrucous Carcinoma Malignant Melanoma of the Anogenital Region Extramammary Paget Disease Kaposi Sarcoma Anogenital Infections

SECTION 35 GENERALIZED PRURITUS WITHOUT SKIN LESIONS (PRURITUS SINE MATERIA) APPENDICES APPENDIX A: Differential Diagnosis of Pigmented Lesions APPENDIX B: Drug use in Pregnancy APPENDIX C: Invasive and Disseminated Fungal Infections

Subcutaneous Mycoses Sporotrichosis Phaeohyphomycoses Systemic Fungal Infections With Dissemination to Skin Cryptococcosis Histoplasmosis Blastomycosis Coccidioidomycosis Penicilliosis

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