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Cover
Frontmatter
1. The Machinery of Selenoprotein Biosynthesis
Part Frontmatter
1. Selenocysteine tRNA[Ser]Sec: From Nonsense Suppressor tRNA to the Quintessential Constituent in Selenoprotein Biosynthesis
2. Eukaryotic Mechanisms of Selenocysteine Incorporation and Its Reconstitution In Vitro
3. Probing Selenoprotein Translation by Ribosome Profiling
4. Pathways in De Novo Biosynthesis of Selenocysteine and Cysteine in Eukaryotes
5. Prokaryotic Selenoprotein Biosynthesis and Function
6. The Role of Selenium in Human Evolution
7. The Chemistry of Selenocysteine in Proteins
8. Evolution of Selenophosphate Synthetase
9. Structure and Mechanism of Selenocysteine Synthases
10. Mechanism, Structure, and Biological Role of Selenocysteine Lyase
2. Selenoproteins, Their Occurrence and Function
Part Frontmatter
11. Eukaryotic Selenoproteomes
12. Prokaryotic Selenoproteins and Selenoproteomes
13. Functional Genomics of Selenoproteins and Se-responsive Pathways
14. Selenium Regulation of the Selenoprotein and Non-selenoprotein Transcriptomes in a Variety of Species
15. 77Se NMR Spectroscopy of Selenoproteins
16. Thioredoxin Reductase 1 as an Anticancer Drug Target
17. Basics and News on Glutathione Peroxidases
18. Glutathione Peroxidase 4
19. The 15 kDa Selenoprotein: Insights into Its Regulation and Function
20. Selenoprotein K and Protein Palmitoylation in Regulating Immune Cell Functions
21. Selenoprotein M: Structure, Expression and Functional Relevance
22. Selenoprotein P and Selenium Distribution in Mammals
23. Selenoprotein T: From Discovery to Functional Studies Using Conditional Knockout Mice
24. Biochemistry and Function of Methionine Sulfoxide Reductase
3. Dietary Selenium and Its Impact on Human Health
Part Frontmatter
25. Selenium: Dietary Sources, Human Nutritional Requirements and Intake Across Populations
26. Human Clinical Trials Involving Selenium
27. Status of Dietary Selenium in Cancer Prevention
28. Selenium in HIV/AIDS
29. Genetic Variations in the Genes for Selenoproteins Implicate the Encoded Proteins in Cancer Etiology
30. Is Adequate Selenium Important for Healthy Human Pregnancy?
31. The Epidemiology of Selenium and Human Health
32. Sex-Specific Differences in Biological Effects and Metabolism of Selenium
33. Selenium and Endocrine Tissues
34. Selenium Antagonism with Mercury and Arsenic: From Chemistry to Population Health and Demography
35. Biological Selenium Species and Selenium Speciation in Biological Samples
4. Selenoproteins in Human Health
Part Frontmatter
36. Selenoproteins in Nervous System Development, Function and Degeneration
37. Interplay of Selenoproteins and Different Antioxidant Systems in Various Cancers
38. Glutathione Peroxidase 2, a Selenoprotein Exhibiting a Dual Personality in Preventing and Promoting Cancer
39. Selenoproteins in Cardiovascular Redox Pathology
40. What Do We Know About Selenium Contributions to Muscle Physiology?
41. Tissue-Specific Regulation of Thyroid Status by Selenodeiodinases
42. The Role of Selenoproteins in Resolution of Inflammation
43. Glutathione Peroxidase 4 and Ferroptosis
44. Mutations in Humans That Adversely Affect the Selenoprotein Synthesis Pathway
45. Alteration of Selenoprotein Expression During Stress and in Aging
5. Biological Models for Elucidating the Role of Selenium and Selenoproteins in Biology and Medicine
Part Frontmatter
46. Selenocysteine tRNA[Ser]Sec Mouse Models for Elucidating Roles of Selenoproteins in Health and Development
47. Mouse Models that Target Individual Selenoproteins
48. The Naked Mole Rat and Selenium
49. Glutathione Peroxidase 1: Models for Diabetes and Obesity
50. Selenium in Livestock and Other Domestic Animals
Backmatter
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